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Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine.

Gould HJ, James LK.

J Allergy Clin Immunol. 2019 Jun 7. pii: S0091-6749(19)30746-8. doi: 10.1016/j.jaci.2019.05.027. [Epub ahead of print] No abstract available.


Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway.

Ramadani F, Bowen H, Gould HJ, Fear DJ.

Front Immunol. 2019 Mar 11;10:402. doi: 10.3389/fimmu.2019.00402. eCollection 2019.


AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper.

Untersmayr E, Bax HJ, Bergmann C, Bianchini R, Cozen W, Gould HJ, Hartmann K, Josephs DH, Levi-Schaffer F, Penichet ML, O'Mahony L, Poli A, Redegeld FA, Roth-Walter F, Turner MC, Vangelista L, Karagiannis SN, Jensen-Jarolim E.

Allergy. 2019 Jun;74(6):1037-1051. doi: 10.1111/all.13718. Epub 2019 Mar 6.


Peanut allergen-specific antibodies go public.

Gould HJ, Ramadani F.

Science. 2018 Dec 14;362(6420):1247-1248. doi: 10.1126/science.aav3709. No abstract available.


Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa.

Ohm-Laursen L, Meng H, Chen J, Zhou JQ, Corrigan CJ, Gould HJ, Kleinstein SH.

Front Immunol. 2018 Sep 7;9:1976. doi: 10.3389/fimmu.2018.01976. eCollection 2018.


Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.

Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ, James LK, Sutton BJ.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8707-E8716. doi: 10.1073/pnas.1806840115. Epub 2018 Aug 27.


Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.

Chen JB, Ramadani F, Pang MOY, Beavil RL, Holdom MD, Mitropoulou AN, Beavil AJ, Gould HJ, Chang TW, Sutton BJ, McDonnell JM, Davies AM.

Sci Rep. 2018 Aug 1;8(1):11548. doi: 10.1038/s41598-018-29664-4.


IgE repertoire and immunological memory: compartmental regulation and antibody function.

Gould HJ, Wu YB.

Int Immunol. 2018 Aug 30;30(9):403-412. doi: 10.1093/intimm/dxy048.


An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

Josephs DH, Nakamura M, Bax HJ, Dodev TS, Muirhead G, Saul L, Karagiannis P, Ilieva KM, Crescioli S, Gazinska P, Woodman N, Lombardelli C, Kareemaghay S, Selkirk C, Lentfer H, Barton C, Canevari S, Figini M, Downes N, Dombrowicz D, Corrigan CJ, Nestle FO, Jones PS, Gould HJ, Blower PJ, Tsoka S, Spicer JF, Karagiannis SN.

Allergy. 2018 Dec;73(12):2328-2341. doi: 10.1111/all.13455. Epub 2018 Oct 8.


Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps.

Gould HJ 3rd, Norleans J, Ward TD, Reid C, Paul D.

Oncotarget. 2018 Feb 26;9(21):15606-15615. doi: 10.18632/oncotarget.24581. eCollection 2018 Mar 20.


Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.

Doré KA, Kashiwakura JI, McDonnell JM, Gould HJ, Kawakami T, Sutton BJ, Davies AM.

Mol Immunol. 2018 Jan;93:216-222. doi: 10.1016/j.molimm.2017.11.022. Epub 2017 Dec 5.


AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer.

Jensen-Jarolim E, Bax HJ, Bianchini R, Crescioli S, Daniels-Wells TR, Dombrowicz D, Fiebiger E, Gould HJ, Irshad S, Janda J, Josephs DH, Levi-Schaffer F, O'Mahony L, Pellizzari G, Penichet ML, Redegeld F, Roth-Walter F, Singer J, Untersmayr E, Vangelista L, Karagiannis SN.

Allergy. 2018 Feb;73(2):328-340. doi: 10.1111/all.13311. Epub 2017 Oct 5. Review.


IgE Trimers Drive SPE-7 Cytokinergic Activity.

Bax HJ, Bowen H, Beavil RL, Chung R, Ward M, Davies AM, Dodev TS, McDonnell JM, Beavil AJ, Sutton BJ, Gould HJ.

