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Items: 46


Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing.

González Besteiro MA, Calzetta NL, Loureiro SM, Habif M, Bétous R, Pillaire MJ, Maffia A, Sabbioneda S, Hoffmann JS, Gottifredi V.

EMBO J. 2019 Aug 15;38(16):e101284. doi: 10.15252/embj.2018101284. Epub 2019 Jul 11.


Development and Optimization of a Miniaturized Western Blot-Based Screening Platform to Identify Regulators of Post-Translational Modifications.

Villafañez F, Gottifredi V, Soria G.

High Throughput. 2019 Jun 3;8(2). pii: E15. doi: 10.3390/ht8020015.


Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction.

Carbajosa S, Pansa MF, Paviolo NS, Castellaro AM, Andino DL, Nigra AD, García IA, Racca AC, Rodriguez-Berdini L, Angiolini V, Guantay L, Villafañez F, Federico MB, Rodríguez-Baili MC, Caputto BL, Drewes G, Madauss KP, Gloger I, Fernandez E, Gil GA, Bocco JL, Gottifredi V, Soria G.

Clin Cancer Res. 2019 Jul 1;25(13):4049-4062. doi: 10.1158/1078-0432.CCR-18-3516. Epub 2019 Mar 19.


AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress.

Villafañez F, García IA, Carbajosa S, Pansa MF, Mansilla S, Llorens MC, Angiolini V, Guantay L, Jacobs H, Madauss KP, Gloger I, Gottifredi V, Bocco JL, Soria G.

Oncogene. 2019 May;38(22):4310-4324. doi: 10.1038/s41388-019-0724-7. Epub 2019 Jan 31.


The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.

Gottifredi V, Wiesmüller L.

Cancers (Basel). 2018 Jul 28;10(8). pii: E250. doi: 10.3390/cancers10080250. Review.


Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA.

Federico MB, Campodónico P, Paviolo NS, Gottifredi V.

Mutat Res. 2018 Mar;808:83-92. doi: 10.1016/j.mrfmmm.2017.09.004. Epub 2017 Sep 14. Review.


ACCIDENTAL DUPLICATION: Beyond interstrand crosslinks repair: Contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA.

Federico MB, Campodónico P, Paviolo NS, Gottifredi V.

Mutat Res. 2017 Sep 25. pii: S0027-5107(17)30167-7. doi: 10.1016/j.mrfmmm.2017.09.006. [Epub ahead of print]


Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells.

Lerner LK, Francisco G, Soltys DT, Rocha CR, Quinet A, Vessoni AT, Castro LP, David TI, Bustos SO, Strauss BE, Gottifredi V, Stary A, Sarasin A, Chammas R, Menck CF.

Nucleic Acids Res. 2017 Feb 17;45(3):1270-1280. doi: 10.1093/nar/gkw1196.


Predictive Outcomes for HER2-enriched Cancer Using Growth and Metastasis Signatures Driven By SPARC.

Güttlein LN, Benedetti LG, Fresno C, Spallanzani RG, Mansilla SF, Rotondaro C, Raffo Iraolagoitia XL, Salvatierra E, Bravo AI, Fernández EA, Gottifredi V, Zwirner NW, Llera AS, Podhajcer OL.

Mol Cancer Res. 2017 Mar;15(3):304-316. doi: 10.1158/1541-7786.MCR-16-0243-T. Epub 2016 Dec 28.


Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.

Mansilla SF, Bertolin AP, Bergoglio V, Pillaire MJ, González Besteiro MA, Luzzani C, Miriuka SG, Cazaux C, Hoffmann JS, Gottifredi V.

Elife. 2016 Oct 14;5. pii: e18020. doi: 10.7554/eLife.18020.


DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.

Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4311-9. doi: 10.1073/pnas.1605828113. Epub 2016 Jul 12.


The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii.

Fenoy IM, Bogado SS, Contreras SM, Gottifredi V, Angel SO.

Front Microbiol. 2016 May 3;7:627. doi: 10.3389/fmicb.2016.00627. eCollection 2016. Review.


Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.

Federico MB, Vallerga MB, Radl A, Paviolo NS, Bocco JL, Di Giorgio M, Soria G, Gottifredi V.

