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Items: 1 to 50 of 84

1.

Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.

Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK, Ying J, Li Y, Han Y, Ji X, Chen W, Wu X, Gorlov IP, Na J, de Andrade M, Liu G, Brhane Y, Diao N, Wenzlaff A, Davies MPA, Liloglou T, Timofeeva M, Muley T, Rennert H, Saliba W, Ryan BM, Bowman E, Barros-Dios JM, Pérez-Ríos M, Morgenstern H, Zienolddiny S, Skaug V, Ugolini D, Bonassi S, van der Heijden EHFM, Tardon A, Bojesen SE, Landi MT, Johansson M, Bickeböller H, Arnold S, Le Marchand L, Melander O, Andrew A, Grankvist K, Caporaso N, Teare MD, Schabath MB, Aldrich MC, Kiemeney LA, Wichmann HE, Lazarus P, Mayordomo J, Neri M, Haugen A, Zhang ZF, Ruano-Raviña A, Brenner H, Harris CC, Orlow I, Rennert G, Risch A, Brennan P, Christiani DC, Amos CI, Yang P, Gorlova OY.

J Thorac Oncol. 2019 Apr 19. pii: S1556-0864(19)30289-8. doi: 10.1016/j.jtho.2019.04.008. [Epub ahead of print]

2.

Untouchable genes in the human genome: Identifying ideal targets for cancer treatment.

Gorlov IP, Gorlova OY, Amos CI.

Cancer Genet. 2019 Feb;231-232:67-79. doi: 10.1016/j.cancergen.2019.01.005. Epub 2019 Jan 24.

PMID:
30803560
3.

Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.

Gorlov IP, Pikielny CW, Frost HR, Her SC, Cole MD, Strohbehn SD, Wallace-Bradley D, Kimmel M, Gorlova OY, Amos CI.

BMC Bioinformatics. 2018 Nov 19;19(1):430. doi: 10.1186/s12859-018-2455-0.

4.

A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis.

Zhao Y, Schaafsma E, Gorlov IP, Hernando E, Thomas NE, Shen R, Turk MJ, Berwick M, Amos CI, Cheng C.

Mol Cancer Res. 2019 Jan;17(1):109-119. doi: 10.1158/1541-7786.MCR-18-0173. Epub 2018 Aug 31.

PMID:
30171176
5.

A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease.

Ji X, Niu X, Qian J, Martucci V, Pendergrass SA, Gorlov IP, Amos CI, Denny JC, Massion PP, Aldrich MC.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):777-779. doi: 10.1165/rcmb.2017-0409LE. No abstract available.

6.

Ancestry inference using principal component analysis and spatial analysis: a distance-based analysis to account for population substructure.

Byun J, Han Y, Gorlov IP, Busam JA, Seldin MF, Amos CI.

BMC Genomics. 2017 Oct 16;18(1):789. doi: 10.1186/s12864-017-4166-8.

7.

Downstream targets of GWAS-detected genes for breast, lung, and prostate and colon cancer converge to G1/S transition pathway.

Gorlova OY, Demidenko EI, Amos CI, Gorlov IP.

Hum Mol Genet. 2017 Apr 15;26(8):1465-1471. doi: 10.1093/hmg/ddx050.

8.

Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.

Kim J, Davis JW, Klein EA, Magi-Galluzzi C, Lotan Y, Ward JF, Pisters LL, Basler JW, Pettaway CA, Stephenson A, Li Ning Tapia EM, Efstathiou E, Wang X, Do KA, Lee JJ, Gorlov IP, Vornik LA, Hoque AM, Prokhorova IN, Parnes HL, Lippman SM, Thompson IM, Brown PH, Logothetis CJ, Troncoso P.

EBioMedicine. 2016 May;7:85-93. doi: 10.1016/j.ebiom.2016.03.047. Epub 2016 Apr 7.

10.

Prediction of the gene expression in normal lung tissue by the gene expression in blood.

Halloran JW, Zhu D, Qian DC, Byun J, Gorlova OY, Amos CI, Gorlov IP.

BMC Med Genomics. 2015 Nov 17;8:77. doi: 10.1186/s12920-015-0152-7.

11.

Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center.

Tafe LJ, Gorlov IP, de Abreu FB, Lefferts JA, Liu X, Pettus JR, Marotti JD, Bloch KJ, Memoli VA, Suriawinata AA, Dragnev KH, Fadul CE, Schwartz GN, Morgan CR, Holderness BM, Peterson JD, Tsongalis GJ, Miller TW, Chamberlin MD.

Oncologist. 2015 Sep;20(9):1011-8. doi: 10.1634/theoncologist.2015-0097. Epub 2015 Jul 23.

12.

Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.

Gorlov IP, Gorlova OY, Amos CI.

PLoS Genet. 2015 Jul 22;11(7):e1005371. doi: 10.1371/journal.pgen.1005371. eCollection 2015 Jul.

