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Items: 1 to 50 of 82

1.

A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.

Tan K, Keegan P, Rogers M, Lu M, Gosset JR, Charest J, Bale SS.

Lab Chip. 2019 Apr 23;19(9):1556-1566. doi: 10.1039/c8lc01262h.

PMID:
30855604
2.

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

Sammons MF, Kharade SV, Filipski KJ, Boehm M, Smith AC, Shavnya A, Fernando DP, Dowling MS, Carpino PA, Castle NA, Zellmer SG, Antonio BM, Gosset JR, Carlo A, Denton JS.

ACS Med Chem Lett. 2018 Jan 19;9(2):125-130. doi: 10.1021/acsmedchemlett.7b00481. eCollection 2018 Feb 8.

3.

A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

Gosset JR, Beaumont K, Matsuura T, Winchester W, Attkins N, Glatt S, Lightbown I, Ulrich K, Roberts S, Harris J, Mesic E, van Steeg T, Hijdra D, van der Graaf PH.

Eur J Pharm Sci. 2017 Nov 15;109S:S161-S167. doi: 10.1016/j.ejps.2017.06.009. Epub 2017 Jun 7.

PMID:
28603038
4.

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.

Dong JQ, Gosset JR, Fahmi OA, Lin Z, Chabot JR, Terra SG, Le V, Chidsey K, Nouri P, Kim A, Buckbinder L, Kalgutkar AS.

Drug Metab Dispos. 2017 May;45(5):501-511. doi: 10.1124/dmd.116.074476. Epub 2017 Mar 2.

PMID:
28254951
5.

Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.

Futatsugi K, Huard K, Kung DW, Pettersen JC, Flynn DA, Gosset JR, Aspnes GE, Barnes RJ, Cabral S, Dowling MS, Fernando DP, Goosen TC, Gorczyca WP, Hepworth D, Herr M, Lavergne S, Li Q, Niosi M, Orr STM, Pardo ID, Perez SM, Purkal J, Schmahai TJ, Shirai N, Shoieb AM, Zhou J, Goodwin B.

Medchemcomm. 2016 Nov 22;8(4):771-779. doi: 10.1039/c6md00564k. eCollection 2017 Apr 1.

6.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

Huard K, Gosset JR, Montgomery JI, Gilbert A, Hayward MM, Magee TV, Cabral S, Uccello DP, Bahnck K, Brown J, Purkal J, Gorgoglione M, Lanba A, Futatsugi K, Herr M, Genung NE, Aspnes G, Polivkova J, Garcia-Irizarry CN, Li Q, Canterbury D, Niosi M, Vera NB, Li Z, Khunte B, Siderewicz J, Rolph T, Erion DM.

J Med Chem. 2016 Feb 11;59(3):1165-75. doi: 10.1021/acs.jmedchem.5b01752. Epub 2016 Jan 27.

PMID:
26734723
7.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).

Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM.

Sci Rep. 2015 Dec 1;5:17391. doi: 10.1038/srep17391.

8.

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).

Futatsugi K, Kung DW, Orr ST, Cabral S, Hepworth D, Aspnes G, Bader S, Bian J, Boehm M, Carpino PA, Coffey SB, Dowling MS, Herr M, Jiao W, Lavergne SY, Li Q, Clark RW, Erion DM, Kou K, Lee K, Pabst BA, Perez SM, Purkal J, Jorgensen CC, Goosen TC, Gosset JR, Niosi M, Pettersen JC, Pfefferkorn JA, Ahn K, Goodwin B.

J Med Chem. 2015 Sep 24;58(18):7173-85. doi: 10.1021/acs.jmedchem.5b01006.

PMID:
26349027
9.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

Huard K, Londregan AT, Tesz G, Bahnck KB, Magee TV, Hepworth D, Polivkova J, Coffey SB, Pabst BA, Gosset JR, Nigam A, Kou K, Sun H, Lee K, Herr M, Boehm M, Carpino PA, Goodwin B, Perreault C, Li Q, Jorgensen CC, Tkalcevic GT, Subashi TA, Ahn K.

J Med Chem. 2015 Sep 24;58(18):7164-72. doi: 10.1021/acs.jmedchem.5b01008. Epub 2015 Sep 8.

PMID:
26258602
10.

Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.

