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Items: 1 to 50 of 208

1.

Conditioning attenuates kidney and heart injury in rats following transient suprarenal occlusion of the abdominal aorta.

Karageorgiadi DM, Tsilimigras DI, Selemenakis P, Vlachou V, de Lastic AL, Rodi M, Chatziathanasiou D, Savvatakis K, Antoniou N, Deli AC, Papalampros A, Filis KA, Mouzaki A, Varvarigou A, Zografos G, Gorgoulis VG, Pateras IS, Sigala F.

Sci Rep. 2020 Mar 19;10(1):5040. doi: 10.1038/s41598-020-61268-9.

2.

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.

Moukengue B, Brown HK, Charrier C, Battaglia S, Baud'huin M, Quillard T, Pham TM, Pateras IS, Gorgoulis VG, Helleday T, Heymann D, Berglund UW, Ory B, Lamoureux F.

EBioMedicine. 2020 Mar 6;53:102704. doi: 10.1016/j.ebiom.2020.102704. [Epub ahead of print]

3.

Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution.

Barbouti A, Vasileiou PVS, Evangelou K, Vlasis KG, Papoudou-Bai A, Gorgoulis VG, Kanavaros P.

Oxid Med Cell Longev. 2020 Feb 5;2020:7986071. doi: 10.1155/2020/7986071. eCollection 2020. Review.

4.

mTORC1-dependent protein synthesis and autophagy uncouple in the regulation of Apolipoprotein A-I expression.

Georgila K, Gounis M, Havaki S, Gorgoulis VG, Eliopoulos AG.

Metabolism. 2020 Apr;105:154186. doi: 10.1016/j.metabol.2020.154186. Epub 2020 Feb 18.

PMID:
32084429
5.

Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome.

Vakrakou AG, Svolaki IP, Evangelou K, Gorgoulis VG, Manoussakis MN.

J Autoimmun. 2020 Mar;108:102381. doi: 10.1016/j.jaut.2019.102381. Epub 2020 Jan 7.

PMID:
31919014
6.

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA.

Nat Commun. 2020 Jan 2;11(1):42. doi: 10.1038/s41467-019-13894-9.

7.

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.

Antoniou N, Lagopati N, Balourdas DI, Nikolaou M, Papalampros A, Vasileiou PVS, Myrianthopoulos V, Kotsinas A, Shiloh Y, Liontos M, Gorgoulis VG.

Cancers (Basel). 2019 Dec 24;12(1). pii: E62. doi: 10.3390/cancers12010062. Review.

8.

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG.

Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. doi: 10.1016/j.celrep.2019.11.017.

9.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.

Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Review.

PMID:
31374225
10.

Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia.

Harvati K, Röding C, Bosman AM, Karakostis FA, Grün R, Stringer C, Karkanas P, Thompson NC, Koutoulidis V, Moulopoulos LA, Gorgoulis VG, Kouloukoussa M.

Nature. 2019 Jul;571(7766):500-504. doi: 10.1038/s41586-019-1376-z. Epub 2019 Jul 10.

PMID:
31292546
11.

Mitochondrial Homeostasis and Cellular Senescence.

Vasileiou PVS, Evangelou K, Vlasis K, Fildisis G, Panayiotidis MI, Chronopoulos E, Passias PG, Kouloukoussa M, Gorgoulis VG, Havaki S.

Cells. 2019 Jul 6;8(7). pii: E686. doi: 10.3390/cells8070686. Review.

12.

Correction to: A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:C1-C2. doi: 10.1007/978-1-4939-8931-7_19.

PMID:
30725385
13.

Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth.

Pappas AG, Magkouta S, Pateras IS, Skianis I, Moschos C, Vazakidou ME, Psarra K, Gorgoulis VG, Kalomenidis I.

Oncoimmunology. 2018 Nov 2;8(2):e1537427. doi: 10.1080/2162402X.2018.1537427. eCollection 2019.

14.

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2019 Feb;18(1):e12845. doi: 10.1111/acel.12845. Epub 2018 Dec 10.

15.

Cura"x"ing Cancer and Beyond.

Gorgoulis VG, Kotsinas A.

Bioessays. 2019 Jan;41(1):e1800223. doi: 10.1002/bies.201800223. Epub 2018 Dec 3. No abstract available.

PMID:
30507004
16.

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Cooks T, Theodorou SD, Paparouna E, Rizou SV, Myrianthopoulos V, Gorgoulis VG, Pateras IS.

Histol Histopathol. 2019 Apr;34(4):335-352. doi: 10.14670/HH-18-069. Epub 2018 Nov 27. Review.

PMID:
30480312
17.

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:119-138. doi: 10.1007/978-1-4939-8931-7_12. Erratum in: Methods Mol Biol. 2019;1896:C1-C2.

PMID:
30474845
18.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.

19.

Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics.

Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C.

Br J Pharmacol. 2019 Feb;176(3):436-450. doi: 10.1111/bph.14542. Epub 2018 Dec 13.

20.

Ageing, Cellular Senescence and Neurodegenerative Disease.

Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2937. doi: 10.3390/ijms19102937. Review.

21.

Senescence and senotherapeutics: a new field in cancer therapy.

Myrianthopoulos V, Evangelou K, Vasileiou PVS, Cooks T, Vassilakopoulos TP, Pangalis GA, Kouloukoussa M, Kittas C, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2019 Jan;193:31-49. doi: 10.1016/j.pharmthera.2018.08.006. Epub 2018 Aug 16. Review.

