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MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.

Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B Jr, Siveke JT, Rodriguez-Aznar E, Hermann PC.

Stem Cells Int. 2019 Jun 2;2019:8475389. doi: 10.1155/2019/8475389. eCollection 2019.


Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks.

Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO.

Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019.


Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms.

Fritsch C, Gout JP, Vermulst M.

J Vis Exp. 2018 Sep 13;(139). doi: 10.3791/57731.


Precision medicine meets the DNA damage response in pancreatic cancer.

Perkhofer L, Illing A, Gout J, Frappart PO, Kleger A.

Oncoscience. 2018 Feb 22;5(1-2):6-8. doi: 10.18632/oncoscience.392. eCollection 2018 Jan. No abstract available.


The landscape of transcription errors in eukaryotic cells.

Gout JF, Li W, Fritsch C, Li A, Haroon S, Singh L, Hua D, Fazelinia H, Smith Z, Seeholzer S, Thomas K, Lynch M, Vermulst M.

Sci Adv. 2017 Oct 20;3(10):e1701484. doi: 10.1126/sciadv.1701484. eCollection 2017 Oct.


Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.

Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L.

Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282. doi: 10.1016/j.jcmgh.2017.05.005. eCollection 2017 Sep.


Early stages of functional diversification in the Rab GTPase gene family revealed by genomic and localization studies in Paramecium species.

Bright LJ, Gout JF, Lynch M.

Mol Biol Cell. 2017 Apr 15;28(8):1101-1110. doi: 10.1091/mbc.E16-06-0361. Epub 2017 Mar 1.


Genetic drift, selection and the evolution of the mutation rate.

Lynch M, Ackerman MS, Gout JF, Long H, Sung W, Thomas WK, Foster PL.

Nat Rev Genet. 2016 Oct 14;17(11):704-714. doi: 10.1038/nrg.2016.104. Review.


Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution.

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D.

Oncotarget. 2016 May 31;7(22):32100-12. doi: 10.18632/oncotarget.8527.


TIF1γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability.

Pommier RM, Gout J, Vincent DF, Alcaraz LB, Chuvin N, Arfi V, Martel S, Kaniewski B, Devailly G, Fourel G, Bernard P, Moyret-Lalle C, Ansieau S, Puisieux A, Valcourt U, Sentis S, Bartholin L.

Cancer Res. 2015 Oct 15;75(20):4335-50. doi: 10.1158/0008-5472.CAN-14-3426. Epub 2015 Aug 17.


Maintenance and Loss of Duplicated Genes by Dosage Subfunctionalization.

Gout JF, Lynch M.

Mol Biol Evol. 2015 Aug;32(8):2141-8. doi: 10.1093/molbev/msv095. Epub 2015 Apr 22.


Asymmetric Context-Dependent Mutation Patterns Revealed through Mutation-Accumulation Experiments.

Sung W, Ackerman MS, Gout JF, Miller SF, Williams E, Foster PL, Lynch M.

Mol Biol Evol. 2015 Jul;32(7):1672-83. doi: 10.1093/molbev/msv055. Epub 2015 Mar 6.


The first water-soluble bowl complex: molecular recognition of acetate by the biomimetic tris(imidazole) Zn(II) system at pH 7.4.

Rat S, Gout J, Bistri O, Reinaud O.

Org Biomol Chem. 2015 Mar 21;13(11):3194-7. doi: 10.1039/c4ob02514h.


Differential retention and divergent resolution of duplicate genes following whole-genome duplication.

McGrath CL, Gout JF, Johri P, Doak TG, Lynch M.

Genome Res. 2014 Oct;24(10):1665-75. doi: 10.1101/gr.173740.114. Epub 2014 Aug 1.


Supramolecular control of a mononuclear biomimetic copper(II) center: bowl complexes vs funnel complexes.

Gout J, Višnjevac A, Rat S, Parrot A, Hessani A, Bistri O, Le Poul N, Le Mest Y, Reinaud O.

Inorg Chem. 2014 Jun 16;53(12):6224-34. doi: 10.1021/ic500740r. Epub 2014 Jun 5.


Insights into three whole-genome duplications gleaned from the Paramecium caudatum genome sequence.

McGrath CL, Gout JF, Doak TG, Yanagi A, Lynch M.

Genetics. 2014 Aug;197(4):1417-28. doi: 10.1534/genetics.114.163287. Epub 2014 May 19.


Genome-defence small RNAs exapted for epigenetic mating-type inheritance.

Singh DP, Saudemont B, Guglielmi G, Arnaiz O, Goût JF, Prajer M, Potekhin A, Przybòs E, Aubusson-Fleury A, Bhullar S, Bouhouche K, Lhuillier-Akakpo M, Tanty V, Blugeon C, Alberti A, Labadie K, Aury JM, Sperling L, Duharcourt S, Meyer E.

Nature. 2014 May 22;509(7501):447-52. doi: 10.1038/nature13318. Epub 2014 May 7.


Large-scale detection of in vivo transcription errors.

