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Items: 1 to 50 of 126

1.

Covalent Aurora A regulation by the metabolic integrator coenzyme A.

Tsuchiya Y, Byrne DP, Burgess SG, Bormann J, Baković J, Huang Y, Zhyvoloup A, Yu BYK, Peak-Chew S, Tran T, Bellany F, Tabor AB, Chan AE, Guruprasad L, Garifulin O, Filonenko V, Vonderach M, Ferries S, Eyers CE, Carroll J, Skehel M, Bayliss R, Eyers PA, Gout I.

Redox Biol. 2019 Sep 5;28:101318. doi: 10.1016/j.redox.2019.101318. [Epub ahead of print]

2.

A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification.

Baković J, Yu BYK, Silva D, Chew SP, Kim S, Ahn SH, Palmer L, Aloum L, Stanzani G, Malanchuk O, Duchen MR, Singer M, Filonenko V, Lee TH, Skehel M, Gout I.

Mol Cell Biochem. 2019 Nov;461(1-2):91-102. doi: 10.1007/s11010-019-03593-w. Epub 2019 Aug 2.

3.

Coenzyme A and protein CoAlation levels are regulated in response to oxidative stress and during morphogenesis in Dictyostelium discoideum.

Aloum L, Brimson CA, Zhyvoloup A, Baines R, Baković J, Filonenko V, Thompson CRL, Gout I.

Biochem Biophys Res Commun. 2019 Apr 2;511(2):294-299. doi: 10.1016/j.bbrc.2019.02.031. Epub 2019 Feb 21.

4.

Coenzyme A: a protective thiol in bacterial antioxidant defence.

Gout I.

Biochem Soc Trans. 2019 Feb 28;47(1):469-476. doi: 10.1042/BST20180415. Epub 2019 Feb 19. Review.

PMID:
30783014
5.

Three-dimensional cancer cell culture in high-yield multiscale scaffolds by shear spinning.

Ahmed AA, Luo CJ, Perez-Garrido S, Browse CR, Thrasivoulou C, Stoyanov SD, Smoukov SK, Gout I.

Biotechnol Prog. 2019 Mar;35(2):e2750. doi: 10.1002/btpr.2750. Epub 2018 Dec 6.

PMID:
30457210
6.

Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma.

Kaye AE, Hawkes ED, Gout II, El-Amir AN, Neffendorf JE.

Mult Scler Relat Disord. 2018 Nov;26:74-76. doi: 10.1016/j.msard.2018.09.012. Epub 2018 Sep 12.

PMID:
30237107
7.

Coenzyme A, protein CoAlation and redox regulation in mammalian cells.

Gout I.

Biochem Soc Trans. 2018 Jun 19;46(3):721-728. doi: 10.1042/BST20170506. Epub 2018 May 25. Review.

8.

Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells.

Tsuchiya Y, Zhyvoloup A, Baković J, Thomas N, Yu BYK, Das S, Orengo C, Newell C, Ward J, Saladino G, Comitani F, Gervasio FL, Malanchuk OM, Khoruzhenko AI, Filonenko V, Peak-Chew SY, Skehel M, Gout I.

Biochem J. 2018 Jun 6;475(11):1909-1937. doi: 10.1042/BCJ20180043.

9.

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.

Arber C, Angelova PR, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, Bhatia KP, Mills K, Gout I, Abramov AY, Hardy J, Duce JA, Houlden H, Wray S.

PLoS One. 2017 Sep 1;12(9):e0184104. doi: 10.1371/journal.pone.0184104. eCollection 2017.

10.

Systemic PTEN-Akt1-mTOR pathway activity in patients with normal tension glaucoma and ocular hypertension: A case series.

Lascaratos G, Chau KY, Zhu H, Gkotsi D, Kamal D, Gout I, Luthert PJ, Schapira AHV, Garway-Heath DF.

Mitochondrion. 2017 Sep;36:96-102. doi: 10.1016/j.mito.2017.05.003. Epub 2017 May 9.

PMID:
28499984
11.

Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.

Tsuchiya Y, Peak-Chew SY, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Bakovic J, Malanchuk O, Pereira GC, Kotiadis V, Szabadkai G, Duchen MR, Campbell M, Cuenca SR, Vidal-Puig A, James AM, Murphy MP, Filonenko V, Skehel M, Gout I.

Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.

12.

