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Items: 1 to 50 of 222

1.

New Insights into Haematopoietic Differentiation Landscapes from scRNA-seq.

Watcham S, Kucinski I, Gottgens B.

Blood. 2019 Feb 6. pii: blood-2018-08-835355. doi: 10.1182/blood-2018-08-835355. [Epub ahead of print]

PMID:
30728144
2.

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.

Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambile D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P.

Haematologica. 2019 Jan 24. pii: haematol.2018.202044. doi: 10.3324/haematol.2018.202044. [Epub ahead of print]

3.

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.

Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, Bonfanti P, Göttgens B, Huch M, Simons B, Philpott A.

Sci Rep. 2018 Oct 18;8(1):15374. doi: 10.1038/s41598-018-33838-5.

4.

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors.

Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E.

Nat Commun. 2018 Oct 5;9(1):4100. doi: 10.1038/s41467-018-06442-4.

5.

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Kauts ML, De Leo B, Rodríguez-Seoane C, Ronn R, Glykofrydis F, Maglitto A, Kaimakis P, Basi M, Taylor H, Forrester L, Wilkinson AC, Göttgens B, Saunders P, Dzierzak E.

Stem Cell Reports. 2018 Oct 9;11(4):1009-1020. doi: 10.1016/j.stemcr.2018.08.007. Epub 2018 Sep 6.

6.

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD.

Dev Cell. 2018 Aug 6;46(3):360-375.e5. doi: 10.1016/j.devcel.2018.06.028. Epub 2018 Jul 26.

7.

T cell cytolytic capacity is independent of initial stimulation strength.

Richard AC, Lun ATL, Lau WWY, Göttgens B, Marioni JC, Griffiths GM.

Nat Immunol. 2018 Aug;19(8):849-858. doi: 10.1038/s41590-018-0160-9. Epub 2018 Jul 16.

8.

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.

Shepherd MS, Li J, Wilson NK, Oedekoven CA, Li J, Belmonte M, Fink J, Prick JCM, Pask DC, Hamilton TL, Loeffler D, Rao A, Schröder T, Göttgens B, Green AR, Kent DG.

Blood. 2018 Aug 23;132(8):791-803. doi: 10.1182/blood-2017-12-821066. Epub 2018 Jul 10.

PMID:
29991556
9.

SCNS: a graphical tool for reconstructing executable regulatory networks from single-cell genomic data.

Woodhouse S, Piterman N, Wintersteiger CM, Göttgens B, Fisher J.

BMC Syst Biol. 2018 May 25;12(1):59. doi: 10.1186/s12918-018-0581-y.

10.

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.

Gozdecka M, Meduri E, Mazan M, Tzelepis K, Dudek M, Knights AJ, Pardo M, Yu L, Choudhary JS, Metzakopian E, Iyer V, Yun H, Park N, Varela I, Bautista R, Collord G, Dovey O, Garyfallos DA, De Braekeleer E, Kondo S, Cooper J, Göttgens B, Bullinger L, Northcott PA, Adams D, Vassiliou GS, Huntly BJP.

Nat Genet. 2018 Jun;50(6):883-894. doi: 10.1038/s41588-018-0114-z. Epub 2018 May 7.

11.

Sorting apples from oranges in single-cell expression comparisons.

Hamey FK, Göttgens B.

Nat Methods. 2018 Apr 27;15(5):321-322. doi: 10.1038/nmeth.4675. No abstract available.

PMID:
29702635
12.

Single-cell transcriptional profiling: a window into embryonic cell-type specification.

Pijuan-Sala B, Guibentif C, Göttgens B.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):399-412. doi: 10.1038/s41580-018-0002-5. Review.

PMID:
29666443
13.

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.

Dahlin JS, Hamey FK, Pijuan-Sala B, Shepherd M, Lau WWY, Nestorowa S, Weinreb C, Wolock S, Hannah R, Diamanti E, Kent DG, Göttgens B, Wilson NK.

Blood. 2018 May 24;131(21):e1-e11. doi: 10.1182/blood-2017-12-821413. Epub 2018 Mar 27.

PMID:
29588278
14.

Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq.

Lescroart F, Wang X, Lin X, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C.

Science. 2018 Mar 9;359(6380):1177-1181. doi: 10.1126/science.aao4174. Epub 2018 Jan 25.

PMID:
29371425
15.

From haematopoietic stem cells to complex differentiation landscapes.

Laurenti E, Göttgens B.

Nature. 2018 Jan 24;553(7689):418-426. doi: 10.1038/nature25022. Review.

PMID:
29364285
16.

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.

Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC.

Nat Cell Biol. 2018 Feb;20(2):127-134. doi: 10.1038/s41556-017-0013-z. Epub 2018 Jan 8.

17.

The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants.

Elife. 2017 Dec 5;6. pii: e27041. doi: 10.7554/eLife.27041.

18.

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.