PLoS Genet. 2016 Jan 14;12(1):e1005792. doi: 10.1371/journal.pgen.1005792. eCollection 2016 Jan.


Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.

Vallerga MB, Mansilla SF, Federico MB, Bertolin AP, Gottifredi V.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6624-33. doi: 10.1073/pnas.1508543112. Epub 2015 Nov 16.


The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.

Bertolin AP, Mansilla SF, Gottifredi V.

DNA Repair (Amst). 2015 Aug;32:158-164. doi: 10.1016/j.dnarep.2015.04.027. Epub 2015 May 12. Review.


The fork and the kinase: a DNA replication tale from a CHK1 perspective.

González Besteiro MA, Gottifredi V.

Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:168-80. doi: 10.1016/j.mrrev.2014.10.003. Epub 2014 Oct 22. Review.


Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

Quinet A, Vessoni AT, Rocha CR, Gottifredi V, Biard D, Sarasin A, Menck CF, Stary A.

DNA Repair (Amst). 2014 Feb;14:27-38. doi: 10.1016/j.dnarep.2013.12.005. Epub 2013 Dec 28.


UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability.

Mansilla SF, Soria G, Vallerga MB, Habif M, Martínez-López W, Prives C, Gottifredi V.

Nucleic Acids Res. 2013 Aug;41(14):6942-51. doi: 10.1093/nar/gkt475. Epub 2013 May 30.


The spatial and temporal regulation of the hormonal signal. Role of mitochondria in the formation of a protein complex required for the activation of cholesterol transport and steroids synthesis.

Poderoso C, Duarte A, Cooke M, Orlando U, Gottifredi V, Solano AR, Lemos JR, Podestá EJ.

Mol Cell Endocrinol. 2013 May 22;371(1-2):26-33. doi: 10.1016/j.mce.2012.12.024. Epub 2013 Jan 26. Review.


The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers.

Costantino VV, Mansilla SF, Speroni J, Amaya C, Cuello-Carrión D, Ciocca DR, Priestap HA, Barbieri MA, Gottifredi V, Lopez LA.

PLoS One. 2013;8(1):e53168. doi: 10.1371/journal.pone.0053168. Epub 2013 Jan 14.


Mitochondrial fusion is essential for steroid biosynthesis.

Duarte A, Poderoso C, Cooke M, Soria G, Cornejo Maciel F, Gottifredi V, Podestá EJ.

PLoS One. 2012;7(9):e45829. doi: 10.1371/journal.pone.0045829. Epub 2012 Sep 21.


A monoclonal antibody against p53 cross-reacts with processing bodies.

Thomas MG, Luchelli L, Pascual M, Gottifredi V, Boccaccio GL.

PLoS One. 2012;7(5):e36447. doi: 10.1371/journal.pone.0036447. Epub 2012 May 10.


Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.

Speroni J, Federico MB, Mansilla SF, Soria G, Gottifredi V.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7344-9. doi: 10.1073/pnas.1116345109. Epub 2012 Apr 23.


p21 Regulates the cell cycle...or the other way around?

Speroni J, Gottifredi V.

Cell Cycle. 2011 Oct 15;10(20):3430. doi: 10.4161/cc.10.20.17530. Epub 2011 Oct 15. No abstract available.


PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

Soria G, Gottifredi V.

DNA Repair (Amst). 2010 Apr 4;9(4):358-64. doi: 10.1016/j.dnarep.2009.12.003. Epub 2010 Jan 8. Review.


DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase.

Soria G, Belluscio L, van Cappellen WA, Kanaar R, Essers J, Gottifredi V.

Cell Cycle. 2009 Oct 15;8(20):3340-8. Epub 2009 Oct 17.


Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Ahn J, Poyurovsky MV, Baptiste N, Beckerman R, Cain C, Mattia M, McKinney K, Zhou J, Zupnick A, Gottifredi V, Prives C.

Cell Cycle. 2009 May 15;8(10):1603-15.


Suppression of cancer growth by nonviral gene therapy based on a novel reactive oxygen species-responsive promoter.

