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A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

Yeung ATY, Choi YH, Lee AHY, Hale C, Ponstingl H, Pickard D, Goulding D, Thomas M, Gill E, Kim JK, Bradley A, Hancock REW, Dougan G.

MBio. 2019 Oct 8;10(5). pii: e02169-19. doi: 10.1128/mBio.02169-19.


The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.

Dunstan RA, Pickard D, Dougan S, Goulding D, Cormie C, Hardy J, Li F, Grinter R, Harcourt K, Yu L, Song J, Schreiber F, Choudhary J, Clare S, Coulibaly F, Strugnell RA, Dougan G, Lithgow T.

Mol Microbiol. 2019 Sep 25. doi: 10.1111/mmi.14396. [Epub ahead of print]


Excitable interplay between lasing quantum dot states.

Dillane M, Dubinkin I, Fedorov N, Erneux T, Goulding D, Kelleher B, Viktorov EA.

Phys Rev E. 2019 Jul;100(1-1):012202. doi: 10.1103/PhysRevE.100.012202.


Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia.

Braun DJ, Abner E, Bakshi V, Goulding DS, Grau EM, Lin AL, Norris CM, Sudduth TL, Webster SJ, Wilcock DM, Van Eldik LJ.

ASN Neuro. 2019 Jan-Dec;11:1759091419865788. doi: 10.1177/1759091419865788. No abstract available.


Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.

Goulding DR, Kraft A, Mouton PR, McPherson CA, Avdoshina V, Mocchetti I, Harry GJ.

Neurotox Res. 2019 Oct;36(3):563-582. doi: 10.1007/s12640-019-00077-z. Epub 2019 Jul 8.


A U.S. population-based study of insurance disparities in cancer survival among adolescents and young adults.

Colton MD, Goulding D, Beltrami A, Cost C, Franklin A, Cockburn MG, Green AL.

Cancer Med. 2019 Aug;8(10):4867-4874. doi: 10.1002/cam4.2230. Epub 2019 Jun 26.


A supervised exercise intervention fails to improve depressive symptoms and quality of life among sedentary older adults with HIV infection.

Goulding D, Wilson MP, MaWhinney S, Jankowski CM, Erlandson KM.

AIDS Care. 2019 Jun 25:1-8. doi: 10.1080/09540121.2019.1634788. [Epub ahead of print]


Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens.

Lees EA, Forbester JL, Forrest S, Kane L, Goulding D, Dougan G.

J Vis Exp. 2019 May 12;(147). doi: 10.3791/59478.


Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice.

Morganti JM, Goulding DS, Van Eldik LJ.

J Neuroinflammation. 2019 May 10;16(1):98. doi: 10.1186/s12974-019-1493-5.


The history, genome and biology of NCTC 30: a non-pandemic Vibrio cholerae isolate from World War One.

Dorman MJ, Kane L, Domman D, Turnbull JD, Cormie C, Fazal MA, Goulding DA, Russell JE, Alexander S, Thomson NR.

Proc Biol Sci. 2019 Apr 10;286(1900):20182025. doi: 10.1098/rspb.2018.2025.


Experimental electric field visualisation of multi-mode dynamics in a short cavity swept laser designed for OCT applications.

Butler TP, Goulding D, Slepneva S, O'Shaughnessy B, Hegarty SP, Huyet G, Kelleher B.

Opt Express. 2019 Mar 4;27(5):7307-7318. doi: 10.1364/OE.27.007307.


FBXO7 sensitivity of phenotypic traits elucidated by a hypomorphic allele.

Ballesteros Reviriego C, Clare S, Arends MJ, Cambridge EL, Swiatkowska A, Caetano S, Abu-Helil B, Kane L, Harcourt K, Goulding DA, Gleeson D, Ryder E, Doe B, White JK, van der Weyden L, Dougan G, Adams DJ, Speak AO.

PLoS One. 2019 Mar 6;14(3):e0212481. doi: 10.1371/journal.pone.0212481. eCollection 2019.


Separating Bacteria by Capsule Amount Using a Discontinuous Density Gradient.

