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Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.

Duplomb L, Rivière J, Jego G, Da Costa R, Hammann A, Racine J, Schmitt A, Droin N, Capron C, Gougerot-Pocidalo MA, Dubrez L, Aral B, Lafon A, Edery P, Ghoumid J, Blair E, El Chehadeh-Djebbar S, Carmignac V, Thevenon J, Guy J, Girodon F, Bastie JN, Delva L, Faivre L, Thauvin-Robinet C, Solary E.

J Mol Med (Berl). 2019 May;97(5):633-645. doi: 10.1007/s00109-019-01754-4. Epub 2019 Mar 7.


The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.

Arabi-Derkawi R, O'Dowd Y, Cheng N, Rolas L, Boussetta T, Raad H, Marzaioli V, Pintard C, Fasseu M, Kroviarski Y, Belambri SA, Dang PM, Ye RD, Gougerot-Pocidalo MA, El-Benna J.

J Immunol. 2019 Mar 1;202(5):1549-1558. doi: 10.4049/jimmunol.1800610. Epub 2019 Jan 21.


Aspergillus-induced pneumonia in adult without obvious immunodeficiency: test the burst!

Flament H, Granger V, Vezinet C, Marzaioli V, Kannengiesser C, de Chaisemartin L, Hurtado-Nedelec M, Litvinova E, Messika J, Adam N, Gougerot-Pocidalo MA, Dang PM, Monteiro R, El Benna J, Langeron O, Chollet-Martin S, Monsel A.

Eur Respir J. 2018 Apr 26;51(4). pii: 1702711. doi: 10.1183/13993003.02711-2017. Print 2018 Apr. No abstract available.


NOX5 and p22phox are 2 novel regulators of human monocytic differentiation into dendritic cells.

Marzaioli V, Hurtado-Nedelec M, Pintard C, Tlili A, Marie JC, Monteiro RC, Gougerot-Pocidalo MA, Dang PM, El-Benna J.

Blood. 2017 Oct 12;130(15):1734-1745. doi: 10.1182/blood-2016-10-746347. Epub 2017 Aug 22.


Chronic Granulomatous Disease in Patients Reaching Adulthood: A Nationwide Study in France.

Dunogué B, Pilmis B, Mahlaoui N, Elie C, Coignard-Biehler H, Amazzough K, Noël N, Salvator H, Catherinot E, Couderc LJ, Sokol H, Lanternier F, Fouyssac F, Bardet J, Bustamante J, Gougerot-Pocidalo MA, Barlogis V, Masseau A, Durieu I, Lecuit M, Suarez F, Fischer A, Blanche S, Hermine O, Lortholary O.

Clin Infect Dis. 2017 Mar 15;64(6):767-775. doi: 10.1093/cid/ciw837.


Priming of the neutrophil respiratory burst: role in host defense and inflammation.

El-Benna J, Hurtado-Nedelec M, Marzaioli V, Marie JC, Gougerot-Pocidalo MA, Dang PM.

Immunol Rev. 2016 Sep;273(1):180-93. doi: 10.1111/imr.12447. Review.


Xanthine Oxidase-Derived ROS Display a Biphasic Effect on Endothelial Cells Adhesion and FAK Phosphorylation.

Ben-Mahdi MH, Dang PM, Gougerot-Pocidalo MA, O'Dowd Y, El-Benna J, Pasquier C.

Oxid Med Cell Longev. 2016;2016:9346242. doi: 10.1155/2016/9346242. Epub 2016 Jul 27.


TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils.

Makni-Maalej K, Marzaioli V, Boussetta T, Belambri SA, Gougerot-Pocidalo MA, Hurtado-Nedelec M, Dang PM, El-Benna J.

J Leukoc Biol. 2015 Jun;97(6):1081-7. doi: 10.1189/jlb.2A1214-623R. Epub 2015 Apr 15.


Pulmonary manifestations in adult patients with chronic granulomatous disease.

Salvator H, Mahlaoui N, Catherinot E, Rivaud E, Pilmis B, Borie R, Crestani B, Tcherakian C, Suarez F, Dunogue B, Gougerot-Pocidalo MA, Hurtado-Nedelec M, Dreyfus JF, Durieu I, Fouyssac F, Hermine O, Lortholary O, Fischer A, Couderc LJ.

