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Assessing the role of the acid-sensing ion channel asic4b in sodium uptake by larval zebrafish.

Zimmer AM, Dymowska AK, Kumai Y, Goss GG, Perry SF, Kwong RWM.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Jun 15. pii: S1095-6433(18)30097-7. doi: 10.1016/j.cbpa.2018.06.012. [Epub ahead of print]


Association of ERBB Mutations With Clinical Outcomes of Afatinib- or Erlotinib-Treated Patients With Lung Squamous Cell Carcinoma: Secondary Analysis of the LUX-Lung 8 Randomized Clinical Trial.

Goss GD, Felip E, Cobo M, Lu S, Syrigos K, Lee KH, Göker E, Georgoulias V, Li W, Guclu S, Isla D, Min YJ, Morabito A, Ardizzoni A, Gadgeel SM, Fülöp A, Bühnemann C, Gibson N, Krämer N, Solca F, Cseh A, Ehrnrooth E, Soria JC.

JAMA Oncol. 2018 Jun 14. doi: 10.1001/jamaoncol.2018.0775. [Epub ahead of print]


Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads.

Tasker TL, Burgos WD, Piotrowski P, Castillo-Meza L, Blewett TA, Ganow KB, Stallworth A, Delompré PLM, Goss GG, Fowler LB, Vanden Heuvel JP, Dorman F, Warner NR.

Environ Sci Technol. 2018 Jun 19;52(12):7081-7091. doi: 10.1021/acs.est.8b00716. Epub 2018 May 30.


Canadian Cancer Trials Group (CCTG) IND211: A randomized trial of pelareorep (Reolysin) in patients with previously treated advanced or metastatic non-small cell lung cancer receiving standard salvage therapy.

Bradbury PA, Morris DG, Nicholas G, Tu D, Tehfe M, Goffin JR, Shepherd FA, Gregg RW, Rothenstein J, Lee C, Kuruvilla S, Keith BD, Torri V, Blais N, Hao D, Korpanty GJ, Goss G, Melosky BL, Mates M, Leighl N, Ayoub JP, Sederias J, Feilotter H, Seymour L, Laurie SA.

Lung Cancer. 2018 Jun;120:142-148. doi: 10.1016/j.lungcan.2018.03.005. Epub 2018 Mar 9.


Physical immobility as a sensitive indicator of hydraulic fracturing fluid toxicity towards Daphnia magna.

Blewett TA, Delompré PLM, Glover CN, Goss GG.

Sci Total Environ. 2018 Sep 1;635:639-643. doi: 10.1016/j.scitotenv.2018.04.165. Epub 2018 Apr 24.


Update on International Cooperative Groups Studies in Thoracic Malignancies: The Emergence of Immunotherapy.

Shukla ND, Salahudeen AA, Taylor GA, Ramalingam SS, Vokes EE, Goss GD, Decker RH, Kelly K, Scagliotti GV, Mok TS, Wakelee HA.

Clin Lung Cancer. 2018 Mar 17. pii: S1525-7304(18)30046-9. doi: 10.1016/j.cllc.2018.03.004. [Epub ahead of print] Review.


Efficacy and safety results of depatuxizumab mafodotin (ABT-414) in patients with advanced solid tumors likely to overexpress epidermal growth factor receptor.

Goss GD, Vokes EE, Gordon MS, Gandhi L, Papadopoulos KP, Rasco DW, Fischer JS, Chu KL, Ames WW, Mittapalli RK, Lee HJ, Zeng J, Roberts-Rapp LA, Loberg LI, Ansell PJ, Reilly EB, Ocampo CJ, Holen KD, Tolcher AW.

Cancer. 2018 May 15;124(10):2174-2183. doi: 10.1002/cncr.31304. Epub 2018 Mar 13.


Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish ( Danio rerio).

He Y, Sun C, Zhang Y, Folkerts EJ, Martin JW, Goss GG.

Environ Sci Technol. 2018 Mar 20;52(6):3820-3830. doi: 10.1021/acs.est.7b06557. Epub 2018 Feb 8.


CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials.