WIDESPREAD MACULAR NEUROSENSORY DETACHMENT AFTER OCRIPLASMIN INTRAVITREAL INJECTION.

Neffendorf JE, Lim LT, Gout II, El-Amir A.

Retin Cases Brief Rep. 2016 Fall;10(4):354-6. doi: 10.1097/ICB.0000000000000260.

PMID:
26674272
13.

Application of serex-analysis for identification of human colon cancer antigens.

Garifulin OM, Kykot VO, Gridina NY, Kiyamova RG, Gout IT, Filonenko VV.

Exp Oncol. 2015 Sep;37(3):173-80.

PMID:
26422100
14.

Resistance to the most common optic neuropathy is associated with systemic mitochondrial efficiency.

Lascaratos G, Chau KY, Zhu H, Gkotsi D, King R, Gout I, Kamal D, Luthert PJ, Schapira AHV, Garway-Heath DF.

Neurobiol Dis. 2015 Oct;82:78-85. doi: 10.1016/j.nbd.2015.05.012. Epub 2015 Jun 6.

PMID:
26054436
15.

Research reforms: Ukrainian science needs elixir of youth.

Vassetzky Y, Gout I, Kuznicki J.

Nature. 2015 Jun 4;522(7554):34. doi: 10.1038/522034a. No abstract available.

PMID:
26040884
16.

Coenzyme A biosynthetic machinery in mammalian cells.

Martinez DL, Tsuchiya Y, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1112-7. doi: 10.1042/BST20140124. Review.

PMID:
25110011
17.

Methods for measuring CoA and CoA derivatives in biological samples.

Tsuchiya Y, Pham U, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1107-11. doi: 10.1042/BST20140123. Review.

PMID:
25110010
18.

Signalling functions of coenzyme A and its derivatives in mammalian cells.

Davaapil H, Tsuchiya Y, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1056-62. doi: 10.1042/BST20140146. Review.

PMID:
25110002
19.

Coenzyme A and its derivatives: renaissance of a textbook classic.

Theodoulou FL, Sibon OC, Jackowski S, Gout I.

Biochem Soc Trans. 2014 Aug;42(4):1025-32. doi: 10.1042/BST20140176. Review.

PMID:
25109997
20.

Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis.

Tsuchiya Y, Pham U, Hu W, Ohnuma S, Gout I.

PLoS One. 2014 May 15;9(5):e97693. doi: 10.1371/journal.pone.0097693. eCollection 2014.

21.

Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation.

Dusi S, Valletta L, Haack TB, Tsuchiya Y, Venco P, Pasqualato S, Goffrini P, Tigano M, Demchenko N, Wieland T, Schwarzmayr T, Strom TM, Invernizzi F, Garavaglia B, Gregory A, Sanford L, Hamada J, Bettencourt C, Houlden H, Chiapparini L, Zorzi G, Kurian MA, Nardocci N, Prokisch H, Hayflick S, Gout I, Tiranti V.

Am J Hum Genet. 2014 Jan 2;94(1):11-22. doi: 10.1016/j.ajhg.2013.11.008. Epub 2013 Dec 19.

22.

Ibrutinib in relapsed chronic lymphocytic leukemia.

Neffendorf JE, Gout I, Hildebrand GD.

N Engl J Med. 2013 Sep 26;369(13):1277. doi: 10.1056/NEJMc1309710. No abstract available.

PMID:
24066759
23.

S6 kinase 2 is bound to chromatin-nuclear matrix cellular fractions and is able to phosphorylate histone H3 at threonine 45 in vitro and in vivo.

Ismail HM, Hurd PJ, Khalil MI, Kouzarides T, Bannister A, Gout I.

J Cell Biochem. 2014 Jun;115(6):1048-62. doi: 10.1002/jcb.24566.

PMID:
23564320
24.

Analysis of tyrosine phosphorylation and phosphotyrosine-binding proteins in germinating seeds from Scots pine.

Kovaleva V, Cramer R, Krynytskyy H, Gout I, Gout R.

Plant Physiol Biochem. 2013 Jun;67:33-40. doi: 10.1016/j.plaphy.2013.02.008. Epub 2013 Mar 6.

PMID:
23542181
25.

Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 kinase 2.

Ismail HM, Myronova O, Tsuchiya Y, Niewiarowski A, Tsaneva I, Gout I.