Karamitros D, Stoilova B, Aboukhalil Z, Hamey F, Reinisch A, Samitsch M, Quek L, Otto G, Repapi E, Doondeea J, Usukhbayar B, Calvo J, Taylor S, Goardon N, Six E, Pflumio F, Porcher C, Majeti R, Göttgens B, Vyas P.

Nat Immunol. 2018 Jan;19(1):85-97. doi: 10.1038/s41590-017-0001-2. Epub 2017 Nov 21.

19.

Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.

Wahlestedt M, Ladopoulos V, Hidalgo I, Sanchez Castillo M, Hannah R, Säwén P, Wan H, Dudenhöffer-Pfeifer M, Magnusson M, Norddahl GL, Göttgens B, Bryder D.

Cell Rep. 2017 Nov 21;21(8):2251-2263. doi: 10.1016/j.celrep.2017.10.112.

20.

Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity.

Wilkinson AC, Nakauchi H, Göttgens B.

Cell Syst. 2017 Oct 25;5(4):319-331. doi: 10.1016/j.cels.2017.07.004. Review.

21.

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM.

Mol Metab. 2017 Oct;6(10):1296-1303. doi: 10.1016/j.molmet.2017.07.014. Epub 2017 Aug 1.

22.

Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data.

Lun ATL, Calero-Nieto FJ, Haim-Vilmovsky L, Göttgens B, Marioni JC.

Genome Res. 2017 Nov;27(11):1795-1806. doi: 10.1101/gr.222877.117. Epub 2017 Oct 13.

23.

Establishment of mouse expanded potential stem cells.

Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.

Nature. 2017 Oct 19;550(7676):393-397. doi: 10.1038/nature24052. Epub 2017 Oct 11.

24.

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Göttgens B, Jacobsen SEW, Mead AJ, Hendrich B, Green AR.

J Exp Med. 2017 Oct 2;214(10):3085-3104. doi: 10.1084/jem.20161827. Epub 2017 Sep 12.

25.

Reconstructing blood stem cell regulatory network models from single-cell molecular profiles.

Hamey FK, Nestorowa S, Kinston SJ, Kent DG, Wilson NK, Göttgens B.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5822-5829. doi: 10.1073/pnas.1610609114.

26.

Blood: Education for stem cells.

Guibentif C, Göttgens B.

Nature. 2017 May 25;545(7655):415-417. doi: 10.1038/nature22496. Epub 2017 May 17. No abstract available.

PMID:
28514445
27.

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A.

Dev Cell. 2017 May 8;41(3):274-286.e5. doi: 10.1016/j.devcel.2017.04.004. Epub 2017 Apr 27.

28.

Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.

Basilico S, Göttgens B.

J Mol Med (Berl). 2017 Jul;95(7):719-727. doi: 10.1007/s00109-017-1535-3. Epub 2017 Apr 20. Review.

29.

Demystifying blood stem cell fates.

Hamey FK, Göttgens B.

Nat Cell Biol. 2017 Mar 31;19(4):261-263. doi: 10.1038/ncb3494.

PMID:
28361939
30.

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E.

Nature. 2017 Apr 6;544(7648):53-58. doi: 10.1038/nature21693. Epub 2017 Mar 29.

31.

Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia.

Silverbush D, Grosskurth S, Wang D, Powell F, Gottgens B, Dry J, Fisher J.

Cancer Res. 2017 Feb 15;77(4):827-838. doi: 10.1158/0008-5472.CAN-16-1578. Epub 2016 Dec 13.

32.

A graphical model approach visualizes regulatory relationships between genome-wide transcription factor binding profiles.

Ng FSL, Ruau D, Wernisch L, Göttgens B.

Brief Bioinform. 2018 Jan 1;19(1):162-173. doi: 10.1093/bib/bbw102.

33.

Dissecting stem cell differentiation using single cell expression profiling.

Moignard V, Göttgens B.

Curr Opin Cell Biol. 2016 Dec;43:78-86. doi: 10.1016/j.ceb.2016.08.005. Epub 2016 Sep 22. Review.

PMID:
27665068
34.

Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multiorgan Endothelial Reconstitution Potential.

Cañete A, Comaills V, Prados I, Castro AM, Hammad S, Ybot-Gonzalez P, Bockamp E, Hengstler JG, Gottgens B, Sánchez MJ.

Stem Cells. 2017 Feb;35(2):507-521. doi: 10.1002/stem.2494. Epub 2016 Sep 28.

35.

BTR: training asynchronous Boolean models using single-cell expression data.

Lim CY, Wang H, Woodhouse S, Piterman N, Wernisch L, Fisher J, Göttgens B.

BMC Bioinformatics. 2016 Sep 6;17(1):355. doi: 10.1186/s12859-016-1235-y.

36.

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.

