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Items: 50

1.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
2.

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.

Wade KR, Lawrence SL, Farrand AJ, Hotze EM, Kuiper MJ, Gorman MA, Christie MP, Panjikar S, Morton CJ, Parker MW, Tweten RK.

MBio. 2019 Apr 23;10(2). pii: e00538-19. doi: 10.1128/mBio.00538-19.

3.

Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations.

Molakarimi M, Gorman MA, Mohseni A, Pashandi Z, Taghdir M, Naderi-Manesh H, Sajedi RH, Parker MW.

J Biol Chem. 2019 Jan 4;294(1):20-27. doi: 10.1074/jbc.RA118.006053. Epub 2018 Nov 12.

PMID:
30420427
4.

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.

5.

QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins.

Molakarimi M, Mohseni A, Taghdir M, Pashandi Z, Gorman MA, Parker MW, Naderi-Manesh H, Sajedi RH.

PLoS One. 2017 Aug 4;12(8):e0182317. doi: 10.1371/journal.pone.0182317. eCollection 2017.

6.

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.

Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW.

Structure. 2016 Sep 6;24(9):1488-98. doi: 10.1016/j.str.2016.06.017. Epub 2016 Aug 4.

7.

Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target.

Soares da Costa TP, Desbois S, Dogovski C, Gorman MA, Ketaren NE, Paxman JJ, Siddiqui T, Zammit LM, Abbott BM, Robins-Browne RM, Parker MW, Jameson GB, Hall NE, Panjikar S, Perugini MA.

Structure. 2016 Aug 2;24(8):1282-1291. doi: 10.1016/j.str.2016.05.019. Epub 2016 Jul 14.

8.

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Broughton SE, Hercus TR, Nero TL, Dottore M, McClure BJ, Dhagat U, Taing H, Gorman MA, King-Scott J, Lopez AF, Parker MW.

Structure. 2016 Aug 2;24(8):1271-1281. doi: 10.1016/j.str.2016.05.017. Epub 2016 Jul 7.

9.

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Langendorf CG, Ngoei KRW, Scott JW, Ling NXY, Issa SMA, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE.

Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912.

10.

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.

Lawrence SL, Feil SC, Morton CJ, Farrand AJ, Mulhern TD, Gorman MA, Wade KR, Tweten RK, Parker MW.

Sci Rep. 2015 Sep 25;5:14352. doi: 10.1038/srep14352.

11.

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.

Mobbs JI, Koay A, Di Paolo A, Bieri M, Petrie EJ, Gorman MA, Doughty L, Parker MW, Stapleton DI, Griffin MD, Gooley PR.

Biochem J. 2015 Jun 1;468(2):245-57. doi: 10.1042/BJ20150270.

PMID:
25774984
12.

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health.

Gorman MA, Seers CA, Michell BJ, Feil SC, Huq NL, Cross KJ, Reynolds EC, Parker MW.

Protein Sci. 2015 Jan;24(1):162-6. doi: 10.1002/pro.2589. Epub 2014 Dec 3.

13.

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae.

Dogovski C, Gorman MA, Ketaren NE, Praszkier J, Zammit LM, Mertens HD, Bryant G, Yang J, Griffin MD, Pearce FG, Gerrard JA, Jameson GB, Parker MW, Robins-Browne RM, Perugini MA.

PLoS One. 2013 Dec 13;8(12):e83419. doi: 10.1371/journal.pone.0083419. eCollection 2013.

14.

Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions.

Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW.

Protein Sci. 2011 Jun;20(6):1060-8. doi: 10.1002/pro.631. Epub 2011 Apr 27.

15.

Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.

Gunn NJ, Gorman MA, Dobson RC, Parker MW, Mulhern TD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):336-9. doi: 10.1107/S1744309110053728. Epub 2011 Feb 23.

16.

Proteins: membrane binding and pore formation. Introduction.

Feil SC, Polekhina G, Gorman MA, Parker MW.

Adv Exp Med Biol. 2010;677:1-13. Review.

PMID:
20687476
17.

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.

Low WY, Feil SC, Ng HL, Gorman MA, Morton CJ, Pyke J, McConville MJ, Bieri M, Mok YF, Robin C, Gooley PR, Parker MW, Batterham P.

J Mol Biol. 2010 Jun 11;399(3):358-66. doi: 10.1016/j.jmb.2010.04.020. Epub 2010 Apr 24.

PMID:
20417639
18.

Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Dommaraju S, Gorman MA, Dogovski C, Pearce FG, Gerrard JA, Dobson RC, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):57-60. doi: 10.1107/S1744309109047964. Epub 2009 Dec 25.

19.

Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae.

Sibarani NE, Gorman MA, Dogovski C, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):32-6. doi: 10.1107/S174430910904771X. Epub 2009 Dec 25.

20.

Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria.

Feil SC, Tang J, Hansen G, Gorman MA, Wiktelius E, Stenberg G, Parker MW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):475-7. doi: 10.1107/S1744309109011634. Epub 2009 Apr 24.

21.

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate.

Atkinson SC, Dobson RC, Newman JM, Gorman MA, Dogovski C, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):253-5. doi: 10.1107/S1744309108039018. Epub 2009 Feb 14.

22.

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum.

Dobson RC, Atkinson SC, Gorman MA, Newman JM, Parker MW, Perugini MA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):206-8. doi: 10.1107/S1744309108002819. Epub 2008 Feb 29.

23.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).

Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Board PG, Parker MW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):961-3. Epub 2007 Oct 24.

24.