Policastro LL, Ibañez IL, Durán HA, Soria G, Gottifredi V, Podhajcer OL.

Mol Ther. 2009 Aug;17(8):1355-64. doi: 10.1038/mt.2009.103. Epub 2009 May 12.


The p21 and PCNA partnership: a new twist for an old plot.

Prives C, Gottifredi V.

Cell Cycle. 2008 Dec 15;7(24):3840-6. Epub 2008 Dec 21. Review.


p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.

Soria G, Speroni J, Podhajcer OL, Prives C, Gottifredi V.

J Cell Sci. 2008 Oct 1;121(Pt 19):3271-82. doi: 10.1242/jcs.027730. Epub 2008 Sep 9.


SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated.

Haber CL, Gottifredi V, Llera AS, Salvatierra E, Prada F, Alonso L, Sage EH, Podhajcer OL.

Int J Cancer. 2008 Apr 1;122(7):1465-75. Erratum in: Int J Cancer. 2008 Jul 1;123(1):245. Helene, Sage E [corrected to Sage, E Helene].


p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.

Mattia M, Gottifredi V, McKinney K, Prives C.

Mol Cell Biol. 2007 Feb;27(4):1309-20. Epub 2006 Dec 11.


P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

Soria G, Podhajcer O, Prives C, Gottifredi V.

Oncogene. 2006 May 11;25(20):2829-38.


The S phase checkpoint: when the crowd meets at the fork.

Gottifredi V, Prives C.

Semin Cell Dev Biol. 2005 Jun;16(3):355-68. Review.


p53 linear diffusion along DNA requires its C terminus.

McKinney K, Mattia M, Gottifredi V, Prives C.

Mol Cell. 2004 Nov 5;16(3):413-24.


Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block.

Gottifredi V, McKinney K, Poyurovsky MV, Prives C.

J Biol Chem. 2004 Feb 13;279(7):5802-10. Epub 2003 Nov 3.


Regulation of p53 after different forms of stress and at different cell cycle stages.

Gottifredi V, Shieh SY, Prives C.

Cold Spring Harb Symp Quant Biol. 2000;65:483-8. Review. No abstract available.


Molecular biology. Getting p53 out of the nucleus.

Gottifredi V, Prives C.

Science. 2001 Jun 8;292(5523):1851-2. No abstract available.


P53 and PML: new partners in tumor suppression.

Gottifredi V, Prives C.

Trends Cell Biol. 2001 May;11(5):184-7. No abstract available.


p53 accumulates but is functionally impaired when DNA synthesis is blocked.

Gottifredi V, Shieh S, Taya Y, Prives C.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1036-41. Epub 2001 Jan 23.


p53 down-regulates CHK1 through p21 and the retinoblastoma protein.

Gottifredi V, Karni-Schmidt O, Shieh SS, Prives C.

Mol Cell Biol. 2001 Feb;21(4):1066-76.


The polyomavirus major capsid protein VP1 interacts with the nuclear matrix regulatory protein YY1.

Palková Z, Spanielová H, Gottifredi V, Hollanderová D, Forstová J, Amati P.

FEBS Lett. 2000 Feb 11;467(2-3):359-64.


p53-independent apoptosis induced by muscle differentiation stimuli in polyomavirus large T-expressing myoblasts.

Gottifredi V, Peschiaroli A, Fimia GM, Maione R.

J Cell Sci. 1999 Jul;112 ( Pt 14):2397-407.


Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.

Gottifredi V, Pelicci G, Munarriz E, Maione R, Pelicci PG, Amati P.

J Virol. 1999 Feb;73(2):1427-37.


The activity of differentiation factors induces apoptosis in polyomavirus large T-expressing myoblasts.

Fimia GM, Gottifredi V, Bellei B, Ricciardi MR, Tafuri A, Amati P, Maione R.

Mol Biol Cell. 1998 Jun;9(6):1449-63.


Double-stranded internucleosomal cleavage of apoptotic DNA is dependent on the degree of differentiation in muscle cells.

Fimia GM, Gottifredi V, Passananti C, Maione R.

J Biol Chem. 1996 Jun 28;271(26):15575-9.

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