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Items: 48

1.

Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes.

Rudman N, Gornik O, Lauc G.

FEBS Lett. 2019 Jul;593(13):1598-1615. doi: 10.1002/1873-3468.13495. Epub 2019 Jun 28. Review.

PMID:
31215021
2.

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease.

Pavić T, Dilber D, Kifer D, Selak N, Keser T, Ljubičić Đ, Vukić Dugac A, Lauc G, Rumora L, Gornik O.

J Transl Med. 2018 Nov 21;16(1):323. doi: 10.1186/s12967-018-1695-0.

3.

Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.

Juszczak A, Pavić T, Vučković F, Bennett AJ, Shah N, Pape Medvidović E, Groves CJ, Šekerija M, Chandler K, Burrows C, Rojnić Putarek N, Vučić Lovrenčić M, Ćuća Knežević J, James TJ, Gloyn AL, Lauc G, McCarthy MI, Owen KR, Gornik O.

Diabetes Care. 2019 Jan;42(1):17-26. doi: 10.2337/dc18-0422. Epub 2018 Nov 19.

PMID:
30455330
4.

Comparison of 2-Aminobenzamide, Procainamide and RapiFluor-MS as Derivatizing Agents for High-Throughput HILIC-UPLC-FLR-MS N-glycan Analysis.

Keser T, Pavić T, Lauc G, Gornik O.

Front Chem. 2018 Jul 26;6:324. doi: 10.3389/fchem.2018.00324. eCollection 2018.

5.

Maturity onset diabetes of the young due to HNF1A variants in Croatia.

Pavić T, Juszczak A, Pape Medvidović E, Burrows C, Šekerija M, Bennett AJ, Ćuća Knežević J, Gloyn AL, Lauc G, McCarthy MI, Gornik O, Owen KR.

Biochem Med (Zagreb). 2018 Jun 15;28(2):020703. doi: 10.11613/BM.2018.020703. Epub 2018 Apr 15.

6.

Correction to: Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.

Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, Gudelj I, Gašparović H, Biočina B, Tilin T, Wennerström A, Männistö S, Salomaa V, Havulinna A, Wang W, Wilson JF, Chaturvedi N, Perola M, Campbell H, Lauc G, Gornik O.

Diabetologia. 2018 Feb;61(2):506. doi: 10.1007/s00125-017-4515-9.

PMID:
29188337
7.

N-Glycan Profile and Kidney Disease in Type 1 Diabetes.

Bermingham ML, Colombo M, McGurnaghan SJ, Blackbourn LAK, Vučković F, Pučić Baković M, Trbojević-Akmačić I, Lauc G, Agakov F, Agakova AS, Hayward C, Klarić L, Palmer CNA, Petrie JR, Chalmers J, Collier A, Green F, Lindsay RS, Macrury S, McKnight JA, Patrick AW, Thekkepat S, Gornik O, McKeigue PM, Colhoun HM; SDRN Type 1 Bioresource Investigators.

Diabetes Care. 2018 Jan;41(1):79-87. doi: 10.2337/dc17-1042. Epub 2017 Nov 16.

PMID:
29146600
8.

Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.

Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, Gudelj I, Gašparović H, Biočina B, Tilin T, Wennerström A, Männistö S, Salomaa V, Havulinna A, Wang W, Wilson JF, Chaturvedi N, Perola M, Campbell H, Lauc G, Gornik O.

Diabetologia. 2017 Dec;60(12):2352-2360. doi: 10.1007/s00125-017-4426-9. Epub 2017 Sep 13. Erratum in: Diabetologia. 2017 Nov 29;:.

PMID:
28905229
9.

IgG glycan patterns are associated with type 2 diabetes in independent European populations.

Lemmers RFH, Vilaj M, Urda D, Agakov F, Šimurina M, Klaric L, Rudan I, Campbell H, Hayward C, Wilson JF, Lieverse AG, Gornik O, Sijbrands EJG, Lauc G, van Hoek M.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2240-2249. doi: 10.1016/j.bbagen.2017.06.020. Epub 2017 Jun 28.

