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Items: 1 to 50 of 76

1.

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signaling in monocyte-derived alveolar macrophages.

Joshi N, Watanabe S, Verma R, Jablonski RP, Chen CI, Cheresh P, Markov NS, Reyfman PA, McQuattie-Pimentel AC, Sichizya L, Lu Z, Piseaux R, Kirchenbuechler D, Flozak AS, Gottardi CJ, Cuda CM, Perlman H, Jain M, Kamp DW, Scott Budinger GR, Misharin AV.

Eur Respir J. 2019 Oct 10. pii: 1900646. doi: 10.1183/13993003.00646-2019. [Epub ahead of print]

PMID:
31601718
2.

Macrophages as a Source and Recipient of Wnt Signals.

Malsin ES, Kim S, Lam AP, Gottardi CJ.

Front Immunol. 2019 Jul 31;10:1813. doi: 10.3389/fimmu.2019.01813. eCollection 2019. Review.

3.

IPF and Lung Cancer: Finding Similarities within Differences.

Reyfman PA, Gottardi CJ.

Am J Respir Cell Mol Biol. 2019 Jun 5. doi: 10.1165/rcmb.2019-0172ED. [Epub ahead of print] No abstract available.

PMID:
31167078
4.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

5.

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.

Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M.

Nat Commun. 2018 Nov 30;9(1):5121. doi: 10.1038/s41467-018-07481-7.

6.

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.

Chiarella SE, Rabin EE, Ostilla LA, Flozak AS, Gottardi CJ.

Tissue Barriers. 2018;6(2):e1463896. doi: 10.1080/21688370.2018.1463896. Epub 2018 May 10. Review.

7.

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

Wood MN, Ishiyama N, Singaram I, Chung CM, Flozak AS, Yemelyanov A, Ikura M, Cho W, Gottardi CJ.

J Cell Biol. 2017 Nov 6;216(11):3767-3783. doi: 10.1083/jcb.201612006. Epub 2017 Sep 5.

8.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

9.

Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.

Loffredo LF, Abdala-Valencia H, Anekalla KR, Cuervo-Pardo L, Gottardi CJ, Berdnikovs S.

Allergy. 2017 Dec;72(12):1988-2004. doi: 10.1111/all.13222. Epub 2017 Jul 6.

10.

Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma?

Folmsbee SS, Gottardi CJ.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):512-518. doi: 10.1165/rcmb.2016-0261TR. Review.

11.

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.

Serebryannyy LA, Yemelyanov A, Gottardi CJ, de Lanerolle P.

J Cell Sci. 2017 May 15;130(10):1717-1729. doi: 10.1242/jcs.199893. Epub 2017 Mar 27.

12.

Lrp5/β-Catenin Signaling Controls Lung Macrophage Differentiation and Inhibits Resolution of Fibrosis.

Sennello JA, Misharin AV, Flozak AS, Berdnikovs S, Cheresh P, Varga J, Kamp DW, Budinger GR, Gottardi CJ, Lam AP.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):191-201. doi: 10.1165/rcmb.2016-0147OC.

13.

A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells.

Flozak AS, Lam AP, Gottardi CJ.

Methods Mol Biol. 2016;1481:49-60. doi: 10.1007/978-1-4939-6393-5_6.

14.

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

Serebryannyy LA, Parilla M, Annibale P, Cruz CM, Laster K, Gratton E, Kudryashov D, Kosak ST, Gottardi CJ, de Lanerolle P.

J Cell Sci. 2016 Sep 15;129(18):3412-25. doi: 10.1242/jcs.195867. Epub 2016 Aug 2.

15.

αT-catenin in restricted brain cell types and its potential connection to autism.

Folmsbee SS, Wilcox DR, Tyberghein K, De Bleser P, Tourtellotte WG, van Hengel J, van Roy F, Gottardi CJ.

J Mol Psychiatry. 2016 Jun 21;4:2. doi: 10.1186/s40303-016-0017-9. eCollection 2016.

16.

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation.

Folmsbee SS, Budinger GRS, Bryce PJ, Gottardi CJ.

