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Items: 1 to 50 of 111


Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors.

Jones BE, Tovar KR, Goehring A, Jalali-Yazdi F, Okada NJ, Gouaux E, Westbrook GL.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaaw0044. doi: 10.1126/scitranslmed.aaw0044.


Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.

Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E.

Nature. 2019 May;569(7754):141-145. doi: 10.1038/s41586-019-1135-1. Epub 2019 Apr 24.


Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.

Zhao Y, Chen S, Swensen AC, Qian WJ, Gouaux E.

Science. 2019 Apr 26;364(6438):355-362. doi: 10.1126/science.aaw8250. Epub 2019 Apr 11.


Insights into the mechanism and pharmacology of neurotransmitter sodium symporters.

Navratna V, Gouaux E.

Curr Opin Struct Biol. 2019 Feb;54:161-170. doi: 10.1016/ Epub 2019 Mar 25. Review.


Structure and mechanism of AMPA receptor - auxiliary protein complexes.

Chen S, Gouaux E.

Curr Opin Struct Biol. 2019 Feb;54:104-111. doi: 10.1016/ Epub 2019 Feb 27. Review.


Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3.

Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, Stockner T, Bellan LM, Matthies HJG, Gouaux E, Mchaourab HS, Galli A.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3853-3862. doi: 10.1073/pnas.1816247116. Epub 2019 Feb 12.


Correction: Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.

Yoder N, Gouaux E.

PLoS One. 2018 Dec 10;13(12):e0209147. doi: 10.1371/journal.pone.0209147. eCollection 2018.


Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.

Jalali-Yazdi F, Chowdhury S, Yoshioka C, Gouaux E.

Cell. 2018 Nov 29;175(6):1520-1532.e15. doi: 10.1016/j.cell.2018.10.043.


Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.

Yoder N, Gouaux E.

PLoS One. 2018 Aug 29;13(8):e0202134. doi: 10.1371/journal.pone.0202134. eCollection 2018. Erratum in: PLoS One. 2018 Dec 10;13(12):e0209147.


Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.

Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E.

Elife. 2018 Aug 2;7. pii: e38770. doi: 10.7554/eLife.38770.


Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA.

Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E.

Elife. 2018 Jul 25;7. pii: e39383. doi: 10.7554/eLife.39383.


Expression and purification of a functional heteromeric GABAA receptor for structural studies.

Claxton DP, Gouaux E.

PLoS One. 2018 Jul 20;13(7):e0201210. doi: 10.1371/journal.pone.0201210. eCollection 2018.


Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation.

Navratna V, Tosh DK, Jacobson KA, Gouaux E.

PLoS One. 2018 Jul 2;13(7):e0200085. doi: 10.1371/journal.pone.0200085. eCollection 2018.


Mechanism of NMDA receptor channel block by MK-801 and memantine.

Song X, Jensen MØ, Jogini V, Stein RA, Lee CH, Mchaourab HS, Shaw DE, Gouaux E.

Nature. 2018 Apr;556(7702):515-519. doi: 10.1038/s41586-018-0039-9. Epub 2018 Apr 18.


Gating mechanisms of acid-sensing ion channels.

Yoder N, Yoshioka C, Gouaux E.

Nature. 2018 Mar 15;555(7696):397-401. doi: 10.1038/nature25782. Epub 2018 Mar 7.


Structural basis for recognition of diverse antidepressants by the human serotonin transporter.

Coleman JA, Gouaux E.

Nat Struct Mol Biol. 2018 Feb;25(2):170-175. doi: 10.1038/s41594-018-0026-8. Epub 2018 Jan 29.


Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.

Chen S, Zhao Y, Wang Y, Shekhar M, Tajkhorshid E, Gouaux E.

Cell. 2017 Sep 7;170(6):1234-1246.e14. doi: 10.1016/j.cell.2017.07.045. Epub 2017 Aug 17.


Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.

Lü W, Du J, Goehring A, Gouaux E.

Science. 2017 Mar 24;355(6331). pii: eaal3729. doi: 10.1126/science.aal3729. Epub 2017 Feb 23.


Structure and symmetry inform gating principles of ionotropic glutamate receptors.

Zhu S, Gouaux E.

Neuropharmacology. 2017 Jan;112(Pt A):11-15. doi: 10.1016/j.neuropharm.2016.08.034. Epub 2016 Sep 20. Review.


X-ray structures define human P2X(3) receptor gating cycle and antagonist action.

Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E.

Nature. 2016 Oct 6;538(7623):66-71. doi: 10.1038/nature19367. Epub 2016 Sep 14.


Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.

Zhao Y, Chen S, Yoshioka C, Baconguis I, Gouaux E.

Nature. 2016 Aug 4;536(7614):108-11. Epub 2016 Jul 1.


Mechanism of NMDA Receptor Inhibition and Activation.

Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E.

Cell. 2016 Apr 21;165(3):704-14. doi: 10.1016/j.cell.2016.03.028. Epub 2016 Apr 7.


X-ray structures and mechanism of the human serotonin transporter.

Coleman JA, Green EM, Gouaux E.

Nature. 2016 Apr 21;532(7599):334-9. doi: 10.1038/nature17629. Epub 2016 Apr 6.


Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation.

Green EM, Coleman JA, Gouaux E.

PLoS One. 2015 Dec 22;10(12):e0145688. doi: 10.1371/journal.pone.0145688. eCollection 2015.


Glycine receptor mechanism elucidated by electron cryo-microscopy.