10.

Micronucleus, cell-free DNA, and plasma glycan composition in the newborns of healthy and diabetic mothers.

Fucic A, Guszak V, Keser T, Wagner J, Juretić E, Plavec D, Stojković R, Gornik O, Lauc G.

Mutat Res. 2017 Mar;815:6-15. doi: 10.1016/j.mrgentox.2017.01.002. Epub 2017 Feb 7.

PMID:
28283092
11.

Effects of statins on the immunoglobulin G glycome.

Keser T, Vučković F, Barrios C, Zierer J, Wahl A, Akinkuolie AO, Štambuk J, Nakić N, Pavić T, Periša J, Mora S, Gieger C, Menni C, Spector TD, Gornik O, Lauc G.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1152-1158. doi: 10.1016/j.bbagen.2017.02.029. Epub 2017 Mar 2.

12.

Analysis of N-Glycosylation of Total Membrane Proteins.

Pavić T, Gornik O.

Methods Mol Biol. 2017;1503:197-205.

PMID:
27743368
13.

Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery.

Gudelj I, Baciarello M, Ugrina I, De Gregori M, Napolioni V, Ingelmo PM, Bugada D, De Gregori S, Đerek L, Pučić-Baković M, Novokmet M, Gornik O, Saccani Jotti G, Meschi T, Lauc G, Allegri M.

Sci Rep. 2016 Aug 9;6:31234. doi: 10.1038/srep31234.

14.

Enrichment of hydrophobic membrane proteins using Triton X-114 and subsequent analysis of their N-glycosylation.

Pavić T, Gudelj I, Keser T, Pučić-Baković M, Gornik O.

Biochim Biophys Acta. 2016 Aug;1860(8):1710-5. doi: 10.1016/j.bbagen.2015.12.025. Epub 2015 Dec 31.

PMID:
26746104
15.

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

Vučković F, Krištić J, Gudelj I, Teruel M, Keser T, Pezer M, Pučić-Baković M, Štambuk J, Trbojević-Akmačić I, Barrios C, Pavić T, Menni C, Wang Y, Zhou Y, Cui L, Song H, Zeng Q, Guo X, Pons-Estel BA, McKeigue P, Leslie Patrick A, Gornik O, Spector TD, Harjaček M, Alarcon-Riquelme M, Molokhia M, Wang W, Lauc G.

Arthritis Rheumatol. 2015 Nov;67(11):2978-89. doi: 10.1002/art.39273.

16.

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.

Trbojević Akmačić I, Ventham NT, Theodoratou E, Vučković F, Kennedy NA, Krištić J, Nimmo ER, Kalla R, Drummond H, Štambuk J, Dunlop MG, Novokmet M, Aulchenko Y, Gornik O, Campbell H, Pučić Baković M, Satsangi J, Lauc G; IBD-BIOM Consortium.

Inflamm Bowel Dis. 2015 Jun;21(6):1237-47. doi: 10.1097/MIB.0000000000000372.

17.

Estimation of human age using N-glycan profiles from bloodstains.

Gudelj I, Keser T, Vučković F, Škaro V, Goreta SŠ, Pavić T, Dumić J, Primorac D, Lauc G, Gornik O.

Int J Legal Med. 2015 Sep;129(5):955-61. doi: 10.1007/s00414-015-1162-x. Epub 2015 Mar 19.

18.

Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research.

Huffman JE, Pučić-Baković M, Klarić L, Hennig R, Selman MH, Vučković F, Novokmet M, Krištić J, Borowiak M, Muth T, Polašek O, Razdorov G, Gornik O, Plomp R, Theodoratou E, Wright AF, Rudan I, Hayward C, Campbell H, Deelder AM, Reichl U, Aulchenko YS, Rapp E, Wuhrer M, Lauc G.

Mol Cell Proteomics. 2014 Jun;13(6):1598-610. doi: 10.1074/mcp.M113.037465. Epub 2014 Apr 9.