Goss G, Tsai CM, Shepherd FA, Ahn MJ, Bazhenova L, Crinò L, de Marinis F, Felip E, Morabito A, Hodge R, Cantarini M, Johnson M, Mitsudomi T, Jänne PA, Yang JC.

Ann Oncol. 2018 Mar 1;29(3):687-693. doi: 10.1093/annonc/mdx820.


Dropping the base: recovery from extreme hypercarbia in the CO2 tolerant Pacific hagfish (Eptatretus stoutii).

Clifford AM, Weinrauch AM, Goss GG.

J Comp Physiol B. 2018 May;188(3):421-435. doi: 10.1007/s00360-017-1141-2. Epub 2017 Dec 30.


A novel pathway of nutrient absorption in crustaceans: branchial amino acid uptake in the green shore crab (Carcinus maenas).

Blewett TA, Goss GG.

Proc Biol Sci. 2017 Dec 6;284(1868). pii: 20171298. doi: 10.1098/rspb.2017.1298.


Functional redundancy of glucose acquisition mechanisms in the hindgut of Pacific hagfish (Eptatretus stoutii).

Weinrauch AM, Clifford AM, Goss GG.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Feb;216:8-13. doi: 10.1016/j.cbpa.2017.10.034. Epub 2017 Nov 7.


Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium.

Kurtenbach S, Ding W, Goss GM, Hare JM, Goldstein BJ, Shehadeh LA.

PLoS One. 2017 Nov 6;12(11):e0187576. doi: 10.1371/journal.pone.0187576. eCollection 2017.


Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study.

Tammemagi MC, Schmidt H, Martel S, McWilliams A, Goffin JR, Johnston MR, Nicholas G, Tremblay A, Bhatia R, Liu G, Soghrati K, Yasufuku K, Hwang DM, Laberge F, Gingras M, Pasian S, Couture C, Mayo JR, Nasute Fauerbach PV, Atkar-Khattra S, Peacock SJ, Cressman S, Ionescu D, English JC, Finley RJ, Yee J, Puksa S, Stewart L, Tsai S, Haider E, Boylan C, Cutz JC, Manos D, Xu Z, Goss GD, Seely JM, Amjadi K, Sekhon HS, Burrowes P, MacEachern P, Urbanski S, Sin DD, Tan WC, Leighl NB, Shepherd FA, Evans WK, Tsao MS, Lam S; PanCan Study Team.

Lancet Oncol. 2017 Nov;18(11):1523-1531. doi: 10.1016/S1470-2045(17)30597-1. Epub 2017 Oct 18.


A phase I study of foretinib plus erlotinib in patients with previously treated advanced non-small cell lung cancer: Canadian cancer trials group IND.196.

Leighl NB, Tsao MS, Liu G, Tu D, Ho C, Shepherd FA, Murray N, Goffin JR, Nicholas G, Sakashita S, Chen Z, Kim L, Powers J, Seymour L, Goss G, Bradbury PA.

Oncotarget. 2017 Jun 28;8(41):69651-69662. doi: 10.18632/oncotarget.18753. eCollection 2017 Sep 19.


Alterations to Juvenile Zebrafish (Danio rerio) Swim Performance after Acute Embryonic Exposure to Sub-lethal Exposures of Hydraulic Fracturing Flowback and Produced Water.

Folkerts EJ, Blewett TA, He Y, Goss GG.

Aquat Toxicol. 2017 Dec;193:50-59. doi: 10.1016/j.aquatox.2017.10.003. Epub 2017 Oct 7.


Cadmium bioaccumulates after acute exposure but has no effect on locomotion or shelter-seeking behaviour in the invasive green shore crab (Carcinus maenas).

Blewett TA, Newton D, Flynn SL, Alessi DS, Goss GG, Hamilton TJ.

Conserv Physiol. 2017 Sep 28;5(1):cox057. doi: 10.1093/conphys/cox057. eCollection 2017.


Cardio-respirometry disruption in zebrafish (Danio rerio) embryos exposed to hydraulic fracturing flowback and produced water.

Folkerts EJ, Blewett TA, He Y, Goss GG.

Environ Pollut. 2017 Dec;231(Pt 2):1477-1487. doi: 10.1016/j.envpol.2017.09.011. Epub 2017 Sep 18.


