Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 66

1.

Fe₃O₄ Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy.

Dukenbayev K, Korolkov IV, Tishkevich DI, Kozlovskiy AL, Trukhanov SV, Gorin YG, Shumskaya EE, Kaniukov EY, Vinnik DA, Zdorovets MV, Anisovich M, Trukhanov AV, Tosi D, Molardi C.

Nanomaterials (Basel). 2019 Mar 31;9(4). pii: E494. doi: 10.3390/nano9040494.

2.

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression.

Das F, Ghosh-Choudhury N, Lee DY, Gorin Y, Kasinath BS, Choudhury GG.

PLoS One. 2018 Nov 16;13(11):e0207285. doi: 10.1371/journal.pone.0207285. eCollection 2018.

3.

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases.

Pasha M, Eid AH, Eid AA, Gorin Y, Munusamy S.

Oxid Med Cell Longev. 2017;2017:3296294. doi: 10.1155/2017/3296294. Epub 2017 Jun 11. Review.

4.

Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.

Lee HJ, Lee DY, Mariappan MM, Feliers D, Ghosh-Choudhury G, Abboud HE, Gorin Y, Kasinath BS.

J Biol Chem. 2017 Apr 7;292(14):5665-5675. doi: 10.1074/jbc.M116.766758. Epub 2017 Feb 10.

5.

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.

Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, Rashid A, Moodad S, Block K, Gorin Y, Abboud HE, Eid AA.

Antioxid Redox Signal. 2016 Nov 1;25(13):703-719. Epub 2016 Sep 12.

6.

The Kidney: An Organ in the Front Line of Oxidative Stress-Associated Pathologies.

Gorin Y.

Antioxid Redox Signal. 2016 Oct 20;25(12):639-641. Epub 2016 Aug 1. Review.

7.

Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis.

Drel VR, Tan C, Barnes JL, Gorin Y, Lee DY, Wagner B.

FASEB J. 2016 Sep;30(9):3026-38. doi: 10.1096/fj.201500188R. Epub 2016 May 24.

8.

Pathophysiology of gadolinium-associated systemic fibrosis.

Wagner B, Drel V, Gorin Y.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F1-F11. doi: 10.1152/ajprenal.00166.2016. Epub 2016 May 4. Review.

9.

Activation of AMP-activated protein kinase prevents TGF-β1-induced epithelial-mesenchymal transition and myofibroblast activation.

Thakur S, Viswanadhapalli S, Kopp JB, Shi Q, Barnes JL, Block K, Gorin Y, Abboud HE.

Am J Pathol. 2015 Aug;185(8):2168-80. doi: 10.1016/j.ajpath.2015.04.014. Epub 2015 Jun 10.

10.

Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.

Gorin Y, Wauquier F.

Mol Cells. 2015 Apr;38(4):285-96. doi: 10.14348/molcells.2015.0010. Epub 2015 Mar 31. Review.

11.

Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes.

Lee HJ, Feliers D, Mariappan MM, Sataranatarajan K, Choudhury GG, Gorin Y, Kasinath BS.

J Biol Chem. 2015 May 8;290(19):12014-26. doi: 10.1074/jbc.M114.615377. Epub 2015 Mar 9.

12.

Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.

Gorin Y, Cavaglieri RC, Khazim K, Lee DY, Bruno F, Thakur S, Fanti P, Szyndralewiez C, Barnes JL, Block K, Abboud HE.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1276-87. doi: 10.1152/ajprenal.00396.2014. Epub 2015 Feb 4.

13.

Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells.

Feliers D, Lee DY, Gorin Y, Kasinath BS.

Cell Signal. 2015 Jan;27(1):1-5. doi: 10.1016/j.cellsig.2014.09.024. Epub 2014 Oct 8.

PMID:
25283600
14.

RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013. Epub 2014 May 28.

15.

A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF.

Bera A, Das F, Ghosh-Choudhury N, Li X, Pal S, Gorin Y, Kasinath BS, Abboud HE, Ghosh Choudhury G.

Am J Physiol Cell Physiol. 2014 Jun 1;306(11):C1089-100. doi: 10.1152/ajpcell.00387.2013. Epub 2014 Apr 16.