Gout JF, Thomas WK, Smith Z, Okamoto K, Lynch M.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18584-9. doi: 10.1073/pnas.1309843110. Epub 2013 Oct 28.


Isolation and culture of mouse primary pancreatic acinar cells.

Gout J, Pommier RM, Vincent DF, Kaniewski B, Martel S, Valcourt U, Bartholin L.

J Vis Exp. 2013 Aug 13;(78). doi: 10.3791/50514.


The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions.

Gout J, Pommier RM, Vincent DF, Ripoche D, Goddard-Léon S, Colombe A, Treilleux I, Valcourt U, Tomasini R, Dufresne M, Bertolino P, Bartholin L.

Pancreatology. 2013 May-Jun;13(3):191-5. doi: 10.1016/j.pan.2013.02.001. Epub 2013 Feb 18.


Visualization of embolism formation in the xylem of liana stems using neutron radiography.

Tötzke C, Miranda T, Konrad W, Gout J, Kardjilov N, Dawson M, Manke I, Roth-Nebelsick A.

Ann Bot. 2013 Apr;111(4):723-30. doi: 10.1093/aob/mct014. Epub 2013 Feb 7.


Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.

Chassaing S, Collin F, Dorlet P, Gout J, Hureau C, Faller P.

Curr Top Med Chem. 2012;12(22):2573-95. Review.


Generation of a conditional mouse model to target Acvr1b disruption in adult tissues.

Ripoche D, Gout J, Pommier RM, Jaafar R, Zhang CX, Bartholin L, Bertolino P.

Genesis. 2013 Feb;51(2):120-7. doi: 10.1002/dvg.22352. Epub 2012 Nov 7.


The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway.

Pommier RM, Gout J, Vincent DF, Cano CE, Kaniewski B, Martel S, Rodriguez J, Fourel G, Valcourt U, Marie JC, Iovanna JL, Bartholin L.

Biochem J. 2012 Jul 15;445(2):285-93. doi: 10.1042/BJ20120368.


Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.

Am J Pathol. 2012 Jun;180(6):2214-21. doi: 10.1016/j.ajpath.2012.02.006. Epub 2012 Mar 31.


Very few RNA and DNA sequence differences in the human transcriptome.

Schrider DR, Gout JF, Hahn MW.

PLoS One. 2011;6(10):e25842. doi: 10.1371/journal.pone.0025842. Epub 2011 Oct 12.


The repatterning of eukaryotic genomes by random genetic drift.

Lynch M, Bobay LM, Catania F, Gout JF, Rho M.

Annu Rev Genomics Hum Genet. 2011;12:347-66. doi: 10.1146/annurev-genom-082410-101412. Review.


Functional study of genes essential for autogamy and nuclear reorganization in Paramecium.

Nowak JK, Gromadka R, Juszczuk M, Jerka-Dziadosz M, Maliszewska K, Mucchielli MH, Gout JF, Arnaiz O, Agier N, Tang T, Aggerbeck LP, Cohen J, Delacroix H, Sperling L, Herbert CJ, Zagulski M, Bétermier M.

Eukaryot Cell. 2011 Mar;10(3):363-72. doi: 10.1128/EC.00258-10. Epub 2011 Jan 21.


Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling.

Bouhouche K, Gout JF, Kapusta A, Bétermier M, Meyer E.

Nucleic Acids Res. 2011 May;39(10):4249-64. doi: 10.1093/nar/gkq1283. Epub 2011 Jan 7.


Gene expression in a paleopolyploid: a transcriptome resource for the ciliate Paramecium tetraurelia.

Arnaiz O, Goût JF, Bétermier M, Bouhouche K, Cohen J, Duret L, Kapusta A, Meyer E, Sperling L.

BMC Genomics. 2010 Oct 8;11:547. doi: 10.1186/1471-2164-11-547.


The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution.

Gout JF, Kahn D, Duret L; Paramecium Post-Genomics Consortium.

PLoS Genet. 2010 May 13;6(5):e1000944. doi: 10.1371/journal.pgen.1000944. Erratum in: PLoS Genet. 2010;6(6). doi: 10.1371/annotation/c55d5089-ba2f-449d-8696-2bc8395978db.


First Zn(II) bowl-complexes modeling the tris(histidine) metallo-site of enzymes.

Visnjevac A, Gout J, Ingert N, Bistri O, Reinaud O.

Org Lett. 2010 May 7;12(9):2044-7. doi: 10.1021/ol100512n.


Metabolic and melanocortin gene expression alterations in male offspring of obese mice.

Gout J, Sarafian D, Mutel E, Vigier M, Rajas F, Mithieux G, Begeot M, Naville D.

Mol Cell Endocrinol. 2010 May 5;319(1-2):99-108. doi: 10.1016/j.mce.2010.01.021. Epub 2010 Jan 25.


Hormonal regulation of the mouse adrenal melanocortinergic system.

Soltani Y, Doghman M, Gout J, Rebuffet V, Vigier M, Bekkouche FH, Naville D, Begeot M.

J Endocrinol Invest. 2009 Jan;32(1):46-51.