Nasrallah R, Fast EM, Solaimani P, Knezevic K, Eliades A, Patel R, Thambyrajah R, Unnikrishnan A, Thoms J, Beck D, Vink CS, Smith A, Wong J, Shepherd M, Kent D, Roychoudhuri R, Paul F, Klippert J, Hammes A, Willnow T, Göttgens B, Dzierzak E, Zon LI, Lacaud G, Kouskoff V, Pimanda JE.

Blood. 2016 Oct 13;128(15):1928-1939. Epub 2016 Aug 23. Erratum in: Blood. 2017 Nov 16;130(20):2234.

37.

Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data.

Ezer D, Moignard V, Göttgens B, Adryan B.

PLoS Comput Biol. 2016 Aug 23;12(8):e1005072. doi: 10.1371/journal.pcbi.1005072. eCollection 2016 Aug.

38.

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA.

Cancer Cell. 2016 Aug 8;30(2):363-365. doi: 10.1016/j.ccell.2016.07.015. Epub 2016 Aug 8. No abstract available.

39.

Resolving early mesoderm diversification through single-cell expression profiling.

Scialdone A, Tanaka Y, Jawaid W, Moignard V, Wilson NK, Macaulay IC, Marioni JC, Göttgens B.

Nature. 2016 Jul 14;535(7611):289-293. doi: 10.1038/nature18633. Epub 2016 Jul 6.

40.

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation.

Nestorowa S, Hamey FK, Pijuan Sala B, Diamanti E, Shepherd M, Laurenti E, Wilson NK, Kent DG, Göttgens B.

Blood. 2016 Aug 25;128(8):e20-31. doi: 10.1182/blood-2016-05-716480. Epub 2016 Jun 30.

41.

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA.

Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. Erratum in: Cancer Cell. 2016 Aug 8;30(2):363-365.

42.

Advancing haematopoietic stem and progenitor cell biology through single-cell profiling.

Hamey FK, Nestorowa S, Wilson NK, Göttgens B.

FEBS Lett. 2016 Nov;590(22):4052-4067. doi: 10.1002/1873-3468.12231. Epub 2016 Jun 21. Review.

43.

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Goode DK, Obier N, Vijayabaskar MS, Lie-A-Ling M, Lilly AJ, Hannah R, Lichtinger M, Batta K, Florkowska M, Patel R, Challinor M, Wallace K, Gilmour J, Assi SA, Cauchy P, Hoogenkamp M, Westhead DR, Lacaud G, Kouskoff V, Göttgens B, Bonifer C.

Dev Cell. 2016 Mar 7;36(5):572-87. doi: 10.1016/j.devcel.2016.01.024. Epub 2016 Feb 25.

44.

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.

Schütte J, Wang H, Antoniou S, Jarratt A, Wilson NK, Riepsaame J, Calero-Nieto FJ, Moignard V, Basilico S, Kinston SJ, Hannah RL, Chan MC, Nürnberg ST, Ouwehand WH, Bonzanni N, de Bruijn MF, Göttgens B.

Elife. 2016 Feb 22;5:e11469. doi: 10.7554/eLife.11469.

45.

Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model.

Wilson NK, Schoenfelder S, Hannah R, Sánchez Castillo M, Schütte J, Ladopoulos V, Mitchelmore J, Goode DK, Calero-Nieto FJ, Moignard V, Wilkinson AC, Jimenez-Madrid I, Kinston S, Spivakov M, Fraser P, Göttgens B.

Blood. 2016 Mar 31;127(13):e12-23. doi: 10.1182/blood-2015-10-677393. Epub 2016 Jan 25.

46.

ConBind: motif-aware cross-species alignment for the identification of functional transcription factor binding sites.

Lelieveld SH, Schütte J, Dijkstra MJ, Bawono P, Kinston SJ, Göttgens B, Heringa J, Bonzanni N.

Nucleic Acids Res. 2016 May 5;44(8):e72. doi: 10.1093/nar/gkv1518. Epub 2015 Dec 31.

47.

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

Park HJ, Li J, Hannah R, Biddie S, Leal-Cervantes AI, Kirschner K, Flores Santa Cruz D, Sexl V, Göttgens B, Green AR.

EMBO J. 2016 Mar 15;35(6):580-94. doi: 10.15252/embj.201592383. Epub 2015 Dec 23.

48.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G.

Nat Cell Biol. 2016 Jan;18(1):21-32. doi: 10.1038/ncb3276. Epub 2015 Nov 30.

PMID:
26619147
49.

Processing, visualising and reconstructing network models from single-cell data.

Woodhouse S, Moignard V, Göttgens B, Fisher J.

Immunol Cell Biol. 2016 Mar;94(3):256-65. doi: 10.1038/icb.2015.102. Epub 2015 Nov 18. Review.

PMID:
26577213
50.

The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.

Bonadies N, Göttgens B, Calero-Nieto FJ.

PLoS One. 2015 Jul 10;10(7):e0131577. doi: 10.1371/journal.pone.0131577. eCollection 2015.

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