13.

SNP characteristics predict replication success in association studies.

Gorlov IP, Moore JH, Peng B, Jin JL, Gorlova OY, Amos CI.

Hum Genet. 2014 Dec;133(12):1477-86. doi: 10.1007/s00439-014-1493-6. Epub 2014 Oct 2.

14.

INPP4B suppresses prostate cancer cell invasion.

Hodgson MC, Deryugina EI, Suarez E, Lopez SM, Lin D, Xue H, Gorlov IP, Wang Y, Agoulnik IU.

Cell Commun Signal. 2014 Sep 25;12:61. doi: 10.1186/s12964-014-0061-y.

15.

How to get the most from microarray data: advice from reverse genomics.

Gorlov IP, Yang JY, Byun J, Logothetis C, Gorlova OY, Do KA, Amos C.

BMC Genomics. 2014 Mar 21;15:223. doi: 10.1186/1471-2164-15-223.

16.

Modified logistic regression models using gene coexpression and clinical features to predict prostate cancer progression.

Zhao H, Logothetis CJ, Gorlov IP, Zeng J, Dai J.

Comput Math Methods Med. 2013;2013:917502. doi: 10.1155/2013/917502. Epub 2013 Dec 4.

17.

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans.

Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, Spitz MR, Hansen HM, Lu EY, Wei C, Zhang H, Chen W, Lloyd SM, Frazier ML, Bracci PM, Seldin MF, Wrensch MR, Schwartz AG, Wiencke JK.

Oncotarget. 2012 Nov;3(11):1428-38.

18.

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.

Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI.

Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60. doi: 10.1158/1055-9965.EPI-12-1007-T. Epub 2012 Dec 5.

19.

Building a statistical model for predicting cancer genes.

Gorlov IP, Logothetis CJ, Fang S, Gorlova OY, Amos C.

PLoS One. 2012;7(11):e49175. doi: 10.1371/journal.pone.0049175. Epub 2012 Nov 15.

20.

Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.

Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML.

Carcinogenesis. 2013 Feb;34(2):299-306. doi: 10.1093/carcin/bgs344. Epub 2012 Nov 3.

21.

Beyond comparing means: the usefulness of analyzing interindividual variation in gene expression for identifying genes associated with cancer development.

Gorlov IP, Byun J, Zhao H, Logothetis CJ, Gorlova OY.

J Bioinform Comput Biol. 2012 Apr;10(2):1241013. doi: 10.1142/S0219720012410132.

22.

Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases.

Gorlova OY, Ying J, Amos CI, Spitz MR, Peng B, Gorlov IP.

J Bioinform Comput Biol. 2012 Apr;10(2):1241008. doi: 10.1142/S0219720012410089.

23.

In silico functional profiling of individual prostate cancer tumors: many genes, few functions.

Gorlov IP, Byun J, Logothetis CJ.

Cancer Genomics Proteomics. 2012 May-Jun;9(3):109-14.

24.

Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke.

Spitz MR, Gorlov IP, Amos CI, Dong Q, Chen W, Etzel CJ, Gorlova OY, Chang DW, Pu X, Zhang D, Wang L, Cunningham JM, Yang P, Wu X.

Cancer Discov. 2011 Oct;1(5):420-9. doi: 10.1158/2159-8290.CD-11-0080. Epub 2011 Aug 25.

25.

Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.

Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, Brennan P, Albanes D, Shi J, Thun M, Landi MT, Amos CI.

Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1213-21. doi: 10.1158/1055-9965.EPI-12-0352-T. Epub 2012 May 9.

26.

Initial medical attention on patients with early-stage non-small cell lung cancer.

Chen X, Gorlov IP, Ying J, Merriman KW, Kimmel M, Lu C, Reyes-Gibby CC, Gorlova OY.

PLoS One. 2012;7(3):e32644. doi: 10.1371/journal.pone.0032644. Epub 2012 Mar 7.

27.

Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis.

Kaftanovskaya EM, Huang Z, Barbara AM, De Gendt K, Verhoeven G, Gorlov IP, Agoulnik AI.

Mol Endocrinol. 2012 Apr;26(4):598-607. doi: 10.1210/me.2011-1283. Epub 2012 Feb 9.

28.

Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.

Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI.

Carcinogenesis. 2011 Oct;32(10):1493-9. doi: 10.1093/carcin/bgr136. Epub 2011 Jul 18.

29.

Association of smoking with tumor size at diagnosis in non-small cell lung cancer.

Chen X, Gorlov IP, Merriman KW, Weng SF, Foy M, Keener G, Amos CI, Spitz MR, Kimmel M, Gorlova OY.

Lung Cancer. 2011 Dec;74(3):378-83. doi: 10.1016/j.lungcan.2011.04.020. Epub 2011 Jun 8.

30.

Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development.

