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Items: 1 to 50 of 195

1.

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2018 Dec 10:e12845. doi: 10.1111/acel.12845. [Epub ahead of print]

2.

Cura"x"ing Cancer and Beyond.

Gorgoulis VG, Kotsinas A.

Bioessays. 2018 Dec 3:e1800223. doi: 10.1002/bies.201800223. [Epub ahead of print] No abstract available.

PMID:
30507004
3.

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Cooks T, Theodorou SD, Paparouna E, Rizou SV, Myrianthopoulos V, Gorgoulis VG, Pateras IS.

Histol Histopathol. 2018 Nov 27:18069. doi: 10.14670/HH-18-069. [Epub ahead of print] Review.

PMID:
30480312
4.

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:119-138. doi: 10.1007/978-1-4939-8931-7_12.

PMID:
30474845
5.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.

6.

Ex Vivo Culture of Cells Derived From Circulating Tumour Cell Xenograft to support Small Cell Lung Cancer Research and Experimental Therapeutics.

Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C.

Br J Pharmacol. 2018 Nov 14. doi: 10.1111/bph.14542. [Epub ahead of print]

PMID:
30427531
7.

Ageing, Cellular Senescence and Neurodegenerative Disease.

Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2937. doi: 10.3390/ijms19102937. Review.

8.

Senescence and senotherapeutics: a new field in cancer therapy.

Myrianthopoulos V, Evangelou K, Vasileiou PVS, Cooks T, Vassilakopoulos TP, Pangalis GA, Kouloukoussa M, Kittas C, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2018 Aug 16. pii: S0163-7258(18)30144-X. doi: 10.1016/j.pharmthera.2018.08.006. [Epub ahead of print] Review.

9.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.

PMID:
29952003
10.

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.

Magkouta S, Pappas A, Pateras IS, Kollintza A, Moschos C, Vazakidou ME, Karavana V, Gorgoulis VG, Kalomenidis I.

Oncotarget. 2018 Apr 24;9(31):21783-21796. doi: 10.18632/oncotarget.25004. eCollection 2018 Apr 24.

11.

Integrating the DNA damage and protein stress responses during cancer development and treatment.

Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP.

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097. Epub 2018 Jul 19. Review.

12.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

13.

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.

Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2018 Feb 25. pii: S0047-6374(17)30300-7. doi: 10.1016/j.mad.2018.02.005. [Epub ahead of print]

PMID:
29490231
14.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

15.

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.

PMID:
29343849
16.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG.

BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1.

17.

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses.

Ventura J, Lobachevsky PN, Palazzolo JS, Forrester H, Haynes NM, Ivashkevich A, Stevenson AW, Hall CJ, Ntargaras A, Kotsaris V, Pollakis GC, Potsi G, Skordylis K, Terzoudi G, Pateras IS, Gorgoulis VG, Georgakilas AG, Sprung CN, Martin OA.

Cancer Res. 2017 Nov 15;77(22):6389-6399. doi: 10.1158/0008-5472.CAN-17-1066. Epub 2017 Nov 7.

18.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance.

Myrianthopoulos V, Lozach O, Zareifi D, Alexopoulos L, Meijer L, Gorgoulis VG, Mikros E.

Int J Mol Sci. 2017 Oct 6;18(10). pii: E2102. doi: 10.3390/ijms18102102.

19.

Proteome Stability as a Key Factor of Genome Integrity.

Gumeni S, Evangelakou Z, Gorgoulis VG, Trougakos IP.

Int J Mol Sci. 2017 Sep 22;18(10). pii: E2036. doi: 10.3390/ijms18102036. Review.

20.

Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway.

Havaki S, Vlachou V, Zampetidis CP, Selemenakis P, Kotsinas A, Mavrogonatou E, Rizou SV, Kyrodimos E, Evangelou K, Kletsas D, Giatromanolaki A, Gorgoulis VG.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1920. doi: 10.3390/ijms18091920.