Differential retention of metabolic genes following whole-genome duplication.

Gout JF, Duret L, Kahn D.

Mol Biol Evol. 2009 May;26(5):1067-72. doi: 10.1093/molbev/msp026. Epub 2009 Feb 13.


Silencing-associated and meiosis-specific small RNA pathways in Paramecium tetraurelia.

Lepère G, Nowacki M, Serrano V, Gout JF, Guglielmi G, Duharcourt S, Meyer E.

Nucleic Acids Res. 2009 Feb;37(3):903-15. doi: 10.1093/nar/gkn1018. Epub 2008 Dec 22.


Leptin infusion and obesity in mouse cause alterations in the hypothalamic melanocortin system.

Gout J, Sarafian D, Tirard J, Blondet A, Vigier M, Rajas F, Mithieux G, Begeot M, Naville D.

Obesity (Silver Spring). 2008 Aug;16(8):1763-9. doi: 10.1038/oby.2008.303. Epub 2008 Jun 12.


Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: a somatic view of the germline.

Duret L, Cohen J, Jubin C, Dessen P, Goût JF, Mousset S, Aury JM, Jaillon O, Noël B, Arnaiz O, Bétermier M, Wincker P, Meyer E, Sperling L.

Genome Res. 2008 Apr;18(4):585-96. doi: 10.1101/gr.074534.107. Epub 2008 Feb 6.


Translational control of intron splicing in eukaryotes.

Jaillon O, Bouhouche K, Gout JF, Aury JM, Noel B, Saudemont B, Nowacki M, Serrano V, Porcel BM, Ségurens B, Le Mouël A, Lepère G, Schächter V, Bétermier M, Cohen J, Wincker P, Sperling L, Duret L, Meyer E.

Nature. 2008 Jan 17;451(7176):359-62. doi: 10.1038/nature06495.


[Epidemiology and clinical characteristics of childhood parapneumonic empyemas].

Desrumaux A, François P, Pascal C, Cans C, Croizé J, Gout JP, Pin I.

Arch Pediatr. 2007 Nov;14(11):1298-303. Epub 2007 Jul 13. French.


[Performance of the Breastfeeding Assessment Score for the prediction of early weaning in France].

Laborde L, Fulcheri J, Gelbert-Baudino N, Schelstraete C, Mathieu M, Durand M, Baudino F, Vié Le Sage F, Gothie I, Roche F, Devoldere C, Salinier C, Gout JP, Plasse M, Caron FM, François P, Labarere J.

Arch Pediatr. 2007 Aug;14(8):978-84. Epub 2007 May 23. French.


A novel inhibitory protein in adipose tissue, the aldo-keto reductase AKR1B7: its role in adipogenesis.

Tirard J, Gout J, Lefrançois-Martinez AM, Martinez A, Begeot M, Naville D.

Endocrinology. 2007 May;148(5):1996-2005. Epub 2007 Feb 1.


CCAAT/enhancer-binding proteins (C/EBPs) regulate the basal and cAMP-induced transcription of the human 11beta-hydroxysteroid dehydrogenase encoding gene in adipose cells.

Gout J, Tirard J, Thévenon C, Riou JP, Bégeot M, Naville D.

Biochimie. 2006 Sep;88(9):1115-24. Epub 2006 Jul 5.


Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.

Blondet A, Gout J, Durand P, Bégeot M, Naville D.

J Mol Endocrinol. 2005 Apr;34(2):317-29.


[Future prospects in the management of cystic fibrosis].

Pin I, Pilenko C, Gout JP.

Arch Pediatr. 2003 Sep;10 Suppl 2:376s-379s. Review. French.


[What previous deductions can be used for optimizing analysis of bronchial secretions in cystic fibrosis?].

Pin I, Pilenko C, Gout JP, Bost M.

Rev Mal Respir. 2003 Apr;20(2 Pt 2):S63-7. Review. French. No abstract available.


[Acute organophosphate intoxication after using a anti-lice insecticide shampoo].

Paget C, Menard S, Wroblewski I, Gout JP, Danel V, Bost M.

Arch Pediatr. 2002 Sep;9(9):913-6. French.


A novel 3600+11.5 kb C>G homozygous splicing mutation in a black African, consanguineous CF family.

Monnier N, Gout JP, Pin I, Gauthier G, Lunardi J.

J Med Genet. 2001 Jan;38(1):E4. No abstract available.


Itraconazole in the treatment of aspergillosis: a study of 16 cases.

Lebeau B, Pelloux H, Pinel C, Michallet M, Goût JP, Pison C, Delormas P, Bru JP, Brion JP, Ambroise-Thomas P, et al.

Mycoses. 1994 Jun-Jul;37(5-6):171-9.


Effect of double-blind crossover selenium supplementation on biological indices of selenium status in cystic fibrosis patients.

Portal B, Richard MJ, Ducros V, Aguilaniu B, Brunel F, Faure H, Gout JP, Bost M, Favier A.

Clin Chem. 1993 Jun;39(6):1023-8.

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