J Allergy Clin Immunol. 2016 Jul;138(1):123-129.e2. doi: 10.1016/j.jaci.2015.11.037. Epub 2016 Mar 3.

17.

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.

Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, Lin K, Zhang S, Zhang N, Gottardi CJ, Huang S.

EMBO J. 2016 Mar 15;35(6):668-84. doi: 10.15252/embj.201592810. Epub 2016 Feb 24.

18.

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.

Reinke L, Lam AP, Flozak AS, Varga J, Gottardi CJ.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):606-612. doi: 10.1016/j.bbrc.2016.01.097. Epub 2016 Jan 23.

19.

Beyond β-catenin: prospects for a larger catenin network in the nucleus.

McCrea PD, Gottardi CJ.

Nat Rev Mol Cell Biol. 2016 Jan;17(1):55-64. doi: 10.1038/nrm.2015.3. Epub 2015 Nov 18. Review.

20.

Nuclear signaling from cadherin adhesion complexes.

McCrea PD, Maher MT, Gottardi CJ.

Curr Top Dev Biol. 2015;112:129-96. doi: 10.1016/bs.ctdb.2014.11.018. Epub 2015 Feb 12. Review.

21.

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ.

J Cell Sci. 2015 Mar 15;128(6):1150-65. doi: 10.1242/jcs.163824. Epub 2015 Feb 4.

22.

The cardiac protein αT-catenin contributes to chemical-induced asthma.

Folmsbee SS, Morales-Nebreda L, Van Hengel J, Tyberghein K, Van Roy F, Budinger GR, Bryce PJ, Gottardi CJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L253-8. doi: 10.1152/ajplung.00331.2014. Epub 2014 Dec 5.

23.

The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype.

Valenti F, Ibetti J, Komiya Y, Baxter M, Lucchese AM, Derstine L, Covaciu C, Rizzo V, Vento R, Russo G, Macaluso M, Cotelli F, Castiglia D, Gottardi CJ, Habas R, Giordano A, Bellipanni G.

J Cell Biochem. 2015 Mar;116(3):418-30. doi: 10.1002/jcb.24993.

PMID:
25335865
24.

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.

McEwen AE, Maher MT, Mo R, Gottardi CJ.

Mol Biol Cell. 2014 Aug 15;25(16):2365-74. doi: 10.1091/mbc.E14-01-0690. Epub 2014 Jun 25.

25.

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.

Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):185-95. doi: 10.1164/rccm.201401-0079OC.

26.

α-Catenin is an inhibitor of transcription.

Daugherty RL, Serebryannyy L, Yemelyanov A, Flozak AS, Yu HJ, Kosak ST, deLanerolle P, Gottardi CJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5260-5. doi: 10.1073/pnas.1308663111. Epub 2014 Mar 25.

27.

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.

Ono M, Yin P, Navarro A, Moravek MB, Coon V JS, Druschitz SA, Gottardi CJ, Bulun SE.

Fertil Steril. 2014 May;101(5):1441-9. doi: 10.1016/j.fertnstert.2014.01.017. Epub 2014 Feb 15.

28.

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction.

Barry AK, Tabdili H, Muhamed I, Wu J, Shashikanth N, Gomez GA, Yap AS, Gottardi CJ, de Rooij J, Wang N, Leckband DE.

J Cell Sci. 2014 Apr 15;127(Pt 8):1779-91. doi: 10.1242/jcs.139014. Epub 2014 Feb 12.

29.

Fat in fibrosis.

Lam AP, Gottardi CJ.

Am J Respir Crit Care Med. 2013 Nov 15;188(10):1268-9. doi: 10.1164/rccm.201305-0971LE. No abstract available.

30.

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.

Ono M, Yin P, Navarro A, Moravek MB, Coon JS 5th, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17053-8. doi: 10.1073/pnas.1313650110. Epub 2013 Sep 30.

31.

Considerations for targeting β-catenin signaling in fibrosis.

Gottardi CJ, Königshoff M.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):566-8. doi: 10.1164/rccm.201301-0144ED. No abstract available.

PMID:
23504360
32.

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS.

Sci Signal. 2013 Feb 5;6(261):ra8. doi: 10.1126/scisignal.2003638.

33.

