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Items: 1 to 50 of 383

1.

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation.

Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM.

Cell Metab. 2019 Jul 17. pii: S1550-4131(19)30319-5. doi: 10.1016/j.cmet.2019.06.016. [Epub ahead of print]

PMID:
31327667
2.

Metabolic reprogramming in memory CD4 T cell responses of old adults.

Yanes RE, Zhang H, Shen Y, Weyand CM, Goronzy JJ.

Clin Immunol. 2019 Jul 4;207:58-67. doi: 10.1016/j.clim.2019.07.003. [Epub ahead of print]

PMID:
31279855
3.

[Utilization of individual out-of-pocket health services (IGeL) in persons with osteoarthritis in Germany : Results of a survey from the PROCLAIR study].

Jacobs H, Hoffmann F, Callhoff J, Postler A, Saam J, Zink A, Günther KP, Goronzy J.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Aug;62(8):1013-1019. doi: 10.1007/s00103-019-02986-y. German.

PMID:
31273415
4.

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.

Hu B, Li G, Ye Z, Gustafson CE, Tian L, Weyand CM, Goronzy JJ.

Aging Cell. 2019 Aug;18(4):e12957. doi: 10.1111/acel.12957. Epub 2019 Jul 1.

5.

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade.

Jadhav RR, Im SJ, Hu B, Hashimoto M, Li P, Lin JX, Leonard WJ, Greenleaf WJ, Ahmed R, Goronzy JJ.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14113-14118. doi: 10.1073/pnas.1903520116. Epub 2019 Jun 21.

6.

Mechanisms underlying T cell ageing.

Goronzy JJ, Weyand CM.

Nat Rev Immunol. 2019 Jun 11. doi: 10.1038/s41577-019-0180-1. [Epub ahead of print] Review.

PMID:
31186548
7.

[Management of complications following tumor endoprosthetic replacement].

Fritzsche H, Hofbauer C, Winkler D, Günther KP, Goronzy J, Lützner J, Kisel W, Schaser KD.

Orthopade. 2019 Jul;48(7):588-597. doi: 10.1007/s00132-019-03756-z. Review. German.

PMID:
31127332
8.

CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis.

Zhang H, Watanabe R, Berry GJ, Nadler SG, Goronzy JJ, Weyand CM.

J Am Coll Cardiol. 2019 Apr 16;73(14):1811-1823. doi: 10.1016/j.jacc.2019.01.049.

PMID:
30975299
9.

Cytokines, growth factors and proteases in medium and large vessel vasculitis.

Weyand CM, Watanabe R, Zhang H, Akiyama M, Berry GJ, Goronzy JJ.

Clin Immunol. 2019 Feb 14. pii: S1521-6616(19)30023-3. doi: 10.1016/j.clim.2019.02.007. [Epub ahead of print]

PMID:
30772599
10.

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation.

Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM.

Nat Immunol. 2019 Mar;20(3):313-325. doi: 10.1038/s41590-018-0296-7. Epub 2019 Feb 4.

11.

[Effects of serial mud baths on inflammatory rheumatic and degenerative diseases].

Dischereit G, Goronzy JE, Müller-Ladner U, Fetaj S, Lange U.

Z Rheumatol. 2019 Mar;78(2):143-154. doi: 10.1007/s00393-018-0582-7. German.

PMID:
30627845
12.

Prevalence and treatment of hip and knee osteoarthritis in people aged 60 years or older in Germany: an analysis based on health insurance claims data.

Postler A, Ramos AL, Goronzy J, Günther KP, Lange T, Schmitt J, Zink A, Hoffmann F.

Clin Interv Aging. 2018 Nov 14;13:2339-2349. doi: 10.2147/CIA.S174741. eCollection 2018.

13.

Functional pathways regulated by microRNA networks in CD8 T-cell aging.

Gustafson CE, Cavanagh MM, Jin J, Weyand CM, Goronzy JJ.

Aging Cell. 2019 Feb;18(1):e12879. doi: 10.1111/acel.12879. Epub 2018 Nov 28.

14.

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.

Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ.

Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074.

15.

Glucose metabolism controls disease-specific signatures of macrophage effector functions.

Watanabe R, Hilhorst M, Zhang H, Zeisbrich M, Berry GJ, Wallis BB, Harrison DG, Giacomini JC, Goronzy JJ, Weyand CM.

JCI Insight. 2018 Oct 18;3(20). pii: 123047. doi: 10.1172/jci.insight.123047.

16.

Prospective randomized controlled trial in the treatment of lateral epicondylitis with a new dynamic wrist orthosis.