Sci Rep. 2017 Aug 15;7(1):8164. doi: 10.1038/s41598-017-08212-6.


IgE binds asymmetrically to its B cell receptor CD23.

Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ.

Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533.


Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P, Cheung A, Herraiz C, Ilieva KM, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S, Chiaruttini G, Gilbert AE, Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan CJ, Beavil AJ, Nestle FO, Jones PS, Gould HJ, Sanz-Moreno V, Blower PJ, Spicer JF, Karagiannis SN.

Cancer Res. 2017 Mar 1;77(5):1127-1141. doi: 10.1158/0008-5472.CAN-16-1829. Epub 2017 Jan 17.


AllergoOncology - the impact of allergy in oncology: EAACI position paper.

Jensen-Jarolim E, Bax HJ, Bianchini R, Capron M, Corrigan C, Castells M, Dombrowicz D, Daniels-Wells TR, Fazekas J, Fiebiger E, Gatault S, Gould HJ, Janda J, Josephs DH, Karagiannis P, Levi-Schaffer F, Meshcheryakova A, Mechtcheriakova D, Mekori Y, Mungenast F, Nigro EA, Penichet ML, Redegeld F, Saul L, Singer J, Spicer JF, Siccardi AG, Spillner E, Turner MC, Untersmayr E, Vangelista L, Karagiannis SN.

Allergy. 2017 Jun;72(6):866-887. doi: 10.1111/all.13119. Epub 2017 Jan 23. Review.


Omalizumab reduces bronchial mucosal IgE and improves lung function in non-atopic asthma.

Pillai P, Chan YC, Wu SY, Ohm-Laursen L, Thomas C, Durham SR, Menzies-Gow A, Rajakulasingam RK, Ying S, Gould HJ, Corrigan CJ.

Eur Respir J. 2016 Dec;48(6):1593-1601. doi: 10.1183/13993003.01501-2015. Epub 2016 Oct 20.


Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps.

Chen JB, James LK, Davies AM, Wu YB, Rimmer J, Lund VJ, Chen JH, McDonnell JM, Chan YC, Hutchins GH, Chang TW, Sutton BJ, Kariyawasam HH, Gould HJ.

J Allergy Clin Immunol. 2017 Apr;139(4):1195-1204.e11. doi: 10.1016/j.jaci.2016.06.066. Epub 2016 Sep 19.


Ranolazine: A potential treatment for refractory neuropathic pain.

Gould HJ 3rd, Diamond I.

J Neurol Sci. 2016 Oct 15;369:310-311. doi: 10.1016/j.jns.2016.08.047. Epub 2016 Aug 28. No abstract available.


Ontogeny of human IgE-expressing B cells and plasma cells.

Ramadani F, Bowen H, Upton N, Hobson PS, Chan YC, Chen JB, Chang TW, McDonnell JM, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2017 Jan;72(1):66-76. doi: 10.1111/all.12911. Epub 2016 Jun 8.


Chronic Daily Headache: Mechanisms and Principles of Management.

Voigt AW, Gould HJ 3rd.

Curr Pain Headache Rep. 2016 Feb;20(2):10. doi: 10.1007/s11916-016-0542-3. Review.


Critical appraisal of extended-release hydrocodone for chronic pain: patient considerations.

Gould HJ 3rd, Paul D.

Ther Clin Risk Manag. 2015 Oct 22;11:1635-40. doi: 10.2147/TCRM.S81979. eCollection 2015. Review.


Epitope specificity determines cross-protection of a SIT-induced IgG4 antibody.

Gadermaier E, James LK, Shamji MH, Blatt K, Fauland K, Zieglmayer P, Garmatiuk T, Focke-Tejkl M, Villalba M, Beavil R, Keller W, Valent P, Durham SR, Gould HJ, Flicker S, Valenta R.

Allergy. 2016 Jan;71(1):36-46. doi: 10.1111/all.12710. Epub 2015 Sep 30.


Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE.

Ramadani F, Upton N, Hobson P, Chan YC, Mzinza D, Bowen H, Kerridge C, Sutton BJ, Fear DJ, Gould HJ.

