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Items: 1 to 50 of 207

1.

Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems.

Peters SMB, Meyer Viol SL, van der Werf NR, de Jong N, van Velden FHP, Meeuwis A, Konijnenberg MW, Gotthardt M, de Jong HWAM, Segbers M.

EJNMMI Phys. 2020 Feb 11;7(1):9. doi: 10.1186/s40658-020-0278-3.

PMID:
32048097
2.

Targeted optical imaging of the glucagon-like peptide 1 receptor using exendin-4-IRDye800CW.

Boss M, Bos D, Frielink C, Sandker G, Ekim S, Marciniak C, Pattou F, van Dam GM, van Lith S, Brom M, Gotthardt M, Buitinga M.

J Nucl Med. 2020 Jan 10. pii: jnumed.119.234542. doi: 10.2967/jnumed.119.234542. [Epub ahead of print]

PMID:
31924726
3.

PET/MRI enables simultaneous in vivo quantification of β-cell mass and function.

Michelotti FC, Bowden G, Küppers A, Joosten L, Maczewsky J, Nischwitz V, Drews G, Maurer A, Gotthardt M, Schmid AM, Pichler BJ.

Theranostics. 2020 Jan 1;10(1):398-410. doi: 10.7150/thno.33410. eCollection 2020.

4.

Occult insulinoma, glucagonoma and pancreatic endocrine pseudotumour in a patient with multiple endocrine neoplasia type 1.

Erichsen TD, Detlefsen S, Andersen KØ, Pedersen H, Rasmussen L, Gotthardt M, Pörksen S, Christesen HT.

Pancreatology. 2019 Dec 24. pii: S1424-3903(19)30814-2. doi: 10.1016/j.pan.2019.12.017. [Epub ahead of print] No abstract available.

PMID:
31889623
5.

Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy.

Mugahid DA, Sengul TG, You X, Wang Y, Steil L, Bergmann N, Radke MH, Ofenbauer A, Gesell-Salazar M, Balogh A, Kempa S, Tursun B, Robbins CT, Völker U, Chen W, Nelson L, Gotthardt M.

Sci Rep. 2019 Dec 27;9(1):19976. doi: 10.1038/s41598-019-56007-8.

6.

Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study.

Peters SMB, van der Werf NR, Segbers M, van Velden FHP, Wierts R, Blokland KJAK, Konijnenberg MW, Lazarenko SV, Visser EP, Gotthardt M.

EJNMMI Phys. 2019 Dec 26;6(1):29. doi: 10.1186/s40658-019-0268-5.

7.

Comprehensive Analysis of the Alternaria Mycobolome Using Mass Spectrometry Based Metabolomics.

Gotthardt M, Kanawati B, Schmidt F, Asam S, Hammerl R, Frank O, Hofmann T, Schmitt-Kopplin P, Rychlik M.

Mol Nutr Food Res. 2020 Feb;64(3):e1900558. doi: 10.1002/mnfr.201900558. Epub 2020 Jan 9.

PMID:
31802615
8.

Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.

Rudolph F, Hüttemeister J, da Silva Lopes K, Jüttner R, Yu L, Bergmann N, Friedrich D, Preibisch S, Wagner E, Lehnart SE, Gregorio CC, Gotthardt M.

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25126-25136. doi: 10.1073/pnas.1904385116. Epub 2019 Nov 22.

PMID:
31757849
9.

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes.

Cadar AG, Feaster TK, Bersell KR, Wang L, Hong T, Balsamo JA, Zhang Z, Chun YW, Nam YJ, Gotthardt M, Knollmann BC, Roden DM, Lim CC, Hong CC.

Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C163-C173. doi: 10.1152/ajpcell.00107.2019. Epub 2019 Nov 20.

PMID:
31747312
10.

Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer.

Westdorp H, Creemers JHA, van Oort IM, Schreibelt G, Gorris MAJ, Mehra N, Simons M, de Goede AL, van Rossum MM, Croockewit AJ, Figdor CG, Witjes JA, Aarntzen EHJG, Mus RDM, Brüning M, Petry K, Gotthardt M, Barentsz JO, de Vries IJM, Gerritsen WR.

J Immunother Cancer. 2019 Nov 14;7(1):302. doi: 10.1186/s40425-019-0787-6.

11.

Multicentre quantitative 68Ga PET/CT performance harmonisation.