Cellular uptake and intracellular localization of poly (acrylic acid) nanoparticles in a rainbow trout (Oncorhynchus mykiss) gill epithelial cell line, RTgill-W1.

Felix LC, Ortega VA, Goss GG.

Aquat Toxicol. 2017 Nov;192:58-68. doi: 10.1016/j.aquatox.2017.09.008. Epub 2017 Sep 7.


Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy.

Felip E, Hirsh V, Popat S, Cobo M, Fülöp A, Dayen C, Trigo JM, Gregg R, Waller CF, Soria JC, Goss GD, Gordon J, Wang B, Palmer M, Ehrnrooth E, Gadgeel SM.

Clin Lung Cancer. 2018 Jan;19(1):74-83.e11. doi: 10.1016/j.cllc.2017.06.002. Epub 2017 Jun 23.


Post-prandial physiology and intestinal morphology of the Pacific hagfish (Eptatretus stoutii).

Weinrauch AM, Clifford AM, Goss GG.

J Comp Physiol B. 2018 Jan;188(1):101-112. doi: 10.1007/s00360-017-1118-1. Epub 2017 Jul 18.


Ammonia-independent sodium uptake mediated by Na+ channels and NHEs in the freshwater ribbon leech Nephelopsis obscura.

Quijada-Rodriguez AR, Schultz AG, Wilson JM, He Y, Allen GJP, Goss GG, Weihrauch D.

J Exp Biol. 2017 Sep 15;220(Pt 18):3270-3279. doi: 10.1242/jeb.159459. Epub 2017 Jul 6.


Physiological and morphological investigation of Arctic grayling (Thymallus arcticus) gill filaments with high salinity exposure and recovery.

Blair SD, Matheson D, Goss GG.

Conserv Physiol. 2017 Jun 28;5(1):cox040. doi: 10.1093/conphys/cox040. eCollection 2017.


The Impact of Baseline Edmonton Symptom Assessment Scale Scores on Treatment and Survival in Patients With Advanced Non-small-cell Lung Cancer.

McGee SF, Zhang T, Jonker H, Laurie SA, Goss G, Nicholas G, Albaimani K, Wheatley-Price P.

Clin Lung Cancer. 2018 Jan;19(1):e91-e99. doi: 10.1016/j.cllc.2017.05.018. Epub 2017 Jun 8.


Evaluation of the VeriStrat® serum protein test in patients with advanced squamous cell carcinoma of the lung treated with second-line afatinib or erlotinib in the phase III LUX-Lung 8 study.

Gadgeel S, Goss G, Soria JC, Felip E, Georgoulias V, Lu S, Cobo M, Syrigos K, Lee KH, Göker E, Guclu SZ, Isla D, Morabito A, Dupuis N, Bühnemann C, Krämer N, Solca F, Ehrnrooth E, Ardizzoni A.

Lung Cancer. 2017 Jul;109:101-108. doi: 10.1016/j.lungcan.2017.05.010. Epub 2017 May 11.


Flexible ammonia handling strategies using both cutaneous and branchial epithelia in the highly ammonia-tolerant Pacific hagfish.

Clifford AM, Weinrauch AM, Edwards SL, Wilkie MP, Goss GG.

Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1;313(2):R78-R90. doi: 10.1152/ajpregu.00351.2016. Epub 2017 May 17.


The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.

Cressman S, Peacock SJ, Tammemägi MC, Evans WK, Leighl NB, Goffin JR, Tremblay A, Liu G, Manos D, MacEachern P, Bhatia R, Puksa S, Nicholas G, McWilliams A, Mayo JR, Yee J, English JC, Pataky R, McPherson E, Atkar-Khattra S, Johnston MR, Schmidt H, Shepherd FA, Soghrati K, Amjadi K, Burrowes P, Couture C, Sekhon HS, Yasufuku K, Goss G, Ionescu DN, Hwang DM, Martel S, Sin DD, Tan WC, Urbanski S, Xu Z, Tsao MS, Lam S.

J Thorac Oncol. 2017 Aug;12(8):1210-1222. doi: 10.1016/j.jtho.2017.04.021. Epub 2017 May 10.


Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non-Small Cell Lung Cancer.