Nowotny J, El-Zayat B, Goronzy J, Biewener A, Bausenhart F, Greiner S, Kasten P.

Eur J Med Res. 2018 Sep 15;23(1):43. doi: 10.1186/s40001-018-0342-9.

17.

T follicular helper cell development and functionality in immune ageing.

Gustafson CE, Weyand CM, Goronzy JJ.

Clin Sci (Lond). 2018 Sep 5;132(17):1925-1935. doi: 10.1042/CS20171157. Print 2018 Sep 14. Review.

PMID:
30185614
18.

[Prescription frequency of physical therapy and analgesics before total hip and knee arthroplasy : An epidemiological analysis of routine health care data from Germany].

Lange T, Luque Ramos A, Albrecht K, Günther KP, Jacobs H, Schmitt J, Hoffmann F, Goronzy J, Postler A.

Orthopade. 2018 Dec;47(12):1018-1026. doi: 10.1007/s00132-018-3629-1. German.

PMID:
30171290
19.

Is MRI an adequate replacement for CT scans in the three-dimensional assessment of acetabular morphology?

Goronzy J, Blum S, Hartmann A, Plodeck V, Franken L, Günther KP, Thielemann F.

Acta Radiol. 2019 Jun;60(6):726-734. doi: 10.1177/0284185118795331. Epub 2018 Aug 27.

PMID:
30149750
20.

A Mitochondrial Checkpoint in Autoimmune Disease.

Weyand CM, Goronzy JJ.

Cell Metab. 2018 Aug 7;28(2):185-186. doi: 10.1016/j.cmet.2018.07.014.

21.

Regulation of miR-181a expression in T cell aging.

Ye Z, Li G, Kim C, Hu B, Jadhav RR, Weyand CM, Goronzy JJ.

Nat Commun. 2018 Aug 3;9(1):3060. doi: 10.1038/s41467-018-05552-3.

22.

MMP (Matrix Metalloprotease)-9-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis.

Watanabe R, Maeda T, Zhang H, Berry GJ, Zeisbrich M, Brockett R, Greenstein AE, Tian L, Goronzy JJ, Weyand CM.

Circ Res. 2018 Aug 31;123(6):700-715. doi: 10.1161/CIRCRESAHA.118.313206.

PMID:
29970365
23.

Epigenetics of T cell aging.

Goronzy JJ, Hu B, Kim C, Jadhav RR, Weyand CM.

J Leukoc Biol. 2018 Oct;104(4):691-699. doi: 10.1002/JLB.1RI0418-160R. Epub 2018 Jun 27. Review.

PMID:
29947427
24.

Vaccination programs for older adults in an era of demographic change.

Doherty TM, Connolly MP, Del Giudice G, Flamaing J, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Maggi S, McElhaney JE, Nagai H, Schaffner W, Schmidt-Ott R, Walsh E, Di Pasquale A.

Eur Geriatr Med. 2018;9(3):289-300. doi: 10.1007/s41999-018-0040-8. Epub 2018 Mar 19. Review.

25.

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease.

Weyand CM, Shen Y, Goronzy JJ.

Free Radic Biol Med. 2018 Sep;125:36-43. doi: 10.1016/j.freeradbiomed.2018.03.004. Epub 2018 Mar 7. Review.

PMID:
29524605
26.

[Periacetabular osteotomy-what influence does age have on patient-relevant results? : A prospective 5‑year investigation].

Franken L, Thielemann F, Postler A, Blum S, Hartmann A, Günther KP, Goronzy J.

Orthopade. 2018 Mar;47(3):228-237. doi: 10.1007/s00132-017-3523-2. German.

PMID:
29435594
27.

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.

Zeisbrich M, Yanes RE, Zhang H, Watanabe R, Li Y, Brosig L, Hong J, Wallis BB, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM.

Ann Rheum Dis. 2018 Jul;77(7):1053-1062. doi: 10.1136/annrheumdis-2017-212647. Epub 2018 Feb 3.

28.

Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging.

Del Giudice G, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Mrkvan T, Stoddard JJ, Doherty TM.

NPJ Aging Mech Dis. 2017 Dec 21;4:1. doi: 10.1038/s41514-017-0020-0. eCollection 2018.

29.

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis.

Zhang H, Watanabe R, Berry GJ, Tian L, Goronzy JJ, Weyand CM.

Circulation. 2018 May 1;137(18):1934-1948. doi: 10.1161/CIRCULATIONAHA.117.030423. Epub 2017 Dec 18.

30.

Origin and differentiation of human memory CD8 T cells after vaccination.

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R.

Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13.

