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Items: 1 to 50 of 759

1.

Ribonucleoside-5'-diphosphates (NDPs) support RNA polymerase transcription, suggesting NDPs may have been substrates for primordial nucleic acid biosynthesis.

Gottesman ME, Mustaev A.

J Biol Chem. 2019 Jun 12. pii: jbc.RA119.009074. doi: 10.1074/jbc.RA119.009074. [Epub ahead of print]

2.

Model systems for studying the blood-brain barrier: Applications and challenges.

Jackson S, Meeks C, Vézina A, Robey RW, Tanner K, Gottesman MM.

Biomaterials. 2019 Sep;214:119217. doi: 10.1016/j.biomaterials.2019.05.028. Epub 2019 May 18. Review.

PMID:
31146177
3.

DksA and DNA double-strand break repair.

Myka KK, Gottesman ME.

Curr Genet. 2019 May 10. doi: 10.1007/s00294-019-00983-x. [Epub ahead of print] Review.

PMID:
31076845
4.

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells.

Baglo Y, Liang BJ, Robey RW, Ambudkar SV, Gottesman MM, Huang HC.

Cancer Lett. 2019 Aug 10;457:110-118. doi: 10.1016/j.canlet.2019.04.037. Epub 2019 May 6.

PMID:
31071369
5.

Heterogeneity in refractory acute myeloid leukemia.

Horibata S, Gui G, Lack J, DeStefano CB, Gottesman MM, Hourigan CS.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10494-10503. doi: 10.1073/pnas.1902375116. Epub 2019 May 7.

PMID:
31064876
6.

Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function.

Robinson AN, Tebase BG, Francone SC, Huff LM, Kozlowski H, Cossari D, Lee JM, Esposito D, Robey RW, Gottesman MM.

Drug Metab Dispos. 2019 Jul;47(7):715-723. doi: 10.1124/dmd.118.086181. Epub 2019 May 2.

7.

Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression.

Wulftange WJ, Rose MA, Garmendia-Cedillos M, da Silva D, Poprawski JE, Srinivasachar D, Sullivan T, Lim L, Bliskovsky VV, Hall MD, Pohida TJ, Robey RW, Morgan NY, Gottesman MM.

J Cell Physiol. 2019 Apr 22. doi: 10.1002/jcp.28665. [Epub ahead of print]

PMID:
31012116
8.

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities.

Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP.

J Invest Dermatol. 2019 Mar 21. pii: S0022-202X(19)31330-2. doi: 10.1016/j.jid.2019.01.036. [Epub ahead of print]

9.

Response.

Collins FS, Tabak LA, Wolinetz CD, Lauer MS, Gottesman MM.

Science. 2019 Mar 22;363(6433):1292-1294. doi: 10.1126/science.aaw8810. No abstract available.

PMID:
30898925
10.

RNA Stabilizes Transcription-Dependent Chromatin Loops Induced By Nuclear Hormones.

Pezone A, Zuchegna C, Tramontano A, Romano A, Russo G, de Rosa M, Vinciguerra M, Porcellini A, Gottesman ME, Avvedimento EV.

Sci Rep. 2019 Mar 8;9(1):3925. doi: 10.1038/s41598-019-40123-6.

11.

DksA-RNA polymerase interactions support new origin formation and DNA repair in Escherichia coli.

Myka KK, Küsters K, Washburn R, Gottesman ME.

Mol Microbiol. 2019 May;111(5):1382-1397. doi: 10.1111/mmi.14227. Epub 2019 Mar 22.

12.

Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models.

McDonald AJ, Curt KM, Patel RP, Kozlowski H, Sackett DL, Robey RW, Gottesman MM, Bates SE.

Exp Cell Res. 2019 Feb 15;375(2):106-112. doi: 10.1016/j.yexcr.2018.12.012. Epub 2018 Dec 21.

PMID:
30579954
13.

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein.

Vahedi S, Lusvarghi S, Pluchino K, Shafrir Y, Durell SR, Gottesman MM, Ambudkar SV.

Sci Rep. 2018 Aug 24;8(1):12716. doi: 10.1038/s41598-018-30984-8.

14.

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.

Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y.

J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24.

PMID:
30143532
15.

Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF.

Zuber PK, Hahn L, Reinl A, Schweimer K, Knauer SH, Gottesman ME, Rösch P, Wöhrl BM.

Sci Rep. 2018 Aug 3;8(1):11660. doi: 10.1038/s41598-018-30042-3.

16.

Pluripotent Stem Cell Platforms for Drug Discovery.

Chen KG, Mallon BS, Park K, Robey PG, McKay RDG, Gottesman MM, Zheng W.

Trends Mol Med. 2018 Sep;24(9):805-820. doi: 10.1016/j.molmed.2018.06.009. Epub 2018 Jul 11. Review.

PMID:
30006147
17.

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J.

Nature. 2018 Jul;559(7712):61-66. doi: 10.1038/s41586-018-0237-5. Epub 2018 Jun 20.

18.