Allergy. 2015 Oct;70(10):1269-77. doi: 10.1111/all.12679. Epub 2015 Jul 24.


Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro.

Bax HJ, Bowen H, Dodev TS, Sutton BJ, Gould HJ.

Sci Rep. 2015 Apr 20;5:9538. doi: 10.1038/srep09538.


Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class.

Dodev TS, Bowen H, Shamji MH, Bax HJ, Beavil AJ, McDonnell JM, Durham SR, Sutton BJ, Gould HJ, James LK.

Allergy. 2015 Jun;70(6):720-4. doi: 10.1111/all.12607. Epub 2015 Mar 28.


IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens.

Santos AF, James LK, Bahnson HT, Shamji MH, Couto-Francisco NC, Islam S, Houghton S, Clark AT, Stephens A, Turcanu V, Durham SR, Gould HJ, Lack G.

J Allergy Clin Immunol. 2015 May;135(5):1249-56. doi: 10.1016/j.jaci.2015.01.012. Epub 2015 Feb 7.


A plea for rational mitigation of poor outcomes in the 'off-label use' of medications for the management of pain.

Khursheed F, Ioffe J, Gould HJ 3rd.

J Neurol Sci. 2015 Feb 15;349(1-2):72-6. doi: 10.1016/j.jns.2014.12.028. Epub 2014 Dec 27.


Increased IgA production by B-cells in COPD via lung epithelial interleukin-6 and TACI pathways.

Ladjemi MZ, Lecocq M, Weynand B, Bowen H, Gould HJ, Van Snick J, Detry B, Pilette C.

Eur Respir J. 2015 Apr;45(4):980-93. doi: 10.1183/09031936.00063914. Epub 2014 Dec 23.


IgE responses in mouse and man and the persistence of IgE memory.

Gould HJ, Ramadani F.

Trends Immunol. 2015 Jan;36(1):40-8. doi: 10.1016/ Epub 2014 Dec 9. Review.


Local IgE in non-allergic rhinitis.

Campo P, Rondón C, Gould HJ, Barrionuevo E, Gevaert P, Blanca M.

Clin Exp Allergy. 2015 May;45(5):872-881. doi: 10.1111/cea.12476. Review.


Hydrocodone extended-release: pharmacodynamics, pharmacokinetics and behavioral pharmacology of a controversy.

Gould HJ 3rd, Paul D.

Pharmacol Res. 2015 Jan;91:99-103. doi: 10.1016/j.phrs.2014.09.006. Epub 2014 Oct 6. Review.


Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis.

Wu YC, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ.

J Allergy Clin Immunol. 2014 Sep;134(3):604-12. doi: 10.1016/j.jaci.2014.07.010.


Ranolazine attenuates mechanical allodynia associated with demyelination injury.

Gould HJ 3rd, Soignier RD, Cho SR, Hernandez C, Diamond I, Taylor BK, Paul D.

Pain Med. 2014 Oct;15(10):1771-80. doi: 10.1111/pme.12516. Epub 2014 Aug 4.


"Auto-anti-IgE": naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation.

Chan YC, Ramadani F, Santos AF, Pillai P, Ohm-Laursen L, Harper CE, Fang C, Dodev TS, Wu SY, Ying S, Corrigan CJ, Gould HJ.

J Allergy Clin Immunol. 2014 Dec;134(6):1394-1401.e4. doi: 10.1016/j.jaci.2014.06.029. Epub 2014 Aug 10.


A tool kit for rapid cloning and expression of recombinant antibodies.

Dodev TS, Karagiannis P, Gilbert AE, Josephs DH, Bowen H, James LK, Bax HJ, Beavil R, Pang MO, Gould HJ, Karagiannis SN, Beavil AJ.

Sci Rep. 2014 Jul 30;4:5885. doi: 10.1038/srep05885.


Allergen-specific IgE is not detectable in the bronchial mucosa of nonatopic asthmatic patients.

Pillai P, Fang C, Chan YC, Shamji MH, Harper C, Wu SY, Ohm-Laursen L, Durham SR, Menzies-Gow A, Rajakulasingam RK, Ying S, Corrigan CJ, Gould HJ.