Du J, Lü W, Wu S, Cheng Y, Gouaux E.

Nature. 2015 Oct 8;526(7572):224-9. doi: 10.1038/nature14853. Epub 2015 Sep 7.


Neurotransmitter and psychostimulant recognition by the dopamine transporter.

Wang KH, Penmatsa A, Gouaux E.

Nature. 2015 May 21;521(7552):322-7. doi: 10.1038/nature14431. Epub 2015 May 11.


X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.

Penmatsa A, Wang KH, Gouaux E.

Nat Struct Mol Biol. 2015 Jun;22(6):506-508. doi: 10.1038/nsmb.3029. Epub 2015 May 11.


Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.

Goehring A, Lee CH, Wang KH, Michel JC, Claxton DP, Baconguis I, Althoff T, Fischer S, Garcia KC, Gouaux E.

Nat Protoc. 2014 Nov;9(11):2574-85. doi: 10.1038/nprot.2014.173. Epub 2014 Oct 9.


X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

Althoff T, Hibbs RE, Banerjee S, Gouaux E.

Nature. 2014 Aug 21;512(7514):333-7. doi: 10.1038/nature13669.


Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.

Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E.

Cell. 2014 Aug 14;158(4):778-792. doi: 10.1016/j.cell.2014.07.023. Epub 2014 Aug 7.


X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.

Chen L, Dürr KL, Gouaux E.

Science. 2014 Aug 29;345(6200):1021-6. doi: 10.1126/science.1258409. Epub 2014 Aug 7.


NMDA receptor structures reveal subunit arrangement and pore architecture.

Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E.

Nature. 2014 Jul 10;511(7508):191-7. doi: 10.1038/nature13548. Epub 2014 Jun 22.


X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel.

Baconguis I, Bohlen CJ, Goehring A, Julius D, Gouaux E.

Cell. 2014 Feb 13;156(4):717-29. doi: 10.1016/j.cell.2014.01.011. Epub 2014 Feb 6.


Structural basis for action by diverse antidepressants on biogenic amine transporters.

Wang H, Goehring A, Wang KH, Penmatsa A, Ressler R, Gouaux E.

Nature. 2013 Nov 7;503(7474):141-5. doi: 10.1038/nature12648. Epub 2013 Oct 13.


X-ray structure of dopamine transporter elucidates antidepressant mechanism.

Penmatsa A, Wang KH, Gouaux E.

Nature. 2013 Nov 7;503(7474):85-90. doi: 10.1038/nature12533. Epub 2013 Sep 15.


Novel dicarboxylate selectivity in an insect glutamate transporter homolog.

Wang H, Rascoe AM, Holley DC, Gouaux E, Kavanaugh MP.

PLoS One. 2013 Aug 7;8(8):e70947. doi: 10.1371/journal.pone.0070947. eCollection 2013.


How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters.

Penmatsa A, Gouaux E.

J Physiol. 2014 Mar 1;592(5):863-9. doi: 10.1113/jphysiol.2013.259051. Epub 2013 Jul 22. Review.


Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels.

Baconguis I, Hattori M, Gouaux E.

Curr Opin Struct Biol. 2013 Apr;23(2):277-84. doi: 10.1016/ Epub 2013 Apr 26. Review.


A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening.

Hattori M, Hibbs RE, Gouaux E.

Structure. 2012 Aug 8;20(8):1293-9. doi: 10.1016/j.str.2012.06.009.


Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.

Baconguis I, Gouaux E.

Nature. 2012 Sep 20;489(7416):400-5. doi: 10.1038/nature11375. Epub 2012 Jul 29.


Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.

Wang H, Gouaux E.

EMBO Rep. 2012 Sep;13(9):861-6. doi: 10.1038/embor.2012.110. Epub 2012 Jul 27.


Molecular mechanism of ATP binding and ion channel activation in P2X receptors.

Hattori M, Gouaux E.

Nature. 2012 May 10;485(7397):207-12. doi: 10.1038/nature11010.


Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.

Wang H, Elferich J, Gouaux E.

Nat Struct Mol Biol. 2012 Jan 15;19(2):212-9. doi: 10.1038/nsmb.2215.


X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.

Krishnamurthy H, Gouaux E.

Nature. 2012 Jan 9;481(7382):469-74. doi: 10.1038/nature10737.


Insights into transport mechanism from LeuT engineered to transport tryptophan.

Piscitelli CL, Gouaux E.

EMBO J. 2012 Jan 4;31(1):228-35. doi: 10.1038/emboj.2011.353. Epub 2011 Sep 27.


Principles of activation and permeation in an anion-selective Cys-loop receptor.

Hibbs RE, Gouaux E.

Nature. 2011 Jun 2;474(7349):54-60. doi: 10.1038/nature10139. Epub 2011 May 15.


Amino terminal domains of the NMDA receptor are organized as local heterodimers.

Lee CH, Gouaux E.

PLoS One. 2011 Apr 22;6(4):e19180. doi: 10.1371/journal.pone.0019180.


Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

Piscitelli CL, Krishnamurthy H, Gouaux E.

Nature. 2010 Dec 23;468(7327):1129-32. doi: 10.1038/nature09581.


Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density.

Giannone G, Hosy E, Levet F, Constals A, Schulze K, Sobolevsky AI, Rosconi MP, Gouaux E, Tampé R, Choquet D, Cognet L.

Biophys J. 2010 Aug 9;99(4):1303-10. doi: 10.1016/j.bpj.2010.06.005.

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