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Aging, Metabolism, Synaptic Activity, and Aβ in Alzheimer's Disease.

Gouras GK.

Front Aging Neurosci. 2019 Jul 23;11:185. doi: 10.3389/fnagi.2019.00185. eCollection 2019. No abstract available.


APP depletion alters selective pre- and post-synaptic proteins.

Martinsson I, Capetillo-Zarate E, Faideau M, Willén K, Esteras N, Frykman S, Tjernberg LO, Gouras GK.

Mol Cell Neurosci. 2019 Mar;95:86-95. doi: 10.1016/j.mcn.2019.02.003. Epub 2019 Feb 11.


Prion-like seeding and nucleation of intracellular amyloid-β.

Olsson TT, Klementieva O, Gouras GK.

Neurobiol Dis. 2018 May;113:1-10. doi: 10.1016/j.nbd.2018.01.015. Epub 2018 Feb 4.


Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses.

Willén K, Sroka A, Takahashi RH, Gouras GK.

J Alzheimers Dis. 2017;60(2):511-524. doi: 10.3233/JAD-170262.


Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.

Willén K, Edgar JR, Hasegawa T, Tanaka N, Futter CE, Gouras GK.

Mol Neurodegener. 2017 Aug 23;12(1):61. doi: 10.1186/s13024-017-0203-y.


Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP.

Klementieva O, Willén K, Martinsson I, Israelsson B, Engdahl A, Cladera J, Uvdal P, Gouras GK.

Nat Commun. 2017 Mar 13;8:14726. doi: 10.1038/ncomms14726.


Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease.

Takahashi RH, Nagao T, Gouras GK.

Pathol Int. 2017 Apr;67(4):185-193. doi: 10.1111/pin.12520. Epub 2017 Mar 5. Review.


Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T.

J Alzheimers Dis. 2016 Sep 6;54(2):669-78. doi: 10.3233/JAD-160036.


Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

Dunning CJ, McGauran G, Willén K, Gouras GK, O'Connell DJ, Linse S.

ACS Chem Neurosci. 2016 Feb 17;7(2):161-70. doi: 10.1021/acschemneuro.5b00262. Epub 2015 Dec 15.


ADAM10 and BACE1 are localized to synaptic vesicles.

Lundgren JL, Ahmed S, Schedin-Weiss S, Gouras GK, Winblad B, Tjernberg LO, Frykman S.

J Neurochem. 2015 Nov;135(3):606-15. doi: 10.1111/jnc.13287. Epub 2015 Sep 17.


ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.

Edgar JR, Willén K, Gouras GK, Futter CE.

J Cell Sci. 2015 Jul 15;128(14):2520-8. doi: 10.1242/jcs.170233. Epub 2015 May 22.


β-Amyloid peptides and amyloid plaques in Alzheimer's disease.

Gouras GK, Olsson TT, Hansson O.

Neurotherapeutics. 2015 Jan;12(1):3-11. doi: 10.1007/s13311-014-0313-y. Review.


Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

Lundgren JL, Ahmed S, Winblad B, Gouras GK, Tjernberg LO, Frykman S.

Neurosci Lett. 2014 Apr 30;566:125-30. doi: 10.1016/j.neulet.2014.02.050. Epub 2014 Mar 3.


Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

George S, Rönnbäck A, Gouras GK, Petit GH, Grueninger F, Winblad B, Graff C, Brundin P.

Acta Neuropathol Commun. 2014 Feb 11;2:17. doi: 10.1186/2051-5960-2-17.


Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases.

Gouras GK.

Int J Cell Biol. 2013;2013:141083. doi: 10.1155/2013/141083. Epub 2013 Nov 7. Review.


The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease.

Gouras GK, Willén K, Faideau M.

Neurodegener Dis. 2014;13(2-3):142-6. doi: 10.1159/000354776. Epub 2013 Sep 24. Review.


Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.

George S, Petit GH, Gouras GK, Brundin P, Olsson R.

ACS Chem Neurosci. 2013 Dec 18;4(12):1537-48. doi: 10.1021/cn400133s. Epub 2013 Sep 25.


Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.

Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK.

PLoS One. 2013;8(1):e51965. doi: 10.1371/journal.pone.0051965. Epub 2013 Jan 23.


mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.

Gouras GK.

J Neurochem. 2013 Mar;124(6):747-8. doi: 10.1111/jnc.12098. Epub 2012 Dec 26. No abstract available.


Pathology of synapses and dendritic spines.

Knafo S, Gouras GK, Yan XX, Spires-Jones T.

Neural Plast. 2012;2012:972432. doi: 10.1155/2012/972432. Epub 2012 Sep 23. No abstract available.


Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

Gouras GK, Willén K, Tampellini D.