Revisiting the role of ABC transporters in multidrug-resistant cancer.

Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE, Gottesman MM.

Nat Rev Cancer. 2018 Jul;18(7):452-464. doi: 10.1038/s41568-018-0005-8. Review.

19.

Escherichia coli transcription factor NusG binds to 70S ribosomes.

Saxena S, Myka KK, Washburn R, Costantino N, Court DL, Gottesman ME.

Mol Microbiol. 2018 Jun;108(5):495-504. doi: 10.1111/mmi.13953. Epub 2018 Apr 6.

20.

Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold.

Gottesman ME, Mustaev A.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2746-2751. doi: 10.1073/pnas.1720370115. Epub 2018 Feb 26.

21.

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J.

Cell Rep. 2017 Oct 31;21(5):1375-1385. doi: 10.1016/j.celrep.2017.10.032.

22.

High-coverage methylation data of a gene model before and after DNA damage and homologous repair.

Pezone A, Russo G, Tramontano A, Florio E, Scala G, Landi R, Zuchegna C, Romano A, Chiariotti L, Muller MT, Gottesman ME, Porcellini A, Avvedimento EV.

Sci Data. 2017 Apr 11;4:170043. doi: 10.1038/sdata.2017.43.

23.

Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex.

Kang JY, Olinares PD, Chen J, Campbell EA, Mustaev A, Chait BT, Gottesman ME, Darst SA.

Elife. 2017 Mar 20;6. pii: e25478. doi: 10.7554/eLife.25478.

24.

Transcription elongation.

Mustaev A, Roberts J, Gottesman M.

Transcription. 2017 May 27;8(3):150-161. doi: 10.1080/21541264.2017.1289294. Epub 2017 Feb 8. Review.

25.

Correction: DNA Damage, Homology-Directed Repair, and DNA Methylation.

Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Pardo AD, Messina S, Iuliano R, Fusco A, Santillo MR, Muller MT, Chiariotti L, Gottesman ME, Avvedimento EV.

PLoS Genet. 2017 Feb 10;13(2):e1006605. doi: 10.1371/journal.pgen.1006605. eCollection 2017 Feb.

26.

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.

Esser L, Zhou F, Pluchino KM, Shiloach J, Ma J, Tang WK, Gutierrez C, Zhang A, Shukla S, Madigan JP, Zhou T, Kwong PD, Ambudkar SV, Gottesman MM, Xia D.

J Biol Chem. 2017 Jan 13;292(2):446-461. doi: 10.1074/jbc.M116.755884. Epub 2016 Nov 18.

27.

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.

Bahr JC, Robey RW, Luchenko V, Basseville A, Chakraborty AR, Kozlowski H, Pauly GT, Patel P, Schneider JP, Gottesman MM, Bates SE.

Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001.

28.

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism.

Russo G, Landi R, Pezone A, Morano A, Zuchegna C, Romano A, Muller MT, Gottesman ME, Porcellini A, Avvedimento EV.

Sci Rep. 2016 Sep 15;6:33222. doi: 10.1038/srep33222.

29.

An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.

Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2062-2075. doi: 10.1177/0271678X16660984. Epub 2016 Jan 1.

30.

Probing the structure of Nun transcription arrest factor bound to RNA polymerase.

Mustaev A, Vitiello CL, Gottesman ME.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8693-8. doi: 10.1073/pnas.1601056113. Epub 2016 Jul 19.

31.

In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood-Brain Barrier.

Bakhsheshian J, Wei BR, Hall MD, Simpson RM, Gottesman MM.

Methods Mol Biol. 2016;1461:227-39. doi: 10.1007/978-1-4939-3813-1_19.

PMID:
27424909
32.

Factors associated with benign multiple sclerosis in the New York State MS Consortium (NYSMSC).

Zivadinov R, Cookfair DL, Krupp L, Miller AE, Lava N, Coyle PK, Goodman AD, Jubelt B, Lenihan M, Herbert J, Gottesman M, Snyder DH, Apatoff BR, Teter BE, Perel AB, Munschauer F, Weinstock-Guttman B.

BMC Neurol. 2016 Jul 15;16:102. doi: 10.1186/s12883-016-0623-2.

33.

Outcomes From the NIH Clinical Research Training Program: A Mentored Research Experience to Enhance Career Development of Clinician-Scientists.

Ognibene FP, Gallin JI, Baum BJ, Wyatt RG, Gottesman MM.

Acad Med. 2016 Dec;91(12):1684-1690. doi: 10.1097/ACM.0000000000001245.

34.

(18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier.

Liow JS, Zoghbi SS, Hu S, Hall MD, Hines CS, Shetty HU, Araneta MD, Page EM, Pike VW, Kreisl WC, Herscovitch P, Gottesman MM, Theodore WH, Innis RB.

Neuroimage. 2016 Sep;138:134-140. doi: 10.1016/j.neuroimage.2016.05.045. Epub 2016 May 19.

35.

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S.

