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Items: 1 to 50 of 69

1.

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.

Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K.

Genes Dev. 2019 Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23.

PMID:
31123064
2.

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.

Emmanuel AO, Arnovitz S, Haghi L, Mathur PS, Mondal S, Quandt J, Okoreeh MK, Maienschein-Cline M, Khazaie K, Dose M, Gounari F.

Nat Immunol. 2018 Dec;19(12):1366-1378. doi: 10.1038/s41590-018-0254-4. Epub 2018 Nov 12.

PMID:
30420627
3.

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.

Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1588-1592. doi: 10.1073/pnas.1716804115. Epub 2018 Feb 2.

4.

The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.

Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K.

Cancer Immunol Immunother. 2018 Jan;67(1):13-23. doi: 10.1007/s00262-017-2057-0. Epub 2017 Sep 5.

5.

Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.

Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K.

Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116.

6.

Correction: Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the notch signaling pathway.

Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL.

J Immunol. 2015 Jun 15;194(12):6191. doi: 10.4049/jimmunol.1500914. No abstract available.

7.

Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer.

Phillips JD, Knab LM, Blatner NR, Haghi L, DeCamp MM, Meyerson SL, Heiferman MJ, Heiferman JR, Gounari F, Bentrem DJ, Khazaie K.

Cancer Immunol Immunother. 2015 Sep;64(9):1185-91. doi: 10.1007/s00262-015-1725-1. Epub 2015 Jun 6.

8.

T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.

Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K.

Cancer Immunol Res. 2015 Jul;3(7):806-14. doi: 10.1158/2326-6066.CIR-14-0169. Epub 2015 Apr 8.

9.

Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.

Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL.

J Immunol. 2015 Apr 1;194(7):3191-200. doi: 10.4049/jimmunol.1402443. Epub 2015 Feb 20. Erratum in: J Immunol. 2015 Jun 15;194(12):6191. Akinola, Emmanuel Olumide [Corrected to Emanuelle, Akinola Olumide].

10.

Robin Holliday 1932-2014.

Jeggo P, Gounari F.

Nat Struct Mol Biol. 2014 Jun;21(6):501-2. doi: 10.1038/nsmb.2835. No abstract available.

PMID:
24896809
11.

β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.

Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F.

Sci Transl Med. 2014 Feb 26;6(225):225ra28. doi: 10.1126/scitranslmed.3007607.

12.

β-Catenin induces T-cell transformation by promoting genomic instability.

Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26.

13.

Current status of interleukin-10 and regulatory T-cells in cancer.

Dennis KL, Blatner NR, Gounari F, Khazaie K.

Curr Opin Oncol. 2013 Nov;25(6):637-45. doi: 10.1097/CCO.0000000000000006. Review.

14.

Fingerprinting ikaros.

Gounari F, Kee BL.

Nat Immunol. 2013 Oct;14(10):1034-5. doi: 10.1038/ni.2709. No abstract available.

15.

Transcriptional regulation of the Ikzf1 locus.

Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K.

Blood. 2013 Oct 31;122(18):3149-59. doi: 10.1182/blood-2013-01-474916. Epub 2013 Sep 3.

16.

The two faces of regulatory T cells in cancer.

Blatner NR, Gounari F, Khazaie K.

Oncoimmunology. 2013 May 1;2(5):e23852. Epub 2013 Apr 15.

17.

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.

Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV.

Blood. 2013 Aug 8;122(6):902-11. doi: 10.1182/blood-2012-08-447839. Epub 2013 Jun 5.

18.

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, Ham S, Sandall BP, Khan MW, Mahvi DM, Halverson AL, Stryker SJ, Boller AM, Singal A, Sneed RK, Sarraj B, Ansari MJ, Oft M, Iwakura Y, Zhou L, Bonertz A, Beckhove P, Gounari F, Khazaie K.

Sci Transl Med. 2012 Dec 12;4(164):164ra159. doi: 10.1126/scitranslmed.3004566.

19.

Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells.

Aghajani K, Keerthivasan S, Yu Y, Gounari F.

Genesis. 2012 Dec;50(12):908-13. doi: 10.1002/dvg.22052. Epub 2012 Sep 12.

20.

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.

Khazaie K, Zadeh M, Khan MW, Bere P, Gounari F, Dennis K, Blatner NR, Owen JL, Klaenhammer TR, Mohamadzadeh M.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7. doi: 10.1073/pnas.1207230109. Epub 2012 Jun 11.

21.

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20060-5. doi: 10.1073/pnas.1110230108. Epub 2011 Nov 22.

22.

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

Zhang J, Jackson AF, Naito T, Dose M, Seavitt J, Liu F, Heller EJ, Kashiwagi M, Yoshida T, Gounari F, Petrie HT, Georgopoulos K.

Nat Immunol. 2011 Nov 13;13(1):86-94. doi: 10.1038/ni.2150.

23.

Sleeping beauty: does ETP-ALL awaken later?

Dose M, Gounari F.

