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Items: 27


Mouse Models of Asthma.

Gorska MM.

Methods Mol Biol. 2018;1809:351-362. doi: 10.1007/978-1-4939-8570-8_23.


Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations.

Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R.

J Allergy Clin Immunol. 2018 Sep;142(3):793-803.e8. doi: 10.1016/j.jaci.2017.10.020. Epub 2017 Nov 10.


Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A.

Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM.

J Allergy Clin Immunol. 2018 Mar;141(3):1118-1122.e3. doi: 10.1016/j.jaci.2017.09.002. Epub 2017 Sep 21. No abstract available.


Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin.

Liu S, Verma M, Michalec L, Liu W, Sripada A, Rollins D, Good J, Ito Y, Chu H, Gorska MM, Martin RJ, Alam R.

J Allergy Clin Immunol. 2018 Jan;141(1):257-268.e6. doi: 10.1016/j.jaci.2017.03.032. Epub 2017 Apr 20.


Natural killer cells in asthma.

Gorska MM.

Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):50-54. doi: 10.1097/ACI.0000000000000327. Review.


Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma.

Liu W, Liu S, Verma M, Zafar I, Good JT, Rollins D, Groshong S, Gorska MM, Martin RJ, Alam R.

J Allergy Clin Immunol. 2017 May;139(5):1548-1558.e4. doi: 10.1016/j.jaci.2016.08.032. Epub 2016 Oct 1.


Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.

Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT Jr, Rollins DR, Gorentla B, Liu W, Gorska MM, Chu H, Martin RJ, Alam R.

J Allergy Clin Immunol. 2015 Jul;136(1):59-68.e14. doi: 10.1016/j.jaci.2014.11.037. Epub 2015 Jan 21.


Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.

Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, Martin RJ, Alam R.

J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7. doi: 10.1016/j.jaci.2014.05.038. Epub 2014 Jul 18.


A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust.

Manners S, Alam R, Schwartz DA, Gorska MM.

J Allergy Clin Immunol. 2014 Jul;134(1):63-72. doi: 10.1016/j.jaci.2013.10.047. Epub 2013 Dec 22.


Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.

Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R.

J Immunol. 2013 Jan 1;190(1):159-67. doi: 10.4049/jimmunol.1201657. Epub 2012 Dec 5.


Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.

Gorska MM, Alam R.

Curr Allergy Asthma Rep. 2012 Oct;12(5):396-401. doi: 10.1007/s11882-012-0281-4. Review.


ERK1 is important for Th2 differentiation and development of experimental asthma.

Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R.

FASEB J. 2012 May;26(5):1934-45. doi: 10.1096/fj.11-196477. Epub 2012 Jan 18.


A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.

Gorska MM, Alam R.

Blood. 2012 Feb 9;119(6):1399-406. doi: 10.1182/blood-2011-04-350686. Epub 2011 Dec 19. Erratum in: Blood. 2014 Jan 16;123(3):457.


Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.

Alam R, Gorska MM.

Clin Exp Allergy. 2011 Feb;41(2):149-59. doi: 10.1111/j.1365-2222.2010.03658.x. Epub 2010 Dec 1. Review.


IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma.

Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R.

J Immunol. 2010 Nov 15;185(10):5704-13. doi: 10.4049/jimmunol.1000690. Epub 2010 Oct 6.


Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.

Gorska MM, Goplen N, Liang Q, Alam R.

J Immunol. 2010 Apr 15;184(8):4488-96. doi: 10.4049/jimmunol.0903115. Epub 2010 Mar 10.


Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

Gorska MM, Liang Q, Karim Z, Alam R.

J Immunol. 2009 Aug 1;183(3):1675-84. doi: 10.4049/jimmunol.0900792. Epub 2009 Jul 10.


Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma.

Goplen N, Karim MZ, Liang Q, Gorska MM, Rozario S, Guo L, Alam R.

J Allergy Clin Immunol. 2009 Apr;123(4):925-32.e11. doi: 10.1016/j.jaci.2009.02.009.


A phosphosite screen identifies autocrine TGF-beta-driven activation of protein kinase R as a survival-limiting factor for eosinophils.

Goplen N, Gorska MM, Stafford SJ, Rozario S, Guo L, Liang Q, Alam R.

J Immunol. 2008 Mar 15;180(6):4256-64.


Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.

Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R.

J Immunol. 2007 Jul 1;179(1):682-90.


MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation.

Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R.

J Exp Med. 2007 Jul 9;204(7):1637-52. Epub 2007 Jun 25.


Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity.

Gorska-Ciebiada M, Ciebiada M, Gorska MM, Gorski P, Grzelewska-Rzymowska I.

Ann Allergy Asthma Immunol. 2006 Jul;97(1):66-72.


Differential regulation of interleukin 5-stimulated signaling pathways by dynamin.

Gorska MM, Cen O, Liang Q, Stafford SJ, Alam R.

J Biol Chem. 2006 May 19;281(20):14429-39. Epub 2006 Mar 23.


The signaling mechanism of eosinophil activation.

Gorska MM, Alam R.

Expert Rev Clin Immunol. 2005 Jul;1(2):247-56. doi: 10.1586/1744666X.1.2.247.


Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

Gorska MM, Stafford SJ, Cen O, Sur S, Alam R.

J Exp Med. 2004 Feb 2;199(3):369-79. Epub 2004 Jan 23.


Signaling molecules as therapeutic targets in allergic diseases.

Gorska MM, Alam R.

J Allergy Clin Immunol. 2003 Aug;112(2):241-50; quiz 251. Review.


Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.

Cen O, Gorska MM, Stafford SJ, Sur S, Alam R.

J Biol Chem. 2003 Mar 7;278(10):8837-45. Epub 2002 Dec 19.

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