19.

Changes in IgG and total plasma protein glycomes in acute systemic inflammation.

Novokmet M, Lukić E, Vučković F, Ðurić Ž, Keser T, Rajšl K, Remondini D, Castellani G, Gašparović H, Gornik O, Lauc G.

Sci Rep. 2014 Mar 11;4:4347. doi: 10.1038/srep04347.

20.

Glycans are a novel biomarker of chronological and biological ages.

Krištić J, Vučković F, Menni C, Klarić L, Keser T, Beceheli I, Pučić-Baković M, Novokmet M, Mangino M, Thaqi K, Rudan P, Novokmet N, Sarac J, Missoni S, Kolčić I, Polašek O, Rudan I, Campbell H, Hayward C, Aulchenko Y, Valdes A, Wilson JF, Gornik O, Primorac D, Zoldoš V, Spector T, Lauc G.

J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):779-89. doi: 10.1093/gerona/glt190. Epub 2013 Dec 10.

21.

Glycosylation of immunoglobulin g: role of genetic and epigenetic influences.

Menni C, Keser T, Mangino M, Bell JT, Erte I, Akmačić I, Vučković F, Pučić Baković M, Gornik O, McCarthy MI, Zoldoš V, Spector TD, Lauc G, Valdes AM.

PLoS One. 2013 Dec 6;8(12):e82558. doi: 10.1371/journal.pone.0082558. eCollection 2013.

22.

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission.

Gornik I, Wagner J, Gašparović V, Miličić D, Degoricija V, Skorić B, Gornik O, Lauc G.

Resuscitation. 2014 Feb;85(2):233-7. doi: 10.1016/j.resuscitation.2013.10.008. Epub 2013 Oct 18.

PMID:
24145040
23.

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, Huffman JE, Pučić M, Zgaga L, Adamczyk B, Mužinić A, Novokmet M, Polašek O, Gornik O, Krištić J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kolčić I, Lukić IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I.

PLoS Genet. 2013;9(1):e1003225. doi: 10.1371/journal.pgen.1003225. Epub 2013 Jan 31.

24.

Mutations in HNF1A result in marked alterations of plasma glycan profile.

Thanabalasingham G, Huffman JE, Kattla JJ, Novokmet M, Rudan I, Gloyn AL, Hayward C, Adamczyk B, Reynolds RM, Muzinic A, Hassanali N, Pucic M, Bennett AJ, Essafi A, Polasek O, Mughal SA, Redzic I, Primorac D, Zgaga L, Kolcic I, Hansen T, Gasperikova D, Tjora E, Strachan MW, Nielsen T, Stanik J, Klimes I, Pedersen OB, Njølstad PR, Wild SH, Gyllensten U, Gornik O, Wilson JF, Hastie ND, Campbell H, McCarthy MI, Rudd PM, Owen KR, Lauc G, Wright AF.

Diabetes. 2013 Apr;62(4):1329-37. doi: 10.2337/db12-0880. Epub 2012 Dec 28.

25.

Changes in plasma and IgG N-glycome during childhood and adolescence.

Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O.

Glycobiology. 2012 Jul;22(7):975-82. doi: 10.1093/glycob/cws062. Epub 2012 Mar 16.

PMID:
22426998
26.

Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome.

Zoldoš V, Horvat T, Novokmet M, Cuenin C, Mužinić A, Pučić M, Huffman JE, Gornik O, Polašek O, Campbell H, Hayward C, Wright AF, Rudan I, Owen K, McCarthy MI, Herceg Z, Lauc G.

Epigenetics. 2012 Feb;7(2):164-72. doi: 10.4161/epi.7.2.18918.

27.

Robustness testing of the high throughput HPLC-based analysis of plasma N-glycans.

Novokmet M, Pučić M, Redžić I, Mužinić A, Gornik O.

Biochim Biophys Acta. 2012 Sep;1820(9):1399-404. doi: 10.1016/j.bbagen.2012.01.002. Epub 2012 Jan 15.