Blood. 2011 Oct 27;118(17):4500-1. doi: 10.1182/blood-2011-09-375121. No abstract available.

24.

CDK6 kinase activity is required for thymocyte development.

Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW.

Blood. 2011 Jun 9;117(23):6120-31. doi: 10.1182/blood-2010-08-300517. Epub 2011 Apr 20.

25.

The significant role of mast cells in cancer.

Khazaie K, Blatner NR, Khan MW, Gounari F, Gounaris E, Dennis K, Bonertz A, Tsai FN, Strouch MJ, Cheon E, Phillips JD, Beckhove P, Bentrem DJ.

Cancer Metastasis Rev. 2011 Mar;30(1):45-60. doi: 10.1007/s10555-011-9286-z. Review.

PMID:
21287360
26.

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation.

Driessens G, Zheng Y, Locke F, Cannon JL, Gounari F, Gajewski TF.

J Immunol. 2011 Jan 15;186(2):784-90. doi: 10.4049/jimmunol.1001562. Epub 2010 Dec 13.

27.

The TLX1 oncogene drives aneuploidy in T cell transformation.

De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cavé H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA.

Nat Med. 2010 Nov;16(11):1321-7. doi: 10.1038/nm.2246. Epub 2010 Oct 24.

28.

The My(c)stery of iNKT cell ontogeny.

Dose M, Gounari F.

Cell Cycle. 2009 Oct 1;8(19):3082-5. Epub 2009 Oct 25. Review.

PMID:
19738416
29.

Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.

Kovalovsky D, Yu Y, Dose M, Emmanouilidou A, Konstantinou T, Germar K, Aghajani K, Guo Z, Mandal M, Gounari F.

J Immunol. 2009 Sep 15;183(6):3873-84. doi: 10.4049/jimmunol.0901369. Epub 2009 Aug 28.

30.

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. doi: 10.1073/pnas.0903895106. Epub 2009 Jul 15.

31.

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.

Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K.

Cancer Res. 2009 Jul 1;69(13):5490-7. doi: 10.1158/0008-5472.CAN-09-0304.

32.

Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8641-6. doi: 10.1073/pnas.0812255106. Epub 2009 May 7.

33.

A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.

Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW.

Cancer Res. 2009 Feb 1;69(3):810-8. doi: 10.1158/0008-5472.CAN-08-2473. Epub 2009 Jan 20.

34.

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H.

J Exp Med. 2008 Nov 24;205(12):2851-61. doi: 10.1084/jem.20081561. Epub 2008 Nov 3.

35.

Fifty ways to Notch T-ALL.

Dose M, Gounari F.

Blood. 2008 Aug 1;112(3):457-8. doi: 10.1182/blood-2008-05-155747. No abstract available.

36.

Mast cells are an essential hematopoietic component for polyp development.

Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82. Epub 2007 Dec 6.

37.

Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.

Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN.

J Immunol. 2007 May 1;178(9):5443-53.

38.

Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.

Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F.

Blood. 2007 Jun 15;109(12):5463-72. Epub 2007 Feb 22.

39.

c-Myc mediates pre-TCR-induced proliferation but not developmental progression.

Dose M, Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F.

Blood. 2006 Oct 15;108(8):2669-77. Epub 2006 Jun 20.

40.

Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

Garbe AI, Krueger A, Gounari F, Zúñiga-Pflücker JC, von Boehmer H.

J Exp Med. 2006 Jun 12;203(6):1579-90. Epub 2006 Jun 5.

41.

Loss of adenomatous polyposis coli gene function disrupts thymic development.

Gounari F, Chang R, Cowan J, Guo Z, Dose M, Gounaris E, Khazaie K.

Nat Immunol. 2005 Aug;6(8):800-9. Epub 2005 Jul 17.

42.

Novel adenomatous polyposis coli gene promoter is located 40 kb upstream of the initiating methionine.

Karagianni N, Ly MC, Psarras S, Chlichlia K, Schirrmacher V, Gounari F, Khazaie K.

Genomics. 2005 Feb;85(2):231-7.

PMID:
15676281
43.

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.

Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H.

J Exp Med. 2004 Mar 1;199(5):607-15.

44.

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.

Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F.

Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17.

PMID:
12925850
45.

Thymic selection revisited: how essential is it?

von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L.

Immunol Rev. 2003 Feb;191:62-78. Review.

PMID:
12614352
46.

Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia.

Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K.

Oncogene. 2002 Jun 13;21(26):4099-107.

47.

A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.

Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H.

Nat Immunol. 2002 May;3(5):483-8. Epub 2002 Apr 1. Erratum in: Nat Immunol 2002 Jun;3(6):591.

PMID:
11927911
48.

Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.

Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B.

Nat Immunol. 2002 May;3(5):489-96. Epub 2002 Apr 1.

PMID:
11927910
49.

On the brink of becoming a T cell.

Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H.

Curr Opin Immunol. 2002 Apr;14(2):200-6. Review.

PMID:
11869893
50.

Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L, Khazaie K.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):219-24. Epub 2002 Jan 2.

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