Feltwell T, Dorman MJ, Goulding DA, Parkhill J, Short FL.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58679.


Square wave excitability in quantum dot lasers under optical injection.

Dillane M, Tykalewicz B, Goulding D, Garbin B, Barland S, Kelleher B.

Opt Lett. 2019 Jan 15;44(2):347-350. doi: 10.1364/OL.44.000347.


Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

Duque-Correa MA, Karp NA, McCarthy C, Forman S, Goulding D, Sankaranarayanan G, Jenkins TP, Reid AJ, Cambridge EL, Ballesteros Reviriego C; Sanger Mouse Genetics Project; 3i consortium, Müller W, Cantacessi C, Dougan G, Grencis RK, Berriman M.

PLoS Pathog. 2019 Jan 14;15(1):e1007265. doi: 10.1371/journal.ppat.1007265. eCollection 2019 Jan.


The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort.

Dorman MJ, Feltwell T, Goulding DA, Parkhill J, Short FL.

MBio. 2018 Nov 20;9(6). pii: e01863-18. doi: 10.1128/mBio.01863-18.


A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa.

Nolan LM, Whitchurch CB, Barquist L, Katrib M, Boinett CJ, Mayho M, Goulding D, Charles IG, Filloux A, Parkhill J, Cain AK.

Microb Genom. 2018 Nov;4(11). doi: 10.1099/mgen.0.000229. Epub 2018 Nov 1.


Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

Murai K, Skrupskelyte G, Piedrafita G, Hall M, Kostiou V, Ong SH, Nagy T, Cagan A, Goulding D, Klein AM, Hall BA, Jones PH.

Cell Stem Cell. 2018 Nov 1;23(5):687-699.e8. doi: 10.1016/j.stem.2018.08.017. Epub 2018 Sep 27.


Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123. doi: 10.1073/pnas.1811866115. Epub 2018 Sep 14.


New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.

Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S, Goulding DA, Hoang NTD, Tuyen HT, Lan NPH, Thompson CN, Trang NHT, Carrique-Mas J, Tue NT, Campbell JI, Rabaa MA, Thanh DP, Harcourt K, Hoa NT, Trung NV, Schultsz C, Perron GG, Coia JE, Brown DJ, Okoro C, Parkhill J, Thomson NR, Chau NVV, Thwaites GE, Maskell DJ, Dougan G, Kenney LJ, Baker S.

MBio. 2018 Sep 4;9(5). pii: e01056-18. doi: 10.1128/mBio.01056-18.


Socioeconomics, race, and ethnicity in childhood cancer survival: Accessing and addressing root causes of disparities.

Colton MD, Hawkins M, Goulding D, Cockburn M, Green AL.

Cancer. 2018 Oct 15;124(20):3975-3978. doi: 10.1002/cncr.31558. Epub 2018 Aug 20. No abstract available.


Inter-α-inhibitor deficiency in the mouse is associated with alterations in anxiety-like behavior, exploration and social approach.

Goulding DR, Nikolova VD, Mishra L, Zhuo L, Kimata K, McBride SJ, Moy SS, Harry GJ, Garantziotis S.

Genes Brain Behav. 2019 Jan;18(1):e12505. doi: 10.1111/gbb.12505. Epub 2018 Aug 6.


Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.

Cain AK, Boinett CJ, Barquist L, Dordel J, Fookes M, Mayho M, Ellington MJ, Goulding D, Pickard D, Wick RR, Holt KE, Parkhill J, Thomson NR.

Sci Rep. 2018 Jun 29;8(1):9868. doi: 10.1038/s41598-018-28199-y.


Lysogenic conversion of atypical enteropathogenic Escherichia coli (aEPEC) from human, murine, and bovine origin with bacteriophage Φ3538 Δstx2::cat proves their enterohemorrhagic E. coli (EHEC) progeny.

Eichhorn I, Heidemanns K, Ulrich RG, Schmidt H, Semmler T, Fruth A, Bethe A, Goulding D, Pickard D, Karch H, Wieler LH.