Kaftanovskaya EM, Feng S, Huang Z, Tan Y, Barbara AM, Kaur S, Truong A, Gorlov IP, Agoulnik AI.

Mol Endocrinol. 2011 Jan;25(1):170-83. doi: 10.1210/me.2010-0330. Epub 2010 Dec 8.

31.

Prioritizing genes associated with prostate cancer development.

Gorlov IP, Sircar K, Zhao H, Maity SN, Navone NM, Gorlova OY, Troncoso P, Pettaway CA, Byun JY, Logothetis CJ.

BMC Cancer. 2010 Nov 2;10:599. doi: 10.1186/1471-2407-10-599.

32.

Evolutionary evidence of the effect of rare variants on disease etiology.

Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI.

Clin Genet. 2011 Mar;79(3):199-206. doi: 10.1111/j.1399-0004.2010.01535.x. Epub 2010 Sep 10. Review.

33.

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

Hirschfield GM, Liu X, Han Y, Gorlov IP, Lu Y, Xu C, Lu Y, Chen W, Juran BD, Coltescu C, Mason AL, Milkiewicz P, Myers RP, Odin JA, Luketic VA, Speiciene D, Vincent C, Levy C, Gregersen PK, Zhang J, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA.

Nat Genet. 2010 Aug;42(8):655-7. doi: 10.1038/ng.631. Epub 2010 Jul 18.

34.

Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study.

Amos CI, Gorlov IP, Dong Q, Wu X, Zhang H, Lu EY, Scheet P, Greisinger AJ, Mills GB, Spitz MR.

J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205. doi: 10.1093/jnci/djq232. Epub 2010 Jun 16.

35.

Usefulness of the top-scoring pairs of genes for prediction of prostate cancer progression.

Zhao H, Logothetis CJ, Gorlov IP.

Prostate Cancer Prostatic Dis. 2010 Sep;13(3):252-9. doi: 10.1038/pcan.2010.9. Epub 2010 Apr 13.

36.

Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data.

Gorlov IP, Byun J, Gorlova OY, Aparicio AM, Efstathiou E, Logothetis CJ.

BMC Med Genomics. 2009 Aug 4;2:48. doi: 10.1186/1755-8794-2-48.

37.

GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example.

Gorlov IP, Gallick GE, Gorlova OY, Amos C, Logothetis CJ.

PLoS One. 2009 Aug 4;4(8):e6511. doi: 10.1371/journal.pone.0006511.

38.

Housekeeping genes in prostate tumorigenesis.

Byun J, Logothetis CJ, Gorlov IP.

Int J Cancer. 2009 Dec 1;125(11):2603-8. doi: 10.1002/ijc.24680.

39.

Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome.

Gorlov IP, Gorlova OY, Amos CI.

BMC Genomics. 2008 Jun 17;9:292. doi: 10.1186/1471-2164-9-292.

41.

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS.

Nat Genet. 2008 May;40(5):616-22. doi: 10.1038/ng.109. Epub 2008 Apr 2.

42.

Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.

Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI.

Am J Hum Genet. 2008 Jan;82(1):100-12. doi: 10.1016/j.ajhg.2007.09.006.

43.

Seizure 6-like (SEZ6L) gene and risk for lung cancer.

Gorlov IP, Meyer P, Liloglou T, Myles J, Boettger MB, Cassidy A, Girard L, Minna JD, Fischer R, Duffy S, Spitz MR, Haeussinger K, Kammerer S, Cantor C, Dierkesmann R, Field JK, Amos CI.

Cancer Res. 2007 Sep 1;67(17):8406-11.

44.

ATM sequence variants associate with susceptibility to non-small cell lung cancer.

Yang H, Spitz MR, Stewart DJ, Lu C, Gorlov IP, Wu X.

Int J Cancer. 2007 Nov 15;121(10):2254-9.

45.

Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome.

Gorlov IP, Kimmel M, Amos CI.

Hum Mol Genet. 2006 Apr 1;15(7):1143-50. Epub 2006 Feb 24.

PMID:
16500998
47.

Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs).

Gorlov IP, Gorlova OY, Frazier ML, Amos CI.

Mutat Res. 2004 Oct 4;554(1-2):175-83.

PMID:
15450416
48.

Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.

Lin J, Spitz MR, Wang Y, Schabath MB, Gorlov IP, Hernandez LM, Pillow PC, Grossman HB, Wu X.

Carcinogenesis. 2004 Sep;25(9):1639-47. Epub 2004 Apr 29.

PMID:
15117811
49.

Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers.

Gorlov IP, Gorlova OY, Frazier ML, Amos CI.

Am J Hum Genet. 2003 Nov;73(5):1157-61. Epub 2003 Oct 1.

50.

A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms.

Gorlov IP, Saunders GF.

Anal Biochem. 2002 Sep 15;308(2):401-4. No abstract available.

PMID:
12419357

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