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Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury.

de Jong IEM, Matton APM, van Praagh JB, van Haaften WT, Wiersema-Buist J, van Wijk LA, Oosterhuis D, Iswandana R, Suriguga S, Overi D, Lisman T, Carpino G, Gouw ASH, Olinga P, Gaudio E, Porte RJ.

Hepatology. 2018 Dec 2. doi: 10.1002/hep.30365. [Epub ahead of print]


Biliary Bicarbonate, pH and Glucose Are Suitable Biomarkers of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers.

Matton APM, de Vries Y, Burlage LC, van Rijn R, Fujiyoshi M, de Meijer VE, de Boer MT, de Kleine RHJ, Verkade HJ, Gouw ASH, Lisman T, Porte RJ.

Transplantation. 2018 Nov 1. doi: 10.1097/TP.0000000000002500. [Epub ahead of print]


Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.

Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND.

Alzheimers Res Ther. 2018 Oct 12;10(1):107. doi: 10.1186/s13195-018-0431-6.


Clinical correlates of quantitative EEG in Parkinson disease: A systematic review.

Geraedts VJ, Boon LI, Marinus J, Gouw AA, van Hilten JJ, Stam CJ, Tannemaat MR, Contarino MF.

Neurology. 2018 Nov 6;91(19):871-883. doi: 10.1212/WNL.0000000000006473. Epub 2018 Oct 5. Review.


EEG Characteristics of Dementia With Lewy Bodies, Alzheimer's Disease and Mixed Pathology.

van der Zande JJ, Gouw AA, van Steenoven I, Scheltens P, Stam CJ, Lemstra AW.

Front Aging Neurosci. 2018 Jul 3;10:190. doi: 10.3389/fnagi.2018.00190. eCollection 2018.


Practical guidelines for clinical magnetoencephalography - Another step towards best practice.

Hillebrand A, Gaetz W, Furlong PL, Gouw AA, Stam CJ.

Clin Neurophysiol. 2018 Aug;129(8):1709-1711. doi: 10.1016/j.clinph.2018.05.007. Epub 2018 Jun 2. No abstract available.


Quantitative EEG reflects non-dopaminergic disease severity in Parkinson's disease.

Geraedts VJ, Marinus J, Gouw AA, Mosch A, Stam CJ, van Hilten JJ, Contarino MF, Tannemaat MR.

Clin Neurophysiol. 2018 Aug;129(8):1748-1755. doi: 10.1016/j.clinph.2018.04.752. Epub 2018 May 29.


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A.

Oncogene. 2018 Oct;37(40):5435-5450. doi: 10.1038/s41388-018-0315-z. Epub 2018 Jun 5.


Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk.

Van Someren EJW, Oosterman JM, Van Harten B, Vogels RL, Gouw AA, Weinstein HC, Poggesi A, Scheltens P, Scherder EJA.

Neurobiol Learn Mem. 2018 Jun 1. pii: S1074-7427(18)30128-X. doi: 10.1016/j.nlm.2018.05.017. [Epub ahead of print]


An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease.

Scheltens P, Prins N, Lammertsma A, Yaqub M, Gouw A, Wink AM, Chu HM, van Berckel BNM, Alam J.

Ann Clin Transl Neurol. 2018 Mar 6;5(4):464-473. doi: 10.1002/acn3.549. eCollection 2018 Apr.


Engaging a Community for Rare Genetic Disease: Best Practices and Education From Individual Crowdfunding Campaigns.

Ortiz RA, Witte S, Gouw A, Sanfilippo A, Tsai R, Fumagalli D, Yu C, Lant K, Lipitz N, Shepphird J, Alvina FB, Cheng-Ho Lin J.

Interact J Med Res. 2018 Feb 5;7(1):e3. doi: 10.2196/ijmr.7176.


Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers.

van Rijn R, van Leeuwen OB, Matton APM, Burlage LC, Wiersema-Buist J, van den Heuvel MC, de Kleine RHJ, de Boer MT, Gouw ASH, Porte RJ.

Liver Transpl. 2018 May;24(5):655-664. doi: 10.1002/lt.25023. Epub 2018 Apr 6.


cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

Brunt E, Aishima S, Clavien PA, Fowler K, Goodman Z, Gores G, Gouw A, Kagen A, Klimstra D, Komuta M, Kondo F, Miksad R, Nakano M, Nakanuma Y, Ng I, Paradis V, Nyun Park Y, Quaglia A, Roncalli M, Roskams T, Sakamoto M, Saxena R, Sempoux C, Sirlin C, Stueck A, Thung S, Tsui WMS, Wang XW, Wee A, Yano H, Yeh M, Zen Y, Zucman-Rossi J, Theise N.