J Allergy Clin Immunol. 2014 Jun;133(6):1770-2.e11. doi: 10.1016/j.jaci.2014.03.027. Epub 2014 May 1. No abstract available.


Regulation and pharmacological blockade of sodium-potassium ATPase: a novel pathway to neuropathy.

Paul D, Soignier RD, Minor L, Tau H, Songu-Mize E, Gould HJ 3rd.

J Neurol Sci. 2014 May 15;340(1-2):139-43. doi: 10.1016/j.jns.2014.03.012. Epub 2014 Mar 13.


A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma.

Cohen ES, Dobson CL, Käck H, Wang B, Sims DA, Lloyd CO, England E, Rees DG, Guo H, Karagiannis SN, O'Brien S, Persdotter S, Ekdahl H, Butler R, Keyes F, Oakley S, Carlsson M, Briend E, Wilkinson T, Anderson IK, Monk PD, von Wachenfeldt K, Eriksson PO, Gould HJ, Vaughan TJ, May RD.

MAbs. 2014 May-Jun;6(3):756-64. doi: 10.4161/mabs.28394. Epub 2014 Feb 28.


Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency.

Saul L, Josephs DH, Cutler K, Bradwell A, Karagiannis P, Selkirk C, Gould HJ, Jones P, Spicer JF, Karagiannis SN.

MAbs. 2014 Mar-Apr;6(2):509-22. doi: 10.4161/mabs.27828. Epub 2014 Jan 14.


Human IgE against the major allergen Bet v 1--defining an epitope with limited cross-reactivity between different PR-10 family proteins.

Levin M, Davies AM, Liljekvist M, Carlsson F, Gould HJ, Sutton BJ, Ohlin M.

Clin Exp Allergy. 2014 Feb;44(2):288-99. doi: 10.1111/cea.12230.


IgE immunotherapy: a novel concept with promise for the treatment of cancer.

Josephs DH, Spicer JF, Karagiannis P, Gould HJ, Karagiannis SN.

MAbs. 2014 Jan-Feb;6(1):54-72. doi: 10.4161/mabs.27029. Review.


Structural determinants of unique properties of human IgG4-Fc.

Davies AM, Rispens T, Ooijevaar-de Heer P, Gould HJ, Jefferis R, Aalberse RC, Sutton BJ.

J Mol Biol. 2014 Feb 6;426(3):630-44. doi: 10.1016/j.jmb.2013.10.039. Epub 2013 Nov 6.


Epidemiological associations of allergy, IgE and cancer.

Josephs DH, Spicer JF, Corrigan CJ, Gould HJ, Karagiannis SN.

Clin Exp Allergy. 2013 Oct;43(10):1110-23. doi: 10.1111/cea.12178. Review.


Immunoglobulin E and Allergy: Antibodies in Immune Inflammation and Treatment.

Karagiannis SN, Karagiannis P, Josephs DH, Saul L, Gilbert AE, Upton N, Gould HJ.

Microbiol Spectr. 2013 Oct;1(1). doi: 10.1128/microbiolspec.AID-0006-2012.


Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.

Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ.

Mol Immunol. 2013 Dec;56(4):693-7. doi: 10.1016/j.molimm.2013.07.005. Epub 2013 Aug 7.


Morphine-induced cognitive impairment is attenuated by induced pain in rats.

Baiamonte BA, Lee FA, Gould HJ 3rd, Soignier RD.

Behav Neurosci. 2013 Aug;127(4):524-34. doi: 10.1037/a0033027. Epub 2013 Jun 24.


Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.

Yuan D, Keeble AH, Hibbert RG, Fabiane S, Gould HJ, McDonnell JM, Beavil AJ, Sutton BJ, Dhaliwal B.

J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.


Comprehensive FISH probe design tool applied to imaging human immunoglobulin class switch recombination.

Nedbal J, Hobson PS, Fear DJ, Heintzmann R, Gould HJ.

PLoS One. 2012;7(12):e51675. doi: 10.1371/journal.pone.0051675. Epub 2012 Dec 14.

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