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Items: 20


Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.

Quintana-Bustamante O, Fañanas-Baquero S, Orman I, Torres R, Duchateau P, Poirot L, Gouble A, Bueren JA, Segovia JC.

PLoS One. 2019 Oct 16;14(10):e0223775. doi: 10.1371/journal.pone.0223775. eCollection 2019.


Selection and characterization of antibody clones are critical for accurate flow cytometry-based monitoring of CD123 in acute myeloid leukemia.

Cruz NM, Sugita M, Ewing-Crystal N, Lam L, Galetto R, Gouble A, Smith J, Hassane DC, Roboz GJ, Guzman ML.

Leuk Lymphoma. 2018 Apr;59(4):978-982. doi: 10.1080/10428194.2017.1361023. Epub 2017 Aug 10. No abstract available.


Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Garate Z, Quintana-Bustamante O, Crane AM, Olivier E, Poirot L, Galetto R, Kosinski P, Hill C, Kung C, Agirre X, Orman I, Cerrato L, Alberquilla O, Rodriguez-Fornes F, Fusaki N, Garcia-Sanchez F, Maia TM, Ribeiro ML, Sevilla J, Prosper F, Jin S, Mountford J, Guenechea G, Gouble A, Bueren JA, Davis BR, Segovia JC.

Stem Cell Reports. 2015 Dec 8;5(6):1053-1066. doi: 10.1016/j.stemcr.2015.10.002. Epub 2015 Nov 5.


TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells.

Menger L, Gouble A, Marzolini MA, Pachnio A, Bergerhoff K, Henry JY, Smith J, Pule M, Moss P, Riddell SR, Quezada SA, Peggs KS.

Blood. 2015 Dec 24;126(26):2781-9. doi: 10.1182/blood-2015-08-664755. Epub 2015 Oct 27.


Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies.

Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, Potrel P, Bas C, Lemaire L, Galetto R, Lebuhotel C, Eyquem J, Cheung GW, Duclert A, Gouble A, Arnould S, Peggs K, Pule M, Scharenberg AM, Smith J.

Cancer Res. 2015 Sep 15;75(18):3853-64. doi: 10.1158/0008-5472.CAN-14-3321. Epub 2015 Jul 16.


Lentiviral protein delivery of meganucleases in human cells mediates gene targeting and alleviates toxicity.

He C, Gouble A, Bourdel A, Manchev V, Poirot L, Paques F, Duchateau P, Edelman A, Danos O.

Gene Ther. 2014 Aug;21(8):759-66. doi: 10.1038/gt.2014.51. Epub 2014 Jun 12.


Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells.

Rivière J, Hauer J, Poirot L, Brochet J, Souque P, Mollier K, Gouble A, Charneau P, Fischer A, Pâques F, de Villartay JP, Cavazzana M.

Gene Ther. 2014 May;21(5):529-32. doi: 10.1038/gt.2014.20. Epub 2014 Mar 13.


Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells.

Galetto R, Lebuhotel C, Poirot L, Gouble A, Toribio ML, Smith J, Scharenberg A.

Mol Ther Methods Clin Dev. 2014 Jun 11;1:14021. doi: 10.1038/mtm.2014.21. eCollection 2014.


megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM.

Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26.


Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN™.

Dupuy A, Valton J, Leduc S, Armier J, Galetto R, Gouble A, Lebuhotel C, Stary A, Pâques F, Duchateau P, Sarasin A, Daboussi F.

PLoS One. 2013 Nov 13;8(11):e78678. doi: 10.1371/journal.pone.0078678. eCollection 2013.


Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in.

Popplewell L, Koo T, Leclerc X, Duclert A, Mamchaoui K, Gouble A, Mouly V, Voit T, Pâques F, Cédrone F, Isman O, Yáñez-Muñoz RJ, Dickson G.

Hum Gene Ther. 2013 Jul;24(7):692-701. doi: 10.1089/hum.2013.081.


Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.

Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM.

Nat Methods. 2012 Oct;9(10):973-5. doi: 10.1038/nmeth.2177. Epub 2012 Sep 2.


Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases.

Daboussi F, Zaslavskiy M, Poirot L, Loperfido M, Gouble A, Guyot V, Leduc S, Galetto R, Grizot S, Oficjalska D, Perez C, Delacôte F, Dupuy A, Chion-Sotinel I, Le Clerre D, Lebuhotel C, Danos O, Lemaire F, Oussedik K, Cédrone F, Epinat JC, Smith J, Yáñez-Muñoz RJ, Dickson G, Popplewell L, Koo T, VandenDriessche T, Chuah MK, Duclert A, Duchateau P, Pâques F.

Nucleic Acids Res. 2012 Jul;40(13):6367-79. Epub 2012 Mar 29.


Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells.

Arnould S, Perez C, Cabaniols JP, Smith J, Gouble A, Grizot S, Epinat JC, Duclert A, Duchateau P, Pâques F.

J Mol Biol. 2007 Aug 3;371(1):49-65. Epub 2007 May 10.


Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break.

Gouble A, Smith J, Bruneau S, Perez C, Guyot V, Cabaniols JP, Leduc S, Fiette L, Avé P, Micheau B, Duchateau P, Pâques F.

J Gene Med. 2006 May;8(5):616-22.


Factors affecting double-strand break-induced homologous recombination in mammalian cells.

Perez C, Guyot V, Cabaniols JP, Gouble A, Micheaux B, Smith J, Leduc S, Pâques F, Duchateau P.

Biotechniques. 2005 Jul;39(1):109-15.


Impaired gametogenesis in mice that overexpress the RNA-binding protein HuR.

Levadoux-Martin M, Gouble A, Jégou B, Vallet-Erdtmann V, Auriol J, Mercier P, Morello D.

EMBO Rep. 2003 Apr;4(4):394-9.


A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice.

Gouble A, Grazide S, Meggetto F, Mercier P, Delsol G, Morello D.

Cancer Res. 2002 Mar 1;62(5):1489-95.


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