22.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.

PMID:
29952003
23.

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.

Magkouta S, Pappas A, Pateras IS, Kollintza A, Moschos C, Vazakidou ME, Karavana V, Gorgoulis VG, Kalomenidis I.

Oncotarget. 2018 Apr 24;9(31):21783-21796. doi: 10.18632/oncotarget.25004. eCollection 2018 Apr 24.

24.

Integrating the DNA damage and protein stress responses during cancer development and treatment.

Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP.

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097. Epub 2018 Jul 19. Review.

25.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

26.

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.

Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2019 Jan;177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25.

PMID:
29490231
27.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

28.

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.

29.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG.

BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1.

30.

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses.

Ventura J, Lobachevsky PN, Palazzolo JS, Forrester H, Haynes NM, Ivashkevich A, Stevenson AW, Hall CJ, Ntargaras A, Kotsaris V, Pollakis GC, Potsi G, Skordylis K, Terzoudi G, Pateras IS, Gorgoulis VG, Georgakilas AG, Sprung CN, Martin OA.

Cancer Res. 2017 Nov 15;77(22):6389-6399. doi: 10.1158/0008-5472.CAN-17-1066. Epub 2017 Nov 7.

31.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance.

Myrianthopoulos V, Lozach O, Zareifi D, Alexopoulos L, Meijer L, Gorgoulis VG, Mikros E.

Int J Mol Sci. 2017 Oct 6;18(10). pii: E2102. doi: 10.3390/ijms18102102.

32.

Proteome Stability as a Key Factor of Genome Integrity.

Gumeni S, Evangelakou Z, Gorgoulis VG, Trougakos IP.

Int J Mol Sci. 2017 Sep 22;18(10). pii: E2036. doi: 10.3390/ijms18102036. Review.

33.

Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway.

Havaki S, Vlachou V, Zampetidis CP, Selemenakis P, Kotsinas A, Mavrogonatou E, Rizou SV, Kyrodimos E, Evangelou K, Kletsas D, Giatromanolaki A, Gorgoulis VG.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1920. doi: 10.3390/ijms18091920.

34.

MiR-signing gastrointestinal (con-)tract cancer.

Gorgoulis VG, Pateras IS, Kotsinas A.

Oncotarget. 2017 May 2;8(18):29536-29537. doi: 10.18632/oncotarget.15701. No abstract available.

35.

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses.

Souli MP, Klonos P, Fragopoulou AF, Mavragani IV, Pateras IS, Kostomitsopoulos N, Margaritis LH, Zoumpoulis P, Kaklamanis L, Kletsas D, Gorgoulis VG, Kyritsis A, Pissis P, Georgakilas AG.

Int J Mol Sci. 2017 Apr 15;18(4). pii: E838. doi: 10.3390/ijms18040838.

36.

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis.

Kalisperati P, Spanou E, Pateras IS, Korkolopoulou P, Varvarigou A, Karavokyros I, Gorgoulis VG, Vlachoyiannopoulos PG, Sougioultzis S.

Front Genet. 2017 Feb 27;8:20. doi: 10.3389/fgene.2017.00020. eCollection 2017. Review.

37.

Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15].

Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG.

Semin Cancer Biol. 2017 Apr;43:180. doi: 10.1016/j.semcancer.2017.02.002. Epub 2017 Feb 21. No abstract available.

PMID:
28254408
38.

Robust, universal biomarker assay to detect senescent cells in biological specimens.

Evangelou K, Lougiakis N, Rizou SV, Kotsinas A, Kletsas D, Muñoz-Espín D, Kastrinakis NG, Pouli N, Marakos P, Townsend P, Serrano M, Bartek J, Gorgoulis VG.

Aging Cell. 2017 Feb;16(1):192-197. doi: 10.1111/acel.12545. Epub 2016 Nov 17.

39.

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.

40.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.

Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, Halazonetis TD.

Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.

41.

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN, Georgopoulou U, Gorgoulis VG, Dalekos GN, Aidinis V.

Hepatology. 2017 Apr;65(4):1369-1383. doi: 10.1002/hep.28973. Epub 2017 Feb 7.

PMID:
27981605
42.

DNA Damage Response and Autophagy: A Meaningful Partnership.

Eliopoulos AG, Havaki S, Gorgoulis VG.

Front Genet. 2016 Nov 21;7:204. eCollection 2016. Review.

43.

The Janus face of p21.

Evangelou K, Galanos P, Gorgoulis VG.

Mol Cell Oncol. 2016 Jul 29;3(5):e1215776. eCollection 2016.

44.

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T.

Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8.

45.
46.

p21WAF1/Cip1 - PCNA: Fatal attraction.

Galanos P, Pappas G, Gorgoulis VG.

Cell Cycle. 2016 Dec;15(23):3153-3154. Epub 2016 Aug 11. No abstract available.

47.

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.

Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5757-64. doi: 10.1073/pnas.1603252113. Epub 2016 Aug 11.

48.

Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus.

Souliotis VL, Vougas K, Gorgoulis VG, Sfikakis PP.

Arthritis Res Ther. 2016 Aug 4;18(1):182. doi: 10.1186/s13075-016-1081-3.

49.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Liakou E, Mavrogonatou E, Pratsinis H, Rizou S, Evangelou K, Panagiotou PN, Karamanos NK, Gorgoulis VG, Kletsas D.

Aging (Albany NY). 2016 Aug;8(8):1650-69. doi: 10.18632/aging.100989.

50.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.

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