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In vitro and in vivo characterization of a 18F-AlF-labeled PSMA ligand for imaging of PSMA-expressing xenografts.

Lütje S, Franssen GM, Herrmann K, Boerman OC, Rijpkema M, Gotthardt M, Heskamp S.

J Nucl Med. 2019 Jan 17. pii: jnumed.118.218941. doi: 10.2967/jnumed.118.218941. [Epub ahead of print]


Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.

Slater RE, Strom JG, Methawasin M, Liss M, Gotthardt M, Sweitzer N, Granzier HL.

J Gen Physiol. 2019 Jan 7;151(1):42-52. doi: 10.1085/jgp.201812259. Epub 2018 Dec 19.


Succinylated gelatin improves the theranostic potential of radiolabeled exendin-4 in insulinoma patients.

Buitinga M, Jansen TJP, van der Kroon I, Woliner-van der Weg W, Boss M, Janssen M, Aarntzen E, Behe M, Wild D, Visser E, Brom M, Gotthardt M.

J Nucl Med. 2018 Nov 30. pii: jnumed.118.219980. doi: 10.2967/jnumed.118.219980. [Epub ahead of print]


Metabolic subtyping of pheochromocytoma and paraganglioma by 18F-FDG pharmacokinetics using dynamic PET/CT scanning.

van Berkel A, Vriens D, Visser E, Janssen M, Gotthardt M, Hermus A, de Geus-Oei LF, Timmers H.

J Nucl Med. 2018 Nov 9. pii: jnumed.118.216796. doi: 10.2967/jnumed.118.216796. [Epub ahead of print]


Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer.

Gotthardt M, Eizirik DL, Aanstoot HJ, Korsgren O, Mul D, Martin F, Boss M, Jansen TJP, van Lith SAM, Buitinga M, Eriksson O, Cnop M, Brom M.

Diabetologia. 2018 Dec;61(12):2516-2519. doi: 10.1007/s00125-018-4745-5. Epub 2018 Oct 3.


Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.

Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla SNM, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL.

Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100.


[Development of a national competency-based learning objective catalogue for undergraduate medical education in Germany].

Marienhagen J, Brenner W, Buck A, Franzius C, Freudenberg LS, Gotthardt M, Lindner O, Mottaghy FM, Hellwig D.

Nuklearmedizin. 2018 Aug;57(4):137-145. doi: 10.3413/Nukmed-0969-18-03. Epub 2018 Aug 20. German.


Validation of 111In-Exendin SPECT for the Determination of the β-Cell Mass in BioBreeding Diabetes-Prone Rats.

Brom M, Joosten L, Frielink C, Peeters H, Bos D, van Zanten M, Boerman O, Gotthardt M.

Diabetes. 2018 Oct;67(10):2012-2018. doi: 10.2337/db17-1312. Epub 2018 Jul 25.


Evaluation of bone mineralization in former preterm born children: Phalangeal quantitative ultrasound cannot replace dual-energy X-ray absorptiometry.

Lageweg CMT, van der Putten ME, van Goudoever JB, Feuth T, Gotthardt M, van Heijst AFJ, Christmann V.

Bone Rep. 2018 Jan 28;8:38-45. doi: 10.1016/j.bonr.2018.01.004. eCollection 2018 Jun.


Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.

Macquart C, Jüttner R, Le Dour C, Chatzifrangkeskou M, Schmitt A, Gotthardt M, Bonne G, Muchir A.

Hum Mol Genet. 2018 Jun 8. doi: 10.1093/hmg/ddy227. [Epub ahead of print]


Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Liss M, Radke MH, Eckhard J, Neuenschwander M, Dauksaite V, von Kries JP, Gotthardt M.

PLoS One. 2018 Jun 11;13(6):e0198492. doi: 10.1371/journal.pone.0198492. eCollection 2018.


Activity of decitabine in pericardial myeloid sarcoma.

Evers D, Bär BMAM, Gotthardt M, van der Velden WJFM.

Int J Hematol. 2018 Aug;108(2):121-122. doi: 10.1007/s12185-018-2470-y. Epub 2018 May 19. No abstract available.


Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

Dauksaite V, Gotthardt M.

Nucleic Acids Res. 2018 Jun 1;46(10):5227-5238. doi: 10.1093/nar/gky165.


Characterization of 111In-labeled Glucose-Dependent Insulinotropic Polypeptide as a Radiotracer for Neuroendocrine Tumors.

Willekens SMA, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2018 Feb 13;8(1):2948. doi: 10.1038/s41598-018-21259-3.


Effect of early nutritional intake on long-term growth and bone mineralization of former very low birth weight infants.

Christmann V, van der Putten ME, Rodwell L, Steiner K, Gotthardt M, van Goudoever JB, van Heijst AFJ.

Bone. 2018 Mar;108:89-97. doi: 10.1016/j.bone.2017.12.022. Epub 2017 Dec 29.


Enhanced Specific Activity by Multichelation of Exendin-3 Leads To Improved Image Quality and In Vivo Beta Cell Imaging.

Joosten L, Brom M, Peeters H, Heskamp S, Béhé M, Boerman O, Gotthardt M.

Mol Pharm. 2018 Feb 5;15(2):486-494. doi: 10.1021/acs.molpharmaceut.7b00853. Epub 2017 Dec 21.


Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period.

Körnmann MN, Christmann V, Gradussen CJW, Rodwell L, Gotthardt M, Van Goudoever JB, Van Heijst AFJ.

Nutrients. 2017 Dec 2;9(12). pii: E1318. doi: 10.3390/nu9121318.


Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.

Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B.

Eur Heart J. 2017 Dec 7;38(46):3449-3460. doi: 10.1093/eurheartj/ehx545.


Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

Hinze F, Drewe-Boss P, Milek M, Ohler U, Landthaler M, Gotthardt M.

RNA Biol. 2018 Mar 4;15(3):359-368. doi: 10.1080/15476286.2017.1384120. Epub 2018 Jan 24.


Gastric pouch emptying of solid food in patients with successful and unsuccessful weight loss after Roux-en-Y gastric bypass surgery.

Deden LN, Cooiman MI, Aarts EO, Janssen IMC, Gotthardt M, Hendrickx BW, Berends FJ.

Surg Obes Relat Dis. 2017 Nov;13(11):1840-1846. doi: 10.1016/j.soard.2017.07.031. Epub 2017 Aug 12.


Non-invasive in vivo determination of viable islet graft volume by 111In-exendin-3.

Eter WA, Van der Kroon I, Andralojc K, Buitinga M, Willekens SMA, Frielink C, Bos D, Joosten L, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2017 Aug 3;7(1):7232. doi: 10.1038/s41598-017-07815-3.


Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia.

Mooij CF, van Alfen-van der Velden JAEM, Netea-Maier RT, Ten Broek R, Gotthardt M, Hagleitner MM.

J Pediatr Hematol Oncol. 2018 Mar;40(2):145-147. doi: 10.1097/MPH.0000000000000869.


Preclinical evaluation of PAC1 targeting with radiolabeled Maxadilan.

Joosten L, Brom M, Schäfer MKH, Boerman OC, Weihe E, Gotthardt M.

Sci Rep. 2017 May 11;7(1):1751. doi: 10.1038/s41598-017-01852-8.


Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.


Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.

van der Kroon I, Woliner-van der Weg W, Brom M, Joosten L, Frielink C, Konijnenberg MW, Visser EP, Gotthardt M.

Sci Rep. 2017 Jan 9;7:39800. doi: 10.1038/srep39800.


Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [ 123 I]IBZM.

Willekens SM, van der Kroon I, Bos D, Joosten L, Frielink C, Boerman OC, Brom M, Gotthardt M.

Diabetes Obes Metab. 2017 Apr;19(4):604-608. doi: 10.1111/dom.12857. Epub 2017 Jan 30.


A 3D-printed anatomical pancreas and kidney phantom for optimizing SPECT/CT reconstruction settings in beta cell imaging using 111In-exendin.

Woliner-van der Weg W, Deden LN, Meeuwis AP, Koenrades M, Peeters LH, Kuipers H, Laanstra GJ, Gotthardt M, Slump CH, Visser EP.