Huizing DMV, Koopman D, van Dalen JA, Gotthardt M, Boellaard R, Sera T, Sinaasappel M, Stokkel MPM, de Wit-van der Veen BJ.

EJNMMI Phys. 2019 Nov 8;6(1):19. doi: 10.1186/s40658-019-0253-z.

12.

Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer.

Wierstra P, Sandker G, Aarntzen E, Gotthardt M, Adema G, Bussink J, Raavé R, Heskamp S.

EJNMMI Radiopharm Chem. 2019 Nov 6;4(1):29. doi: 10.1186/s41181-019-0078-z. Review.

13.

PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery.

Derks YHW, Löwik DWPM, Sedelaar JPM, Gotthardt M, Boerman OC, Rijpkema M, Lütje S, Heskamp S.

Theranostics. 2019 Sep 20;9(23):6824-6839. doi: 10.7150/thno.36739. eCollection 2019. Review.

14.

PET-Based Human Dosimetry of 68Ga-NODAGA-Exendin-4, a Tracer for β-Cell Imaging.

Boss M, Buitinga M, Jansen TJP, Brom M, Visser EP, Gotthardt M.

J Nucl Med. 2020 Jan;61(1):112-116. doi: 10.2967/jnumed.119.228627. Epub 2019 Sep 13.

15.

Exendin-4 Derivatives with an Albumin-Binding Moiety Show Decreased Renal Retention and Improved GLP-1 Receptor Targeting.

Kaeppeli SAM, Jodal A, Gotthardt M, Schibli R, Béhé M.

Mol Pharm. 2019 Sep 3;16(9):3760-3769. doi: 10.1021/acs.molpharmaceut.9b00271. Epub 2019 Aug 21.

PMID:
31393738
16.

Measuring the Pancreatic β Cell Mass in Vivo with Exendin SPECT during Hyperglycemia and Severe Insulitis.

Joosten L, Brom M, Peeters H, Bos D, Himpe E, Bouwens L, Boerman O, Gotthardt M.

Mol Pharm. 2019 Sep 3;16(9):4024-4030. doi: 10.1021/acs.molpharmaceut.9b00728. Epub 2019 Aug 8.

PMID:
31345042
17.

Development and characterization of a theranostic multimodal anti-PSMA targeting agent for imaging, surgical guidance, and targeted photodynamic therapy of PSMA-expressing tumors.

Lütje S, Heskamp S, Franssen GM, Frielink C, Kip A, Hekman M, Fracasso G, Colombatti M, Herrmann K, Boerman OC, Gotthardt M, Rijpkema M.

Theranostics. 2019 May 4;9(10):2924-2938. doi: 10.7150/thno.35274. eCollection 2019.

18.

Exendin-4 analogs in insulinoma theranostics.

Jansen TJP, van Lith SAM, Boss M, Brom M, Joosten L, Béhé M, Buitinga M, Gotthardt M.

J Labelled Comp Radiopharm. 2019 Aug;62(10):656-672. doi: 10.1002/jlcr.3750.

19.

The cell adhesion protein CAR is a negative regulator of synaptic transmission.

Wrackmeyer U, Kaldrack J, Jüttner R, Pannasch U, Gimber N, Freiberg F, Purfürst B, Kainmueller D, Schmitz D, Haucke V, Rathjen FG, Gotthardt M.

Sci Rep. 2019 May 1;9(1):6768. doi: 10.1038/s41598-019-43150-5.

20.

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Friebel J, Weithauser A, Witkowski M, Rauch BH, Savvatis K, Dörner A, Tabaraie T, Kasner M, Moos V, Bösel D, Gotthardt M, Radke MH, Wegner M, Bobbert P, Lassner D, Tschöpe C, Schutheiss HP, Felix SB, Landmesser U, Rauch U.

Eur Heart J. 2019 Oct 21;40(40):3318-3332. doi: 10.1093/eurheartj/ehz117.

PMID:
31004144
21.

PET imaging during hypoglycaemia to study adipose tissue metabolism.

Boss M, Rooijackers HMM, Buitinga M, Janssen MJR, Arens AIJ, de Geus-Oei LF, Salm LP, de Galan BE, Gotthardt M.

Eur J Clin Invest. 2019 Jul;49(7):e13120. doi: 10.1111/eci.13120. Epub 2019 Apr 29.

