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Items: 39


Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.


Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells.

Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW, Chiarle R.

Nature. 2017 Feb 23;542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15.


Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW.

Nature. 2015 Sep 3;525(7567):134-139. doi: 10.1038/nature14970. Epub 2015 Aug 26.


A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW.

Cancer Immunol Res. 2015 Jun;3(6):641-9. doi: 10.1158/2326-6066.CIR-15-0058. Epub 2015 May 1.


Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.

Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S.

Blood. 2015 Apr 23;125(17):2665-8. doi: 10.1182/blood-2015-01-622621. Epub 2015 Feb 26.


Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10269-74. doi: 10.1073/pnas.1410112111. Epub 2014 Jun 30.


Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.

Tepsuporn S, Hu J, Gostissa M, Alt FW.

Cancer Immunol Res. 2014 Sep;2(9):857-66. doi: 10.1158/2326-6066.CIR-14-0090. Epub 2014 Jun 9.


IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.

Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2644-9. doi: 10.1073/pnas.1324176111. Epub 2014 Feb 3.


Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC 3rd, Bassing CH, Alt FW.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2934-9. doi: 10.1073/pnas.1222570110. Epub 2013 Feb 4.


Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2473-8. doi: 10.1073/pnas.1121470109. Epub 2012 Jan 30. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5731.


Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW.

Cell. 2011 Sep 30;147(1):107-19. doi: 10.1016/j.cell.2011.07.049. Erratum in: Cell. 2011 Dec 23;147(7):1640.


Mechanisms that promote and suppress chromosomal translocations in lymphocytes.

Gostissa M, Alt FW, Chiarle R.

Annu Rev Immunol. 2011;29:319-50. doi: 10.1146/annurev-immunol-031210-101329. Review.


The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.

Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW.

Adv Immunol. 2010;106:93-133. doi: 10.1016/S0065-2776(10)06004-9. Review.


Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.

Nature. 2009 Dec 10;462(7274):803-7. doi: 10.1038/nature08633.


Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.

Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G.

Stem Cells. 2010 Jan;28(1):64-74. doi: 10.1002/stem.255.


Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.


Chromosomal location targets different MYC family gene members for oncogenic translocations.

Gostissa M, Ranganath S, Bianco JM, Alt FW.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2265-70. doi: 10.1073/pnas.0812763106. Epub 2009 Jan 27.


Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.

Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT.

J Exp Med. 2008 Dec 22;205(13):3079-90. doi: 10.1084/jem.20082271. Epub 2008 Dec 8.


Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.

Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH.

Genes Dev. 2008 Jun 15;22(12):1662-76. doi: 10.1101/gad.1656808.


H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.


MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.

Mol Cell. 2006 Jan 20;21(2):187-200.


Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R.

Mol Cell Biol. 2005 May;25(9):3737-51.


DNA repair, genome stability, and aging.

Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.

Cell. 2005 Feb 25;120(4):497-512. Review.


The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.

Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, Brancolini C, Schneider C, Del Sal G.

J Biol Chem. 2004 Nov 12;279(46):48013-23. Epub 2004 Aug 31.


KeePin' the p53 family in good shape.

Mantovani F, Gostissa M, Collavin L, Del Sal G.

Cell Cycle. 2004 Jul;3(7):905-11. Epub 2004 Jul 2. Review.


Pin1 links the activities of c-Abl and p300 in regulating p73 function.

Mantovani F, Piazza S, Gostissa M, Strano S, Zacchi P, Mantovani R, Blandino G, Del Sal G.

Mol Cell. 2004 Jun 4;14(5):625-36.


Modification of the erythroid transcription factor GATA-1 by SUMO-1.

Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, Del Sal G.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8870-5. Epub 2004 Jun 1.


Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

Tullo A, Mastropasqua G, Bourdon JC, Centonze P, Gostissa M, Costanzo A, Levrero M, Del Sal G, Saccone C, Sbisà E.

Oncogene. 2003 Nov 27;22(54):8738-48.


Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V, Manfioletti G.

Mol Cell Biol. 2003 Dec;23(24):9104-16.


Regulation of p53 functions: let's meet at the nuclear bodies.

Gostissa M, Hofmann TG, Will H, Del Sal G.

Curr Opin Cell Biol. 2003 Jun;15(3):351-7. Review.


The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.

Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C, Del Sal G.

Nature. 2002 Oct 24;419(6909):853-7. Epub 2002 Oct 2.


Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S.

Nat Cell Biol. 2002 Jan;4(1):11-9.


Regulation of p53 activity in nuclear bodies by a specific PML isoform.

Fogal V, Gostissa M, Sandy P, Zacchi P, Sternsdorf T, Jensen K, Pandolfi PP, Will H, Schneider C, Del Sal G.

EMBO J. 2000 Nov 15;19(22):6185-95.


p53 is involved in the p120E4F-mediated growth arrest.

Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G.

Oncogene. 2000 Jan 13;19(2):188-99.


Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G.

EMBO J. 1999 Nov 15;18(22):6462-71.


Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids.

Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G.

Cytogenet Cell Genet. 1998;82(1-2):99-100. No abstract available.


The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.

Goruppi S, Yamane H, Marcandalli P, Garcia A, Clogston C, Gostissa M, Varnum B, Schneider C.

FEBS Lett. 1997 Sep 22;415(1):59-63.


Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6.

Marcandalli P, Gostissa M, Varnum B, Goruppi S, Schneider C.

FEBS Lett. 1997 Sep 22;415(1):56-8.


Assignment of the human GAS6 gene to chromosome 13q34 by fluorescence in situ hybridization.

Saccone S, Marcandalli P, Gostissa M, Schneider C, Della Valle G.

Genomics. 1995 Nov 1;30(1):129-31. No abstract available.


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