Hepatology. 2018 Jul;68(1):113-126. doi: 10.1002/hep.29789. Epub 2018 May 9.


Normothermic machine perfusion of donor livers without the need for human blood products.

Matton APM, Burlage LC, van Rijn R, de Vries Y, Karangwa SA, Nijsten MW, Gouw ASH, Wiersema-Buist J, Adelmeijer J, Westerkamp AC, Lisman T, Porte RJ.

Liver Transpl. 2018 Apr;24(4):528-538. doi: 10.1002/lt.25005. Erratum in: Liver Transpl. 2018 Aug;24(8):1151.


Gray matter network measures are associated with cognitive decline in mild cognitive impairment.

Dicks E, Tijms BM, Ten Kate M, Gouw AA, Benedictus MR, Teunissen CE, Barkhof F, Scheltens P, van der Flier WM.

Neurobiol Aging. 2018 Jan;61:198-206. doi: 10.1016/j.neurobiolaging.2017.09.029. Epub 2017 Oct 6.


Gray matter networks and clinical progression in subjects with predementia Alzheimer's disease.

Tijms BM, Ten Kate M, Gouw AA, Borta A, Verfaillie S, Teunissen CE, Scheltens P, Barkhof F, van der Flier WM.

Neurobiol Aging. 2018 Jan;61:75-81. doi: 10.1016/j.neurobiolaging.2017.09.011. Epub 2017 Sep 20.


Neural network topology in ADHD; evidence for maturational delay and default-mode network alterations.

Janssen TWP, Hillebrand A, Gouw A, Geladé K, Van Mourik R, Maras A, Oosterlaan J.

Clin Neurophysiol. 2017 Nov;128(11):2258-2267. doi: 10.1016/j.clinph.2017.09.004. Epub 2017 Sep 23.


Do travel clinic visitors read information on sexual risk abroad in travel health brochures?

Croughs M, de Gouw A, Remmen R, Van den Ende J.

J Infect Prev. 2017 Jan;18(1):18-22. doi: 10.1177/1757177416661405. Epub 2016 Sep 26.


Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease.

de Haan W, van Straaten ECW, Gouw AA, Stam CJ.

PLoS Comput Biol. 2017 Sep 22;13(9):e1005707. doi: 10.1371/journal.pcbi.1005707. eCollection 2017 Sep.


Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs.

Demuru M, Gouw AA, Hillebrand A, Stam CJ, van Dijk BW, Scheltens P, Tijms BM, Konijnenberg E, Ten Kate M, den Braber A, Smit DJA, Boomsma DI, Visser PJ.

Sci Rep. 2017 Aug 29;7(1):9685. doi: 10.1038/s41598-017-10235-y.


Repopulating the biliary tree from the peribiliary glands.

de Jong IEM, van Leeuwen OB, Lisman T, Gouw ASH, Porte RJ.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1524-1531. doi: 10.1016/j.bbadis.2017.07.037. Epub 2017 Aug 2. Review.


Directional information flow in patients with Alzheimer's disease. A source-space resting-state MEG study.

Engels MMA, Yu M, Stam CJ, Gouw AA, van der Flier WM, Scheltens P, van Straaten ECW, Hillebrand A.

Neuroimage Clin. 2017 Jun 17;15:673-681. doi: 10.1016/j.nicl.2017.06.025. eCollection 2017.


EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects.

Gouw AA, Alsema AM, Tijms BM, Borta A, Scheltens P, Stam CJ, van der Flier WM.

Neurobiol Aging. 2017 Sep;57:133-142. doi: 10.1016/j.neurobiolaging.2017.05.017. Epub 2017 Jun 1.


Unique clinical conditions associated with different acinar regions of fibrosis in long-term surviving pediatric liver grafts.

Baas M, Gouw ASH, van den Heuvel MC, Hepkema BG, Peeters PMGJ, Verkade H, Scheenstra R.

Pediatr Transplant. 2017 Nov;21(7). doi: 10.1111/petr.12988. Epub 2017 Jun 18.


Horizontal visibility graph transfer entropy (HVG-TE): A novel metric to characterize directed connectivity in large-scale brain networks.

Yu M, Hillebrand A, Gouw AA, Stam CJ.

Neuroimage. 2017 Aug 1;156:249-264. doi: 10.1016/j.neuroimage.2017.05.047. Epub 2017 May 21.


Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.

Gouw AM, Eberlin LS, Margulis K, Sullivan DK, Toal GG, Tong L, Zare RN, Felsher DW.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4300-4305. doi: 10.1073/pnas.1617709114. Epub 2017 Apr 11.


Oxygenated hypothermic machine perfusion after static cold storage improves endothelial function of extended criteria donor livers.

Burlage LC, Karimian N, Westerkamp AC, Visser N, Matton APM, van Rijn R, Adelmeijer J, Wiersema-Buist J, Gouw ASH, Lisman T, Porte RJ.