Jenkins S, Yang JC, Ramalingam SS, Yu K, Patel S, Weston S, Hodge R, Cantarini M, Jänne PA, Mitsudomi T, Goss GD.

J Thorac Oncol. 2017 Jul;12(7):1061-1070. doi: 10.1016/j.jtho.2017.04.003. Epub 2017 Apr 17.


Drinking and water permeability in the Pacific hagfish, Eptatretus stoutii.

Glover CN, Wood CM, Goss GG.

J Comp Physiol B. 2017 Dec;187(8):1127-1135. doi: 10.1007/s00360-017-1097-2. Epub 2017 Apr 11.


Vulvar Squamous Cell Carcinoma (VSCC) as Two Diseases: HPV Status Identifies Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3.

Weberpals JI, Lo B, Duciaume MM, Spaans JN, Clancy AA, Dimitroulakos J, Goss GD, Sekhon HS.

Clin Cancer Res. 2017 Aug 1;23(15):4501-4510. doi: 10.1158/1078-0432.CCR-16-3230. Epub 2017 Apr 4.


Chemical and toxicological characterizations of hydraulic fracturing flowback and produced water.

He Y, Flynn SL, Folkerts EJ, Zhang Y, Ruan D, Alessi DS, Martin JW, Goss GG.

Water Res. 2017 May 1;114:78-87. doi: 10.1016/j.watres.2017.02.027. Epub 2017 Feb 14.


Sublethal and Reproductive Effects of Acute and Chronic Exposure to Flowback and Produced Water from Hydraulic Fracturing on the Water Flea Daphnia magna.

Blewett TA, Delompré PL, He Y, Folkerts EJ, Flynn SL, Alessi DS, Goss GG.

Environ Sci Technol. 2017 Mar 7;51(5):3032-3039. doi: 10.1021/acs.est.6b05179. Epub 2017 Feb 13.


Regulation of plasma glucose and sulfate excretion in Pacific hagfish, Eptatretus stoutii is not mediated by 11-deoxycortisol.

Clifford AM, Bury NR, Schultz AG, Ede JD, Goss BL, Goss GG.

Gen Comp Endocrinol. 2017 Jun 1;247:107-115. doi: 10.1016/j.ygcen.2017.01.022. Epub 2017 Jan 23.


Chemotherapy in recurrent advanced non-small-cell lung cancer after adjuvant chemotherapy.

Valdes M, Nicholas G, Goss GD, Wheatley-Price P.

Curr Oncol. 2016 Dec;23(6):386-390. doi: 10.3747/co.23.3191. Epub 2016 Dec 21.


Effects on Biotransformation, Oxidative Stress, and Endocrine Disruption in Rainbow Trout (Oncorhynchus mykiss) Exposed to Hydraulic Fracturing Flowback and Produced Water.

He Y, Folkerts EJ, Zhang Y, Martin JW, Alessi DS, Goss GG.

Environ Sci Technol. 2017 Jan 17;51(2):940-947. doi: 10.1021/acs.est.6b04695. Epub 2016 Dec 27.


Peptide-based fluorescence biosensors for detection/measurement of nanoparticles.

Akinloye O, Krishnamurthy R, Wishart D, Goss GG.

Anal Bioanal Chem. 2017 Feb;409(4):903-915. doi: 10.1007/s00216-016-0042-7. Epub 2016 Nov 30.


BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial.

Liu G, Cuffe S, Liang S, Azad AK, Cheng L, Brhane Y, Qiu X, Cescon DW, Bruce J, Chen Z, Cheng D, Patel D, Tse BC, Laurie SA, Goss G, Leighl NB, Hung R, Bradbury PA, Seymour L, Shepherd FA, Tsao MS, Chen BE, Xu W, Reisman DN.

Clin Cancer Res. 2017 May 15;23(10):2460-2470. doi: 10.1158/1078-0432.CCR-16-1640. Epub 2016 Nov 8.


Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.

Goldstein BJ, Goss GM, Choi R, Saur D, Seidler B, Hare JM, Chaudhari N.

Development. 2016 Dec 1;143(23):4394-4404. Epub 2016 Oct 27.