Mol Pharmacol. 2016 Jul;90(1):35-41. doi: 10.1124/mol.116.104190. Epub 2016 May 11.

36.

Transcription is regulated by NusA:NusG interaction.

Strauß M, Vitiello C, Schweimer K, Gottesman M, Rösch P, Knauer SH.

Nucleic Acids Res. 2016 Jul 8;44(12):5971-82. doi: 10.1093/nar/gkw423. Epub 2016 May 12.

37.

The Drug Excipient Cyclodextrin Interacts With d-Luciferin and Interferes With Bioluminescence Imaging.

Kumar JS, Miller Jenkins LM, Gottesman MM, Hall MD.

Mol Imaging. 2016 Jan 27;15. pii: 1536012115625225. doi: 10.1177/1536012115625225. Print 2016.

38.

Basic science: Bedrock of progress.

Collins FS, Anderson JM, Austin CP, Battey JF, Birnbaum LS, Briggs JP, Clayton JA, Cuthbert B, Eisinger RW, Fauci AS, Gallin JI, Gibbons GH, Glass RI, Gottesman MM, Gray PA, Green ED, Greider FB, Hodes R, Hudson KL, Humphreys B, Katz SI, Koob GF, Koroshetz WJ, Lauer MS, Lorsch JR, Lowy DR, McGowan JJ, Murray DM, Nakamura R, Norris A, Perez-Stable EJ, Pettigrew RI, Riley WT, Rodgers GP, Sieving PA, Somerman MJ, Spong CY, Tabak LA, Volkow ND, Wilder EL.

Science. 2016 Mar 25;351(6280):1405. doi: 10.1126/science.351.6280.1405-a. No abstract available.

39.

Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response.

Greene JM, Levy D, Herrada SP, Gottesman MM, Lavi O.

Cancer Res. 2016 May 15;76(10):2882-90. doi: 10.1158/0008-5472.CAN-15-3232. Epub 2016 Mar 1.

40.

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.

Aparicio T, Baer R, Gottesman M, Gautier J.

J Cell Biol. 2016 Feb 15;212(4):399-408. doi: 10.1083/jcb.201504005.

41.

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier.

Kumar JS, Wei BR, Madigan JP, Simpson RM, Hall MD, Gottesman MM.

Sci Rep. 2016 Feb 8;6:20418. doi: 10.1038/srep20418.

42.

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

Pluchino KM, Hall MD, Moen JK, Chufan EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM.

Biochemistry. 2016 Feb 23;55(7):1010-23. doi: 10.1021/acs.biochem.5b01064. Epub 2016 Feb 10.

43.

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM.

Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14.

44.

Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.

Weidner LD, Fung KL, Kannan P, Moen JK, Kumar JS, Mulder J, Innis RB, Gottesman MM, Hall MD.

Drug Metab Dispos. 2016 Feb;44(2):275-82. doi: 10.1124/dmd.115.067785. Epub 2015 Dec 10.

45.

Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers.

Fung KL, Kapoor K, Pixley JN, Talbert DJ, Kwit AD, Ambudkar SV, Gottesman MM.

Drug Metab Dispos. 2016 Feb;44(2):180-8. doi: 10.1124/dmd.115.066506. Epub 2015 Nov 30. Erratum in: Drug Metab Dispos. 2016 Apr;44(4):517.

46.

Toward a Better Understanding of the Complexity of Cancer Drug Resistance.

Gottesman MM, Lavi O, Hall MD, Gillet JP.

Annu Rev Pharmacol Toxicol. 2016;56:85-102. doi: 10.1146/annurev-pharmtox-010715-103111. Epub 2015 Oct 28. Review.

PMID:
26514196
47.

Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs.

Jagodinsky JC, Sulima A, Cao Y, Poprawski JE, Blackman BN, Lloyd JR, Swenson RE, Gottesman MM, Hall MD.

J Biol Inorg Chem. 2015 Oct;20(7):1081-95. doi: 10.1007/s00775-015-1290-2. Epub 2015 Sep 1.

48.

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

Pluchino KM, Esposito D, Moen JK, Hall MD, Madigan JP, Shukla S, Procter LV, Wall VE, Schneider TD, Pringle I, Ambudkar SV, Gill DR, Hyde SC, Gottesman MM.

PLoS One. 2015 Aug 26;10(8):e0136396. doi: 10.1371/journal.pone.0136396. eCollection 2015.

49.

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene.

Gottesman MM, Pastan IH.

J Natl Cancer Inst. 2015 Aug 18;107(9). pii: djv222. doi: 10.1093/jnci/djv222. Print 2015 Sep. No abstract available.

50.

The Inhibitor Ko143 Is Not Specific for ABCG2.

Weidner LD, Zoghbi SS, Lu S, Shukla S, Ambudkar SV, Pike VW, Mulder J, Gottesman MM, Innis RB, Hall MD.

J Pharmacol Exp Ther. 2015 Sep;354(3):384-93. doi: 10.1124/jpet.115.225482. Epub 2015 Jul 6.

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