PMID:
22281527
28.

Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease.

Gornik O, Pavić T, Lauc G.

Biochim Biophys Acta. 2012 Sep;1820(9):1318-26. doi: 10.1016/j.bbagen.2011.12.004. Epub 2011 Dec 13. Review.

PMID:
22183029
29.

High throughput plasma N-glycome profiling using multiplexed labelling and UPLC with fluorescence detection.

Knežević A, Bones J, Kračun SK, Gornik O, Rudd PM, Lauc G.

Analyst. 2011 Nov 21;136(22):4670-3. doi: 10.1039/c1an15684e. Epub 2011 Sep 29.

PMID:
21956149
30.

Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults.

Huffman JE, Knezevic A, Vitart V, Kattla J, Adamczyk B, Novokmet M, Igl W, Pucic M, Zgaga L, Johannson Å, Redzic I, Gornik O, Zemunik T, Polasek O, Kolcic I, Pehlic M, Koeleman CA, Campbell S, Wild SH, Hastie ND, Campbell H, Gyllensten U, Wuhrer M, Wilson JF, Hayward C, Rudan I, Rudd PM, Wright AF, Lauc G.

Hum Mol Genet. 2011 Dec 15;20(24):5000-11. doi: 10.1093/hmg/ddr414. Epub 2011 Sep 9.

PMID:
21908519
31.

Evaluation of cell-free DNA in plasma and serum as early predictors of severity in acute pancreatitis.

Gornik O, Gornik I, Wagner J, Radić D, Lauc G.

Pancreas. 2011 Jul;40(5):787-8. doi: 10.1097/MPA.0b013e3182143e93. No abstract available.

PMID:
21673541
32.

High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.

Pucić M, Knezević A, Vidic J, Adamczyk B, Novokmet M, Polasek O, Gornik O, Supraha-Goreta S, Wormald MR, Redzić I, Campbell H, Wright A, Hastie ND, Wilson JF, Rudan I, Wuhrer M, Rudd PM, Josić D, Lauc G.

Mol Cell Proteomics. 2011 Oct;10(10):M111.010090. doi: 10.1074/mcp.M111.010090. Epub 2011 Jun 8.

33.

Change of transferrin sialylation differs between mild sepsis and severe sepsis and septic shock.

Gornik O, Gornik I, Kolednjak IZ, Lauc G.

Intern Med. 2011;50(8):861-9. Epub 2011 Apr 15.

34.

Does inbreeding affect N-glycosylation of human plasma proteins?

Polašek O, Leutenegger AL, Gornik O, Zgaga L, Kolcic I, McQuillan R, Wilson JF, Hayward C, Wright AF, Lauc G, Campbell H, Rudan I.

Mol Genet Genomics. 2011 May;285(5):427-32. doi: 10.1007/s00438-011-0620-5. Epub 2011 Apr 13.

PMID:
21487732
35.

Glycomics meets lipidomics--associations of N-glycans with classical lipids, glycerophospholipids, and sphingolipids in three European populations.

Igl W, Polašek O, Gornik O, Knežević A, Pučić M, Novokmet M, Huffman J, Gnewuch C, Liebisch G, Rudd PM, Campbell H, Wilson JF, Rudan I, Gyllensten U, Schmitz G, Lauc G.

Mol Biosyst. 2011 Jun;7(6):1852-62. doi: 10.1039/c0mb00095g. Epub 2011 Mar 28.

PMID:
21445428
36.

Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

Lauc G, Essafi A, Huffman JE, Hayward C, Knežević A, Kattla JJ, Polašek O, Gornik O, Vitart V, Abrahams JL, Pučić M, Novokmet M, Redžić I, Campbell S, Wild SH, Borovečki F, Wang W, Kolčić I, Zgaga L, Gyllensten U, Wilson JF, Wright AF, Hastie ND, Campbell H, Rudd PM, Rudan I.