Eur Respir J. 2015 Jun;45(6):1613-23. doi: 10.1183/09031936.00118414. Epub 2015 Jan 22.


Assessment of priming of the human neutrophil respiratory burst.

Hurtado-Nedelec M, Makni-Maalej K, Gougerot-Pocidalo MA, Dang PM, El-Benna J.

Methods Mol Biol. 2014;1124:405-12. doi: 10.1007/978-1-62703-845-4_23.


Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation.

Hurtado-Nedelec M, Csillag-Grange MJ, Boussetta T, Belambri SA, Fay M, Cassinat B, Gougerot-Pocidalo MA, Dang PM, El-Benna J.

Haematologica. 2013 Oct;98(10):1517-24. doi: 10.3324/haematol.2012.082560. Epub 2013 Aug 23.


NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation.

Debbabi M, Kroviarski Y, Bournier O, Gougerot-Pocidalo MA, El-Benna J, Dang PM.

FASEB J. 2013 Apr;27(4):1733-48. doi: 10.1096/fj.12-216432. Epub 2013 Jan 15.


Phosphorylation of p47phox is required for receptor-mediated NADPH oxidase/NOX2 activation in Epstein-Barr virus-transformed human B lymphocytes.

Belambri SA, Hurtado-Nedelec M, Senator A, Makni-Maalej K, Fay M, Gougerot-Pocidalo MA, Marie JC, Dang PM, El-Benna J.

Am J Blood Res. 2012;2(3):187-93. Epub 2012 Oct 20.


Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase.

Makni-Maalej K, Chiandotto M, Hurtado-Nedelec M, Bedouhene S, Gougerot-Pocidalo MA, Dang PM, El-Benna J.

Biochem Pharmacol. 2013 Jan 1;85(1):92-100. doi: 10.1016/j.bcp.2012.10.010. Epub 2012 Oct 22.


The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1.

Makni-Maalej K, Boussetta T, Hurtado-Nedelec M, Belambri SA, Gougerot-Pocidalo MA, El-Benna J.

J Immunol. 2012 Nov 1;189(9):4657-65. doi: 10.4049/jimmunol.1201007. Epub 2012 Sep 21.


The neutrophil and systemic inflammation.

Gougerot-Pocidalo MA.

Joint Bone Spine. 2012 May;79(3):209-11. doi: 10.1016/j.jbspin.2011.12.008. Epub 2012 Feb 5. No abstract available.


Implication of NADPH oxidases in the early inflammation process generated by cystic fibrosis cells.

Pongnimitprasert N, Hurtado M, Lamari F, El Benna J, Dupuy C, Fay M, Foglietti MJ, Bernard M, Gougerot-Pocidalo MA, Braut-Boucher F.

ISRN Inflamm. 2012 Jul 5;2012:481432. doi: 10.5402/2012/481432. eCollection 2012.


Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes.

Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, Hayem G, Gougerot-Pocidalo MA, Frystyk J, Flyvbjerg A, El Benna J, Marie JC.

Am J Pathol. 2012 Feb;180(2):682-92. doi: 10.1016/j.ajpath.2011.10.013. Epub 2011 Nov 23.


The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils: Regulation by a protein tyrosine kinase, MEK1/2 and phosphatases 1/2A.

Dang PM, Raad H, Derkawi RA, Boussetta T, Paclet MH, Belambri SA, Makni-Maalej K, Kroviarski Y, Morel F, Gougerot-Pocidalo MA, El-Benna J.

Biochem Pharmacol. 2011 Nov 1;82(9):1145-52. doi: 10.1016/j.bcp.2011.07.070. Epub 2011 Jul 20.


The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.

Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, Raad H, Arabi Derkawi R, Bournier O, Kroviarski Y, Zhou XZ, Malter JS, Lu PK, Bartegi A, Dang PM, El-Benna J.

Blood. 2010 Dec 23;116(26):5795-802. doi: 10.1182/blood-2010-03-273094. Epub 2010 Oct 18.


Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France.

