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Hepatitis E virus finds its path through the gut.

Oechslin N, Moradpour D, Gouttenoire J.

Gut. 2020 May;69(5):796-798. doi: 10.1136/gutjnl-2019-320206. Epub 2020 Jan 8. No abstract available.


Recombinant Hepatitis E Viruses Harboring Tags in the ORF1 Protein.

Szkolnicka D, Pollán A, Da Silva N, Oechslin N, Gouttenoire J, Moradpour D.

J Virol. 2019 Sep 12;93(19). pii: e00459-19. doi: 10.1128/JVI.00459-19. Print 2019 Oct 1.


Sofosbuvir add-on to ribavirin for chronic hepatitis E in a cirrhotic liver transplant recipient: a case report.

Fraga M, Gouttenoire J, Sahli R, Chtioui H, Marcu C, Pascual M, Moradpour D, Vionnet J.

BMC Gastroenterol. 2019 May 24;19(1):76. doi: 10.1186/s12876-019-0995-z.


Rabbit HEV in immunosuppressed patients with hepatitis E acquired in Switzerland.

Sahli R, Fraga M, Semela D, Moradpour D, Gouttenoire J.

J Hepatol. 2019 May;70(5):1023-1025. doi: 10.1016/j.jhep.2019.01.025. Epub 2019 Feb 22. No abstract available.


Glycogen Synthase Kinase 3β Enhances Hepatitis C Virus Replication by Supporting miR-122.

Saleh M, Rüschenbaum S, Welsch C, Zeuzem S, Moradpour D, Gouttenoire J, Lange CM.

Front Microbiol. 2018 Nov 27;9:2949. doi: 10.3389/fmicb.2018.02949. eCollection 2018.


Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion.

Gouttenoire J, Pollán A, Abrami L, Oechslin N, Mauron J, Matter M, Oppliger J, Szkolnicka D, Dao Thi VL, van der Goot FG, Moradpour D.

PLoS Pathog. 2018 Dec 10;14(12):e1007471. doi: 10.1371/journal.ppat.1007471. eCollection 2018 Dec.


Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs.

Saleh M, Welsch C, Cai C, Döring C, Gouttenoire J, Friedrich J, Haselow K, Sarrazin C, Badenhoop K, Moradpour D, Zeuzem S, Rueschenbaum S, Lange CM.

J Steroid Biochem Mol Biol. 2018 Oct;183:142-151. doi: 10.1016/j.jsbmb.2018.06.008. Epub 2018 Jun 7.


Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems.

Wu X, Dao Thi VL, Liu P, Takacs CN, Xiang K, Andrus L, Gouttenoire J, Moradpour D, Rice CM.

Gastroenterology. 2018 Feb;154(3):663-674.e7. doi: 10.1053/j.gastro.2017.10.041. Epub 2017 Dec 24.


Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication.

Farhat R, Ankavay M, Lebsir N, Gouttenoire J, Jackson CL, Wychowski C, Moradpour D, Dubuisson J, Rouillé Y, Cocquerel L.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12804. Epub 2017 Nov 17.


Akute und chronische Hepatitis E.

Fraga M, Gouttenoire J, Sahli R, Moradpour D.

Ther Umsch. 2017 Jul;74(3):109-113. doi: 10.1024/0040-5930/a000893. Review. German. No abstract available.


Visualization of hepatitis E virus RNA and proteins in the human liver.

Lenggenhager D, Gouttenoire J, Malehmir M, Bawohl M, Honcharova-Biletska H, Kreutzer S, Semela D, Neuweiler J, Hürlimann S, Aepli P, Fraga M, Sahli R, Terracciano L, Rubbia-Brandt L, Müllhaupt B, Sempoux C, Moradpour D, Weber A.

J Hepatol. 2017 Sep;67(3):471-479. doi: 10.1016/j.jhep.2017.04.002. Epub 2017 Apr 13.


[A murine model for an ignored chronic infection: hepatitis E !]

Gilgenkrantz H, Gouttenoire J, Mallet V.

Med Sci (Paris). 2016 Oct;32(10):812-814. Epub 2016 Oct 19. French. No abstract available.


Treatment of chronic hepatitis E with ribavirin: lessons from deep sequencing.

Gouttenoire J, Szkolnicka D, Moradpour D.

Gut. 2016 Oct;65(10):1583-4. doi: 10.1136/gutjnl-2016-312040. Epub 2016 Jun 22. No abstract available.


Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus.

Fogeron ML, Jirasko V, Penzel S, Paul D, Montserret R, Danis C, Lacabanne D, Badillo A, Gouttenoire J, Moradpour D, Bartenschlager R, Penin F, Meier BH, Böckmann A.

J Biomol NMR. 2016 Jun;65(2):87-98. doi: 10.1007/s10858-016-0040-2. Epub 2016 May 27.



Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D, Gouttenoire J.

Gastroenterology. 2016 Jun;150(7):1690-1691. doi: 10.1053/j.gastro.2016.04.036. Epub 2016 Apr 30. No abstract available.


