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Items: 13

1.

Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.

Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, Mann BJ, Hedstrom L.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00939-17. doi: 10.1128/AAC.00939-17. Print 2017 Oct.

2.

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.

Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A.

PLoS One. 2015 Oct 6;10(10):e0138976. doi: 10.1371/journal.pone.0138976. eCollection 2015.

3.

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.

Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):531-8. doi: 10.1107/S2053230X15000187. Epub 2015 Apr 21.

4.

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.

Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A.

J Biol Chem. 2015 Feb 27;290(9):5893-911. doi: 10.1074/jbc.M114.619767. Epub 2015 Jan 8.

5.

Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.

Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L.

ACS Med Chem Lett. 2014 Jun 10;5(8):846-50. doi: 10.1021/ml500203p. eCollection 2014 Aug 14. Erratum in: ACS Med Chem Lett. 2014 Oct 9;5(10):1174.

6.

Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.

Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L.

Antimicrob Agents Chemother. 2014;58(3):1603-14. doi: 10.1128/AAC.02075-13. Epub 2013 Dec 23.

7.

Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.

J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13.

8.

Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1004-7. doi: 10.1016/j.bmcl.2012.12.037. Epub 2012 Dec 27.

9.

Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD.

J Med Chem. 2012 Sep 13;55(17):7759-71. doi: 10.1021/jm3007917. Epub 2012 Sep 5.

10.

Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.

Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1985-8. doi: 10.1016/j.bmcl.2012.01.029. Epub 2012 Jan 24.

11.

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

Gollapalli DR, Macpherson IS, Liechti G, Gorla SK, Goldberg JB, Hedstrom L.

Chem Biol. 2010 Oct 29;17(10):1084-91. doi: 10.1016/j.chembiol.2010.07.014.

12.

Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

Go ML, Leow JL, Gorla SK, Schüller AP, Wang M, Casey PJ.

J Med Chem. 2010 Oct 14;53(19):6838-50. doi: 10.1021/jm1002843.

PMID:
20809634
13.

The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.

Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L.

J Am Chem Soc. 2010 Feb 3;132(4):1230-1. doi: 10.1021/ja909947a. Erratum in: J Am Chem Soc. 2010 May 12;132(18):6610.

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