Beauté J, Obenga G, Le Mignot L, Mahlaoui N, Bougnoux ME, Mouy R, Gougerot-Pocidalo MA, Barlogis V, Suarez F, Lanternier F, Hermine O, Lecuit M, Blanche S, Fischer A, Lortholary O; French PID Study Group CEREDIH.

Pediatr Infect Dis J. 2011 Jan;30(1):57-62. doi: 10.1097/INF.0b013e3181f13b23.


Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation.

Kroviarski Y, Debbabi M, Bachoual R, Périanin A, Gougerot-Pocidalo MA, El-Benna J, Dang PM.

FASEB J. 2010 Jun;24(6):2077-92. doi: 10.1096/fj.09-147629. Epub 2010 Jan 28.


Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats.

Boussetta T, Raad H, Lettéron P, Gougerot-Pocidalo MA, Marie JC, Driss F, El-Benna J.

PLoS One. 2009 Jul 31;4(7):e6458. doi: 10.1371/journal.pone.0006458.


Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease.

Khaldi H, Marchand-Adam S, Kannengiesser C, Fabre A, Debray MP, Danel C, Gougerot-Pocidalo MA, El Benna J, Humbert M, Aubier M, Crestani B.

Eur Respir J. 2009 Jun;33(6):1498-502. doi: 10.1183/09031936.00138107.


p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases.

El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F.

Exp Mol Med. 2009 Apr 30;41(4):217-25. doi: 10.3858/emm.2009.41.4.058. Review.


Increased neutrophil apoptosis in chronically SIV-infected macaques.

Elbim C, Monceaux V, François S, Hurtrel B, Gougerot-Pocidalo MA, Estaquier J.

Retrovirology. 2009 Mar 24;6:29. doi: 10.1186/1742-4690-6-29.


Potential role of the "NADPH oxidases" (NOX/DUOX) family in cystic fibrosis.

Pongnimitprasert N, El-Benna J, Foglietti MJ, Gougerot-Pocidalo MA, Bernard M, Braut-Boucher F.

Ann Biol Clin (Paris). 2008 Nov-Dec;66(6):621-9. doi: 10.1684/abc.2008.0285. Review.


Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates.

Elbim C, Monceaux V, Mueller YM, Lewis MG, François S, Diop O, Akarid K, Hurtrel B, Gougerot-Pocidalo MA, Lévy Y, Katsikis PD, Estaquier J.

J Immunol. 2008 Dec 15;181(12):8613-23.


Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox.

Raad H, Paclet MH, Boussetta T, Kroviarski Y, Morel F, Quinn MT, Gougerot-Pocidalo MA, Dang PM, El-Benna J.

FASEB J. 2009 Apr;23(4):1011-22. doi: 10.1096/fj.08-114553. Epub 2008 Nov 21.


Leukocyte activation: the link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris.

Huisse MG, Pease S, Hurtado-Nedelec M, Arnaud B, Malaquin C, Wolff M, Gougerot-Pocidalo MA, Kermarrec N, Bezeaud A, Guillin MC, Paoletti X, Chollet-Martin S.

Crit Care Med. 2008 Aug;36(8):2288-95. doi: 10.1097/CCM.0b013e318180dd43.


Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations.

Kannengiesser C, Gérard B, El Benna J, Henri D, Kroviarski Y, Chollet-Martin S, Gougerot-Pocidalo MA, Elbim C, Grandchamp B.

Hum Mutat. 2008 Sep;29(9):E132-49. doi: 10.1002/humu.20820.


Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane.

El-Benna J, Dang PM, Gougerot-Pocidalo MA.

Semin Immunopathol. 2008 Jul;30(3):279-89. doi: 10.1007/s00281-008-0118-3. Epub 2008 Jun 7. Review.


ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.

Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA, El-Benna J, Ichijo H, Jo EK.

Cell Microbiol. 2008 Mar;10(3):741-54. Epub 2007 Nov 19.


TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.

Hoarau C, Gérard B, Lescanne E, Henry D, François S, Lacapère JJ, El Benna J, Dang PM, Grandchamp B, Lebranchu Y, Gougerot-Pocidalo MA, Elbim C.

J Immunol. 2007 Oct 1;179(7):4754-65.