31.

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.

Li Y, Goronzy JJ, Weyand CM.

Exp Gerontol. 2018 May;105:118-127. doi: 10.1016/j.exger.2017.10.027. Epub 2017 Nov 8. Review.

32.

The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.

Weyand CM, Berry GJ, Goronzy JJ.

J Leukoc Biol. 2018 Mar;103(3):565-575. doi: 10.1189/jlb.3MA0717-283. Epub 2017 Dec 29. Review.

33.

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells.

Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM.

Nat Immunol. 2017 Sep;18(9):1025-1034. doi: 10.1038/ni.3808. Epub 2017 Jul 24.

34.

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.

Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaal3322. doi: 10.1126/scitranslmed.aal3322.

35.

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.

Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.

36.

Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.

Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM.

J Clin Invest. 2017 Jun 30;127(7):2725-2738. doi: 10.1172/JCI92167. Epub 2017 Jun 12.

37.

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis.

Weyand CM, Zeisbrich M, Goronzy JJ.

Curr Opin Immunol. 2017 Jun;46:112-120. doi: 10.1016/j.coi.2017.04.010. Epub 2017 May 21. Review.

38.

Epigenomics of human CD8 T cell differentiation and aging.

Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ.

Sci Immunol. 2017 Feb;2(8). pii: eaag0192. doi: 10.1126/sciimmunol.aag0192. Epub 2017 Feb 17.

39.

Immunometabolism in early and late stages of rheumatoid arthritis.

Weyand CM, Goronzy JJ.

Nat Rev Rheumatol. 2017 May;13(5):291-301. doi: 10.1038/nrrheum.2017.49. Epub 2017 Mar 31. Review.

PMID:
28360422
40.

Response to Comment on "Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination".

Goronzy J, Qi Q, Weyand C.

Sci Transl Med. 2017 Mar 22;9(382). pii: eaai7891. doi: 10.1126/scitranslmed.aai7891.

PMID:
28330866
41.

Successful and Maladaptive T Cell Aging.

Goronzy JJ, Weyand CM.

Immunity. 2017 Mar 21;46(3):364-378. doi: 10.1016/j.immuni.2017.03.010. Review.

42.

Immune checkpoint dysfunction in large and medium vessel vasculitis.

Watanabe R, Zhang H, Berry G, Goronzy JJ, Weyand CM.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1052-H1059. doi: 10.1152/ajpheart.00024.2017. Epub 2017 Mar 17. Review.

43.

Clinical and pathological evolution of giant cell arteritis: a prospective study of follow-up temporal artery biopsies in 40 treated patients.

Maleszewski JJ, Younge BR, Fritzlen JT, Hunder GG, Goronzy JJ, Warrington KJ, Weyand CM.

Mod Pathol. 2017 Jun;30(6):788-796. doi: 10.1038/modpathol.2017.10. Epub 2017 Mar 3.

44.

Adverse reaction to metal debris in a consecutive series of DUROM™ hip resurfacing: pseudotumour incidence and metal ion concentration.

Hartmann A, Kieback JD, Lützner J, Günther KP, Goronzy J.

Hip Int. 2017 Jul 25;27(4):343-348. doi: 10.5301/hipint.5000468. Epub 2017 Feb 8.

PMID:
28218371
45.

Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.

Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E970-E979. doi: 10.1073/pnas.1616848114. Epub 2017 Jan 23.

46.

Lymphocyte generation and population homeostasis throughout life.

Yanes RE, Gustafson CE, Weyand CM, Goronzy JJ.

Semin Hematol. 2017 Jan;54(1):33-38. doi: 10.1053/j.seminhematol.2016.10.003. Epub 2016 Oct 19. Review.

47.

Aging of the Immune System. Mechanisms and Therapeutic Targets.

Weyand CM, Goronzy JJ.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S422-S428. doi: 10.1513/AnnalsATS.201602-095AW. Review.

48.

The life cycle of a T cell after vaccination - where does immune ageing strike?

Kim C, Fang F, Weyand CM, Goronzy JJ.

Clin Exp Immunol. 2017 Jan;187(1):71-81. doi: 10.1111/cei.12829. Epub 2016 Aug 15. Review.

49.

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.

Qi Q, Cavanagh MM, Le Saux S, Wagar LE, Mackey S, Hu J, Maecker H, Swan GE, Davis MM, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005892. doi: 10.1371/journal.ppat.1005892. eCollection 2016 Oct.

50.

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM.

Immunity. 2016 Oct 18;45(4):903-916. doi: 10.1016/j.immuni.2016.09.013. Epub 2016 Oct 11.

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