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Items: 19


Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.

Jongen JMJ, van der Waals LM, Trumpi K, Laoukili J, Peters NA, Schenning-van Schelven SJ, Govaert KM, Borel Rinkes IHM, Kranenburg O.

Oncotarget. 2017 Sep 21;8(49):86296-86311. doi: 10.18632/oncotarget.21145. eCollection 2017 Oct 17.


Surgery-induced tumor growth in (metastatic) colorectal cancer.

Govaert KM, Jongen JMJ, Kranenburg O, Borel Rinkes IHM.

Surg Oncol. 2017 Dec;26(4):535-543. doi: 10.1016/j.suronc.2017.10.004. Epub 2017 Oct 17. Review.


Neoadjuvant chemotherapy affects molecular classification of colorectal tumors.

Trumpi K, Ubink I, Trinh A, Djafarihamedani M, Jongen JM, Govaert KM, Elias SG, van Hooff SR, Medema JP, Lacle MM, Vermeulen L, Borel Rinkes IHM, Kranenburg O.

Oncogenesis. 2017 Jul 10;6(7):e357. doi: 10.1038/oncsis.2017.48.


Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.

Matondo RB, Toussaint MJ, Govaert KM, van Vuuren LD, Nantasanti S, Nijkamp MW, Pandit SK, Tooten PC, Koster MH, Holleman K, Schot A, Gu G, Spee B, Roskams T, Rinkes IB, Schotanus B, Kranenburg O, de Bruin A.

Oncotarget. 2016 Aug 23;7(34):54662-54675. doi: 10.18632/oncotarget.9952.


Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells.

Fatrai S, van Schelven SJ, Ubink I, Govaert KM, Raats D, Koster J, Verheem A, Borel Rinkes IH, Kranenburg O.

Gastroenterology. 2015 Sep;149(3):692-704. doi: 10.1053/j.gastro.2015.05.003. Epub 2015 May 9.


Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response.

Houthuijzen JM, Daenen LG, Roodhart JM, Oosterom I, van Jaarsveld MT, Govaert KM, Smith ME, Sadatmand SJ, Rosing H, Kruse F, Helms BJ, van Rooijen N, Beijnen JH, Haribabu B, van de Lest CH, Voest EE.

Nat Commun. 2014 Nov 12;5:5275. doi: 10.1038/ncomms6275.


GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer.

Emmink BL, Laoukili J, Kipp AP, Koster J, Govaert KM, Fatrai S, Verheem A, Steller EJ, Brigelius-Flohé R, Jimenez CR, Borel Rinkes IH, Kranenburg O.

Cancer Res. 2014 Nov 15;74(22):6717-30. doi: 10.1158/0008-5472.CAN-14-1645. Epub 2014 Sep 26.


Multipolar radiofrequency ablation for colorectal liver metastases close to major hepatic vessels.

Snoeren N, Nijkamp MW, Berendsen T, Govaert KM, van Kessel CS, Borel Rinkes IH, van Hillegersberg R.

Surgeon. 2015 Apr;13(2):77-82. doi: 10.1016/j.surge.2013.11.013. Epub 2014 Jan 31.


Recurrence location after resection of colorectal liver metastases influences prognosis.

Govaert KM, van Kessel CS, Steller EJ, Emmink BL, Molenaar IQ, Kranenburg O, van Hillegersberg R, Borel Rinkes IH.

J Gastrointest Surg. 2014 May;18(5):952-60. doi: 10.1007/s11605-014-2461-0. Epub 2014 Jan 29.


Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells.

Govaert KM, Emmink BL, Nijkamp MW, Cheung ZJ, Steller EJ, Fatrai S, de Bruijn MT, Kranenburg O, Borel Rinkes IH.

Ann Surg. 2014 Apr;259(4):750-9. doi: 10.1097/SLA.0b013e318295c160.


The secretome of colon cancer stem cells contains drug-metabolizing enzymes.

Emmink BL, Verheem A, Van Houdt WJ, Steller EJ, Govaert KM, Pham TV, Piersma SR, Borel Rinkes IH, Jimenez CR, Kranenburg O.

J Proteomics. 2013 Oct 8;91:84-96. doi: 10.1016/j.jprot.2013.06.027. Epub 2013 Jul 5.


PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells.

Steller EJ, Raats DA, Koster J, Rutten B, Govaert KM, Emmink BL, Snoeren N, van Hooff SR, Holstege FC, Maas C, Borel Rinkes IH, Kranenburg O.

Neoplasia. 2013 Feb;15(2):204-17.


Does Radiofrequency Ablation Add to Chemotherapy for Unresectable Liver Metastases?

Govaert KM, van Kessel CS, Lolkema M, Ruers TJ, Borel Rinkes IH.

Curr Colorectal Cancer Rep. 2012 Jun;8(2):130-137. Epub 2012 Mar 17.


Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation.

Govaert KM, Nijkamp MW, Emmink BL, Steller EJ, Minchinton AI, Kranenburg O, Borel Rinkes IH.

Br J Surg. 2012 Apr;99(4):567-75. doi: 10.1002/bjs.8668. Epub 2012 Feb 13.


The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion.

Steller EJ, Ritsma L, Raats DA, Hoogwater FJ, Emmink BL, Govaert KM, Laoukili J, Rinkes IH, van Rheenen J, Kranenburg O.

EMBO Rep. 2011 Sep 1;12(9):931-7. doi: 10.1038/embor.2011.129.


A role for CD95 signaling in ischemia/reperfusion-induced invasion and outgrowth of colorectal micrometastases in mouse liver.

Nijkamp MW, Hoogwater FJ, Govaert KM, Steller EJ, Verheem A, Kranenburg O, Borel Rinkes IH.

J Surg Oncol. 2011 Aug 1;104(2):198-204. doi: 10.1002/jso.21915. Epub 2011 Mar 24.


Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.

Emmink BL, Van Houdt WJ, Vries RG, Hoogwater FJ, Govaert KM, Verheem A, Nijkamp MW, Steller EJ, Jimenez CR, Clevers H, Borel Rinkes IH, Kranenburg O.

Gastroenterology. 2011 Jul;141(1):269-78. doi: 10.1053/j.gastro.2011.03.052. Epub 2011 Apr 1.


Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia.

See F, Seki T, Psaltis PJ, Sondermeijer HP, Gronthos S, Zannettino AC, Govaert KM, Schuster MD, Kurlansky PA, Kelly DJ, Krum H, Itescu S.

J Cell Mol Med. 2011 Oct;15(10):2117-29. doi: 10.1111/j.1582-4934.2010.01241.x.


Radiofrequency ablation of colorectal liver metastases induces an inflammatory response in distant hepatic metastases but not in local accelerated outgrowth.

Nijkamp MW, Borren A, Govaert KM, Hoogwater FJ, Molenaar IQ, van Diest PJ, Kranenburg O, Borel Rinkes IH.

J Surg Oncol. 2010 Jun 1;101(7):551-6. doi: 10.1002/jso.21570.


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