[Pathogens trapped in neutrophils nets].

Gougerot-Pocidalo MA, El Benna J, My-Chan Dang P, Elbim C.

Med Sci (Paris). 2007 May;23(5):464-5. French. No abstract available.


Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.

Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S.

Nat Cell Biol. 2007 Apr;9(4):367-78. Epub 2007 Mar 11.


Role of the NADPH oxidase systems Nox and Duox in host defense and inflammation.

El-Benna J, Dang PM, Gougerot-Pocidalo MA.

Expert Rev Clin Immunol. 2007 Mar;3(2):111-5. doi: 10.1586/1744666X.3.2.111. No abstract available.


Severe X-linked chronic granulomatous disease in two unrelated females.

Chollet-Martin S, Lopez A, Gaud C, Henry D, Stos B, El Benna J, Chedevile G, Gendrel D, Gougerot-Pocidalo MA, Grandchamp B, Gérard B.

Eur J Pediatr. 2007 Feb;166(2):153-9. Epub 2006 Nov 3.


A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites.

Dang PM, Stensballe A, Boussetta T, Raad H, Dewas C, Kroviarski Y, Hayem G, Jensen ON, Gougerot-Pocidalo MA, El-Benna J.

J Clin Invest. 2006 Jul;116(7):2033-43. Epub 2006 Jun 15.


Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity.

Dang PM, Elbim C, Marie JC, Chiandotto M, Gougerot-Pocidalo MA, El-Benna J.

FASEB J. 2006 Jul;20(9):1504-6. Epub 2006 May 23.


[Primary immune deficiencies in neutrophil functioning].

Gougerot-Pocidalo MA, Elbim C, Dang PM, El Benna J.

Presse Med. 2006 May;35(5 Pt 2):871-8. Review. French.


Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.

Guichard C, Pedruzzi E, Fay M, Marie JC, Braut-Boucher F, Daniel F, Grodet A, Gougerot-Pocidalo MA, Chastre E, Kotelevets L, Lizard G, Vandewalle A, Driss F, Ogier-Denis E.

Carcinogenesis. 2006 Sep;27(9):1812-27. Epub 2006 Mar 7.


An unusual case of dramatic acute bilateral pyelonephritis with systemic bacterial dissemination caused by uropathogenic Escherichia coli.

Khouri N, de Beauregard MA, Tassart M, Callard P, Verdet C, Rossier A, Elbim C, Gougerot-Pocidalo MA, Le Bouguénec C, Rondeau E, Vandewalle A.

Nephrol Dial Transplant. 2006 May;21(5):1423-6. Epub 2006 Jan 23. No abstract available.


Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts.

Guichard C, Pedruzzi E, Dewas C, Fay M, Pouzet C, Bens M, Vandewalle A, Ogier-Denis E, Gougerot-Pocidalo MA, Elbim C.

J Biol Chem. 2005 Nov 4;280(44):37021-32. Epub 2005 Aug 22.


Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses.

El-Benna J, Dang PM, Gougerot-Pocidalo MA, Elbim C.

Arch Immunol Ther Exp (Warsz). 2005 May-Jun;53(3):199-206. Review.


Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.

Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S.

Crit Care Med. 2005 Jun;33(6):1359-64.


Interleukin-18 primes the oxidative burst of neutrophils in response to formyl-peptides: role of cytochrome b558 translocation and N-formyl peptide receptor endocytosis.

Elbim C, Guichard C, Dang PM, Fay M, Pedruzzi E, Demur H, Pouzet C, El Benna J, Gougerot-Pocidalo MA.

Clin Diagn Lab Immunol. 2005 Mar;12(3):436-46.


NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.

Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie JC, Pouzet C, Samadi M, Elbim C, O'dowd Y, Bens M, Vandewalle A, Gougerot-Pocidalo MA, Lizard G, Ogier-Denis E.

Mol Cell Biol. 2004 Dec;24(24):10703-17.


Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils.

O'Dowd Y, Driss F, Dang PM, Elbim C, Gougerot-Pocidalo MA, Pasquier C, El-Benna J.

Biochem Pharmacol. 2004 Nov 15;68(10):2003-8.


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