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Small Airway Hyperresponsiveness in COPD: Relationship Between Structure and Function in Lung Slices.

Maarsingh H, Bidan CM, Brook BS, Zuidhof AB, Elzinga CRS, Smit M, Oldenburger A, Gosens R, Timens W, Meurs H.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 10. doi: 10.1152/ajplung.00325.2018. [Epub ahead of print]


Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting.

Heng WS, Gosens R, Kruyt FAE.

Biochem Pharmacol. 2019 Feb;160:121-133. doi: 10.1016/j.bcp.2018.12.010. Epub 2018 Dec 14. Review.


Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.

Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

EBioMedicine. 2018 Oct;36:461-474. doi: 10.1016/j.ebiom.2018.09.002. Epub 2018 Sep 17.


The mode of action of anticholinergics in asthma.

Gosens R, Gross N.

Eur Respir J. 2018 Oct 4;52(4). pii: 1701247. doi: 10.1183/13993003.01247-2017. Print 2018 Oct.


microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.


International research collaboration: The way forward.

Chotirmall SH, Dahlén SE, Carlsten C, Wong WSF, Chung KF, Gosens R, Knight DA; Singapore International Respiratory Consortium.

Respirology. 2018 Jul;23(7):654-655. doi: 10.1111/resp.13327. Epub 2018 May 17. No abstract available.


Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.

van den Berg MP, Meurs H, Gosens R.

Curr Opin Pharmacol. 2018 Jun;40:126-133. doi: 10.1016/j.coph.2018.04.010. Epub 2018 May 2. Review.


Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.

Zuo H, Han B, Poppinga WJ, Ringnalda L, Kistemaker LEM, Halayko AJ, Gosens R, Nikolaev VO, Schmidt M.

Br J Pharmacol. 2018 Jul;175(14):2988-3006. doi: 10.1111/bph.14347. Epub 2018 Jun 3.


PDE8: A Novel Target in Airway Smooth Muscle.

Zuo H, Schmidt M, Gosens R.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):426-427. doi: 10.1165/rcmb.2017-0427ED. No abstract available.


Research highlights from the 2017 ERS International Congress: airway diseases in focus.

Andersson C, Bonvini SJ, Horvath P, Marquez E, Satia I, Kirkham P, Schleich F, Idzko M, Gosens R, Lopez-Campos JL, Bossios A, Usmani O, Spanevello A, Adcock IM, Mathioudakis AG.

ERJ Open Res. 2018 Mar 13;4(1). pii: 00163-2017. doi: 10.1183/23120541.00163-2017. eCollection 2018 Jan. Review.


WNT receptor signalling in lung physiology and pathology.

Skronska-Wasek W, Gosens R, Königshoff M, Baarsma HA.

Pharmacol Ther. 2018 Jul;187:150-166. doi: 10.1016/j.pharmthera.2018.02.009. Epub 2018 Feb 17. Review.


Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches.

Reid AT, Veerati PC, Gosens R, Bartlett NW, Wark PA, Grainge CL, Stick SM, Kicic A, Moheimani F, Hansbro PM, Knight DA.

Pharmacol Ther. 2018 May;185:155-169. doi: 10.1016/j.pharmthera.2017.12.009. Epub 2017 Dec 27. Review.


β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.

Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R.

Front Immunol. 2017 Sep 8;8:1086. doi: 10.3389/fimmu.2017.01086. eCollection 2017.


Paving the Rho in cancer metastasis: Rho GTPases and beyond.

Jansen S, Gosens R, Wieland T, Schmidt M.

Pharmacol Ther. 2018 Mar;183:1-21. doi: 10.1016/j.pharmthera.2017.09.002. Epub 2017 Sep 11. Review.


Revisiting asthma therapeutics: focus on WNT signal transduction.

Koopmans T, Gosens R.

Drug Discov Today. 2018 Jan;23(1):49-62. doi: 10.1016/j.drudis.2017.09.001. Epub 2017 Sep 7. Review.


Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling.

Tania NP, Maarsingh H, T Bos IS, Mattiotti A, Prakash S, Timens W, Gunst QD, Jimenez-Borreguero LJ, Schmidt M, van den Hoff MJB, Gosens R.

Pulm Circ. 2017 Mar 15;7(1):219-231. doi: 10.1177/2045893217702340. eCollection 2017 Mar.


Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

Gosens R, Giangreco A, Sahai E, Chambers RC.

Eur Respir Rev. 2017 Jun 28;26(144). pii: 170060. doi: 10.1183/16000617.0060-2017. Print 2017 Jun 30. No abstract available.


The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices.