22.

Optimal respiratory-gated [18F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma.

Smeets EMM, Withaar DS, Grootjans W, Hermans JJ, van Laarhoven K, de Geus-Oei LF, Gotthardt M, Aarntzen EHJG.

EJNMMI Res. 2019 Mar 13;9(1):24. doi: 10.1186/s13550-019-0492-y.

23.
24.

Quantitation of Six Alternaria Toxins in Infant Foods Applying Stable Isotope Labeled Standards.

Gotthardt M, Asam S, Gunkel K, Moghaddam AF, Baumann E, Kietz R, Rychlik M.

Front Microbiol. 2019 Feb 6;10:109. doi: 10.3389/fmicb.2019.00109. eCollection 2019.

25.

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

Radke MH, Polack C, Methawasin M, Fink C, Granzier HL, Gotthardt M.

Circulation. 2019 Apr 9;139(15):1813-1827. doi: 10.1161/CIRCULATIONAHA.118.037588.

PMID:
30700140
26.

In Vitro and In Vivo Characterization of an 18F-AlF-Labeled PSMA Ligand for Imaging of PSMA-Expressing Xenografts.

Lütje S, Franssen GM, Herrmann K, Boerman OC, Rijpkema M, Gotthardt M, Heskamp S.

J Nucl Med. 2019 Jul;60(7):1017-1022. doi: 10.2967/jnumed.118.218941. Epub 2019 Jan 17.

PMID:
30655329
27.

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.

Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL.

J Gen Physiol. 2019 Jan 7;151(1):42-52. doi: 10.1085/jgp.201812259. Epub 2018 Dec 19.

28.

Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients.

Buitinga M, Jansen T, van der Kroon I, Woliner-van der Weg W, Boss M, Janssen M, Aarntzen E, Béhé M, Wild D, Visser E, Brom M, Gotthardt M.

J Nucl Med. 2019 Jun;60(6):812-816. doi: 10.2967/jnumed.118.219980. Epub 2018 Nov 30.

PMID:
30504139
29.

Metabolic Subtyping of Pheochromocytoma and Paraganglioma by 18F-FDG Pharmacokinetics Using Dynamic PET/CT Scanning.

van Berkel A, Vriens D, Visser EP, Janssen MJR, Gotthardt M, Hermus ARMM, Geus-Oei LF, Timmers HJLM.

J Nucl Med. 2019 Jun;60(6):745-751. doi: 10.2967/jnumed.118.216796. Epub 2018 Nov 9.

30.

Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.

Gotthardt M, Eizirik DL, Aanstoot HJ, Korsgren O, Mul D, Martin F, Boss M, Jansen TJP, van Lith SAM, Buitinga M, Eriksson O, Cnop M, Brom M.

Diabetologia. 2018 Dec;61(12):2516-2519. doi: 10.1007/s00125-018-4745-5. Epub 2018 Oct 3.

31.

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.

Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla SNM, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL.

Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100.

32.

[Development of a national competency-based learning objective catalogue for undergraduate medical education in Germany].

Marienhagen J, Brenner W, Buck A, Franzius C, Freudenberg LS, Gotthardt M, Lindner O, Mottaghy FM, Hellwig D.

Nuklearmedizin. 2018 Aug;57(4):137-145. doi: 10.3413/Nukmed-0969-18-03. Epub 2018 Aug 20. German.

PMID:
30125926
33.

Validation of 111In-Exendin SPECT for the Determination of the β-Cell Mass in BioBreeding Diabetes-Prone Rats.

Brom M, Joosten L, Frielink C, Peeters H, Bos D, van Zanten M, Boerman O, Gotthardt M.

Diabetes. 2018 Oct;67(10):2012-2018. doi: 10.2337/db17-1312. Epub 2018 Jul 25.

34.

Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry.

Lageweg CMT, van der Putten ME, van Goudoever JB, Feuth T, Gotthardt M, van Heijst AFJ, Christmann V.

Bone Rep. 2018 Jan 28;8:38-45. doi: 10.1016/j.bonr.2018.01.004. eCollection 2018 Jun.

35.

Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.

Macquart C, Jüttner R, Morales Rodriguez B, Le Dour C, Lefebvre F, Chatzifrangkeskou M, Schmitt A, Gotthardt M, Bonne G, Muchir A.