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

Campos ML, Sánchez-Arévalo Lobo VJ, Rodolosse A, Gottardi CJ, Mafficini A, Beghelli S, Scardoni M, Bassi C, Scarpa A, Real FX.

Biochem J. 2013 May 1;451(3):395-405. doi: 10.1042/BJ20120873. Erratum in: Biochem J. 2013 Jul 1;453(1):154.

PMID:
23339455
34.

Signaling from the adherens junction.

McEwen AE, Escobar DE, Gottardi CJ.

Subcell Biochem. 2012;60:171-96. doi: 10.1007/978-94-007-4186-7_8. Review.

35.

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.

Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J.

Arthritis Rheum. 2012 Aug;64(8):2734-45. doi: 10.1002/art.34424.

36.

Tissue-specific knockout/knockdown of type 2 TGF-β receptor and protection against bleomycin injury/fibrosis.

Jain M, Lam A, Gottardi CJ.

Am J Respir Crit Care Med. 2011 Oct 15;184(8):983; author reply 983-4. No abstract available.

PMID:
22003151
37.

β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target.

Lam AP, Gottardi CJ.

Curr Opin Rheumatol. 2011 Nov;23(6):562-7. doi: 10.1097/BOR.0b013e32834b3309. Review.

38.

UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes.

Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, Fischer SM, Pelling JC.

Mol Carcinog. 2012 Sep;51(9):734-45. doi: 10.1002/mc.20840. Epub 2011 Aug 18.

39.

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis.

Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G.

FASEB J. 2011 Sep;25(9):3032-44. doi: 10.1096/fj.10-177824. Epub 2011 Jun 3.

40.

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin.

Mirkovic I, Gault WJ, Rahnama M, Jenny A, Gaengel K, Bessette D, Gottardi CJ, Verheyen EM, Mlodzik M.

Nat Struct Mol Biol. 2011 Jun;18(6):665-72. doi: 10.1038/nsmb.2049. Epub 2011 May 8.

41.

Integrin regulation of beta-catenin signaling in ovarian carcinoma.

Burkhalter RJ, Symowicz J, Hudson LG, Gottardi CJ, Stack MS.

J Biol Chem. 2011 Jul 1;286(26):23467-75. doi: 10.1074/jbc.M110.199539. Epub 2011 Apr 25.

42.

Regenerative pathways and emphysema: a new paradigm?

Lam AP, Gottardi CJ, Tuder R.

Am J Respir Crit Care Med. 2011 Mar 15;183(6):688-90. doi: 10.1164/rccm.201011-1772ED. No abstract available.

PMID:
21471062
43.

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.

Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):915-22. doi: 10.1165/rcmb.2010-0113OC. Epub 2011 Mar 31.

44.

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J.

Arthritis Rheum. 2011 Jun;63(6):1707-17. doi: 10.1002/art.30312.

45.

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I.

J Biol Chem. 2010 Nov 5;285(45):34932-8. doi: 10.1074/jbc.M110.119651. Epub 2010 Aug 26.

46.

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.

Maher MT, Mo R, Flozak AS, Peled ON, Gottardi CJ.

PLoS One. 2010 Apr 16;5(4):e10184. doi: 10.1371/journal.pone.0010184.

47.

Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.

Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GR, Gottardi CJ.

J Biol Chem. 2010 Jan 29;285(5):3157-67. doi: 10.1074/jbc.M109.070326. Epub 2009 Nov 20.

48.

The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.

Mo R, Chew TL, Maher MT, Bellipanni G, Weinberg ES, Gottardi CJ.

J Biol Chem. 2009 Oct 9;284(41):28222-31. doi: 10.1074/jbc.M109.045039. Epub 2009 Aug 25.

49.

Regulation of Wnt/beta-catenin signaling by protein kinases.

Verheyen EM, Gottardi CJ.

Dev Dyn. 2010 Jan;239(1):34-44. doi: 10.1002/dvdy.22019. Review.

50.

Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion.

Maher MT, Flozak AS, Stocker AM, Chenn A, Gottardi CJ.

J Cell Biol. 2009 Jul 27;186(2):219-28. doi: 10.1083/jcb.200811108. Epub 2009 Jul 20.

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