21.

MiR-signing gastrointestinal (con-)tract cancer.

Gorgoulis VG, Pateras IS, Kotsinas A.

Oncotarget. 2017 May 2;8(18):29536-29537. doi: 10.18632/oncotarget.15701. No abstract available.

22.

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses.

Souli MP, Klonos P, Fragopoulou AF, Mavragani IV, Pateras IS, Kostomitsopoulos N, Margaritis LH, Zoumpoulis P, Kaklamanis L, Kletsas D, Gorgoulis VG, Kyritsis A, Pissis P, Georgakilas AG.

Int J Mol Sci. 2017 Apr 15;18(4). pii: E838. doi: 10.3390/ijms18040838.

23.

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis.

Kalisperati P, Spanou E, Pateras IS, Korkolopoulou P, Varvarigou A, Karavokyros I, Gorgoulis VG, Vlachoyiannopoulos PG, Sougioultzis S.

Front Genet. 2017 Feb 27;8:20. doi: 10.3389/fgene.2017.00020. eCollection 2017. Review.

24.

Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15].

Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG.

Semin Cancer Biol. 2017 Apr;43:180. doi: 10.1016/j.semcancer.2017.02.002. Epub 2017 Feb 21. No abstract available.

PMID:
28254408
25.

Robust, universal biomarker assay to detect senescent cells in biological specimens.

Evangelou K, Lougiakis N, Rizou SV, Kotsinas A, Kletsas D, Muñoz-Espín D, Kastrinakis NG, Pouli N, Marakos P, Townsend P, Serrano M, Bartek J, Gorgoulis VG.

Aging Cell. 2017 Feb;16(1):192-197. doi: 10.1111/acel.12545. Epub 2016 Nov 17.

26.

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.

27.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.

Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, Halazonetis TD.

Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.

28.

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN, Georgopoulou U, Gorgoulis VG, Dalekos GN, Aidinis V.

Hepatology. 2017 Apr;65(4):1369-1383. doi: 10.1002/hep.28973. Epub 2017 Feb 7.

PMID:
27981605
29.

DNA Damage Response and Autophagy: A Meaningful Partnership.

Eliopoulos AG, Havaki S, Gorgoulis VG.

Front Genet. 2016 Nov 21;7:204. eCollection 2016. Review.

30.

The Janus face of p21.

Evangelou K, Galanos P, Gorgoulis VG.

Mol Cell Oncol. 2016 Jul 29;3(5):e1215776. eCollection 2016.

31.

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T.

Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8.

PMID:
27827301
32.
33.

p21WAF1/Cip1 - PCNA: Fatal attraction.

Galanos P, Pappas G, Gorgoulis VG.

Cell Cycle. 2016 Dec;15(23):3153-3154. Epub 2016 Aug 11. No abstract available.

34.

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.

Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5757-64. doi: 10.1073/pnas.1603252113. Epub 2016 Aug 11.

35.

Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus.

Souliotis VL, Vougas K, Gorgoulis VG, Sfikakis PP.

Arthritis Res Ther. 2016 Aug 4;18(1):182. doi: 10.1186/s13075-016-1081-3.

36.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Liakou E, Mavrogonatou E, Pratsinis H, Rizou S, Evangelou K, Panagiotou PN, Karamanos NK, Gorgoulis VG, Kletsas D.

Aging (Albany NY). 2016 Aug;8(8):1650-69. doi: 10.18632/aging.100989.

37.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.

PMID:
27323328
38.

Systemic dna damage: Mechanisms, effects and mitigation strategies.

Georgakilas AG, Gorgoulis VG.

Semin Cancer Biol. 2016 Jun;37-38:1-2. doi: 10.1016/j.semcancer.2016.04.001. Epub 2016 Apr 22. No abstract available.

PMID:
27113557
39.

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

Georgakopoulou E, Evangelou K, Havaki S, Townsend P, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2016 Jun;156:17-24. doi: 10.1016/j.mad.2016.03.010. Epub 2016 Apr 6. Review.

