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Items: 1 to 50 of 63

1.

Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress.

Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL.

Mol Biol Cell. 2019 Aug 1;30(17):2141-2154. doi: 10.1091/mbc.E19-02-0094. Epub 2019 May 29.

PMID:
31141470
2.

The Upsides and Downsides of Organelle Interconnectivity.

Gottschling DE, Nyström T.

Cell. 2017 Mar 23;169(1):24-34. doi: 10.1016/j.cell.2017.02.030. Review.

3.

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast.

Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE.

Elife. 2016 Apr 20;5. pii: e13943. doi: 10.7554/eLife.13943.

4.

Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions.

Thayer NH, Leverich CK, Fitzgibbon MP, Nelson ZW, Henderson KA, Gafken PR, Hsu JJ, Gottschling DE.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14019-26. doi: 10.1073/pnas.1416079111. Epub 2014 Sep 16.

5.

Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast.

Henderson KA, Hughes AL, Gottschling DE.

Elife. 2014 Sep 4;3:e03504. doi: 10.7554/eLife.03504.

6.

The good and the bad of being connected: the integrons of aging.

Dillin A, Gottschling DE, Nyström T.

Curr Opin Cell Biol. 2014 Feb;26:107-12. doi: 10.1016/j.ceb.2013.12.003. Epub 2013 Dec 30. Review.

7.

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.

Hughes AL, Gottschling DE.

Nature. 2012 Dec 13;492(7428):261-5. doi: 10.1038/nature11654. Epub 2012 Nov 21.

8.

Molecular biology. Fragile delivery to the genome.

Gottschling DE.

Science. 2012 Jul 13;337(6091):160-1. doi: 10.1126/science.1225852. No abstract available.

PMID:
22798587
9.

Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation.

Hotz M, Leisner C, Chen D, Manatschal C, Wegleiter T, Ouellet J, Lindstrom D, Gottschling DE, Vogel J, Barral Y.

Cell. 2012 Mar 2;148(5):958-72. doi: 10.1016/j.cell.2012.01.041.

10.

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design.

Dymond JS, Richardson SM, Coombes CE, Babatz T, Muller H, Annaluru N, Blake WJ, Schwerzmann JW, Dai J, Lindstrom DL, Boeke AC, Gottschling DE, Chandrasegaran S, Bader JS, Boeke JD.

Nature. 2011 Sep 14;477(7365):471-6. doi: 10.1038/nature10403.

11.

Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae.

Lindstrom DL, Leverich CK, Henderson KA, Gottschling DE.

PLoS Genet. 2011 Mar;7(3):e1002015. doi: 10.1371/journal.pgen.1002015. Epub 2011 Mar 17.

12.

Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.

Rosenbaum JC, Fredrickson EK, Oeser ML, Garrett-Engele CM, Locke MN, Richardson LA, Nelson ZW, Hetrick ED, Milac TI, Gottschling DE, Gardner RG.

Mol Cell. 2011 Jan 7;41(1):93-106. doi: 10.1016/j.molcel.2010.12.004.

13.

Recombination-induced tag exchange to track old and new proteins.

Verzijlbergen KF, Menendez-Benito V, van Welsem T, van Deventer SJ, Lindstrom DL, Ovaa H, Neefjes J, Gottschling DE, van Leeuwen F.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):64-8. doi: 10.1073/pnas.0911164107. Epub 2009 Dec 14.

14.

The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae.

Lindstrom DL, Gottschling DE.

Genetics. 2009 Oct;183(2):413-22, 1SI-13SI. doi: 10.1534/genetics.109.106229. Epub 2009 Aug 3.

15.

Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.

Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE.

Genetics. 2009 Sep;183(1):365-83. doi: 10.1534/genetics.109.104497. Epub 2009 Jul 6.

16.

Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect.

Veatch JR, McMurray MA, Nelson ZW, Gottschling DE.

Cell. 2009 Jun 26;137(7):1247-58. doi: 10.1016/j.cell.2009.04.014.

17.

A mother's sacrifice: what is she keeping for herself?

Henderson KA, Gottschling DE.

Curr Opin Cell Biol. 2008 Dec;20(6):723-8. doi: 10.1016/j.ceb.2008.09.004. Epub 2008 Oct 23. Review.

18.

A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

Andersen MP, Nelson ZW, Hetrick ED, Gottschling DE.

Genetics. 2008 Jul;179(3):1179-95. doi: 10.1534/genetics.108.089250. Epub 2008 Jun 18.

19.

Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.

van Welsem T, Frederiks F, Verzijlbergen KF, Faber AW, Nelson ZW, Egan DA, Gottschling DE, van Leeuwen F.

Mol Cell Biol. 2008 Jun;28(11):3861-72. doi: 10.1128/MCB.02050-07. Epub 2008 Apr 7.

20.

Does age influence loss of heterozygosity?

Carr LL, Gottschling DE.

Exp Gerontol. 2008 Mar;43(3):123-9. Epub 2007 Nov 28. Review.