Int J Med Microbiol. 2018 Oct;308(7):890-898. doi: 10.1016/j.ijmm.2018.06.005. Epub 2018 Jun 19.


Delay induced high order locking effects in semiconductor lasers.

Kelleher B, Wishon MJ, Locquet A, Goulding D, Tykalewicz B, Huyet G, Viktorov EA.

Chaos. 2017 Nov;27(11):114325. doi: 10.1063/1.4994029.


Direct experimental measurement of single-mode and mode-hopping dynamics in frequency swept lasers.

Butler TP, Goulding D, Kelleher B, O'Shaughnessy B, Slepneva S, Hegarty SP, Huyet G.

Opt Express. 2017 Oct 30;25(22):27464-27474. doi: 10.1364/OE.25.027464.


Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome.

Abdi A, Yu L, Goulding D, Rono MK, Bejon P, Choudhary J, Rayner J.

Wellcome Open Res. 2017 Nov 22;2:50. doi: 10.12688/wellcomeopenres.11910.2. eCollection 2017.


Two-color bursting oscillations.

Kelleher B, Tykalewicz B, Goulding D, Fedorov N, Dubinkin I, Erneux T, Viktorov EA.

Sci Rep. 2017 Aug 21;7(1):8414. doi: 10.1038/s41598-017-08751-y.


Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium.

Ondari EM, Heath JN, Klemm EJ, Langridge G, Barquist L, Goulding DA, Clare S, Dougan G, Kingsley RA, MacLennan CA.

Infect Immun. 2017 Aug 18;85(9). pii: e00419-17. doi: 10.1128/IAI.00419-17. Print 2017 Sep.


Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W, Parry-Smith D, Goulding D, Pickard D, Roumeliotis T, Choudhary J, Thomson N, Skarnes WC, Dougan G, Hancock REW.

Nat Commun. 2017 Apr 25;8:15013. doi: 10.1038/ncomms15013.


Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.


Evolution of complexity in the zebrafish synapse proteome.

Bayés À, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG.

Nat Commun. 2017 Mar 2;8:14613. doi: 10.1038/ncomms14613.


Clinical Effectiveness of Dual Nicotine Replacement Therapy in Planned Hospital Admissions to an Epilepsy Monitoring Unit: An Irish Perspective.

McGinty RN, Goulding DM, McCarthy MJ, Moloney SM, Costello DJ, Plant BJ.

Nicotine Tob Res. 2018 Apr 2;20(5):656-658. doi: 10.1093/ntr/ntx029. No abstract available.


A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle.

Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O.

Cell Host Microbe. 2017 Jan 11;21(1):11-22. doi: 10.1016/j.chom.2016.12.003.


Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors.

Goulding DR, White SS, McBride SJ, Fenton SE, Harry GJ.

Neurotoxicology. 2017 Jan;58:110-119. doi: 10.1016/j.neuro.2016.11.008. Epub 2016 Nov 22.


The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity.

Cambridge EL, McIntyre Z, Clare S, Arends MJ, Goulding D, Isherwood C, Caetano SS, Reviriego CB, Swiatkowska A, Kane L, Harcourt K; Sanger Mouse Genetics Project, Adams DJ, White JK, Speak AO.

Exp Hematol. 2017 Jan;45:64-68.e5. doi: 10.1016/j.exphem.2016.09.006. Epub 2016 Sep 22.


Evaluation of buprenorphine hydrochloride Pluronic(®) gel formulation in male C57BL/6NCrl mice.

Blankenship-Paris TL, Dutton JW, Goulding DR, McGee CA, Kissling GE, Myers PH.

Lab Anim (NY). 2016 Sep 21;45(10):370-9. doi: 10.1038/laban.1106.


Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR, Hale C, Heath JN, Wileman T, Clare S, Kane L, Goulding D, Otto TD, Kay S, Doffinger R, Cooke FJ, Carmichael A, Lever AM, Parkhill J, MacLennan CA, Kumararatne D, Dougan G, Kingsley RA.

Nat Microbiol. 2016 Jan 25;1:15023. doi: 10.1038/nmicrobiol.2015.23.