16.

Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cells.

Wagner B, Gorin Y.

Am J Physiol Renal Physiol. 2014 Jan 1;306(1):F85-97. doi: 10.1152/ajprenal.00371.2013. Epub 2013 Nov 6.

17.

Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species.

Lee DY, Wauquier F, Eid AA, Roman LJ, Ghosh-Choudhury G, Khazim K, Block K, Gorin Y.

J Biol Chem. 2013 Oct 4;288(40):28668-86. doi: 10.1074/jbc.M113.470971. Epub 2013 Aug 12.

18.

Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.

Eid AA, Lee DY, Roman LJ, Khazim K, Gorin Y.

Mol Cell Biol. 2013 Sep;33(17):3439-60. doi: 10.1128/MCB.00217-13. Epub 2013 Jul 1.

19.

The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.

Khazim K, Gorin Y, Cavaglieri RC, Abboud HE, Fanti P.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700. doi: 10.1152/ajprenal.00028.2013. Epub 2013 Jun 26.

20.

Nox as a target for diabetic complications.

Gorin Y, Block K.

Clin Sci (Lond). 2013 Oct;125(8):361-82. doi: 10.1042/CS20130065. Review.

PMID:
23767990
21.

ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice.

Ford BM, Eid AA, Göőz M, Barnes JL, Gorin YC, Abboud HE.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F323-32. doi: 10.1152/ajprenal.00522.2012. Epub 2013 May 15.

22.

Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury.

Eid AA, Ford BM, Bhandary B, de Cassia Cavaglieri R, Block K, Barnes JL, Gorin Y, Choudhury GG, Abboud HE.

Diabetes. 2013 Aug;62(8):2935-47. doi: 10.2337/db12-1504. Epub 2013 Apr 4.

23.
24.

Nox4 and diabetic nephropathy: with a friend like this, who needs enemies?

Gorin Y, Block K.

Free Radic Biol Med. 2013 Aug;61:130-42. doi: 10.1016/j.freeradbiomed.2013.03.014. Epub 2013 Mar 23. Review.

25.

Nephrogenic systemic fibrosis: evidence for oxidative stress and bone marrow-derived fibrocytes in skin, liver, and heart lesions using a 5/6 nephrectomy rodent model.

Wagner B, Tan C, Barnes JL, Ahuja S, Davis TL, Gorin Y, Jimenez F.

Am J Pathol. 2012 Dec;181(6):1941-52. doi: 10.1016/j.ajpath.2012.08.026. Epub 2012 Oct 4.

PMID:
23041060
26.

Aiding and abetting roles of NOX oxidases in cellular transformation.

Block K, Gorin Y.

Nat Rev Cancer. 2012 Sep;12(9):627-37. doi: 10.1038/nrc3339. Review.

27.

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.

Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K.

Oncogene. 2013 Jun 27;32(26):3147-55. doi: 10.1038/onc.2012.333. Epub 2012 Aug 6.

28.

Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production.

Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, Eid AA, DeNapoli T, Parekh DJ, Gorin Y, Block K.

PLoS One. 2012;7(1):e30712. doi: 10.1371/journal.pone.0030712. Epub 2012 Jan 27.

29.

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes.

Maalouf RM, Eid AA, Gorin YC, Block K, Escobar GP, Bailey S, Abboud HE.

Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C597-604. doi: 10.1152/ajpcell.00331.2011. Epub 2011 Oct 26.

30.

IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells.

New DD, Block K, Bhandhari B, Gorin Y, Abboud HE.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C122-30. doi: 10.1152/ajpcell.00141.2011. Epub 2011 Sep 21.

31.

Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes.

Graham S, Gorin Y, Abboud HE, Ding M, Lee DY, Shi H, Ding Y, Ma R.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C304-15. doi: 10.1152/ajpcell.00014.2011. Epub 2011 Apr 27.

32.

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases.

Barnes JL, Gorin Y.

Kidney Int. 2011 May;79(9):944-56. doi: 10.1038/ki.2010.516. Epub 2011 Feb 9. Review.

33.

Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation.

Mandal CC, Ganapathy S, Gorin Y, Mahadev K, Block K, Abboud HE, Harris SE, Ghosh-Choudhury G, Ghosh-Choudhury N.