PMID:
27060261
40.

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.

Del Bel Belluz L, Guidi R, Pateras IS, Levi L, Mihaljevic B, Rouf SF, Wrande M, Candela M, Turroni S, Nastasi C, Consolandi C, Peano C, Tebaldi T, Viero G, Gorgoulis VG, Krejsgaard T, Rhen M, Frisan T.

PLoS Pathog. 2016 Apr 7;12(4):e1005528. doi: 10.1371/journal.ppat.1005528. eCollection 2016 Apr.

41.

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.

Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R, Baniyash M, Pikarsky E, Gorgoulis VG, Oren M.

Cell Rep. 2016 Feb 16;14(6):1462-1476. doi: 10.1016/j.celrep.2016.01.020. Epub 2016 Feb 4.

42.

Exploring and exploiting the systemic effects of deregulated replication licensing.

Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG.

Semin Cancer Biol. 2016 Jun;37-38:3-15. doi: 10.1016/j.semcancer.2015.12.002. Epub 2015 Dec 17. Review. Erratum in: Semin Cancer Biol. 2017 Apr;43:180.

PMID:
26707000
43.

Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.

Golomb L, Sagiv A, Pateras IS, Maly A, Krizhanovsky V, Gorgoulis VG, Oren M, Ben-Yehuda A.

Cell Death Differ. 2015 Nov;22(11):1764-74. doi: 10.1038/cdd.2015.21. Epub 2015 Mar 20.

44.

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity.

Bahri R, Pateras IS, D'Orlando O, Goyeneche-Patino DA, Campbell M, Polansky JK, Sandig H, Papaioannou M, Evangelou K, Foukas PG, Gorgoulis VG, Bulfone-Paus S.

Oncoimmunology. 2015 Jan 22;4(9):e1002721. eCollection 2015 Sep.

45.

MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets.

Kotsinas A, Sigala F, Garbis SD, Galyfos G, Filis K, Vougas K, Papalampros A, Johnson EE, Chronopoulos E, Georgakilas AG, Gorgoulis VG.

Curr Med Chem. 2015;22(22):2666-79. Review.

PMID:
26180004
46.

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.

Pateras IS, Havaki S, Nikitopoulou X, Vougas K, Townsend PA, Panayiotidis MI, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2015 Oct;154:36-56. doi: 10.1016/j.pharmthera.2015.06.011. Epub 2015 Jul 3. Review.

PMID:
26145166
47.

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.

Gupta J, Igea A, Papaioannou M, Lopez-Casas PP, Llonch E, Hidalgo M, Gorgoulis VG, Nebreda AR.

Oncotarget. 2015 Apr 20;6(11):8539-51.

48.

The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin.

Kalousi A, Hoffbeck AS, Selemenakis PN, Pinder J, Savage KI, Khanna KK, Brino L, Dellaire G, Gorgoulis VG, Soutoglou E.

Cell Rep. 2015 Apr 7;11(1):149-63. doi: 10.1016/j.celrep.2015.03.005. Epub 2015 Mar 26.

49.

Oncogenic Role of the Ec Peptide of the IGF-1Ec Isoform in Prostate Cancer.

Armakolas A, Kaparelou M, Dimakakos A, Papageorgiou E, Armakolas N, Antonopoulos A, Petraki C, Lekarakou M, Lelovas P, Stathaki M, Psarros C, Donta I, Galanos PS, Msaouel P, Gorgoulis VG, Koutsilieris M.

Mol Med. 2015 Jan 6;21:167-79. doi: 10.2119/molmed.2014.00222.

50.

Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Georgakilas AG, Tsantoulis P, Kotsinas A, Michalopoulos I, Townsend P, Gorgoulis VG.

Cell Mol Life Sci. 2014 Dec;71(23):4519-44. doi: 10.1007/s00018-014-1717-x. Epub 2014 Sep 20. Review.

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