Winchester WJ, Gore K, Glatt S, Petit W, Gardiner JC, Conlon K, Postlethwaite M, Saintot PP, Roberts S, Gosset JR, Matsuura T, Andrews MD, Glossop PA, Palmer MJ, Clear N, Collins S, Beaumont K, Reynolds DS.

J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. doi: 10.1124/jpet.114.216010. Epub 2014 Aug 14.

PMID:
25125580
11.

Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.

Kalgutkar AS, Chen D, Varma MV, Feng B, Terra SG, Scialis RJ, Rotter CJ, Frederick KS, West MA, Goosen TC, Gosset JR, Walsky RL, Francone OL.

Xenobiotica. 2013 Nov;43(11):963-72. doi: 10.3109/00498254.2013.791004. Epub 2013 Apr 30.

PMID:
23631744
12.

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.

Barton HA, Lai Y, Goosen TC, Jones HM, El-Kattan AF, Gosset JR, Lin J, Varma MV.

Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):459-72. doi: 10.1517/17425255.2013.759210. Epub 2013 Jan 21. Review.

PMID:
23331046
13.

Application of PBPK modelling in drug discovery and development at Pfizer.

Jones HM, Dickins M, Youdim K, Gosset JR, Attkins NJ, Hay TL, Gurrell IK, Logan YR, Bungay PJ, Jones BC, Gardner IB.

Xenobiotica. 2012 Jan;42(1):94-106. doi: 10.3109/00498254.2011.627477. Epub 2011 Oct 30.

PMID:
22035569
14.

[To be born or not to be born. The medical profession and contraception].

Gosset JR.

Concours Med. 1965 Oct 2;87(40):5619-26. French. No abstract available.

PMID:
5852335
15.

[What is your diagnosis?].

Gosset JR.

Concours Med. 1965 Sep 25;87(39):5397-8. French. No abstract available.

PMID:
5849182
16.

Traffic accidents on the way to work.

Gosset JR.

World Med J. 1965 Sep-Oct;12(5):145. No abstract available.

PMID:
5173955
17.

[Some reflections on the clinical aspects of biliary lithiasis].

Gosset JR.

Concours Med. 1965 Jul 17;87(29):4707-9. French. No abstract available.

PMID:
5841620
18.

[Planning in the field of health].

Gosset JR.

Concours Med. 1965 Jun 5;87(23):3895-9. French. No abstract available.

PMID:
5843489
19.

PLANNING FOR HEALTH.

GOSSET JR.

World Med J. 1965 May-Jun;12:69 PASSIM. No abstract available.

PMID:
14314151
20.

THE BELGIAN MEDICAL DISPUTE IN RETROSPECT.

GOSSET JR.

World Med J. 1964 Sep;11:296-7. No abstract available.

PMID:
14183002
21.

COMMENTS ON THE POPULATION REPORT.

GOSSET JR, TAMESIS JV.

World Med J. 1964 Sep;11:295. No abstract available.

PMID:
14183001
22.

REPORT ON THE INCREASING WORLD POPULATION.

GOSSET JR.

World Med J. 1964 Sep;11:291-5. No abstract available.

PMID:
14183000
23.

MEDICAL DEMOGRAPHY AND MEDICAL ECONOMICS IN FINLAND.

GOSSET JR.

World Med J. 1964 May;11:183-4. No abstract available.

PMID:
14145204
24.

HEALTH PROBLEMS IN NORTH AFRICAN MUSLIMS LIVING IN FRANCE.

GOSSET JR.

World Med J. 1964 Mar;11:78. No abstract available.

PMID:
14130973
25.

[Methods of approach to the patient in gastroenterology. Observation plan and reflections on the examination].

GOSSET JR.

Concours Med. 1963 Jun 22;85:3973-5. French. No abstract available.

PMID:
13960699
26.

[Methods of approaching a patient in gastroenterology. Plan of observation and reflections on the interrogation of the patient].

GOSSET JR.

Concours Med. 1963 Jun 15;85:3813-23 contd. French. No abstract available.

PMID:
13963366
27.

The European Economic Community and the medical profession in 1962.

GOSSET JR.

World Med J. 1963 Mar;10:89-90. No abstract available.

PMID:
13949409
28.

[Medicine and economics].

GOSSET JR, CHASSERANT M.

World Med J. 1962 Jul;9:235-7. Spanish. No abstract available.

PMID:
13900667
29.

[Vomiting].

LABRAM C, GOSSET JR.

