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Items: 1 to 50 of 408

1.

Amphipathic molecules modulate PIEZO1 activity.

Cox CD, Gottlieb PA.

Biochem Soc Trans. 2019 Nov 22. pii: BST20190372. doi: 10.1042/BST20190372. [Epub ahead of print]

PMID:
31754715
2.

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.

Diabetes Care. 2019 Nov 21. pii: dc190880. doi: 10.2337/dc19-0880. [Epub ahead of print]

PMID:
31753960
3.

Single-Cell Analysis of CD4 T Cells in Type 1 Diabetes: From Mouse to Man, How to Perform Mechanistic Studies.

Sharma S, Pettus J, Gottschalk M, Abe B, Gottlieb P, Teyton L.

Diabetes. 2019 Oct;68(10):1886-1891. doi: 10.2337/dbi18-0064.

PMID:
31540941
4.

Structural characterization of the PCV2d virus-like particle at 3.3 Å resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes.

Khayat R, Wen K, Alimova A, Gavrilov B, Katz A, Galarza JM, Gottlieb P.

Virology. 2019 Sep 3;537:186-197. doi: 10.1016/j.virol.2019.09.001. [Epub ahead of print]

PMID:
31505320
5.

Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes.

Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK; Type 1 Diabetes TrialNet Study Group.

Int J Mol Sci. 2019 Aug 8;20(16). pii: E3857. doi: 10.3390/ijms20163857.

6.

Sonographic appearance of angiomyofibroblastoma-like tumor of the scrotum.

Kass T, Cohen D, Gottlieb P, Strauss S.

J Ultrason. 2019;19(77):158-160. doi: 10.15557/JoU.2019.0023. Epub 2019 Jun 28.

7.

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group.

N Engl J Med. 2019 Aug 15;381(7):603-613. doi: 10.1056/NEJMoa1902226. Epub 2019 Jun 9.

8.

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes.

Baker RL, Rihanek M, Hohenstein AC, Nakayama M, Michels A, Gottlieb PA, Haskins K, Delong T.

Diabetes. 2019 Sep;68(9):1830-1840. doi: 10.2337/db19-0128. Epub 2019 Jun 7.

PMID:
31175101
9.

Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells.

Jetta D, Gottlieb PA, Verma D, Sachs F, Hua SZ.

J Cell Sci. 2019 Jun 12;132(11). pii: jcs226076. doi: 10.1242/jcs.226076.

PMID:
31076516
10.

Biomarker discovery in pre-Type 1 Diabetes; Th40 cells as a predictive risk factor.

Vaitaitis GM, Rihanek M, Alkanani AK, Waid DM, Gottlieb PA, Wagner DH; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2019 May 7. pii: jc.2019-00364. doi: 10.1210/jc.2019-00364. [Epub ahead of print]

PMID:
31063181
11.

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. Epub 2019 Apr 9.

12.

Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.

Gnanasambandam R, Rivera A, Vandorpe DH, Shmukler BE, Brugnara C, Snyder LM, Andolfo I, Iolascon A, Silveira PA, Hamerschlak N, Gottlieb P, Alper SL.

Hemasphere. 2018 Oct;2(5):e55. doi: 10.1097/HS9.0000000000000055. Epub 2018 Oct 2.

13.

Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity.

Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC.

JCI Insight. 2019 Feb 7;4(3). pii: 123384. doi: 10.1172/jci.insight.123384. [Epub ahead of print]

14.

Rationally designed small molecules to prevent type 1 diabetes.

Ostrov DA, Gottlieb PA, Michels AW.

Curr Opin Endocrinol Diabetes Obes. 2019 Apr;26(2):90-95. doi: 10.1097/MED.0000000000000470.

PMID:
30694829
15.

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis.

Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC; Immune Tolerance Network.

Diabetologia. 2019 Apr;62(4):655-664. doi: 10.1007/s00125-018-4786-9. Epub 2018 Dec 19.

PMID:
30569273
16.

Functional analyses of heteromeric human PIEZO1 Channels.

Gnanasambandam R, Bae C, Ziegler L, Sachs F, Gottlieb PA.

PLoS One. 2018 Nov 21;13(11):e0207309. doi: 10.1371/journal.pone.0207309. eCollection 2018.

17.

Abnormal T Cell Frequencies, Including Cytomegalovirus-Associated Expansions, Distinguish Seroconverted Subjects at Risk for Type 1 Diabetes.