Cell Signal. 2013 May;25(5):1054-63. doi: 10.1016/j.cellsig.2013.02.002. Epub 2013 Feb 10.

PMID:
23403125
26.

Combined hamartoma of the retina and retinal pigment epithelium.

Xue K, Mellington F, Gout I, Rokerya S, Olurin OI, El-Amir A.

BMJ Case Rep. 2012 Nov 15;2012. pii: bcr2012006944. doi: 10.1136/bcr-2012-006944.

27.

EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.

Gudkova D, Panasyuk G, Nemazanyy I, Zhyvoloup A, Monteil P, Filonenko V, Gout I.

FEBS Lett. 2012 Oct 19;586(20):3590-5. doi: 10.1016/j.febslet.2012.08.033. Epub 2012 Sep 13.

28.

Development of monoclonal antibodies specific to ribosomal protein S6 kinase 2.

Savinska L, Skorokhod O, Klipa O, Gout I, Filonenko V.

Hybridoma (Larchmt). 2012 Aug;31(4):289-94. doi: 10.1089/hyb.2012.0032.

29.

Serological analysis of SEREX-defined medullary breast carcinoma-associated antigens.

Kostianets O, Shyian M, Sergiy D, Antoniuk S, Gout I, Filonenko V, Kiyamova R.

Cancer Invest. 2012 Aug;30(7):519-27. doi: 10.3109/07357907.2012.697231. Epub 2012 Jun 19.

PMID:
22712734
30.

Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers.

Kiyamova R, Garifulin O, Gryshkova V, Kostianets O, Shyian M, Gout I, Filonenko V.

Biomarkers. 2012 Jun;17(4):362-71. doi: 10.3109/1354750X.2012.677476. Epub 2012 May 22.

PMID:
22612312
31.

Overexpression or downregulation of mTOR in mammalian cells.

Khalil M, Gout I.

Methods Mol Biol. 2012;821:87-103. doi: 10.1007/978-1-61779-430-8_7. Review.

PMID:
22125062
32.

Generation of monoclonal antibodies against tumor-associated antigen MX35/sodium-dependent phosphate transporter NaPi2b.

Gryshkova V, Lituiev D, Savinska L, Ovcharenko G, Gout I, Filonenko V, Kiyamova R.

Hybridoma (Larchmt). 2011 Feb;30(1):37-42. doi: 10.1089/hyb.2010.0064.

PMID:
21466284
33.

Recombinant expression, affinity purification and functional characterization of Scots pine defensin 1.

Kovaleva V, Krynytskyy H, Gout I, Gout R.

Appl Microbiol Biotechnol. 2011 Feb;89(4):1093-101. doi: 10.1007/s00253-010-2935-2. Epub 2010 Oct 19.

PMID:
20957359
34.

Functions and regulation of the 70kDa ribosomal S6 kinases.

Fenton TR, Gout IT.

Int J Biochem Cell Biol. 2011 Jan;43(1):47-59. doi: 10.1016/j.biocel.2010.09.018. Epub 2010 Oct 12. Review.

PMID:
20932932
35.

S6K1 is acetylated at lysine 516 in response to growth factor stimulation.

Fenton TR, Gwalter J, Cramer R, Gout IT.

Biochem Biophys Res Commun. 2010 Jul 30;398(3):400-5. doi: 10.1016/j.bbrc.2010.06.081. Epub 2010 Jun 25.

PMID:
20599721
36.

Identification of tumor-associated antigens from medullary breast carcinoma by a modified SEREX approach.

Kiyamova R, Kostianets O, Malyuchik S, Filonenko V, Usenko V, Gurtovyy V, Khozayenko Y, Antonuk S, Old L, Gout I.

Mol Biotechnol. 2010 Oct;46(2):105-12. doi: 10.1007/s12033-010-9285-2.

PMID:
20440581
37.

Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.

Goh ET, Pardo OE, Michael N, Niewiarowski A, Totty N, Volkova D, Tsaneva IR, Seckl MJ, Gout I.

J Biol Chem. 2010 May 28;285(22):17065-76. doi: 10.1074/jbc.M109.078782. Epub 2010 Mar 22.

38.

Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo.

Fenton TR, Gwalter J, Ericsson J, Gout IT.

Int J Biochem Cell Biol. 2010 Feb;42(2):359-66. doi: 10.1016/j.biocel.2009.11.022. Epub 2009 Dec 2.