Injection-induced, tunable all-optical gating in a two-state quantum dot laser.

Viktorov EA, Dubinkin I, Fedorov N, Erneux T, Tykalewicz B, Hegarty SP, Huyet G, Goulding D, Kelleher B.

Opt Lett. 2016 Aug 1;41(15):3555-8. doi: 10.1364/OL.41.003555.


Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ, Kamuyu G, Goulding D, Bustamante LY, Miles A, Moore SC, Dougan G, Holder AA, Kwiatkowski DP, Rayner JC, Pleass RJ, Wright GJ.

J Biol Chem. 2016 Jul 1;291(27):14285-99. doi: 10.1074/jbc.M116.722074. Epub 2016 May 12.


Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.

Browne HP, Forster SC, Anonye BO, Kumar N, Neville BA, Stares MD, Goulding D, Lawley TD.

Nature. 2016 May 26;533(7604):543-546. doi: 10.1038/nature17645. Epub 2016 May 4.


Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR, Hale C, Heath JN, Wileman T, Clare S, Kane L, Goulding D, Otto TD, Kay S, Doffinger R, Cooke FJ, Carmichael A, Lever AM, Parkhill J, MacLennan CA, Kumararatne D, Dougan G, Kingsley RA.

Nat Microbiol. 2016 Mar;1(3). pii: 15023. doi: 10.1038/nmicrobiol.2015.23. Epub 2016 Jan 25.


Optically induced hysteresis in a two-state quantum dot laser.

Tykalewicz B, Goulding D, Hegarty SP, Huyet G, Dubinkin I, Fedorov N, Erneux T, Viktorov EA, Kelleher B.

Opt Lett. 2016 Mar 1;41(5):1034-7. doi: 10.1364/OL.41.001034.


Emergence of resonant mode-locking via delayed feedback in quantum dot semiconductor lasers.

Tykalewicz B, Goulding D, Hegarty SP, Huyet G, Erneux T, Kelleher B, Viktorov EA.

Opt Express. 2016 Feb 22;24(4):4239-46.


MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ.

PLoS One. 2016 Feb 12;11(2):e0149451. doi: 10.1371/journal.pone.0149451. eCollection 2016.


A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.

Makendi C, Page AJ, Wren BW, Le Thi Phuong T, Clare S, Hale C, Goulding D, Klemm EJ, Pickard D, Okoro C, Hunt M, Thompson CN, Phu Huong Lan N, Tran Do Hoang N, Thwaites GE, Le Hello S, Brisabois A, Weill FX, Baker S, Dougan G.

PLoS Negl Trop Dis. 2016 Feb 11;10(2):e0004446. doi: 10.1371/journal.pntd.0004446. eCollection 2016 Feb.


Optical ultrafast random number generation at 1 Tb/s using a turbulent semiconductor ring cavity laser.

Butler T, Durkan C, Goulding D, Slepneva S, Kelleher B, Hegarty SP, Huyet G.

Opt Lett. 2016 Jan 15;41(2):388-91. doi: 10.1364/OL.41.000388.


Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen.

Hart PJ, O'Shaughnessy CM, Siggins MK, Bobat S, Kingsley RA, Goulding DA, Crump JA, Reyburn H, Micoli F, Dougan G, Cunningham AF, MacLennan CA.

PLoS One. 2016 Jan 7;11(1):e0145945. doi: 10.1371/journal.pone.0145945. eCollection 2016.


Single shot, time-resolved measurement of the coherence properties of OCT swept source lasers.

Butler T, Slepneva S, O'Shaughnessy B, Kelleher B, Goulding D, Hegarty SP, Lyu HC, Karnowski K, Wojtkowski M, Huyet G.

Opt Lett. 2015 May 15;40(10):2277-80. doi: 10.1364/OL.40.002277.


Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.

Forbester JL, Goulding D, Vallier L, Hannan N, Hale C, Pickard D, Mukhopadhyay S, Dougan G.

Infect Immun. 2015 Jul;83(7):2926-34. doi: 10.1128/IAI.00161-15. Epub 2015 May 11.

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