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Germ Cell-Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia.

Peer NR, Law SM, Murdoch B, Goulding EH, Eddy EM, Kim K.

Endocrinology. 2018 Sep 1;159(9):3403-3420. doi: 10.1210/en.2018-00533.


Mobile Phone-Based Measures of Activity, Step Count, and Gait Speed: Results From a Study of Older Ambulatory Adults in a Naturalistic Setting.

Rye Hanton C, Kwon YJ, Aung T, Whittington J, High RR, Goulding EH, Schenk AK, Bonasera SJ.

JMIR Mhealth Uhealth. 2017 Oct 3;5(10):e104. doi: 10.2196/mhealth.5090.


Decreased home cage movement and oromotor impairments in adult Fmr1-KO mice.

Bonasera SJ, Chaudoin TR, Goulding EH, Mittek M, Dunaevsky A.

Genes Brain Behav. 2017 Jun;16(5):564-573. doi: 10.1111/gbb.12374. Epub 2017 Mar 29.


Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits.

Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA.

Aging (Albany NY). 2016 Sep 20;8(9):2153-2181. doi: 10.18632/aging.101040.


Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice.

Busada JT, Velte EK, Serra N, Cook K, Niedenberger BA, Willis WD, Goulding EH, Eddy EM, Geyer CB.

Reproduction. 2016 Nov;152(5):379-88. doi: 10.1530/REP-16-0268. Epub 2016 Aug 2.


Male infertility in mice lacking the store-operated Ca(2+) channel Orai1.

Davis FM, Goulding EH, D'Agostin DM, Janardhan KS, Cummings CA, Bird GS, Eddy EM, Putney JW.

Cell Calcium. 2016 Apr;59(4):189-97. doi: 10.1016/j.ceca.2016.02.007. Epub 2016 Feb 27.


Disrupting Cyclin Dependent Kinase 1 in Spermatocytes Causes Late Meiotic Arrest and Infertility in Mice.

Clement TM, Inselman AL, Goulding EH, Willis WD, Eddy EM.

Biol Reprod. 2015 Dec;93(6):137. doi: 10.1095/biolreprod.115.134940. Epub 2015 Oct 21.


Assessing Smart Phones for Generating Life-space Indicators.

Wan N, Qu W, Whittington J, Witbrodt BC, Henderson MP, Goulding EH, Schenk AK, Bonasera SJ, Lin G.

Environ Plann B Plann Des. 2013 Apr;40(2):350-361. doi: 10.1068/b38200. Epub 2013 Apr 1.


Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility.

Nakamura N, Dai Q, Williams J, Goulding EH, Willis WD, Brown PR, Eddy EM.

Biol Reprod. 2013 Apr 11;88(4):90. doi: 10.1095/biolreprod.112.107128. Print 2013 Apr.


A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment.

Parkison SA, Carlson JD, Chaudoin TR, Hoke TA, Schenk AK, Goulding EH, Pérez LC, Bonasera SJ.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2392-5. doi: 10.1109/EMBC.2012.6346445.


Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function.

Arao Y, Hamilton KJ, Goulding EH, Janardhan KS, Eddy EM, Korach KS.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21140-5. doi: 10.1073/pnas.1216189110. Epub 2012 Dec 4.


Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol.

Davis VL, Newbold RR, Couse JF, Rea SL, Gallagher KM, Hamilton KJ, Goulding EH, Jefferson W, Eddy EM, Bullock BC, Korach KS.

Reprod Toxicol. 2012 Dec;34(4):512-21. doi: 10.1016/j.reprotox.2012.08.005. Epub 2012 Aug 31.


Treadmill gait speeds correlate with physical activity counts measured by cell phone accelerometers.

Carlson RH Jr, Huebner DR, Hoarty CA, Whittington J, Haynatzki G, Balas MC, Schenk AK, Goulding EH, Potter JF, Bonasera SJ.

Gait Posture. 2012 Jun;36(2):241-8. doi: 10.1016/j.gaitpost.2012.02.025. Epub 2012 Apr 2.


A flexible estimating equations approach for mapping function-valued traits.

Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S.

Genetics. 2011 Sep;189(1):305-16. doi: 10.1534/genetics.111.129221. Epub 2011 Jul 29.


Cellular telephones measure activity and lifespace in community-dwelling adults: proof of principle.

Schenk AK, Witbrodt BC, Hoarty CA, Carlson RH Jr, Goulding EH, Potter JF, Bonasera SJ.

J Am Geriatr Soc. 2011 Feb;59(2):345-52. doi: 10.1111/j.1532-5415.2010.03267.x. Epub 2011 Feb 2.


Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.

Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI.

Pain. 2011 May;152(5):990-1000. doi: 10.1016/j.pain.2010.12.003. Epub 2011 Jan 21.


Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype.

Goulding EH, Hewitt SC, Nakamura N, Hamilton K, Korach KS, Eddy EM.

J Endocrinol. 2010 Dec;207(3):281-8. doi: 10.1677/JOE-10-0290. Epub 2010 Sep 10.


The effects of perioperative analgesia on litter size in Crl:CD1(ICR) mice undergoing embryo transfer.

Goulding DR, Myers PH, Goulding EH, Blankenship TL, Grant MF, Forsythe DB.

J Am Assoc Lab Anim Sci. 2010 Jul;49(4):423-6.


Heat shock protein 2 promoter drives Cre expression in spermatocytes of transgenic mice.

Inselman AL, Nakamura N, Brown PR, Willis WD, Goulding EH, Eddy EM.

Genesis. 2010 Feb;48(2):114-20. doi: 10.1002/dvg.20588.


Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice.