PMID:
19961954
39.

NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer.

Gnjatic S, Cao Y, Reichelt U, Yekebas EF, Nölker C, Marx AH, Erbersdobler A, Nishikawa H, Hildebrandt Y, Bartels K, Horn C, Stahl T, Gout I, Filonenko V, Ling KL, Cerundolo V, Luetkens T, Ritter G, Friedrichs K, Leuwer R, Hegewisch-Becker S, Izbicki JR, Bokemeyer C, Old LJ, Atanackovic D.

Int J Cancer. 2010 Jul 15;127(2):381-93. doi: 10.1002/ijc.25058.

40.

Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4.

Gorbenko O, Panayotou G, Zhyvoloup A, Volkova D, Gout I, Filonenko V.

Mol Cell Biochem. 2010 Apr;337(1-2):299-305. doi: 10.1007/s11010-009-0312-1.

PMID:
19911253
41.

CoA Synthase is phosphorylated on tyrosines in mammalian cells, interacts with and is dephosphorylated by Shp2PTP.

Breus O, Panasyuk G, Gout IT, Filonenko V, Nemazanyy I.

Mol Cell Biochem. 2010 Feb;335(1-2):195-202. doi: 10.1007/s11010-009-0255-6. Epub 2009 Sep 18.

PMID:
19763791
42.

mTORbeta splicing isoform promotes cell proliferation and tumorigenesis.

Panasyuk G, Nemazanyy I, Zhyvoloup A, Filonenko V, Davies D, Robson M, Pedley RB, Waterfield M, Gout I.

J Biol Chem. 2009 Nov 6;284(45):30807-14. doi: 10.1074/jbc.M109.056085. Epub 2009 Sep 2.

43.

Purification and molecular cloning of antimicrobial peptides from Scots pine seedlings.

Kovaleva V, Kiyamova R, Cramer R, Krynytskyy H, Gout I, Filonenko V, Gout R.

Peptides. 2009 Dec;30(12):2136-43. doi: 10.1016/j.peptides.2009.08.007. Epub 2009 Aug 14.

PMID:
19683554
44.

Generation of monoclonal antibody targeting fibroblast growth factor receptor 3.

Gorbenko O, Ovcharenko G, Klymenko T, Zhyvoloup O, Gaman N, Volkova D, Gout I, Filonenko V.

Hybridoma (Larchmt). 2009 Aug;28(4):295-300. doi: 10.1089/hyb.2009.0018.

PMID:
19663703
45.

Monoclonal antibodies with selective specificity towards different glycosylation isoforms of FGFR1.

Gorbenko O, Ovcharenko G, Volkova D, Mayilo D, Gaman N, Khozhayenko Y, Usenko V, Gout I, Filonenko V.

Hybridoma (Larchmt). 2009 Aug;28(4):287-93. doi: 10.1089/hyb.2009.0016.

PMID:
19663702
46.

CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway.

Breus O, Panasyuk G, Gout IT, Filonenko V, Nemazanyy I.

Biochem Biophys Res Commun. 2009 Aug 7;385(4):581-5. doi: 10.1016/j.bbrc.2009.05.102. Epub 2009 May 29.

PMID:
19482007
47.

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.

Presneau N, Shalaby A, Idowu B, Gikas P, Cannon SR, Gout I, Diss T, Tirabosco R, Flanagan AM.

Br J Cancer. 2009 May 5;100(9):1406-14. doi: 10.1038/sj.bjc.6605019.

48.

Phosphorylation of histone H3 Thr-45 is linked to apoptosis.

Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T.

J Biol Chem. 2009 Jun 12;284(24):16575-83. doi: 10.1074/jbc.M109.005421. Epub 2009 Apr 10.

49.

The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.

Gryshkova V, Goncharuk I, Gurtovyy V, Khozhayenko Y, Nespryadko S, Vorobjova L, Usenko V, Gout I, Filonenko V, Kiyamova R.

Exp Oncol. 2009 Mar;31(1):37-42.

PMID:
19300415
50.

Generation and characterization of monoclonal antibodies to mTOR kinase.

Nemazanyy I, Breus O, Gout I, Filonenko V, Panasyuk G.

Hybridoma (Larchmt). 2008 Oct;27(5):395-9. doi: 10.1089/hyb.2008.0035.

PMID:
18803507

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