Structure of the Janus protein human CLIC2.

Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW.

J Mol Biol. 2007 Nov 30;374(3):719-31. Epub 2007 Sep 20.

PMID:
17945253
25.

Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.

Webb CT, Gorman MA, Lazarou M, Ryan MT, Gulbis JM.

Mol Cell. 2006 Jan 6;21(1):123-33.

26.
27.

Safe driving: a workplace issue for RNs too.

Gorman MA.

Alta RN. 2002 Nov;58(10):12. No abstract available.

PMID:
12514991
28.

Forensic nursing: RN practice in prison populations.

Gorman MA.

Alta RN. 2002 Oct;58(9):4-5. No abstract available. Erratum in: Alta RN. 2002 Dec;58(11):6..

PMID:
12430365
29.

The effects of zinc supplementation on serum zinc and cholesterol concentrations in hemodialysis patients.

Chevalier CA, Liepa G, Murphy MD, Suneson J, Vanbeber AD, Gorman MA, Cochran C.

J Ren Nutr. 2002 Jul;12(3):183-9.

PMID:
12105816
30.

The healing of art.

Gorman MA.

Alta RN. 2001 Nov;57(6):6-7. No abstract available.

PMID:
11899693
31.

Health care workers shape up.

Gorman MA.

Alta RN. 2002 Jan;58(1):14. No abstract available.

PMID:
11842677
32.

Are lipid values and BMI related to hospitalizations in the hemodialysis population?

Baugh ME, Stoltz ML, Vanbeber AD, Gorman MA.

J Ren Nutr. 2001 Jan;11(1):37-45.

PMID:
11172452
33.

Structure of the AAA ATPase p97.

Zhang X, Shaw A, Bates PA, Newman RH, Gowen B, Orlova E, Gorman MA, Kondo H, Dokurno P, Lally J, Leonard G, Meyer H, van Heel M, Freemont PS.

Mol Cell. 2000 Dec;6(6):1473-84.

34.

The effects of zinc supplementation on serum zinc concentration and protein catabolic rate in hemodialysis patients.

Jern NA, VanBeber AD, Gorman MA, Weber CG, Liepa GU, Cochran CC.

J Ren Nutr. 2000 Jul;10(3):148-53.

PMID:
10921536
35.

Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.

Rothwell DG, Hang B, Gorman MA, Freemont PS, Singer B, Hickson ID.

Nucleic Acids Res. 2000 Jun 1;28(11):2207-13.

36.

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

Gorman MA, Morera S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS.

EMBO J. 1997 Nov 3;16(21):6548-58.

37.

Effect of major dietary modifications on immune system in patients with breast cancer: a pilot study.

Garritson BK, Nikaein A, Peters GN, Gorman MA, King CC, Liepa GU.

Cancer Pract. 1995 Jul-Aug;3(4):239-46.

PMID:
7620489
39.

Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids.

Kirmani ZA, Baxter CR, Gorman MA, Ashby J, Ireton-Jones C, Liepa GU.

J Burn Care Rehabil. 1995 Mar-Apr;16(2 Pt 1):173-9; discussion 172.

PMID:
7775514
40.
41.

Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.

De A, Brown DG, Gorman MA, Carr M, Sanderson MR, Freemont PS.

Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1084-8.

42.

Position of The American Dietetic Association: health implications of dietary fiber.

Gorman MA, Bowman C.

J Am Diet Assoc. 1993 Dec;93(12):1446-7. No abstract available.

PMID:
8245382
43.

Subjective global assessment: alternative nutrition-assessment technique for liver-transplant candidates.

Hasse J, Strong S, Gorman MA, Liepa G.

Nutrition. 1993 Jul-Aug;9(4):339-43.

PMID:
8400590
44.

Crystallization and preliminary X-ray diffraction studies of pancreatic spasmolytic polypeptide.

Gorman MA, De A, Freemont PS.

J Mol Biol. 1992 Dec 5;228(3):991-4.

PMID:
1469732
45.

Lack of effect of vitamin B-6 supplementation on the lipoprotein profile of post-menopausal chronic hemodialysis patients.

Pike S, Prati RC, Cochran C, Gorman MA, Ashby J, Liepa GU.

J Am Diet Assoc. 1990 Jul;90(7):968-72.

PMID:
2365939
46.

Effect of aspartame on plasma amino acid profiles of diabetic patients with chronic renal failure.

Gupta V, Cochran C, Parker TF, Long DL, Ashby J, Gorman MA, Liepa GU.

Am J Clin Nutr. 1989 Jun;49(6):1302-6.

PMID:
2729170
47.

Attributes and qualifications that employers seek when hiring dietitians in business and industry.

Kirk D, Shanklin CW, Gorman MA.

J Am Diet Assoc. 1989 Apr;89(4):494-8.

PMID:
2649536
48.

Documentation of time expenditures of clinical dietitians: results of a statewide time study in Texas.

Shanklin CW, Hernandez HN, Gould RM, Gorman MA.

J Am Diet Assoc. 1988 Jan;88(1):38-43.

PMID:
3335715
49.

Competencies of foodservice directors/managers required in health care operations.

Yates SC, Shanklin CW, Gorman MA.

J Am Diet Assoc. 1987 Dec;87(12):1636-43.

PMID:
3680821
50.

TWIGS--a weight-control program designed for children. Team Watchers in Growth Standards.

Robinson NB, Lankford FP, Gorman MA.

J Am Diet Assoc. 1987 Apr;87(4):500-2. No abstract available.

PMID:
3559013

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