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Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.

Crittenden MR, Zebertavage L, Kramer G, Bambina S, Friedman D, Troesch V, Blair T, Baird JR, Alice A, Gough MJ.

Sci Rep. 2018 May 3;8(1):7012. doi: 10.1038/s41598-018-25482-w.


Spasticity in children with cerebral palsy: what are we treating?

Gough M.

Dev Med Child Neurol. 2018 Jul;60(7):638. doi: 10.1111/dmcn.13770. Epub 2018 Apr 6. No abstract available.


Correction: STING expression and response to treatment with STING ligands in premalignant and malignant disease.

Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ.

PLoS One. 2018 Feb 15;13(2):e0192988. doi: 10.1371/journal.pone.0192988. eCollection 2018.


A couple-level analysis of participation in physical activity during unemployment.

Gough M.

SSM Popul Health. 2017 Mar 4;3:294-304. doi: 10.1016/j.ssmph.2017.03.001. eCollection 2017 Dec.


The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy.

Noble JJ, Chruscikowski E, Fry NRD, Lewis AP, Gough M, Shortland AP.

BMC Neurol. 2017 Dec 29;17(1):223. doi: 10.1186/s12883-017-1005-0.


Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.

Alice AF, Kramer G, Bambina S, Baird JR, Bahjat KS, Gough MJ, Crittenden MR.

J Immunol. 2018 Jan 1;200(1):177-185. doi: 10.4049/jimmunol.1700909. Epub 2017 Nov 17.


STING expression and response to treatment with STING ligands in premalignant and malignant disease.

Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ.

PLoS One. 2017 Nov 14;12(11):e0187532. doi: 10.1371/journal.pone.0187532. eCollection 2017. Erratum in: PLoS One. 2018 Feb 15;13(2):e0192988.


Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine.

Stork G, Yamashita A, Hanson RM, Phan L, Phillips E, Dubé D, Bos PH, Clark AJ, Gough M, Greenlee ML, Jiang Y, Jones K, Kitamura M, Leonard J, Liu T, Parsons PJ, Venkatesan AM.

Org Lett. 2017 Oct 6;19(19):5150-5153. doi: 10.1021/acs.orglett.7b02434. Epub 2017 Sep 6.


Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control.

Baird JR, Monjazeb AM, Shah O, McGee H, Murphy WJ, Crittenden MR, Gough MJ.

Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):362-373. doi: 10.1016/j.ijrobp.2017.04.014. Epub 2017 Apr 19. Review.


Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.

Messenheimer DJ, Jensen SM, Afentoulis ME, Wegmann KW, Feng Z, Friedman DJ, Gough MJ, Urba WJ, Fox BA.

Clin Cancer Res. 2017 Oct 15;23(20):6165-6177. doi: 10.1158/1078-0432.CCR-16-2677. Epub 2017 Aug 28.


The dynamic immunomodulatory effects of vitamin D3 during Mycobacterium infection.

Gough ME, Graviss EA, May EE.

Innate Immun. 2017 Aug;23(6):506-523. doi: 10.1177/1753425917719143.


"Take-home" box trainers are an effective alternative to virtual reality simulators.

Yiasemidou M, de Siqueira J, Tomlinson J, Glassman D, Stock S, Gough M.

J Surg Res. 2017 Jun 1;213:69-74. doi: 10.1016/j.jss.2017.02.038. Epub 2017 Mar 1.


A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.

Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR.

MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17.


Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.

Snell CE, Gough M, Middleton K, Hsieh M, Furnas L, Seidl B, Gibbons K, Pyke C, Shannon C, Woodward N, Armes JE.

J Clin Pathol. 2017 Nov;70(11):954-960. doi: 10.1136/jclinpath-2016-204304. Epub 2017 Apr 17.


José Balaguer-Morris.

Balaguer A, Gough M.

Br Dent J. 2017 Apr 7;222(7):505. doi: 10.1038/sj.bdj.2017.306. No abstract available.


Abnormality of standing posture improves in patients with bilateral spastic cerebral palsy following lower limb surgery.

Buddhdev P, Fry NR, LePage R, Wiley M, Gough M, Shortland AP.

Gait Posture. 2017 May;54:255-258. doi: 10.1016/j.gaitpost.2017.03.014. Epub 2017 Mar 9.


An in silico model of the effects of vitamin D3 on mycobacterium infected macrophage.

Gough M, May E.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1443-1446. doi: 10.1109/EMBC.2016.7590980.


Erratum to 'Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy' [Oral Oncol. 61 (2016) 166-176].

Bell RB, Gough MJ, Seung SK, Jutric Z, Weinberg AD, Fox BA, Crittenden MR, Leidner RS, Curti B.

Oral Oncol. 2017 Mar;66:e3. doi: 10.1016/j.oraloncology.2017.02.001. Epub 2017 Feb 12. No abstract available.


Mining routinely collected acute data to reveal non-linear relationships between nurse staffing levels and outcomes.

Leary A, Cook R, Jones S, Smith J, Gough M, Maxwell E, Punshon G, Radford M.

BMJ Open. 2016 Dec 16;6(12):e011177. doi: 10.1136/bmjopen-2016-011177.


Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model.

McGinnis GJ, Friedman D, Young KH, Torres ER, Thomas CR Jr, Gough MJ, Raber J.

Oncotarget. 2017 Feb 7;8(6):9155-9173. doi: 10.18632/oncotarget.13551.


Selective motor control correlates with gait abnormality in children with cerebral palsy.

Chruscikowski E, Fry NRD, Noble JJ, Gough M, Shortland AP.

Gait Posture. 2017 Feb;52:107-109. doi: 10.1016/j.gaitpost.2016.11.031. Epub 2016 Nov 19.


Taphonomic Analysis of Rodentia and Lagomorpha Bone Gnawing Based Upon Incisor Size.

Pokines JT, Sussman R, Gough M, Ralston C, McLeod E, Brun K, Kearns A, Moore TL.

J Forensic Sci. 2017 Jan;62(1):50-66. doi: 10.1111/1556-4029.13254. Epub 2016 Nov 11.


Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor.

Boldenow E, Gendrin C, Ngo L, Bierle C, Vornhagen J, Coleman M, Merillat S, Armistead B, Whidbey C, Alishetti V, Santana-Ufret V, Ogle J, Gough M, Srinouanprachanh S, MacDonald JW, Bammler TK, Bansal A, Liggitt HD, Rajagopal L, Adams Waldorf KM.

Sci Immunol. 2016 Oct;1(4). pii: eaah4576. doi: 10.1126/sciimmunol.aah4576. Epub 2016 Oct 14.


Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study.

Tsang G, Insel MB, Weis JM, Morgan MA, Gough MS, Frasier LM, Mack CM, Doolin KP, Graves BT, Apostolakos MJ, Pietropaoli AP.

Crit Care. 2016 Oct 21;20(1):335.


Perceptions About the Present and Future of Surgical Simulation: A National Study of Mixed Qualitative and Quantitative Methodology.

Yiasemidou M, Glassman D, Tomlinson J, Song D, Gough MJ.

J Surg Educ. 2017 Jan - Feb;74(1):108-116. doi: 10.1016/j.jsurg.2016.07.011. Epub 2016 Sep 8.


Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy.

Bryan RB, Gough MJ, Seung SK, Jutric Z, Weinberg AD, Fox BA, Crittenden MR, Leidner RS, Curti B.

Oral Oncol. 2016 Oct;61:166-76. doi: 10.1016/j.oraloncology.2016.08.020. Epub 2016 Sep 7. Review. Erratum in: Oral Oncol. 2017 Mar;66:e3.


Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy.

Crittenden MR, Baird J, Friedman D, Savage T, Uhde L, Alice A, Cottam B, Young K, Newell P, Nguyen C, Bambina S, Kramer G, Akporiaye E, Malecka A, Jackson A, Gough MJ.

Oncotarget. 2016 Nov 29;7(48):78653-78666. doi: 10.18632/oncotarget.11823.


Methionine Metabolites in Patients With Sepsis.

Wexler O, Gough MS, Morgan MAM, Mack CM, Apostolakos MJ, Doolin KP, Mooney RA, Arning E, Bottiglieri T, Pietropaoli AP.

J Intensive Care Med. 2018 Jan;33(1):37-47. doi: 10.1177/0885066616666002. Epub 2016 Sep 2.


A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma.

Crocenzi T, Cottam B, Newell P, Wolf RF, Hansen PD, Hammill C, Solhjem MC, To YY, Greathouse A, Tormoen G, Jutric Z, Young K, Bahjat KS, Gough MJ, Crittenden MR.

J Immunother Cancer. 2016 Aug 16;4:45. doi: 10.1186/s40425-016-0149-6. eCollection 2016.


Programmed cell death-1 blockade enhances response to stereotactic radiation in an orthotopic murine model of hepatocellular carcinoma.

Friedman D, Baird JR, Young KH, Cottam B, Crittenden MR, Friedman S, Gough MJ, Newell P.

Hepatol Res. 2017 Jun;47(7):702-714. doi: 10.1111/hepr.12789. Epub 2016 Sep 22.


Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy.

Young KH, Baird JR, Savage T, Cottam B, Friedman D, Bambina S, Messenheimer DJ, Fox B, Newell P, Bahjat KS, Gough MJ, Crittenden MR.

PLoS One. 2016 Jun 9;11(6):e0157164. doi: 10.1371/journal.pone.0157164. eCollection 2016.


Australia softens blow of climate job cuts.

Gough M.

Nature. 2016 May 5;533(7601):16-7. doi: 10.1038/nature.2016.19831. No abstract available.


Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic.

Richter M, Yumul R, Saydaminova K, Wang H, Gough M, Baldessari A, Cattaneo R, Lee F, Wang CH, Jang H, Astier A, Gopal A, Carter D, Lieber A.

Mol Ther Methods Clin Dev. 2016 Mar 30;5:16013. doi: 10.1038/mtm.2016.13. eCollection 2016.


Correlation between experience targets and competence for general surgery certification.

De Siqueira JR, Gough MJ.