Life Sci. 2012 Dec 10;91(23-24):1153-8. doi: 10.1016/j.lfs.2012.06.004. Epub 2012 Jun 19.


Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

Capetillo-Zarate E, Gracia L, Tampellini D, Gouras GK.

Neurodegener Dis. 2012;10(1-4):56-9. doi: 10.1159/000334762. Epub 2012 Jan 21.


Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.

Tampellini D, Rahman N, Lin MT, Capetillo-Zarate E, Gouras GK.

J Neurosci. 2011 Oct 26;31(43):15384-90. doi: 10.1523/JNEUROSCI.2986-11.2011.


High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.

Capetillo-Zarate E, Gracia L, Yu F, Banfelder JR, Lin MT, Tampellini D, Gouras GK.

Am J Pathol. 2011 Nov;179(5):2551-8. doi: 10.1016/j.ajpath.2011.07.045. Epub 2011 Sep 15.


Analysis of vesicular trafficking in primary neurons by live imaging.

Tampellini D, Gouras GK.

Methods Mol Biol. 2011;793:343-50. doi: 10.1007/978-1-61779-328-8_22.


Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.

Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF.

J Alzheimers Dis. 2011;27(1):211-23. doi: 10.3233/JAD-2011-110209.


Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.

Majumdar A, Capetillo-Zarate E, Cruz D, Gouras GK, Maxfield FR.

Mol Biol Cell. 2011 May 15;22(10):1664-76. doi: 10.1091/mbc.E10-09-0745. Epub 2011 Mar 25.


Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.

Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H.

Neuropathology. 2011 Jun;31(3):208-14. doi: 10.1111/j.1440-1789.2010.01158.x. Epub 2010 Nov 9.


Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.

Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, Gouras GK.

J Neurosci. 2010 Oct 27;30(43):14299-304. doi: 10.1523/JNEUROSCI.3383-10.2010.


Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK.

PLoS One. 2010 Sep 20;5(9). pii: e12845. doi: 10.1371/journal.pone.0012845.


Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.

Tampellini D, Gouras GK.

Front Aging Neurosci. 2010 May 21;2. pii: 13. doi: 10.3389/fnagi.2010.00013. eCollection 2010.


Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.

Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E.

Acta Neuropathol. 2010 May;119(5):523-41. doi: 10.1007/s00401-010-0679-9. Epub 2010 Mar 31. Review.


Immunotherapy for Alzheimer disease.

Gouras GK.

MAbs. 2009 Mar-Apr;1(2):112-4. Epub 2009 Mar 11.


Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.

Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK.

J Neurosci. 2009 Aug 5;29(31):9704-13. doi: 10.1523/JNEUROSCI.2292-09.2009.


Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.

Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Nathan C, Flint Beal M, Lin MT.

J Neurochem. 2009 Apr;109(2):502-12. doi: 10.1111/j.1471-4159.2009.05970.x. Epub 2009 Feb 7. Erratum in: J Neurochem. 2009 May;109(4):1192.. Nathan, Carl [added].


Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK.

Neurobiol Aging. 2010 Jul;31(7):1145-52. doi: 10.1016/j.neurobiolaging.2008.07.021. Epub 2008 Sep 3.


Beta-amyloid modulation of synaptic transmission and plasticity.

Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ.

J Neurosci. 2007 Oct 31;27(44):11832-7. Review. No abstract available.


Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

Tampellini D, Magrané J, Takahashi RH, Li F, Lin MT, Almeida CG, Gouras GK.

J Biol Chem. 2007 Jun 29;282(26):18895-906. Epub 2007 Apr 27.


The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.

Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN.

J Neurochem. 2007 May;101(3):854-62.


Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response.

Magrané J, Rosen KM, Smith RC, Walsh K, Gouras GK, Querfurth HW.

J Neurosci. 2005 Nov 23;25(47):10960-9.


Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.

Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK.

Neurobiol Dis. 2005 Nov;20(2):187-98.


Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.


Regulation of NMDA receptor trafficking by amyloid-beta.

Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P.

Nat Neurosci. 2005 Aug;8(8):1051-8. Epub 2005 Jul 17.


Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease.

Gouras GK, Almeida CG, Takahashi RH.

Neurobiol Aging. 2005 Oct;26(9):1235-44. Review.


Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.

Stenh C, Englund H, Lord A, Johansson AS, Almeida CG, Gellerfors P, Greengard P, Gouras GK, Lannfelt L, Nilsson LN.

Ann Neurol. 2005 Jul;58(1):147-50.


Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK.

J Neurochem. 2004 Jun;89(5):1308-12.


Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK.

J Neurosci. 2004 Apr 7;24(14):3592-9.


Current theories for the molecular and cellular pathogenesis of Alzheimers disease.

Gouras GK.

Expert Rev Mol Med. 2001 May 31;2001:1-11. doi: 10.1017/S1462399401003167. No abstract available.


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