A Phase II Study of PF-03446962 in Patients with Advanced Malignant Pleural Mesothelioma. CCTG Trial IND.207.

Wheatley-Price P, Chu Q, Bonomi M, Seely J, Gupta A, Goss G, Hilton J, Feld R, Lee CW, Goffin JR, Maksymiuk A, Murray N, Hagerman L, Bradbury PA.

J Thorac Oncol. 2016 Nov;11(11):2018-2021. doi: 10.1016/j.jtho.2016.06.024. Epub 2016 Jul 20.


Patients' and clinicians' preferences for adjuvant chemotherapy in endometrial cancer: an ANZGOG substudy of the PORTEC-3 intergroup randomised trial.

ANZGOG and PORTEC Group, Blinman P, Mileshkin L, Khaw P, Goss G, Johnson C, Capp A, Brooks S, Wain G, Kolodziej I, Veillard AS, O'Connell R, Creutzberg CL, Stockler MR.

Br J Cancer. 2016 Nov 8;115(10):1179-1185. doi: 10.1038/bjc.2016.323. Epub 2016 Oct 20.


Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study.

Goss G, Tsai CM, Shepherd FA, Bazhenova L, Lee JS, Chang GC, Crino L, Satouchi M, Chu Q, Hida T, Han JY, Juan O, Dunphy F, Nishio M, Kang JH, Majem M, Mann H, Cantarini M, Ghiorghiu S, Mitsudomi T.

Lancet Oncol. 2016 Dec;17(12):1643-1652. doi: 10.1016/S1470-2045(16)30508-3. Epub 2016 Oct 14.


Overview of Thoracic Oncology Trials in Cooperative Groups Around the Globe.

Salahudeen AA, Patel MI, Baas P, Curran WJ, Bradley JD, Gandara DR, Goss GD, Mok TS, Ramalingam SS, Vokes EE, Malik SM, Wakelee HA.

Clin Lung Cancer. 2017 Jan;18(1):5-12. doi: 10.1016/j.cllc.2016.06.007. Epub 2016 Jun 27. Review.


It's all in the gills: evaluation of O2 uptake in Pacific hagfish refutes a major respiratory role for the skin.

Clifford AM, Zimmer AM, Wood CM, Goss GG.

J Exp Biol. 2016 Sep 15;219(Pt 18):2814-2818. Epub 2016 Jul 8.


Characterization of developmental Na(+) uptake in rainbow trout larvae supports a significant role for Nhe3b.

Boyle D, Blair SD, Chamot D, Goss GG.

Comp Biochem Physiol A Mol Integr Physiol. 2016 Nov;201:30-36. doi: 10.1016/j.cbpa.2016.06.027. Epub 2016 Jun 25.


Palliative systemic therapy for advanced non-small cell lung cancer: Investigating disparities between patients who are treated versus those who are not.

Brule SY, Al-Baimani K, Jonker H, Zhang T, Nicholas G, Goss G, Laurie SA, Wheatley-Price P.

Lung Cancer. 2016 Jul;97:15-21. doi: 10.1016/j.lungcan.2016.04.007. Epub 2016 Apr 14. Review.


Application of Engineered Si Nanoparticles in Light-Induced Advanced Oxidation Remediation of a Water-Borne Model Contaminant.

Iqbal M, Purkait TK, Goss GG, Bolton JR, Gamal El-Din M, Veinot JG.

ACS Nano. 2016 May 24;10(5):5405-12. doi: 10.1021/acsnano.6b01619. Epub 2016 Apr 21.


A phase I study of high-dose rosuvastatin with standard dose erlotinib in patients with advanced solid malignancies.

Goss GD, Jonker DJ, Laurie SA, Weberpals JI, Oza AM, Spaans JN, la Porte C, Dimitroulakos J.

J Transl Med. 2016 Mar 31;14:83. doi: 10.1186/s12967-016-0836-6.


Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer.

Howe GA, Xiao B, Zhao H, Al-Zahrani KN, Hasim MS, Villeneuve J, Sekhon HS, Goss GD, Sabourin LA, Dimitroulakos J, Addison CL.

PLoS One. 2016 Mar 10;11(3):e0150567. doi: 10.1371/journal.pone.0150567. eCollection 2016.

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