Biochem J. 2011 Jan 15;433(2):393-402. doi: 10.1042/BJ20100357.

34.

AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes.

Eid AA, Ford BM, Block K, Kasinath BS, Gorin Y, Ghosh-Choudhury G, Barnes JL, Abboud HE.

J Biol Chem. 2010 Nov 26;285(48):37503-12. doi: 10.1074/jbc.M110.136796. Epub 2010 Sep 22.

35.

The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.

Block K, Gorin Y, New DD, Eid A, Chelmicki T, Reed A, Choudhury GG, Parekh DJ, Abboud HE.

Am J Pathol. 2010 May;176(5):2447-55. doi: 10.2353/ajpath.2010.090606. Epub 2010 Mar 19.

36.

NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts.

Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL.

J Am Soc Nephrol. 2010 Jan;21(1):93-102. doi: 10.1681/ASN.2009020146. Epub 2009 Nov 19.

37.

Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts.

Wittrant Y, Gorin Y, Mohan S, Wagner B, Abboud-Werner SL.

Endocrinology. 2009 Nov;150(11):4977-88. doi: 10.1210/en.2009-0248. Epub 2009 Oct 9.

38.

Subcellular localization of Nox4 and regulation in diabetes.

Block K, Gorin Y, Abboud HE.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. doi: 10.1073/pnas.0906805106. Epub 2009 Aug 17.

39.

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE.

Diabetes. 2009 May;58(5):1201-11. doi: 10.2337/db08-1536. Epub 2009 Feb 10.

40.

PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.

Ricono JM, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury GG, Abboud HE.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F406-17. doi: 10.1152/ajprenal.90368.2008. Epub 2008 Nov 19.

41.

Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.

Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL.

Diabetes. 2008 Oct;57(10):2626-36. doi: 10.2337/db07-1579. Epub 2008 Jul 3.

42.

Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.

Block K, Eid A, Griendling KK, Lee DY, Wittrant Y, Gorin Y.

J Biol Chem. 2008 Aug 29;283(35):24061-76. doi: 10.1074/jbc.M803964200. Epub 2008 Jun 16.

43.

High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis.

Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S, Abboud-Werner SL.

Bone. 2008 Jun;42(6):1122-30. doi: 10.1016/j.bone.2008.02.006. Epub 2008 Feb 29.

44.

Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells.

Wagner B, Ricono JM, Gorin Y, Block K, Arar M, Riley D, Choudhury GG, Abboud HE.

J Am Soc Nephrol. 2007 Nov;18(11):2903-11. Epub 2007 Oct 17.

45.

NAD(P)H oxidases regulate HIF-2alpha protein expression.

Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE.

J Biol Chem. 2007 Mar 16;282(11):8019-26. Epub 2007 Jan 2.

46.

Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB.

Block K, Ricono JM, Lee DY, Bhandari B, Choudhury GG, Abboud HE, Gorin Y.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1497-508.

PMID:
16987006
47.

ZO-1 expression and phosphorylation in diabetic nephropathy.

Rincon-Choles H, Vasylyeva TL, Pergola PE, Bhandari B, Bhandari K, Zhang JH, Wang W, Gorin Y, Barnes JL, Abboud HE.

Diabetes. 2006 Apr;55(4):894-900.

48.

Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species.

Feliers D, Gorin Y, Ghosh-Choudhury G, Abboud HE, Kasinath BS.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F927-36. Epub 2005 Oct 25.

49.

Redox dependence of glomerular epithelial cell hypertrophy in response to glucose.

Kim NH, Rincon-Choles H, Bhandari B, Choudhury GG, Abboud HE, Gorin Y.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F741-51. Epub 2005 Oct 18. Erratum in: Am J Physiol Renal Physiol. 2006 Jul;291(1):F254.

50.

PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression.

Venkatesan BA, Mahimainathan L, Ghosh-Choudhury N, Gorin Y, Bhandari B, Valente AJ, Abboud HE, Choudhury GG.

Cell Signal. 2006 Apr;18(4):508-18. Epub 2005 Sep 12.

PMID:
16157472

Supplemental Content

Support Center