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Reprogramming of Adult Retinal Müller Glial Cells into Human-Induced Pluripotent Stem Cells as an Efficient Source of Retinal Cells.

Slembrouck-Brec A, Rodrigues A, Rabesandratana O, Gagliardi G, Nanteau C, Fouquet S, Thuret G, Reichman S, Orieux G, Goureau O.

Stem Cells Int. 2019 Jul 15;2019:7858796. doi: 10.1155/2019/7858796. eCollection 2019.


Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach.

Gagliardi G, Ben M'Barek K, Goureau O.

Prog Retin Eye Res. 2019 Jul;71:1-25. doi: 10.1016/j.preteyeres.2019.03.001. Epub 2019 Mar 16. Review.


Optogenetic Light Sensors in Human Retinal Organoids.

Garita-Hernandez M, Guibbal L, Toualbi L, Routet F, Chaffiol A, Winckler C, Harinquet M, Robert C, Fouquet S, Bellow S, Sahel JA, Goureau O, Duebel J, Dalkara D.

Front Neurosci. 2018 Nov 2;12:789. doi: 10.3389/fnins.2018.00789. eCollection 2018.


Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies.

Rabesandratana O, Goureau O, Orieux G.

Front Neurosci. 2018 Sep 20;12:651. doi: 10.3389/fnins.2018.00651. eCollection 2018. Review.


Defined Xeno-free and Feeder-free Culture Conditions for the Generation of Human iPSC-derived Retinal Cell Models.

Slembrouck-Brec A, Nanteau C, Sahel JA, Goureau O, Reichman S.

J Vis Exp. 2018 Sep 6;(139). doi: 10.3791/57795.


Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells.

Ben M'Barek K, Habeler W, Plancheron A, Jarraya M, Goureau O, Monville C.

J Vis Exp. 2018 Sep 6;(139). doi: 10.3791/58216.


Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids.

Gagliardi G, Ben M'Barek K, Chaffiol A, Slembrouck-Brec A, Conart JB, Nanteau C, Rabesandratana O, Sahel JA, Duebel J, Orieux G, Reichman S, Goureau O.

Stem Cell Reports. 2018 Sep 11;11(3):665-680. doi: 10.1016/j.stemcr.2018.07.005. Epub 2018 Aug 9.


[Treating retinal dystrophies affecting retinal pigment epithelium using tissue engineering obtained from human embryonic stem cells].

Ben M'Barek K, Habeler W, Goureau O, Monville C.

Med Sci (Paris). 2018 May;34(5):383-386. doi: 10.1051/medsci/20183405004. Epub 2018 Jun 13. French. No abstract available.


Noninvasive gene delivery to foveal cones for vision restoration.

Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D.

JCI Insight. 2018 Jan 25;3(2). pii: 96029. doi: 10.1172/jci.insight.96029. eCollection 2018 Jan 25.


Human ESC-derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration.

Ben M'Barek K, Habeler W, Plancheron A, Jarraya M, Regent F, Terray A, Yang Y, Chatrousse L, Domingues S, Masson Y, Sahel JA, Peschanski M, Goureau O, Monville C.

Sci Transl Med. 2017 Dec 20;9(421). pii: eaai7471. doi: 10.1126/scitranslmed.aai7471.


Further Insights into the Ciliary Gene and Protein KIZ and Its Murine Ortholog PLK1S1 Mutated in Rod-Cone Dystrophy.

El Shamieh S, Méjécase C, Bertelli M, Terray A, Michiels C, Condroyer C, Fouquet S, Sadoun M, Clérin E, Liu B, Léveillard T, Goureau O, Sahel JA, Audo I, Zeitz C.

Genes (Basel). 2017 Oct 18;8(10). pii: E277. doi: 10.3390/genes8100277.


Establishment of an induced pluripotent stem (iPS) cell line from dermal fibroblasts of an asymptomatic patient with dominant PRPF31 mutation.

Terray A, Fort V, Slembrouck A, Nanteau C, Sahel JA, Reichman S, Audo I, Goureau O.

Stem Cell Res. 2017 Dec;25:26-29. doi: 10.1016/j.scr.2017.10.007. Epub 2017 Oct 7.


Generation of an induced pluripotent stem cell (iPSC) line from a patient with autosomal dominant retinitis pigmentosa due to a mutation in the NR2E3 gene.

Terray A, Slembrouck A, Nanteau C, Chondroyer C, Zeitz C, Sahel JA, Audo I, Reichman S, Goureau O.

Stem Cell Res. 2017 Oct;24:1-4. doi: 10.1016/j.scr.2017.08.003. Epub 2017 Aug 5.


Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation.

Kole C, Klipfel L, Yang Y, Ferracane V, Blond F, Reichman S, Millet-Puel G, Clérin E, Aït-Ali N, Pagan D, Camara H, Delyfer MN, Nandrot EF, Sahel JA, Goureau O, Léveillard T.

Mol Ther. 2018 Jan 3;26(1):219-237. doi: 10.1016/j.ymthe.2017.09.007. Epub 2017 Sep 8.


Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions.

Reichman S, Slembrouck A, Gagliardi G, Chaffiol A, Terray A, Nanteau C, Potey A, Belle M, Rabesandratana O, Duebel J, Orieux G, Nandrot EF, Sahel JA, Goureau O.

Stem Cells. 2017 May;35(5):1176-1188. doi: 10.1002/stem.2586. Epub 2017 Feb 20.


Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-α.

Mathis T, Housset M, Eandi C, Beguier F, Touhami S, Reichman S, Augustin S, Gondouin P, Sahel JA, Kodjikian L, Goureau O, Guillonneau X, Sennlaub F.

Aging Cell. 2017 Feb;16(1):173-182. doi: 10.1111/acel.12540. Epub 2016 Sep 22.


Let There Be Light: Gene and Cell Therapy for Blindness.

Dalkara D, Goureau O, Marazova K, Sahel JA.

Hum Gene Ther. 2016 Feb;27(2):134-47. doi: 10.1089/hum.2015.147. Review.


The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors.

Orieux G, Slembrouck A, Bensaïd M, Sahel JA, Goureau O.

Neuroscience. 2015 Aug 6;300:276-85. doi: 10.1016/j.neuroscience.2015.05.028. Epub 2015 May 18.


Production of Retinal Cells from Confluent Human iPS Cells.

Reichman S, Goureau O.

Methods Mol Biol. 2016;1357:339-51. doi: 10.1007/7651_2014_143.


[Production of in vitro retina from pluripotent human stem cells: a new therapeutic tool].

Reichman S, Sahel JA, Goureau O.

Med Sci (Paris). 2014 Oct;30(10):845-8. doi: 10.1051/medsci/20143010009. Epub 2014 Oct 14. French. No abstract available.


From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium.

Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8518-23. doi: 10.1073/pnas.1324212111. Epub 2014 May 27.


Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy.

El Shamieh S, Neuillé M, Terray A, Orhan E, Condroyer C, Démontant V, Michiels C, Antonio A, Boyard F, Lancelot ME, Letexier M, Saraiva JP, Léveillard T, Mohand-Saïd S, Goureau O, Sahel JA, Zeitz C, Audo I.

Am J Hum Genet. 2014 Apr 3;94(4):625-33. doi: 10.1016/j.ajhg.2014.03.005. Epub 2014 Mar 27.


Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells.

Orieux G, Picault L, Slembrouck A, Roger JE, Guillonneau X, Sahel JA, Saule S, McPherson JP, Goureau O.

J Neurosci. 2014 Jan 22;34(4):1530-41. doi: 10.1523/JNEUROSCI.3227-13.2014.


The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family.

Audo I, Bujakowska K, Orhan E, El Shamieh S, Sennlaub F, Guillonneau X, Antonio A, Michiels C, Lancelot ME, Letexier M, Saraiva JP, Nguyen H, Luu TD, Léveillard T, Poch O, Dollfus H, Paques M, Goureau O, Mohand-Saïd S, Bhattacharya SS, Sahel JA, Zeitz C.

Hum Mol Genet. 2014 Jan 15;23(2):491-501. doi: 10.1093/hmg/ddt439. Epub 2013 Sep 10.


Human induced pluripotent stem cells as a tool to model a form of Leber congenital amaurosis.

Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

Cell Reprogram. 2013 Jun;15(3):233-46. doi: 10.1089/cell.2012.0076. Epub 2013 May 10.


Temporal and spatial expression of CCN3 during retina development.

Laurent M, Le Dréau G, Guillonneau X, Lelièvre E, Slembrouck A, Goureau O, Martinerie C, Marx M.

Dev Neurobiol. 2012 Nov;72(11):1363-75. doi: 10.1002/dneu.20994. Epub 2012 Jul 13. Erratum in: Dev Neurobiol. 2013 Mar;73(3):257. Maryvonne, Laurent [corrected to Laurent, Maryvonne]; Gwenvaël, Le Dréau [corrected to Le Dréau, Gwenvaël]; Xavier, Guillonneau [corrected to Guillonneau, Xavier]; Cecile, Lelièvre Elise [corrected to Lelièvre, Elise]; Amèlie, Slembrouck [corrected.


Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina.

Lelièvre EC, Lek M, Boije H, Houille-Vernes L, Brajeul V, Slembrouck A, Roger JE, Sahel JA, Matter JM, Sennlaub F, Hallböök F, Goureau O, Guillonneau X.

Dev Biol. 2011 Oct 15;358(2):296-308. doi: 10.1016/j.ydbio.2011.07.033. Epub 2011 Jul 31.


A regulatory domain is required for Foxn4 activity during retinogenesis.

Lelièvre EC, Benayoun BA, Mahieu L, Roger JE, Sahel JA, Sennlaub F, Veitia RA, Goureau O, Guillonneau X.

J Mol Neurosci. 2012 Feb;46(2):315-23. doi: 10.1007/s12031-011-9585-4. Epub 2011 Jun 24.


Foveal damage in habitual poppers users.

Audo I, El Sanharawi M, Vignal-Clermont C, Villa A, Morin A, Conrath J, Fompeydie D, Sahel JA, Gocho-Nakashima K, Goureau O, Paques M.

Arch Ophthalmol. 2011 Jun;129(6):703-8. doi: 10.1001/archophthalmol.2011.6. Epub 2011 Feb 14.


Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.

Lambard S, Reichman S, Berlinicke C, Niepon ML, Goureau O, Sahel JA, Léveillard T, Zack DJ.

PLoS One. 2010 Oct 7;5(10):e13075. doi: 10.1371/journal.pone.0013075.


Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.

Chatzopoulou E, Miguez A, Savvaki M, Levasseur G, Muzerelle A, Muriel MP, Goureau O, Watanabe K, Goutebroze L, Gaspar P, Zalc B, Karagogeos D, Thomas JL.

J Neurosci. 2008 Jul 23;28(30):7624-36. doi: 10.1523/JNEUROSCI.1103-08.2008.


Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cells.

Roger J, Brajeul V, Thomasseau S, Hienola A, Sahel JA, Guillonneau X, Goureau O.

Dev Biol. 2006 Oct 15;298(2):527-39. Epub 2006 Jul 12.


[Retinal stem cells: mechanism of differentiation and therapeutic application].

Goureau O, Sahel JA.

Pathol Biol (Paris). 2006 Mar;54(2):64-71. Review. French.


DNA repair in the degenerating mouse retina.

Menu dit Huart L, Lorentz O, Goureau O, Léveillard T, Sahel JA.

Mol Cell Neurosci. 2004 Jul;26(3):441-9.


Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy.

Sennlaub F, Courtois Y, Goureau O.

J Neurosci. 2002 May 15;22(10):3987-93.


Delayed onset and decreased severity of experimental autoimmune uveoretinitis in mice lacking nitric oxide synthase type 2.

Thillaye-Goldenberg B, Goureau O, Naud MC, de Kozak Y.

J Neuroimmunol. 2000 Oct 2;110(1-2):31-44.


Role of nitric oxide in photoreceptor survival in embryonic chick retinal cell culture.

Goureau O, Régnier-Ricard F, Désiré L, Courtois Y.

J Neurosci Res. 1999 Feb 15;55(4):423-31.


Nitric oxide synthase-II is expressed in severe corneal alkali burns and inhibits neovascularization.

Sennlaub F, Courtois Y, Goureau O.

Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2773-9.


Requirement for nitric oxide in retinal neuronal cell death induced by activated Müller glial cells.

Goureau O, Régnier-Ricard F, Courtois Y.

J Neurochem. 1999 Jun;72(6):2506-15.


Effect of cytokines and nitric oxide on tight junctions in cultured rat retinal pigment epithelium.

Zech JC, Pouvreau I, Cotinet A, Goureau O, Le Varlet B, de Kozak Y.

Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1600-8.


Tyrosine kinase inhibitors and antioxidants modulate NF-kappaB and NOS-II induction in retinal epithelial cells.

Faure V, Courtois Y, Goureau O.

Am J Physiol. 1998 Jul;275(1):C208-15. doi: 10.1152/ajpcell.1998.275.1.C208.


Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis.

Behar-Cohen FF, Savoldelli M, Parel JM, Goureau O, Thillaye-Goldenberg B, Courtois Y, Pouliquen Y, de Kozak Y.

Invest Ophthalmol Vis Sci. 1998 May;39(6):897-904.


Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats.

Behar-Cohen FF, Parel JM, Pouliquen Y, Thillaye-Goldenberg B, Goureau O, Heydolph S, Courtois Y, De Kozak Y.

Exp Eye Res. 1997 Oct;65(4):533-45.


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