PMID:
18054191
21.

DNA repair: corrections in the golden years.

Gottschling DE.

Curr Biol. 2006 Nov 21;16(22):R956-8. Review.

22.

Summary: epigenetics--from phenomenon to field.

Gottschling DE.

Cold Spring Harb Symp Quant Biol. 2004;69:507-19. No abstract available.

PMID:
16117688
23.

Genetic instability in aging yeast: a metastable hyperrecombinational state.

McMurray MA, Gottschling DE.

Cold Spring Harb Symp Quant Biol. 2004;69:339-47. No abstract available.

PMID:
16117666
24.
25.

Degradation-mediated protein quality control in the nucleus.

Gardner RG, Nelson ZW, Gottschling DE.

Cell. 2005 Mar 25;120(6):803-15.

26.

Mutations in the nucleosome core enhance transcriptional silencing.

Xu EY, Bi X, Holland MJ, Gottschling DE, Broach JR.

Mol Cell Biol. 2005 Mar;25(5):1846-59.

27.

Aging and genetic instability in yeast.

McMurray MA, Gottschling DE.

Curr Opin Microbiol. 2004 Dec;7(6):673-9. Review.

PMID:
15556042
28.

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.

Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M.

Genes Dev. 2004 Jun 1;18(11):1263-71.

29.

An age-induced switch to a hyper-recombinational state.

McMurray MA, Gottschling DE.

Science. 2003 Sep 26;301(5641):1908-11.

30.

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE.

Genes Dev. 2003 Oct 1;17(19):2384-95. Epub 2003 Sep 15.

31.

All things must end: telomere dynamics in yeast.

DuBois ML, Diede SJ, Stellwagen AE, Gottschling DE.

Cold Spring Harb Symp Quant Biol. 2000;65:281-96. Review. No abstract available.

PMID:
12760042
32.

Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4.

Smith CM, Gafken PR, Zhang Z, Gottschling DE, Smith JB, Smith DL.

Anal Biochem. 2003 May 1;316(1):23-33.

PMID:
12694723
33.

The histone minority report: the variant shall not be silenced.

van Leeuwen F, Gottschling DE.

Cell. 2003 Mar 7;112(5):591-3. Review.

34.

Genome-wide histone modifications: gaining specificity by preventing promiscuity.

van Leeuwen F, Gottschling DE.

Curr Opin Cell Biol. 2002 Dec;14(6):756-62. Review.

PMID:
12473351
35.

Heritable chromatin structure: mapping "memory" in histones H3 and H4.

Smith CM, Haimberger ZW, Johnson CO, Wolf AJ, Gafken PR, Zhang Z, Parthun MR, Gottschling DE.

Proc Natl Acad Sci U S A. 2002 Dec 10;99 Suppl 4:16454-61. Epub 2002 Aug 26.

36.

A quantitative assay for telomere protection in Saccharomyces cerevisiae.

DuBois ML, Haimberger ZW, McIntosh MW, Gottschling DE.

Genetics. 2002 Jul;161(3):995-1013.

37.

Dot1p modulates silencing in yeast by methylation of the nucleosome core.

van Leeuwen F, Gafken PR, Gottschling DE.

Cell. 2002 Jun 14;109(6):745-56.

38.

Assays for gene silencing in yeast.

van Leeuwen F, Gottschling DE.

Methods Enzymol. 2002;350:165-86. No abstract available.

PMID:
12073311
39.

Identification of a small molecule inhibitor of Sir2p.

Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.

40.
41.

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, Tzoneva M, Gottschling DE.

Nat Genet. 2001 Jan;27(1):64-7.

PMID:
11138000
42.

Gene silencing: two faces of SIR2.

Gottschling DE.

Curr Biol. 2000 Oct 5;10(19):R708-11. Review.

43.

Type B histone acetyltransferase Hat1p participates in telomeric silencing.

Kelly TJ, Qin S, Gottschling DE, Parthun MR.

Mol Cell Biol. 2000 Oct;20(19):7051-8.

44.
45.

DOT4 links silencing and cell growth in Saccharomyces cerevisiae.

Kahana A, Gottschling DE.

Mol Cell Biol. 1999 Oct;19(10):6608-20.

46.

Telomeres: structure of a chromosome's aglet.

Gottschling DE, Stoddard B.

Curr Biol. 1999 Mar 11;9(5):R164-7. Review.

47.

Telomeric chromatin modulates replication timing near chromosome ends.

Stevenson JB, Gottschling DE.

Genes Dev. 1999 Jan 15;13(2):146-51.

48.

Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.

Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, Gottschling DE.

Genetics. 1998 Oct;150(2):613-32.

49.

Chromosome dynamics: yeast pulls it apart.

Gottschling DE, Berg BL.

Curr Biol. 1998 Jan 29;8(3):R76-9. Review.

50.

The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae.

Huang H, Kahana A, Gottschling DE, Prakash L, Liebman SW.

Mol Cell Biol. 1997 Nov;17(11):6693-9.

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