Br J Surg. 2016 Jun;103(7):921-7. doi: 10.1002/bjs.10145. Epub 2016 Apr 6.


Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation.

Malecka A, Wang Q, Shah S, Sutavani RV, Spendlove I, Ramage JM, Greensmith J, Franks HA, Gough MJ, Saalbach A, Patel PM, Jackson AM.

J Leukoc Biol. 2016 Aug;100(2):381-9. doi: 10.1189/jlb.3A1015-474R. Epub 2016 Apr 5.


Conversion to eslicarbazepine acetate monotherapy: A pooled analysis of 2 phase III studies.

Sperling MR, French J, Jacobson MP, Pazdera L, Gough M, Cheng H, Grinnell T, Blum D; Study 045 and 046 Investigators.

Neurology. 2016 Mar 22;86(12):1095-102. doi: 10.1212/WNL.0000000000002497. Epub 2016 Feb 24.


OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment.

Bell RB, Leidner RS, Crittenden MR, Curti BD, Feng Z, Montler R, Gough MJ, Fox BA, Weinberg AD, Urba WJ.

Oral Oncol. 2016 Jan;52:1-10. doi: 10.1016/j.oraloncology.2015.11.009. Epub 2015 Nov 21. Review.


Developing an Immunotherapy Strategy for the Effective Treatment of Oral, Head and Neck Squamous Cell Carcinoma.

Bell RB, Leidner R, Feng Z, Crittenden MR, Gough MJ, Fox BA.

J Oral Maxillofac Surg. 2015 Dec;73(12 Suppl):S107-15. doi: 10.1016/j.joms.2015.05.026. Review. No abstract available.


Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.

Baird JR, Friedman D, Cottam B, Dubensky TW Jr, Kanne DB, Bambina S, Bahjat K, Crittenden MR, Gough MJ.

Cancer Res. 2016 Jan 1;76(1):50-61. doi: 10.1158/0008-5472.CAN-14-3619. Epub 2015 Nov 13.


Successful outcomes following neurorehabilitation in military traumatic brain injury patients in the United Kingdom.

Dharm-Datta S, Gough MR, Porter PJ, Duncan-Anderson J, Olivier E, McGilloway E, Etherington J.

J Trauma Acute Care Surg. 2015 Oct;79(4 Suppl 2):S197-203. doi: 10.1097/TA.0000000000000721.


Comparing equals when evaluating immunotherapy with different doses and fractions of radiation therapy.

Gough MJ, Crittenden MR, Young KH.

Immunotherapy. 2015;7(8):847-9. doi: 10.2217/IMT.15.58. Epub 2015 Aug 13. No abstract available.


Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin.

Richter M, Yumul R, Wang H, Saydaminova K, Ho M, May D, Baldessari A, Gough M, Drescher C, Urban N, Roffler S, Zubieta C, Carter D, Fender P, Lieber A.

Mol Ther Methods Clin Dev. 2015 Mar 11;2:15005. doi: 10.1038/mtm.2015.5. eCollection 2015.


Attitudes towards the surgical safety checklist and factors associated with its use: A global survey of frontline medical professionals.

Vohra RS, Cowley JB, Bhasin N, Barakat HM, Gough MJ;

Ann Med Surg (Lond). 2015 Apr 20;4(2):119-23. doi: 10.1016/j.amsu.2015.04.001. eCollection 2015 Jun.


Tumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy.

Young KH, Gough MJ, Crittenden M.

Oncoimmunology. 2014 Sep 14;4(3):e955696. eCollection 2015 Mar.


Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial.

Brittenden J, Cotton SC, Elders A, Tassie E, Scotland G, Ramsay CR, Norrie J, Burr J, Francis J, Wileman S, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, MacLennan G, Prior M, Bolsover D, Campbell MK.

Health Technol Assess. 2015 Apr;19(27):1-342. doi: 10.3310/hta19270.


The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells.

Gough M, Blanthorn-Hazell S, Delury C, Parkin E.

Biochem Biophys Res Commun. 2014 Oct 31;453(4):741-7. doi: 10.1016/j.bbrc.2014.10.004. Epub 2014 Oct 11.


Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial.

Tassie E, Scotland G, Brittenden J, Cotton SC, Elders A, Campbell MK, Campbell B, Gough M, Burr JM, Ramsay CR; CLASS study team.

Br J Surg. 2014 Nov;101(12):1532-40. doi: 10.1002/bjs.9595.


A randomized trial comparing treatments for varicose veins.

Brittenden J, Cotton SC, Elders A, Ramsay CR, Norrie J, Burr J, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, Francis J, Tassie E, Scotland G, Wileman S, Campbell MK.

N Engl J Med. 2014 Sep 25;371(13):1218-27. doi: 10.1056/NEJMoa1400781.


TGFβ inhibition prior to hypofractionated radiation enhances efficacy in preclinical models.

Young KH, Newell P, Cottam B, Friedman D, Savage T, Baird JR, Akporiaye E, Gough MJ, Crittenden M.

Cancer Immunol Res. 2014 Oct;2(10):1011-22. doi: 10.1158/2326-6066.CIR-13-0207. Epub 2014 Jul 21.

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