Update on hepatitis E virology: Implications for clinical practice.

Debing Y, Moradpour D, Neyts J, Gouttenoire J.

J Hepatol. 2016 Jul;65(1):200-212. doi: 10.1016/j.jhep.2016.02.045. Epub 2016 Mar 8. Review.


A mouse model for hepatitis E virus infection.

Gouttenoire J, Moradpour D.

J Hepatol. 2016 May;64(5):1003-1005. doi: 10.1016/j.jhep.2016.02.015. Epub 2016 Feb 15. No abstract available.


Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin.

Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D, Gouttenoire J.

Gastroenterology. 2016 Jan;150(1):82-85.e4. doi: 10.1053/j.gastro.2015.09.011. Epub 2015 Sep 25.


Hepatitis C virus variants resistant to macrocyclic NS3-4A inhibitors subvert IFN-β induction by efficient MAVS cleavage.

Welsch C, Haselow K, Gouttenoire J, Schneider M, Morikawa K, Martinez Y, Susser S, Sarrazin C, Zeuzem S, Antes I, Moradpour D, Lange CM.

J Hepatol. 2015 Apr;62(4):779-84. doi: 10.1016/j.jhep.2014.11.009. Epub 2014 Nov 21.


Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.

Gouttenoire J, Montserret R, Paul D, Castillo R, Meister S, Bartenschlager R, Penin F, Moradpour D.

PLoS Pathog. 2014 Nov 13;10(10):e1004501. doi: 10.1371/journal.ppat.1004501. eCollection 2014 Oct.


Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins.

Fogeron ML, Badillo A, Jirasko V, Gouttenoire J, Paul D, Lancien L, Moradpour D, Bartenschlager R, Meier BH, Penin F, Böckmann A.

Protein Expr Purif. 2015 Jan;105:39-46. doi: 10.1016/j.pep.2014.10.003. Epub 2014 Oct 12.


GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.

Masin M, Vazquez J, Rossi S, Groeneveld S, Samson N, Schwalie PC, Deplancke B, Frawley LE, Gouttenoire J, Moradpour D, Oliver TG, Meylan E.

Cancer Metab. 2014 Jul 29;2:11. doi: 10.1186/2049-3002-2-11. eCollection 2014.


Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α.

Lange CM, Gouttenoire J, Duong FH, Morikawa K, Heim MH, Moradpour D.

J Immunol. 2014 Jun 15;192(12):6037-44. doi: 10.4049/jimmunol.1302296. Epub 2014 May 12.


NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.

Boukadida C, Marnata C, Montserret R, Cohen L, Blumen B, Gouttenoire J, Moradpour D, Penin F, Martin A.

J Virol. 2014 Jul;88(13):7426-44. doi: 10.1128/JVI.00656-14. Epub 2014 Apr 16.


Determinants for membrane association of the hepatitis C virus NS2 protease domain.

Lange CM, Bellecave P, Dao Thi VL, Tran HT, Penin F, Moradpour D, Gouttenoire J.

J Virol. 2014 Jun;88(11):6519-23. doi: 10.1128/JVI.00224-14. Epub 2014 Mar 19.


[An update on hepatitis E].

Hiroz P, Gouttenoire J, Dao Thi VL, Sahli R, Telenti A, Moradpour D, Doerig C.

Rev Med Suisse. 2013 Sep 4;9(396):1594, 1596-8. French.


Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.

Morikawa K, Gouttenoire J, Hernandez C, Dao Thi VL, Tran HT, Lange CM, Dill MT, Heim MH, Donzé O, Penin F, Quadroni M, Moradpour D.

Hepatology. 2014 Feb;59(2):423-33. doi: 10.1002/hep.26671. Epub 2013 Dec 18.


Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.

Lange CM, Miki D, Ochi H, Nischalke HD, Bojunga J, Bibert S, Morikawa K, Gouttenoire J, Cerny A, Dufour JF, Gorgievski-Hrisoho M, Heim MH, Malinverni R, Müllhaupt B, Negro F, Semela D, Kutalik Z, Müller T, Spengler U, Berg T, Chayama K, Moradpour D, Bochud PY; Hiroshima Liver Study Group; Swiss Hepatitis C Cohort Study Group.

PLoS One. 2013 May 29;8(5):e64053. doi: 10.1371/journal.pone.0064053. Print 2013.


Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V.

Hepatology. 2013 Mar;57(3):953-63. doi: 10.1002/hep.26260. Epub 2013 Feb 7.


NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.

Paul D, Romero-Brey I, Gouttenoire J, Stoitsova S, Krijnse-Locker J, Moradpour D, Bartenschlager R.

J Virol. 2011 Jul;85(14):6963-76. doi: 10.1128/JVI.00502-11. Epub 2011 May 4.


Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.

Morikawa K, Lange CM, Gouttenoire J, Meylan E, Brass V, Penin F, Moradpour D.

J Viral Hepat. 2011 May;18(5):305-15. doi: 10.1111/j.1365-2893.2011.01451.x. Epub 2011 Mar 23. Review.


Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.

Jirasko V, Montserret R, Lee JY, Gouttenoire J, Moradpour D, Penin F, Bartenschlager R.

PLoS Pathog. 2010 Dec 16;6(12):e1001233. doi: 10.1371/journal.ppat.1001233.


Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B.

Gouttenoire J, Roingeard P, Penin F, Moradpour D.

J Virol. 2010 Dec;84(24):12529-37. doi: 10.1128/JVI.01798-10. Epub 2010 Oct 6.


Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase.

Brass V, Gouttenoire J, Wahl A, Pal Z, Blum HE, Penin F, Moradpour D.

J Virol. 2010 Nov;84(21):11580-4. doi: 10.1128/JVI.01519-10. Epub 2010 Aug 25.


BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes.

Gouttenoire J, Bougault C, Aubert-Foucher E, Perrier E, Ronzière MC, Sandell L, Lundgren-Akerlund E, Mallein-Gerin F.

Eur J Cell Biol. 2010 Apr;89(4):307-14. doi: 10.1016/j.ejcb.2009.10.018. Epub 2010 Feb 2.


Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory.

Gouttenoire J, Penin F, Moradpour D.

Rev Med Virol. 2010 Mar;20(2):117-29. doi: 10.1002/rmv.640. Review.


Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system.

Bellecave P, Sarasin-Filipowicz M, Donzé O, Kennel A, Gouttenoire J, Meylan E, Terracciano L, Tschopp J, Sarrazin C, Berg T, Moradpour D, Heim MH.

Hepatology. 2010 Apr;51(4):1127-36. doi: 10.1002/hep.23426.


Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1 alpha-mediated glycolytic adaptation.

Ripoli M, D'Aprile A, Quarato G, Sarasin-Filipowicz M, Gouttenoire J, Scrima R, Cela O, Boffoli D, Heim MH, Moradpour D, Capitanio N, Piccoli C.

J Virol. 2010 Jan;84(1):647-60. doi: 10.1128/JVI.00769-09.


An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association.

Gouttenoire J, Montserret R, Kennel A, Penin F, Moradpour D.

J Virol. 2009 Nov;83(21):11378-84. doi: 10.1128/JVI.01122-09. Epub 2009 Aug 19.


Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B.

Gouttenoire J, Castet V, Montserret R, Arora N, Raussens V, Ruysschaert JM, Diesis E, Blum HE, Penin F, Moradpour D.

J Virol. 2009 Jun;83(12):6257-68. doi: 10.1128/JVI.02663-08. Epub 2009 Apr 8.


Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference.

Bellecave P, Gouttenoire J, Gajer M, Brass V, Koutsoudakis G, Blum HE, Bartenschlager R, Nassal M, Moradpour D.

Hepatology. 2009 Jul;50(1):46-55. doi: 10.1002/hep.22951.


Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish.

Gouttenoire J, Valcourt U, Bougault C, Aubert-Foucher E, Arnaud E, Giraud L, Mallein-Gerin F.

J Biol Chem. 2007 Oct 19;282(42):30960-73. Epub 2007 Aug 24.


Surprises from the crystal structure of the hepatitis C virus NS2-3 protease.

Gouttenoire J, Moradpour D, Penin F.

Hepatology. 2006 Dec;44(6):1690-3. No abstract available.


Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis.

Cortial D, Gouttenoire J, Rousseau CF, Ronzière MC, Piccardi N, Msika P, Herbage D, Mallein-Gerin F, Freyria AM.

Osteoarthritis Cartilage. 2006 Jul;14(7):631-40. Epub 2006 Mar 9.


Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes.

Ronzière MC, Aubert-Foucher E, Gouttenoire J, Bernaud J, Herbage D, Mallein-Gerin F.

Biochim Biophys Acta. 2005 Oct 30;1746(1):55-64. Epub 2005 Sep 7.


Modulation of collagen synthesis in normal and osteoarthritic cartilage.

Gouttenoire J, Valcourt U, Ronzière MC, Aubert-Foucher E, Mallein-Gerin F, Herbage D.

Biorheology. 2004;41(3-4):535-42. Review.


Gene expression analysis in cartilage by in situ hybridization.

Mallein-Gerin F, Gouttenoire J.

Methods Mol Med. 2004;100:105-8.


RNA extraction from cartilage.

Mallein-Gerin F, Gouttenoire J.

Methods Mol Med. 2004;100:101-4.


Alternative splicing of type II procollagen pre-mRNA in chondrocytes is oppositely regulated by BMP-2 and TGF-beta1.

Valcourt U, Gouttenoire J, Aubert-Foucher E, Herbage D, Mallein-Gerin F.

FEBS Lett. 2003 Jun 19;545(2-3):115-9.


Ascorbate modulation of bovine chondrocyte growth, matrix protein gene expression and synthesis in three-dimensional collagen sponges.

Ronzière MC, Roche S, Gouttenoire J, Démarteau O, Herbage D, Freyria AM.

Biomaterials. 2003 Feb;24(5):851-61.

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