EJNMMI Phys. 2016 Dec;3(1):29. Epub 2016 Dec 7.


Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.

Hinze F, Dieterich C, Radke MH, Granzier H, Gotthardt M.

J Mol Med (Berl). 2016 Dec;94(12):1349-1358. Epub 2016 Nov 26.


Imaging of Prostate-Specific Membrane Antigen Expression in Metastatic Differentiated Thyroid Cancer Using 68Ga-HBED-CC-PSMA PET/CT.

Lütje S, Gomez B, Cohnen J, Umutlu L, Gotthardt M, Poeppel TD, Bockisch A, Rosenbaum-Krumme S.

Clin Nucl Med. 2017 Jan;42(1):20-25.


Multi-mycotoxin stable isotope dilution LC-MS/MS method for Fusarium toxins in beer.

Habler K, Gotthardt M, Schüler J, Rychlik M.

Food Chem. 2017 Mar 1;218:447-454. doi: 10.1016/j.foodchem.2016.09.100. Epub 2016 Sep 16.


Axial tubule junctions control rapid calcium signaling in atria.

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE.

J Clin Invest. 2016 Oct 3;126(10):3999-4015. doi: 10.1172/JCI88241. Epub 2016 Sep 19.


Improved Quantification of the Beta Cell Mass after Pancreas Visualization with 99mTc-demobesin-4 and Beta Cell Imaging with 111In-exendin-3 in Rodents.

van der Kroon I, Joosten L, Nock BA, Maina T, Boerman OC, Brom M, Gotthardt M.

Mol Pharm. 2016 Oct 3;13(10):3478-3483. Epub 2016 Aug 31.


Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tübingen, Germany.

Bailey DL, Pichler BJ, Gückel B, Barthel H, Beer AJ, Botnar R, Gillies R, Goh V, Gotthardt M, Hicks RJ, Lanzenberger R, la Fougere C, Lentschig M, Nekolla SG, Niederdraenk T, Nikolaou K, Nuyts J, Olego D, Riklund KÅ, Signore A, Schäfers M, Sossi V, Suminski M, Veit-Haibach P, Umutlu L, Wissmeyer M, Beyer T.

Mol Imaging Biol. 2016 Oct;18(5):637-50. doi: 10.1007/s11307-016-0993-2.


The effect of purification of Ga-68-labeled exendin on in vivo distribution.

Brom M, Franssen GM, Joosten L, Gotthardt M, Boerman OC.

EJNMMI Res. 2016 Dec;6(1):65. doi: 10.1186/s13550-016-0221-8. Epub 2016 Aug 12.


Synthesis of GPR40 targeting 3 H- and 18 F-probes towards selective beta cell imaging.

Bertrand R, Hamp I, Brönstrup M, Weck R, Lukacevic M, Polyak A, Ross TL, Gotthardt M, Plettenburg O, Derdau V.

J Labelled Comp Radiopharm. 2016 Dec;59(14):604-610. doi: 10.1002/jlcr.3412. Epub 2016 Jun 10.


Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting Fluorescent Probe for β-Cell Imaging.

Bertrand R, Wolf A, Ivashchenko Y, Löhn M, Schäfer M, Brönstrup M, Gotthardt M, Derdau V, Plettenburg O.

ACS Chem Biol. 2016 Jun 17;11(6):1745-54. doi: 10.1021/acschembio.5b00791. Epub 2016 Apr 26.


In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use.

Eriksson O, Laughlin M, Brom M, Nuutila P, Roden M, Hwa A, Bonadonna R, Gotthardt M.

Diabetologia. 2016 Jul;59(7):1340-1349. doi: 10.1007/s00125-016-3959-7. Epub 2016 Apr 19. Review.


SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments.

Eter WA, Parween S, Joosten L, Frielink C, Eriksson M, Brom M, Ahlgren U, Gotthardt M.

Sci Rep. 2016 Apr 15;6:24576. doi: 10.1038/srep24576.


Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.

Willekens SM, Joosten L, Boerman OC, Balhuizen A, Eizirik DL, Gotthardt M, Brom M.