PLoS Genet. 2010 Dec 23;6(12):e1001256. doi: 10.1371/journal.pgen.1001256.

37.

Human plasma glycome in attention-deficit hyperactivity disorder and autism spectrum disorders.

Pivac N, Knezević A, Gornik O, Pucić M, Igl W, Peeters H, Crepel A, Steyaert J, Novokmet M, Redzić I, Nikolac M, Hercigonja VN, Curković KD, Curković M, Nedić G, Muck-Seler D, Borovecki F, Rudan I, Lauc G.

Mol Cell Proteomics. 2011 Jan;10(1):M110.004200. doi: 10.1074/mcp.M110.004200. Epub 2010 Oct 25.

38.

Common aberrations from the normal human plasma N-glycan profile.

Pucic M, Pinto S, Novokmet M, Knezevic A, Gornik O, Polasek O, Vlahovicek K, Wang W, Rudd PM, Wright AF, Campbell H, Rudan I, Lauc G.

Glycobiology. 2010 Aug;20(8):970-5. doi: 10.1093/glycob/cwq052. Epub 2010 Apr 8.

PMID:
20378934
39.

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans.

Knezevic A, Gornik O, Polasek O, Pucic M, Redzic I, Novokmet M, Rudd PM, Wright AF, Campbell H, Rudan I, Lauc G.

Glycobiology. 2010 Aug;20(8):959-69. doi: 10.1093/glycob/cwq051. Epub 2010 Mar 30.

PMID:
20356825
40.

Stability of N-glycan profiles in human plasma.

Gornik O, Wagner J, Pucić M, Knezević A, Redzic I, Lauc G.

Glycobiology. 2009 Dec;19(12):1547-53. doi: 10.1093/glycob/cwp134. Epub 2009 Sep 2.

PMID:
19726492
41.

Glycosylation of serum proteins in inflammatory diseases.

Gornik O, Lauc G.

Dis Markers. 2008;25(4-5):267-78. Review.

42.

Variability, heritability and environmental determinants of human plasma N-glycome.

Knezević A, Polasek O, Gornik O, Rudan I, Campbell H, Hayward C, Wright A, Kolcic I, O'Donoghue N, Bones J, Rudd PM, Lauc G.

J Proteome Res. 2009 Feb;8(2):694-701. doi: 10.1021/pr800737u.

PMID:
19035662
43.

Free serum DNA is an early predictor of severity in acute pancreatitis.

Gornik I, Wagner J, Gasparović V, Lauc G, Gornik O.

Clin Biochem. 2009 Jan;42(1-2):38-43. doi: 10.1016/j.clinbiochem.2008.09.121. Epub 2008 Nov 1.

PMID:
18992733
44.

Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis.

Gornik O, Gornik I, Gasparović V, Lauc G.

Clin Biochem. 2008 May;41(7-8):504-10. doi: 10.1016/j.clinbiochem.2008.01.026. Epub 2008 Feb 15.

PMID:
18307987
45.

Changes of serum glycans during sepsis and acute pancreatitis.

Gornik O, Royle L, Harvey DJ, Radcliffe CM, Saldova R, Dwek RA, Rudd P, Lauc G.

Glycobiology. 2007 Dec;17(12):1321-32. Epub 2007 Oct 15.

PMID:
17940056
46.

Enzyme linked lectin assay (ELLA) for direct analysis of transferrin sialylation in serum samples.

Gornik O, Lauc G.

Clin Biochem. 2007 Jun;40(9-10):718-23. Epub 2007 Jan 26.

PMID:
17320850
47.

HbA1c is outcome predictor in diabetic patients with sepsis.

Gornik I, Gornik O, Gasparović V.

Diabetes Res Clin Pract. 2007 Jul;77(1):120-5. Epub 2006 Dec 1.

PMID:
17141350
48.

Glycoscience -- a new frontier in rational drug design.

Gornik O, Dumić J, Flogel M, Lauc G.

Acta Pharm. 2006 Mar;56(1):19-30. Review.

PMID:
16613732

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