Harms RZ, Lorenzo-Arteaga KM, Ostlund KR, Smith VB, Smith LM, Gottlieb P, Sarvetnick N.

Front Immunol. 2018 Oct 22;9:2332. doi: 10.3389/fimmu.2018.02332. eCollection 2018.

18.

Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1.

Maneshi MM, Ziegler L, Sachs F, Hua SZ, Gottlieb PA.

Sci Rep. 2018 Sep 24;8(1):14267. doi: 10.1038/s41598-018-32572-2.

19.

Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes.

Gavin PG, Mullaney JA, Loo D, Cao KL, Gottlieb PA, Hill MM, Zipris D, Hamilton-Williams EE.

Diabetes Care. 2018 Oct;41(10):2178-2186. doi: 10.2337/dc18-0777. Epub 2018 Aug 12.

20.

Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.

Triolo TM, Fouts A, Pyle L, Yu L, Gottlieb PA, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2019 Feb;42(2):192-199. doi: 10.2337/dc18-0288. Epub 2018 Jul 30.

PMID:
30061316
21.

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.

Haller MJ, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Miller JL, Atkinson MA, Becker DJ, Baidal D, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell W, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes Care. 2018 Sep;41(9):1917-1925. doi: 10.2337/dc18-0494. Epub 2018 Jul 16.

22.

Human ossicular-joint flexibility transforms the peak amplitude and width of impulsive acoustic stimuli.

Gottlieb PK, Vaisbuch Y, Puria S.

J Acoust Soc Am. 2018 Jun;143(6):3418. doi: 10.1121/1.5039845.

23.

Learning From Past Failures of Oral Insulin Trials.

Michels AW, Gottlieb PA.

Diabetes. 2018 Jul;67(7):1211-1215. doi: 10.2337/dbi17-0043.

24.

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience.

Greenbaum CJ, Speake C, Krischer J, Buckner J, Gottlieb PA, Schatz DA, Herold KC, Atkinson MA.

Diabetes. 2018 Jul;67(7):1216-1225. doi: 10.2337/db18-0065. Epub 2018 May 16.

25.

Heteroaggregation of an enveloped bacteriophage with colloidal sediments and effect on virus viability.

Katz A, Peña S, Alimova A, Gottlieb P, Xu M, Block KA.

Sci Total Environ. 2018 Oct 1;637-638:104-111. doi: 10.1016/j.scitotenv.2018.04.425. Epub 2018 May 7.

PMID:
29747115
26.

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.

Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW.

J Clin Invest. 2018 May 1;128(5):1888-1902. doi: 10.1172/JCI97739. Epub 2018 Apr 3.

27.

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC.

Diabetes. 2018 Apr;67(4):697-703. doi: 10.2337/db17-0937. Epub 2018 Jan 17.

28.

Component tree analysis of cystovirus φ6 nucleocapsid Cryo-EM single particle reconstructions.

Oliveira LM, Ye Z, Katz A, Alimova A, Wei H, Herman GT, Gottlieb P.

PLoS One. 2018 Jan 4;13(1):e0188858. doi: 10.1371/journal.pone.0188858. eCollection 2018.

29.

Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.

Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC.

J Autoimmun. 2018 May;89:82-89. doi: 10.1016/j.jaut.2017.12.001. Epub 2017 Dec 9.

30.

Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee.

Diabetologia. 2018 Mar;61(3):658-670. doi: 10.1007/s00125-017-4508-8. Epub 2017 Dec 1.

PMID:
29196783
31.

Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M.

Diabetologia. 2017 Dec;60(12):2540. doi: 10.1007/s00125-017-4446-5. No abstract available.

32.

Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Battaglia M, Anderson MS, Buckner JH, Geyer SM, Gottlieb PA, Kay TWH, Lernmark Å, Muller S, Pugliese A, Roep BO, Greenbaum CJ, Peakman M.

Diabetologia. 2017 Nov;60(11):2139-2147. doi: 10.1007/s00125-017-4384-2. Epub 2017 Aug 2. Review. Erratum in: Diabetologia. 2017 Sep 26;:.

33.

Preface.

Gottlieb PA.

Curr Top Membr. 2017;79:xiii-xiv. doi: 10.1016/S1063-5823(17)30019-4. No abstract available.

PMID:
28728826
34.