Kistemaker LEM, Oenema TA, Baarsma HA, Bos IST, Schmidt M, Facchinetti F, Civelli M, Villetti G, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L507-L515. doi: 10.1152/ajplung.00069.2017. Epub 2017 Jun 8.


Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Song J, Heijink IH, Kistemaker LEM, Reinders-Luinge M, Kooistra W, Noordhoek JA, Gosens R, Brandsma CA, Timens W, Hiemstra PS, Rots MG, Hylkema MN.

Clin Epigenetics. 2017 Apr 24;9:42. doi: 10.1186/s13148-017-0341-7. eCollection 2017.


HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice.

Leus NG, van den Bosch T, van der Wouden PE, Krist K, Ourailidou ME, Eleftheriadis N, Kistemaker LE, Bos S, Gjaltema RA, Mekonnen SA, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.

Sci Rep. 2017 Mar 27;7:45047. doi: 10.1038/srep45047.


Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS.

Front Physiol. 2017 Feb 28;8:117. doi: 10.3389/fphys.2017.00117. eCollection 2017.


Suppression of Eosinophil Integrins Prevents Remodeling of Airway Smooth Muscle in Asthma.

Januskevicius A, Gosens R, Sakalauskas R, Vaitkiene S, Janulaityte I, Halayko AJ, Hoppenot D, Malakauskas K.

Front Physiol. 2017 Jan 9;7:680. doi: 10.3389/fphys.2016.00680. eCollection 2016.


Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model.

Van Dijk EM, Culha S, Menzen MH, Bidan CM, Gosens R.

Front Physiol. 2017 Jan 4;7:657. doi: 10.3389/fphys.2016.00657. eCollection 2016.


An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling.

Prakash YS, Halayko AJ, Gosens R, Panettieri RA Jr, Camoretti-Mercado B, Penn RB; ATS Assembly on Respiratory Structure and Function.

Am J Respir Crit Care Med. 2017 Jan 15;195(2):e4-e19. doi: 10.1164/rccm.201611-2248ST.


WNT-5A regulates TGF-β-related activities in liver fibrosis.

Beljaars L, Daliri S, Dijkhuizen C, Poelstra K, Gosens R.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G219-G227. doi: 10.1152/ajpgi.00160.2016. Epub 2017 Jan 5.


Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.

Koopmans T, Crutzen S, Menzen MH, Halayko AJ, Hackett TL, Knight DA, Gosens R.

Br J Pharmacol. 2016 Dec;173(23):3327-3341. doi: 10.1111/bph.13620. Epub 2016 Oct 25.


Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS.

Front Physiol. 2016 Jul 21;7:309. doi: 10.3389/fphys.2016.00309. eCollection 2016. Erratum in: Front Physiol. 2017 Feb 28;8:117.


Consequences of conformational flexibility in hydrogen-bond-driven self-assembly processes.

Berrocal JA, Di Meo F, García-Iglesias M, Gosens RP, Meijer EW, Linares M, Palmans AR.

Chem Commun (Camb). 2016 Sep 18;52(72):10870-3. doi: 10.1039/c6cc05593a. Epub 2016 Aug 15.


Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.

Koopmans T, Kumawat K, Halayko AJ, Gosens R.

Sci Rep. 2016 Jul 29;6:30676. doi: 10.1038/srep30676.


Cooperative signaling by TGF-β1 and WNT-11 drives sm-α-actin expression in smooth muscle via Rho kinase-actin-MRTF-A signaling.

Kumawat K, Koopmans T, Menzen MH, Prins A, Smit M, Halayko AJ, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L529-37. doi: 10.1152/ajplung.00387.2015. Epub 2016 Jul 15.


Author response to letter to editor: Hyperinsulinemia adversely affects lung structure and function.

Singh S, Bodas M, Bhatraju NK, Pattnaik B, Gheware A, Parameswaran PK, Thompson M, Freeman M, Mabalirajan U, Gosens R, Ghosh B, Pabelick C, Linneberg A, Prakash YS, Agrawal A.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L183-4. doi: 10.1152/ajplung.00227.2016. No abstract available.


Antimuscarinic Bronchodilator Response Retained after Bronchoscopic Vagal Denervation in Chronic Obstructive Pulmonary Disease Patients.

Koegelenberg CF, Theron J, Slebos DJ, Klooster K, Mayse M, Gosens R.

Respiration. 2016;92(1):58-60. doi: 10.1159/000447641. Epub 2016 Jun 30. No abstract available.


Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition.

Jansen SR, Poppinga WJ, de Jager W, Lezoualc'h F, Cheng X, Wieland T, Yarwood SJ, Gosens R, Schmidt M.

Oncotarget. 2016 Jul 19;7(29):46354-46370. doi: 10.18632/oncotarget.10128.


Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation by increased extracellular matrix proteins production in asthma.

Januskevicius A, Vaitkiene S, Gosens R, Janulaityte I, Hoppenot D, Sakalauskas R, Malakauskas K.

BMC Pulm Med. 2016 Jun 13;16(1):94. doi: 10.1186/s12890-016-0254-9.


Noncanonical WNT-5B signaling induces inflammatory responses in human lung fibroblasts.

van Dijk EM, Menzen MH, Spanjer AI, Middag LD, Brandsma CA, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1166-76. doi: 10.1152/ajplung.00226.2015. Epub 2016 Apr 1.


HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

Leus NG, van der Wouden PE, van den Bosch T, Hooghiemstra WT, Ourailidou ME, Kistemaker LE, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.

Biochem Pharmacol. 2016 May 15;108:58-74. doi: 10.1016/j.bcp.2016.03.010. Epub 2016 Mar 16.


Hyperinsulinemia adversely affects lung structure and function.

Singh S, Bodas M, Bhatraju NK, Pattnaik B, Gheware A, Parameswaran PK, Thompson M, Freeman M, Mabalirajan U, Gosens R, Ghosh B, Pabelick C, Linneberg A, Prakash YS, Agrawal A.

Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L837-45. doi: 10.1152/ajplung.00091.2015. Epub 2016 Feb 26.


TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.

Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M.

FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5.


Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma.

Kistemaker LE, Bos IS, Menzen MH, Maarsingh H, Meurs H, Gosens R.

Respir Res. 2016 Feb 4;17:13. doi: 10.1186/s12931-016-0327-6.


A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Spanjer AI, Menzen MH, Dijkstra AE, van den Berge M, Boezen HM, Nickle DC, Sin DD, Bossé Y, Brandsma CA, Timens W, Postma DS, Meurs H, Heijink IH, Gosens R.

Thorax. 2016 Apr;71(4):312-22. doi: 10.1136/thoraxjnl-2015-206958. Epub 2016 Jan 21.


Airway and Extracellular Matrix Mechanics in COPD.

Bidan CM, Veldsink AC, Meurs H, Gosens R.

Front Physiol. 2015 Dec 2;6:346. doi: 10.3389/fphys.2015.00346. eCollection 2015. Review.


Exposing Differences in Monomer Exchange Rates of Multicomponent Supramolecular Polymers in Water.

Baker MB, Gosens RP, Albertazzi L, Matsumoto NM, Palmans AR, Meijer EW.

Chembiochem. 2016 Feb 2;17(3):207-13. doi: 10.1002/cbic.201500606. Epub 2015 Dec 23.


WNT-5A: signaling and functions in health and disease.

Kumawat K, Gosens R.

Cell Mol Life Sci. 2016 Feb;73(3):567-87. doi: 10.1007/s00018-015-2076-y. Epub 2015 Oct 29. Review.


Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease.

Wagenaar GT, Hiemstra PS, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1037-40. doi: 10.1152/ajplung.00333.2015. Epub 2015 Oct 2.


Anti-inflammatory effects of targeted lung denervation in patients with COPD.

Kistemaker LE, Slebos DJ, Meurs H, Kerstjens HA, Gosens R.

Eur Respir J. 2015 Nov;46(5):1489-92. doi: 10.1183/13993003.00413-2015. Epub 2015 Sep 4. No abstract available.


Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.

Kistemaker LE, Hiemstra PS, Bos IS, Bouwman S, van den Berge M, Hylkema MN, Meurs H, Kerstjens HA, Gosens R.

Thorax. 2015 Jul;70(7):668-76. doi: 10.1136/thoraxjnl-2014-205731. Epub 2015 May 20.


Bronchoconstriction and airway biology: potential impact and therapeutic opportunities.

Gosens R, Grainge C.

Chest. 2015 Mar;147(3):798-803. doi: 10.1378/chest.14-1142. Review.


Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling.

Kistemaker LE, Gosens R.

Trends Pharmacol Sci. 2015 Mar;36(3):164-71. doi: 10.1016/ Epub 2014 Dec 13. Review.


Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.

Kistemaker LE, van Os RP, Dethmers-Ausema A, Bos IS, Hylkema MN, van den Berge M, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L96-103. doi: 10.1152/ajplung.00259.2014. Epub 2014 Nov 7.


Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.

Jansen SR, Holman R, Hedemann I, Frankes E, Elzinga CR, Timens W, Gosens R, de Bont ES, Schmidt M.

J Cell Mol Med. 2015 Jan;19(1):210-26. doi: 10.1111/jcmm.12418. Epub 2014 Sep 30.

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