Mol Imaging Biol. 2016 Oct;18(5):705-14. doi: 10.1007/s11307-016-0936-y.


Noninvasive Imaging of Islet Transplants with 111In-Exendin-3 SPECT/CT.

van der Kroon I, Andralojc K, Willekens SM, Bos D, Joosten L, Boerman OC, Brom M, Gotthardt M.

J Nucl Med. 2016 May;57(5):799-804. doi: 10.2967/jnumed.115.166330. Epub 2016 Jan 21.


Performance of 3DOSEM and MAP algorithms for reconstructing low count SPECT acquisitions.

Grootjans W, Meeuwis AP, Slump CH, de Geus-Oei LF, Gotthardt M, Visser EP.

Z Med Phys. 2016 Dec;26(4):311-322. doi: 10.1016/j.zemedi.2015.12.004. Epub 2015 Dec 25.


PSMA Ligands for Radionuclide Imaging and Therapy of Prostate Cancer: Clinical Status.

Lütje S, Heskamp S, Cornelissen AS, Poeppel TD, van den Broek SA, Rosenbaum-Krumme S, Bockisch A, Gotthardt M, Rijpkema M, Boerman OC.

Theranostics. 2015 Oct 18;5(12):1388-401. doi: 10.7150/thno.13348. eCollection 2015. Review.


SPECT of Transplanted Islets of Langerhans by Dopamine 2 Receptor Targeting in a Rat Model.

Willekens SM, van der Kroon I, Joosten L, Frielink C, Boerman OC, van den Broek SA, Brom M, Gotthardt M.

Mol Pharm. 2016 Jan 4;13(1):85-91. doi: 10.1021/acs.molpharmaceut.5b00518. Epub 2015 Dec 4.


Genotype-Dependent Brown Adipose Tissue Activation in Patients With Pheochromocytoma and Paraganglioma.

Puar T, van Berkel A, Gotthardt M, Havekes B, Hermus AR, Lenders JW, van Marken Lichtenbelt WD, Xu Y, Brans B, Timmers HJ.

J Clin Endocrinol Metab. 2016 Jan;101(1):224-32. doi: 10.1210/jc.2015-3205. Epub 2015 Nov 17.


Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy.

Woliner-van der Weg W, Schoffelen R, Hobbs RF, Gotthardt M, Goldenberg DM, Sharkey RM, Slump CH, van der Graaf WT, Oyen WJ, Boerman OC, Sgouros G, Visser EP.

EJNMMI Phys. 2015 Dec;2(1):5. doi: 10.1186/s40658-014-0104-x. Epub 2015 Feb 24.


Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.

Eter WA, Bos D, Frielink C, Boerman OC, Brom M, Gotthardt M.

Sci Rep. 2015 Oct 22;5:15521. doi: 10.1038/srep15521.


Synthesis and post-synthetic modification of amine-, alkyne-, azide- and nitro-functionalized metal-organic frameworks based on DUT-5.

Gotthardt MA, Grosjean S, Brunner TS, Kotzel J, Gänzler AM, Wolf S, Bräse S, Kleist W.

Dalton Trans. 2015 Oct 14;44(38):16802-9. doi: 10.1039/c5dt02276b. Epub 2015 Sep 4.


Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.

Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F.

PLoS One. 2015 Jun 15;10(6):e0129424. doi: 10.1371/journal.pone.0129424. eCollection 2015.


Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers.

Berclaz C, Pache C, Bouwens A, Szlag D, Lopez A, Joosten L, Ekim S, Brom M, Gotthardt M, Grapin-Botton A, Lasser T.

Sci Rep. 2015 May 19;5:10385. doi: 10.1038/srep10385.


Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters.

van Berkel A, Rao JU, Lenders JW, Pellegata NS, Kusters B, Piscaer I, Hermus AR, Plantinga TS, Langenhuijsen JF, Vriens D, Janssen MJ, Gotthardt M, Timmers HJ.

J Nucl Med. 2015 Jun;56(6):839-46. doi: 10.2967/jnumed.115.154815. Epub 2015 Apr 16.

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