HPB (Oxford). 2017 Jun;19(6):538-546. doi: 10.1016/j.hpb.2017.02.439. Epub 2017 Mar 25.


Selective impairment of hippocampus and posterior hub areas in Alzheimer's disease: an MEG-based multiplex network study.

Yu M, Engels MMA, Hillebrand A, van Straaten ECW, Gouw AA, Teunissen C, van der Flier WM, Scheltens P, Stam CJ.

Brain. 2017 May 1;140(5):1466-1485. doi: 10.1093/brain/awx050.


Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα.

Altman BJ, Hsieh AL, Gouw AM, Dang CV.

Nat Commun. 2017 Mar 23;8:14862. doi: 10.1038/ncomms14862. No abstract available.


Low normal cerebrospinal fluid Aβ42 levels predict clinical progression in nondemented subjects.

Tijms BM, Bertens D, Slot RE, Gouw AA, Teunissen CE, Scheltens P, van der Flier WM, Visser PJ.

Ann Neurol. 2017 May;81(5):749-753. doi: 10.1002/ana.24921. Epub 2017 May 4.


Somatic and neuritic spines on tyrosine hydroxylase-immunopositive cells of rat retina.

Fasoli A, Dang J, Johnson JS, Gouw AH, Fogli Iseppe A, Ishida AT.

J Comp Neurol. 2017 May 1;525(7):1707-1730. doi: 10.1002/cne.24166. Epub 2017 Feb 13.


Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis.

Gouw AM, Efe G, Barakat R, Preecha A, Mehdizadeh M, Garan SA, Brooks GA.

Physiol Genomics. 2017 Feb 1;49(2):88-95. doi: 10.1152/physiolgenomics.00073.2016. Epub 2016 Dec 23. Review.


Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study.

de Vries EM, de Krijger M, Färkkilä M, Arola J, Schirmacher P, Gotthardt D, Goeppert B, Trivedi PJ, Hirschfield GM, Ytting H, Vainer B, Buuren HR, Biermann K, Harms MH, Chazouilleres O, Wendum D, Kemgang AD, Chapman RW, Wang LM, Williamson KD, Gouw AS, Paradis V, Sempoux C, Beuers U, Hübscher SG, Verheij J, Ponsioen CY.

Hepatology. 2017 Mar;65(3):907-919. doi: 10.1002/hep.28963. Epub 2017 Jan 11.


White Matter Changes and Cognitive Decline in a Ten-Year Follow-Up Period: A Pilot Study on a Single-Center Cohort from the Leukoaraiosis and Disability Study.

Madureira S, Verdelho A, Moleiro C, Santos C, Scheltens P, Gouw A, Ferro J.

Dement Geriatr Cogn Disord. 2016;41(5-6):303-13. doi: 10.1159/000447121. Epub 2016 Jul 6.


2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection.

Demetris AJ, Bellamy C, Hübscher SG, O'Leary J, Randhawa PS, Feng S, Neil D, Colvin RB, McCaughan G, Fung JJ, Del Bello A, Reinholt FP, Haga H, Adeyi O, Czaja AJ, Schiano T, Fiel MI, Smith ML, Sebagh M, Tanigawa RY, Yilmaz F, Alexander G, Baiocchi L, Balasubramanian M, Batal I, Bhan AK, Bucuvalas J, Cerski CTS, Charlotte F, de Vera ME, ElMonayeri M, Fontes P, Furth EE, Gouw ASH, Hafezi-Bakhtiari S, Hart J, Honsova E, Ismail W, Itoh T, Jhala NC, Khettry U, Klintmalm GB, Knechtle S, Koshiba T, Kozlowski T, Lassman CR, Lerut J, Levitsky J, Licini L, Liotta R, Mazariegos G, Minervini MI, Misdraji J, Mohanakumar T, Mölne J, Nasser I, Neuberger J, O'Neil M, Pappo O, Petrovic L, Ruiz P, Sağol Ö, Sanchez Fueyo A, Sasatomi E, Shaked A, Shiller M, Shimizu T, Sis B, Sonzogni A, Stevenson HL, Thung SN, Tisone G, Tsamandas AC, Wernerson A, Wu T, Zeevi A, Zen Y.

Am J Transplant. 2016 Oct;16(10):2816-2835. doi: 10.1111/ajt.13909. Epub 2016 Jul 14.


Different functional connectivity and network topology in behavioral variant of frontotemporal dementia and Alzheimer's disease: an EEG study.

Yu M, Gouw AA, Hillebrand A, Tijms BM, Stam CJ, van Straaten EC, Pijnenburg YA.

