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Items: 25

1.

Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta.

Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR.

J Nat Prod. 2018 Dec 28;81(12):2750-2755. doi: 10.1021/acs.jnatprod.8b00761. Epub 2018 Nov 29.

2.

Harnessing Cyanine Reactivity for Optical Imaging and Drug Delivery.

Gorka AP, Nani RR, Schnermann MJ.

Acc Chem Res. 2018 Dec 18;51(12):3226-3235. doi: 10.1021/acs.accounts.8b00384. Epub 2018 Nov 12.

PMID:
30418020
3.

Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.

Fu Y, Urban DJ, Nani RR, Zhang YF, Li N, Fu H, Shah H, Gorka AP, Guha R, Chen L, Hall MD, Schnermann MJ, Ho M.

Hepatology. 2019 Aug;70(2):563-576. doi: 10.1002/hep.30326. Epub 2019 Feb 19.

PMID:
30353932
4.

Cyanine Photocages Enable Spatial Control of Inducible Cre-Mediated Recombination.

Gorka AP, Yamamoto T, Zhu J, Schnermann MJ.

Chembiochem. 2018 Jun 18;19(12):1239-1243. doi: 10.1002/cbic.201800061. Epub 2018 Apr 16.

5.

Molecularly Targeted Cancer Combination Therapy with Near-Infrared Photoimmunotherapy and Near-Infrared Photorelease with Duocarmycin-Antibody Conjugate.

Nagaya T, Gorka AP, Nani RR, Okuyama S, Ogata F, Maruoka Y, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Cancer Ther. 2018 Mar;17(3):661-670. doi: 10.1158/1535-7163.MCT-17-0851. Epub 2017 Dec 13.

6.

In Vivo Activation of Duocarmycin-Antibody Conjugates by Near-Infrared Light.

Nani RR, Gorka AP, Nagaya T, Yamamoto T, Ivanic J, Kobayashi H, Schnermann MJ.

ACS Cent Sci. 2017 Apr 26;3(4):329-337. doi: 10.1021/acscentsci.7b00026. Epub 2017 Feb 24.

7.

Near-infrared uncaging or photosensitizing dictated by oxygen tension.

Anderson ED, Gorka AP, Schnermann MJ.

Nat Commun. 2016 Nov 17;7:13378. doi: 10.1038/ncomms13378.

8.

Effect of charge localization on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates.

Sato K, Gorka AP, Nagaya T, Michie MS, Nakamura Y, Nani RR, Coble VL, Vasalatiy OV, Swenson RE, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Biosyst. 2016 Oct 20;12(10):3046-56. doi: 10.1039/c6mb00371k. Epub 2016 Jul 25.

9.

Harnessing cyanine photooxidation: from slowing photobleaching to near-IR uncaging.

Gorka AP, Schnermann MJ.

Curr Opin Chem Biol. 2016 Aug;33:117-25. doi: 10.1016/j.cbpa.2016.05.022. Epub 2016 Jun 24. Review.

PMID:
27348157
10.

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry.

Medina SH, Miller SE, Keim AI, Gorka AP, Schnermann MJ, Schneider JP.

Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3369-72. doi: 10.1002/anie.201510518. Epub 2016 Feb 2.

11.

Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates.

Sato K, Gorka AP, Nagaya T, Michie MS, Nani RR, Nakamura Y, Coble VL, Vasalatiy OV, Swenson RE, Choyke PL, Schnermann MJ, Kobayashi H.

Bioconjug Chem. 2016 Feb 17;27(2):404-13. doi: 10.1021/acs.bioconjchem.5b00492. Epub 2015 Oct 23.

PMID:
26444497
12.

Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages.

Nani RR, Gorka AP, Nagaya T, Kobayashi H, Schnermann MJ.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13635-8. doi: 10.1002/anie.201507391. Epub 2015 Sep 25.

13.

Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates.

Sato K, Nagaya T, Nakamura Y, Harada T, Nani RR, Shaum JB, Gorka AP, Kim I, Paik CH, Choyke PL, Schnermann MJ, Kobayashi H.

Mol Pharm. 2015 Sep 8;12(9):3303-11. doi: 10.1021/acs.molpharmaceut.5b00472. Epub 2015 Aug 18.

14.

Cyanine polyene reactivity: scope and biomedical applications.

Gorka AP, Nani RR, Schnermann MJ.

Org Biomol Chem. 2015 Jul 28;13(28):7584-98. doi: 10.1039/c5ob00788g. Review.

PMID:
26052876
15.

Electrophile-integrating Smiles rearrangement provides previously inaccessible C4'-O-alkyl heptamethine cyanine fluorophores.

Nani RR, Shaum JB, Gorka AP, Schnermann MJ.

Org Lett. 2015 Jan 16;17(2):302-5. doi: 10.1021/ol503398f. Epub 2015 Jan 6.

16.

A near-IR uncaging strategy based on cyanine photochemistry.

Gorka AP, Nani RR, Zhu J, Mackem S, Schnermann MJ.

J Am Chem Soc. 2014 Oct 8;136(40):14153-9. doi: 10.1021/ja5065203. Epub 2014 Sep 24.

17.

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms.

Suberu JO, Gorka AP, Jacobs L, Roepe PD, Sullivan N, Barker GC, Lapkin AA.

PLoS One. 2013 Nov 14;8(11):e80790. doi: 10.1371/journal.pone.0080790. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/57ae25b0-d2c8-444b-ab62-f047c5f3e01e.

18.

Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis.

Gorka AP, Jacobs LM, Roepe PD.

Malar J. 2013 Sep 18;12:332. doi: 10.1186/1475-2875-12-332.

19.

Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities.

Gorka AP, de Dios A, Roepe PD.

J Med Chem. 2013 Jul 11;56(13):5231-46. doi: 10.1021/jm400282d. Epub 2013 Apr 29. Review.

PMID:
23586757
20.

Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.

Gorka AP, Alumasa JN, Sherlach KS, Jacobs LM, Nickley KB, Brower JP, de Dios AC, Roepe PD.

Antimicrob Agents Chemother. 2013 Jan;57(1):356-64. doi: 10.1128/AAC.01709-12. Epub 2012 Oct 31.

21.

Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum.

Gorka AP, Sherlach KS, de Dios AC, Roepe PD.

Antimicrob Agents Chemother. 2013 Jan;57(1):365-74. doi: 10.1128/AAC.01234-12. Epub 2012 Oct 31.

22.

Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.

Dinio T, Gorka AP, McGinniss A, Roepe PD, Morgan JB.

Bioorg Med Chem. 2012 May 15;20(10):3292-7. doi: 10.1016/j.bmc.2012.03.042. Epub 2012 Mar 29.

23.

Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.

Pan E, Gorka AP, Alumasa JN, Slebodnick C, Harinantenaina L, Brodie PJ, Roepe PD, Randrianaivo R, Birkinshaw C, Kingston DG.

J Nat Prod. 2011 Oct 28;74(10):2174-80. doi: 10.1021/np200499d. Epub 2011 Oct 13.

24.

Quantification of perchloroethylene residues in dry-cleaned fabrics.

Sherlach KS, Gorka AP, Dantzler A, Roepe PD.

Environ Toxicol Chem. 2011 Nov;30(11):2481-7. doi: 10.1002/etc.665. Epub 2011 Sep 20.

PMID:
21898565
25.

The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.

Alumasa JN, Gorka AP, Casabianca LB, Comstock E, de Dios AC, Roepe PD.

J Inorg Biochem. 2011 Mar;105(3):467-75. doi: 10.1016/j.jinorgbio.2010.08.011. Epub 2010 Sep 22.

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