A Microfluidic Approach for Studying Piezo Channels.

Maneshi MM, Gottlieb PA, Hua SZ.

Curr Top Membr. 2017;79:309-334. doi: 10.1016/bs.ctm.2016.11.005. Epub 2017 Jan 18. Review.

PMID:
28728822
35.

The Kinetics and the Permeation Properties of Piezo Channels.

Gnanasambandam R, Gottlieb PA, Sachs F.

Curr Top Membr. 2017;79:275-307. doi: 10.1016/bs.ctm.2016.11.004. Epub 2017 Jan 11. Review.

PMID:
28728821
36.

A Tour de Force: The Discovery, Properties, and Function of Piezo Channels.

Gottlieb PA.

Curr Top Membr. 2017;79:1-36. doi: 10.1016/bs.ctm.2016.11.007. Epub 2017 Jan 11. Review.

PMID:
28728814
37.

Ultrasound for the Diagnosis of Carotidynia.

Abrahamy M, Werner M, Gottlieb P, Strauss S.

J Ultrasound Med. 2017 Dec;36(12):2605-2609. doi: 10.1002/jum.14321. Epub 2017 Jul 14.

PMID:
28708261
38.

Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives.

Bosi E, Boulware DC, Becker DJ, Buckner JH, Geyer S, Gottlieb PA, Henderson C, Kinderman A, Sosenko JM, Steck AK, Bingley PJ; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2881-2886. doi: 10.1210/jc.2017-00569.

39.

Zika virus-like particle (VLP) based vaccine.

Boigard H, Alimova A, Martin GR, Katz A, Gottlieb P, Galarza JM.

PLoS Negl Trop Dis. 2017 May 8;11(5):e0005608. doi: 10.1371/journal.pntd.0005608. eCollection 2017 May.

40.

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function.

Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC.

J Vis Exp. 2017 Feb 16;(120). doi: 10.3791/55382.

41.

The Use of Electrochemiluminescence Assays to Predict Autoantibody and Glycemic Progression Toward Type 1 Diabetes in Individuals with Single Autoantibodies.

Sosenko JM, Yu L, Skyler JS, Krischer JP, Gottlieb PA, Boulware D, Miao D, Palmer JP, Steck AK.

Diabetes Technol Ther. 2017 Mar;19(3):183-187. doi: 10.1089/dia.2016.0243. Epub 2017 Feb 8.

42.

Functional Outcomes of Heparin-Binding Epidermal Growth Factor-Like Growth Factor for Regeneration of Chronic Tympanic Membrane Perforations in Mice.

Santa Maria PL, Gottlieb P, Santa Maria C, Kim S, Puria S, Yang YP.

Tissue Eng Part A. 2017 May;23(9-10):436-444. doi: 10.1089/ten.TEA.2016.0395. Epub 2017 Feb 24.

43.

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4.

Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A.

Channels (Austin). 2017 May 4;11(3):245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13.

44.

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M.

Diabetes. 2017 Mar;66(3):722-734. doi: 10.2337/db16-1025. Epub 2016 Dec 5.

45.

First results of a novel adjustable-length ossicular reconstruction prosthesis in temporal bones.

Gottlieb PK, Li X, Monfared A, Blevins N, Puria S.

Laryngoscope. 2016 Nov;126(11):2559-2564. doi: 10.1002/lary.25901. Epub 2016 Mar 12.

46.

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA.

Diabetes. 2016 Dec;65(12):3765-3775. Epub 2016 Sep 26.

47.

Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes.

Simmons KM, Gottlieb PA, Michels AW.

Curr Diab Rep. 2016 Oct;16(10):97. doi: 10.1007/s11892-016-0793-8. Review.

48.

Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?

Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2016 Oct;39(10):1738-44. doi: 10.2337/dc16-0302. Epub 2016 Jul 25.

49.

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.

Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, Leiter AB, Farrugia G, Beyder A.

J Physiol. 2017 Jan 1;595(1):79-91. doi: 10.1113/JP272718. Epub 2016 Aug 13.

50.

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial.

Gitelman SE, Gottlieb PA, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Harris KM, Kanaparthi S, Phippard D, Ding L, Bluestone JA, Ehlers MR; ITN START Study Team.

Diabetologia. 2016 Jun;59(6):1153-61. doi: 10.1007/s00125-016-3917-4. Epub 2016 Apr 6.

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