Neurobiol Aging. 2016 Jun;42:150-62. doi: 10.1016/j.neurobiolaging.2016.03.018. Epub 2016 Mar 22.


EEG-directed connectivity from posterior brain regions is decreased in dementia with Lewy bodies: a comparison with Alzheimer's disease and controls.

Dauwan M, van Dellen E, van Boxtel L, van Straaten ECW, de Waal H, Lemstra AW, Gouw AA, van der Flier WM, Scheltens P, Sommer IE, Stam CJ.

Neurobiol Aging. 2016 May;41:122-129. doi: 10.1016/j.neurobiolaging.2016.02.017. Epub 2016 Feb 21.


Intraoperative frozen section analysis of the proximal bile ducts in hilar cholangiocarcinoma is of limited value.

Mantel HT, Westerkamp AC, Sieders E, Peeters PM, de Jong KP, Boer MT, de Kleine RH, Gouw AS, Porte RJ.

Cancer Med. 2016 Jul;5(7):1373-80. doi: 10.1002/cam4.693. Epub 2016 Apr 6.


Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR Jr; Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclinical State of AD”; July 23, 2015; Washington DC, USA.

Alzheimers Dement. 2016 Mar;12(3):292-323. doi: 10.1016/j.jalz.2016.02.002. Review.


Direction of information flow in large-scale resting-state networks is frequency-dependent.

Hillebrand A, Tewarie P, van Dellen E, Yu M, Carbo EW, Douw L, Gouw AA, van Straaten EC, Stam CJ.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3867-72. doi: 10.1073/pnas.1515657113. Epub 2016 Mar 21.


MYC regulates the antitumor immune response through CD47 and PD-L1.

Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M, Felsher DW.

Science. 2016 Apr 8;352(6282):227-31. doi: 10.1126/science.aac9935. Epub 2016 Mar 10. Erratum in: Science. 2016 Apr 8;352(6282). pii: aaf7984. doi: 10.1126/science.aaf7984.


Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers.

Westerkamp AC, Karimian N, Matton AP, Mahboub P, van Rijn R, Wiersema-Buist J, de Boer MT, Leuvenink HG, Gouw AS, Lisman T, Porte RJ.

Transplantation. 2016 Apr;100(4):825-35. doi: 10.1097/TP.0000000000001081.


Metabolic vulnerabilities of MYC-induced cancer.

Gouw AM, Toal GG, Felsher DW.

Oncotarget. 2016 May 24;7(21):29879-80. doi: 10.18632/oncotarget.7223. No abstract available.


Bile ductal injury and ductular reaction are frequent phenomena with different significance in autoimmune hepatitis.

Verdonk RC, Lozano MF, van den Berg AP, Gouw AS.

Liver Int. 2016 Sep;36(9):1362-9. doi: 10.1111/liv.13083. Epub 2016 Mar 14.


Crowdfunding for Personalized Medicine Research.

Fumagalli DC, Gouw AM.

Yale J Biol Med. 2015 Nov 24;88(4):413-4. eCollection 2015 Dec. Review.


MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.

Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.


Old dilemma: asthma with irreversible airway obstruction or COPD.

Fattahi F, Vonk JM, Bulkmans N, Fleischeuer R, Gouw A, Grünberg K, Mauad T, Popper H, Felipe-Silva A, Vrugt B, Wright JL, Yang HM, Kocks JW, Hylkema MN, Postma DS, Timens W, Ten Hacken NH.

Virchows Arch. 2015 Nov;467(5):583-93. doi: 10.1007/s00428-015-1824-6. Epub 2015 Sep 14.


A novel phenotype of a hepatocyte nuclear factor homeobox A (HNF1A) gene mutation, presenting with neonatal cholestasis.

de Vries AG, Bakker-van Waarde WM, Dassel AC, Losekoot M, Duiker EW, Gouw AS, Bodewes FA.

J Hepatol. 2015 Nov;63(5):1295-7. doi: 10.1016/j.jhep.2015.08.005. Epub 2015 Aug 22. No abstract available.


Lymph Node Micrometastases are Associated with Worse Survival in Patients with Otherwise Node-Negative Hilar Cholangiocarcinoma.

Mantel HT, Wiggers JK, Verheij J, Doff JJ, Sieders E, van Gulik TM, Gouw AS, Porte RJ.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1107-15. doi: 10.1245/s10434-015-4723-9. Epub 2015 Jul 16.


End-ischemic machine perfusion reduces bile duct injury in donation after circulatory death rat donor livers independent of the machine perfusion temperature.

Westerkamp AC, Mahboub P, Meyer SL, Hottenrott M, Ottens PJ, Wiersema-Buist J, Gouw AS, Lisman T, Leuvenink HG, Porte RJ.

Liver Transpl. 2015 Oct;21(10):1300-11. doi: 10.1002/lt.24200.

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