Danshina PV, Geyer CB, Dai Q, Goulding EH, Willis WD, Kitto GB, McCarrey JR, Eddy EM, O'Brien DA.

Biol Reprod. 2010 Jan;82(1):136-45. doi: 10.1095/biolreprod.109.079699. Epub 2009 Sep 16.


A robust automated system elucidates mouse home cage behavioral structure.

Goulding EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20575-82. doi: 10.1073/pnas.0809053106. Epub 2008 Dec 23.


Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation.

Jefferson WN, Padilla-Banks E, Goulding EH, Lao SP, Newbold RR, Williams CJ.

Biol Reprod. 2009 Mar;80(3):425-31. doi: 10.1095/biolreprod.108.073171. Epub 2008 Nov 12.


Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.

Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY.

Neuron. 2008 Sep 25;59(6):947-58. doi: 10.1016/j.neuron.2008.07.030.


Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1).

Da Ros VG, Maldera JA, Willis WD, Cohen DJ, Goulding EH, Gelman DM, Rubinstein M, Eddy EM, Cuasnicu PS.

Dev Biol. 2008 Aug 1;320(1):12-8. doi: 10.1016/j.ydbio.2008.03.015. Epub 2008 Mar 20.


Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility.

Odet F, Duan C, Willis WD, Goulding EH, Kung A, Eddy EM, Goldberg E.

Biol Reprod. 2008 Jul;79(1):26-34. doi: 10.1095/biolreprod.108.068353. Epub 2008 Mar 26.


Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors.

Wade JM, Juneja P, MacKay AW, Graham J, Havel PJ, Tecott LH, Goulding EH.

Endocrinology. 2008 Mar;149(3):955-61. Epub 2007 Nov 26.


Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene.

Rivkin E, Eddy EM, Willis WD, Goulding EH, Suganuma R, Yanagimachi R, Kierszenbaum AL.

Mol Reprod Dev. 2005 Oct;72(2):259-71.


Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility.

Miki K, Qu W, Goulding EH, Willis WD, Bunch DO, Strader LF, Perreault SD, Eddy EM, O'Brien DA.

Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16501-6. Epub 2004 Nov 16.


Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.

Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF.

Nat Neurosci. 2003 Jul;6(7):736-42.


Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice.

Cho C, Jung-Ha H, Willis WD, Goulding EH, Stein P, Xu Z, Schultz RM, Hecht NB, Eddy EM.

Biol Reprod. 2003 Jul;69(1):211-7. Epub 2003 Mar 5.


Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice.

Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH.

Diabetes. 2003 Feb;52(2):315-20.


Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.

Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH.

J Neurosci. 2002 Nov 15;22(22):10039-45.


Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.

Miki K, Willis WD, Brown PR, Goulding EH, Fulcher KD, Eddy EM.

Dev Biol. 2002 Aug 15;248(2):331-42.


Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

McAllister KA, Bennett LM, Houle CD, Ward T, Malphurs J, Collins NK, Cachafeiro C, Haseman J, Goulding EH, Bunch D, Eddy EM, Davis BJ, Wiseman RW.

Cancer Res. 2002 Feb 15;62(4):990-4.


Estrogen receptor-alpha is required by the supporting somatic cells for spermatogenesis.

Mahato D, Goulding EH, Korach KS, Eddy EM.

Mol Cell Endocrinol. 2001 Jun 10;178(1-2):57-63.


Haploinsufficiency of protamine-1 or -2 causes infertility in mice.

Cho C, Willis WD, Goulding EH, Jung-Ha H, Choi YC, Hecht NB, Eddy EM.

Nat Genet. 2001 May;28(1):82-6.


Spermatogenic cells do not require estrogen receptor-alpha for development or function.

Mahato D, Goulding EH, Korach KS, Eddy EM.

Endocrinology. 2000 Mar;141(3):1273-6.


Fertilization defects in sperm from mice lacking fertilin beta.

Cho C, Bunch DO, Faure JE, Goulding EH, Eddy EM, Primakoff P, Myles DG.

Science. 1998 Sep 18;281(5384):1857-9.


HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes.

Dix DJ, Allen JW, Collins BW, Poorman-Allen P, Mori C, Blizard DR, Brown PR, Goulding EH, Strong BD, Eddy EM.

Development. 1997 Nov;124(22):4595-603.


Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels.

Tibbs GR, Goulding EH, Siegelbaum SA.

Nature. 1997 Apr 10;386(6625):612-5.


Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, Korach KS.

Endocrinology. 1996 Nov;137(11):4796-805.


Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.

Dix DJ, Allen JW, Collins BW, Mori C, Nakamura N, Poorman-Allen P, Goulding EH, Eddy EM.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3264-8.


Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis.

Dix DJ, Rosario-Herrle M, Gotoh H, Mori C, Goulding EH, Barrett CV, Eddy EM.

Dev Biol. 1996 Mar 15;174(2):310-21.


Boar proacrosin expressed in spermatids of transgenic mice does not reach the acrosome and disrupts spermatogenesis.

O'Brien DA, Welch JE, Goulding EH, Taylor AA Jr, Baba T, Hecht NB, Eddy EM.

Mol Reprod Dev. 1996 Feb;43(2):236-47.


Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating.

Sun ZP, Akabas MH, Goulding EH, Karlin A, Siegelbaum SA.

Neuron. 1996 Jan;16(1):141-9.


Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O.

Cell. 1995 Nov 3;83(3):483-92.


Molecular mechanism of cyclic-nucleotide-gated channel activation.

Goulding EH, Tibbs GR, Siegelbaum SA.

Nature. 1994 Nov 24;372(6504):369-74.


Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.

Davis VL, Couse JF, Goulding EH, Power SG, Eddy EM, Korach KS.

Endocrinology. 1994 Jul;135(1):379-86.


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