Concours Med. 1962 Jan 6;84:39-45. French. No abstract available.

PMID:
14461300
30.

[The emergency kit. Memory aid for some emergency situations].

GOSSET JR.

Concours Med. 1961 Sep 16;83:4473-84. French. No abstract available.

PMID:
13707378
31.

[Principles of public relations for doctors at the local level].

GOSSET JR.

World Med J. 1960 Nov;7:391-2. Spanish. No abstract available.

PMID:
13707377
32.

Dyspepsies et gastrites.

GOSSET JR.

Concours Med. 1957 Apr 20;79(16):1915-6; passim. French. No abstract available.

PMID:
13437619
33.

[The organization of medicine in Yugoslavia].

GOSSET JR.

Concours Med. 1957 Mar 2;79(9):1073-6. French. No abstract available.

PMID:
13427324
34.

[Three years of Permanent Medical Documentation].

BARBIZET J, GOSSET JR.

Concours Med. 1956 May 12;78(19):2193-4. French. No abstract available.

PMID:
13317442
35.

[The milk battle].

GOSSET JR, SAPIN-JALOUSTRE H.

Concours Med. 1955 Sep 17;77(38):3437-9. French. No abstract available.

PMID:
13261538
36.

[Duodenal dystonia].

GOSSET JR, VIVIEN P.

Concours Med. 1955 Mar 12;77(11):1047-9. French. No abstract available.

PMID:
14365125
37.

[Cholecystitis and pancreatitis caused by reflux; clinical and experimental study; role of dystonia of Oddi's sphincter and of the duodenal dyskinesia].

LAMBLING A, GUERRE J, BERNIER JJ, GOSSET JR.

Rev Int Hepatol. 1955;5(6):761-82; discussion, 860-1. French. No abstract available.

PMID:
13311105
38.

[Clinical aspects and evolution of cholelithiasis].

QUENNEVAT J, GOSSET JR.

Concours Med. 1955 Jan 1;77(1):27-34. French. No abstract available.

PMID:
13231460
39.

Gastrite et ulcère gastroduodénal.

GOSSET JR.

Concours Med. 1954 Nov 27;76(48):4413-5. French. No abstract available.

PMID:
13209967
40.

[Nutrition and work].

GOSSET JR.

Concours Med. 1954 Oct 16;76(42):3775-82. French. No abstract available.

PMID:
13209935
41.

[Gastric intubation].

LAMBLING A, BERNIER JJ, GOSSET JR.

Sem Hop. 1954 Oct 2;30(60):3370-2. French. No abstract available.

PMID:
13216251
42.

[Licorice in gastro-enterology].

GOSSET JR.

Concours Med. 1954 Jan 23;76(4):325-6. Undetermined Language. No abstract available.

PMID:
13141621
43.

[The medical year as seen through some learned societies].

GOSSET JR.

Concours Med. 1954 Jan 2;76(1):49-58. Undetermined Language. No abstract available.

PMID:
13127347
44.

[Adhesions].

GOSSET JR.

Concours Med. 1953 Nov 7;75(45):3769. Undetermined Language. No abstract available.

PMID:
13116615
45.

[Notes on the interpretation and clinical value of recorded duodenal intubation].

GOSSET JR.

Concours Med. 1953 Aug 1;75(31):2703-6. Undetermined Language. No abstract available.

PMID:
13082947
46.

[Biologic diagnosis of gastritis].

LAMBLING A, GOSSET JR, BERNIER JJ.

Arch Mal Appar Dig Mal Nutr. 1953 Jul-Aug;42(7-8):885-903. Undetermined Language. No abstract available.

PMID:
13114957
47.

[Regimen in constipation].

GOSSET JR.

Concours Med. 1953 May 16;75(20):1827-8. Undetermined Language. No abstract available.

PMID:
13067591
48.

[The discovery of man].

GOSSET JR.

Concours Med. 1953 Apr 4;75(14):1303-4. Undetermined Language. No abstract available.

PMID:
13067530
49.

[Diet in biliary dyspepsia and gallbladder disease].

GOSSET JR.

Concours Med. 1953 Apr 4;75(14):1273-4. Undetermined Language. No abstract available.

PMID:
13067523
50.

[Application of sleep therapy].

GOSSET JR.

Concours Med. 1953 Mar 28;75(13):1165-6. Undetermined Language. No abstract available.

PMID:
13059998

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