Hum Mol Genet. 2019 Dec 15;28(24):4043-4052. doi: 10.1093/hmg/ddy227.

PMID:
29893868
36.

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Liss M, Radke MH, Eckhard J, Neuenschwander M, Dauksaite V, von Kries JP, Gotthardt M.

PLoS One. 2018 Jun 11;13(6):e0198492. doi: 10.1371/journal.pone.0198492. eCollection 2018.

37.

Activity of decitabine in pericardial myeloid sarcoma.

Evers D, Bär BMAM, Gotthardt M, van der Velden WJFM.

Int J Hematol. 2018 Aug;108(2):121-122. doi: 10.1007/s12185-018-2470-y. Epub 2018 May 19. No abstract available.

PMID:
29779081
38.

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

Dauksaite V, Gotthardt M.

Nucleic Acids Res. 2018 Jun 1;46(10):5227-5238. doi: 10.1093/nar/gky165.

39.

Characterization of 111In-labeled Glucose-Dependent Insulinotropic Polypeptide as a Radiotracer for Neuroendocrine Tumors.

Willekens SMA, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2018 Feb 13;8(1):2948. doi: 10.1038/s41598-018-21259-3.

40.

Effect of early nutritional intake on long-term growth and bone mineralization of former very low birth weight infants.

Christmann V, van der Putten ME, Rodwell L, Steiner K, Gotthardt M, van Goudoever JB, van Heijst AFJ.

Bone. 2018 Mar;108:89-97. doi: 10.1016/j.bone.2017.12.022. Epub 2017 Dec 29.

41.

Enhanced Specific Activity by Multichelation of Exendin-3 Leads To Improved Image Quality and In Vivo Beta Cell Imaging.

Joosten L, Brom M, Peeters H, Heskamp S, Béhé M, Boerman O, Gotthardt M.

Mol Pharm. 2018 Feb 5;15(2):486-494. doi: 10.1021/acs.molpharmaceut.7b00853. Epub 2017 Dec 21.

42.

Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period.

Körnmann MN, Christmann V, Gradussen CJW, Rodwell L, Gotthardt M, Van Goudoever JB, Van Heijst AFJ.

Nutrients. 2017 Dec 2;9(12). pii: E1318. doi: 10.3390/nu9121318.

43.

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.

Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B.

Eur Heart J. 2017 Dec 7;38(46):3449-3460. doi: 10.1093/eurheartj/ehx545.

PMID:
29029073
44.

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

Hinze F, Drewe-Boss P, Milek M, Ohler U, Landthaler M, Gotthardt M.

RNA Biol. 2018 Mar 4;15(3):359-368. doi: 10.1080/15476286.2017.1384120. Epub 2018 Jan 24.

45.

Gastric pouch emptying of solid food in patients with successful and unsuccessful weight loss after Roux-en-Y gastric bypass surgery.

Deden LN, Cooiman MI, Aarts EO, Janssen IMC, Gotthardt M, Hendrickx BW, Berends FJ.

Surg Obes Relat Dis. 2017 Nov;13(11):1840-1846. doi: 10.1016/j.soard.2017.07.031. Epub 2017 Aug 12.

PMID:
28935201
46.

Non-invasive in vivo determination of viable islet graft volume by 111In-exendin-3.

Eter WA, Van der Kroon I, Andralojc K, Buitinga M, Willekens SMA, Frielink C, Bos D, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2017 Aug 3;7(1):7232. doi: 10.1038/s41598-017-07815-3.

47.

Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia.

Mooij CF, van Alfen-van der Velden JAEM, Netea-Maier RT, Ten Broek R, Gotthardt M, Hagleitner MM.

J Pediatr Hematol Oncol. 2018 Mar;40(2):145-147. doi: 10.1097/MPH.0000000000000869.

PMID:
28562510
48.

Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.

Joosten L, Brom M, Schäfer MKH, Boerman OC, Weihe E, Gotthardt M.

Sci Rep. 2017 May 11;7(1):1751. doi: 10.1038/s41598-017-01852-8.

49.

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

PMID:
28428423
50.

Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.

van der Kroon I, Woliner-van der Weg W, Brom M, Joosten L, Frielink C, Konijnenberg MW, Visser EP, Gotthardt M.

Sci Rep. 2017 Jan 9;7:39800. doi: 10.1038/srep39800.

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