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Items: 1 to 50 of 204

1.

Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome.

Vakrakou AG, Svolaki IP, Evangelou K, Gorgoulis VG, Manoussakis MN.

J Autoimmun. 2020 Jan 6:102381. doi: 10.1016/j.jaut.2019.102381. [Epub ahead of print]

PMID:
31919014
2.

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA.

Nat Commun. 2020 Jan 2;11(1):42. doi: 10.1038/s41467-019-13894-9.

3.

The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.

Antoniou N, Lagopati N, Balourdas DI, Nikolaou M, Papalampros A, Vasileiou PVS, Myrianthopoulos V, Kotsinas A, Shiloh Y, Liontos M, Gorgoulis VG.

Cancers (Basel). 2019 Dec 24;12(1). pii: E62. doi: 10.3390/cancers12010062. Review.

4.

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG.

Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. doi: 10.1016/j.celrep.2019.11.017.

5.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.

Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Review.

PMID:
31374225
6.

Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia.

Harvati K, Röding C, Bosman AM, Karakostis FA, Grün R, Stringer C, Karkanas P, Thompson NC, Koutoulidis V, Moulopoulos LA, Gorgoulis VG, Kouloukoussa M.

Nature. 2019 Jul;571(7766):500-504. doi: 10.1038/s41586-019-1376-z. Epub 2019 Jul 10.

PMID:
31292546
7.

Mitochondrial Homeostasis and Cellular Senescence.

Vasileiou PVS, Evangelou K, Vlasis K, Fildisis G, Panayiotidis MI, Chronopoulos E, Passias PG, Kouloukoussa M, Gorgoulis VG, Havaki S.

Cells. 2019 Jul 6;8(7). pii: E686. doi: 10.3390/cells8070686. Review.

8.

Correction to: A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:C1-C2. doi: 10.1007/978-1-4939-8931-7_19.

PMID:
30725385
9.

Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth.

Pappas AG, Magkouta S, Pateras IS, Skianis I, Moschos C, Vazakidou ME, Psarra K, Gorgoulis VG, Kalomenidis I.

Oncoimmunology. 2018 Nov 2;8(2):e1537427. doi: 10.1080/2162402X.2018.1537427. eCollection 2019.

10.

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP.

Aging Cell. 2019 Feb;18(1):e12845. doi: 10.1111/acel.12845. Epub 2018 Dec 10.

11.

Cura"x"ing Cancer and Beyond.

Gorgoulis VG, Kotsinas A.

Bioessays. 2019 Jan;41(1):e1800223. doi: 10.1002/bies.201800223. Epub 2018 Dec 3. No abstract available.

PMID:
30507004
12.

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Cooks T, Theodorou SD, Paparouna E, Rizou SV, Myrianthopoulos V, Gorgoulis VG, Pateras IS.

Histol Histopathol. 2019 Apr;34(4):335-352. doi: 10.14670/HH-18-069. Epub 2018 Nov 27. Review.

PMID:
30480312
13.

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids.

Rizou SV, Evangelou K, Myrianthopoulos V, Mourouzis I, Havaki S, Athanasiou A, Vasileiou PVS, Margetis A, Kotsinas A, Kastrinakis NG, Sfikakis P, Townsend P, Mikros E, Pantos C, Gorgoulis VG.

Methods Mol Biol. 2019;1896:119-138. doi: 10.1007/978-1-4939-8931-7_12. Erratum in: Methods Mol Biol. 2019;1896:C1-C2.

PMID:
30474845
14.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state.

Furth N, Pateras IS, Rotkopf R, Vlachou V, Rivkin I, Schmitt I, Bakaev D, Gershoni A, Ainbinder E, Leshkowitz D, Johnson RL, Gorgoulis VG, Oren M, Aylon Y.

Life Sci Alliance. 2018 Oct 30;1(5):e201800171. doi: 10.26508/lsa.201800171. eCollection 2018 Oct.

15.

Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics.

Lallo A, Gulati S, Schenk MW, Khandelwal G, Berglund UW, Pateras IS, Chester CPE, Pham TM, Kalderen C, Frese KK, Gorgoulis VG, Miller C, Blackhall F, Helleday T, Dive C.

Br J Pharmacol. 2019 Feb;176(3):436-450. doi: 10.1111/bph.14542. Epub 2018 Dec 13.

PMID:
30427531
16.

Ageing, Cellular Senescence and Neurodegenerative Disease.

Kritsilis M, V Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2937. doi: 10.3390/ijms19102937. Review.

17.

Senescence and senotherapeutics: a new field in cancer therapy.

Myrianthopoulos V, Evangelou K, Vasileiou PVS, Cooks T, Vassilakopoulos TP, Pangalis GA, Kouloukoussa M, Kittas C, Georgakilas AG, Gorgoulis VG.

Pharmacol Ther. 2019 Jan;193:31-49. doi: 10.1016/j.pharmthera.2018.08.006. Epub 2018 Aug 16. Review.

18.

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.

Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S.

J Pathol. 2018 Oct;246(2):134-140. doi: 10.1002/path.5128. Epub 2018 Aug 21.

PMID:
29952003
19.

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications.

Magkouta S, Pappas A, Pateras IS, Kollintza A, Moschos C, Vazakidou ME, Karavana V, Gorgoulis VG, Kalomenidis I.

Oncotarget. 2018 Apr 24;9(31):21783-21796. doi: 10.18632/oncotarget.25004. eCollection 2018 Apr 24.

20.

Integrating the DNA damage and protein stress responses during cancer development and treatment.

Gorgoulis VG, Pefani DE, Pateras IS, Trougakos IP.

J Pathol. 2018 Sep;246(1):12-40. doi: 10.1002/path.5097. Epub 2018 Jul 19. Review.

21.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis NN, Glytsou C, Pateras IS, Swain U, Souliotis VL, Georgakilas AG, Geacintov N, Scorrano L, Lukas C, Lukas J, Livneh Z, Lygerou Z, Chowdhury D, Sørensen CS, Bartek J, Gorgoulis VG.

Genome Biol. 2018 Mar 16;19(1):37. doi: 10.1186/s13059-018-1401-9.

22.

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution.

Barbouti A, Evangelou K, Pateras IS, Papoudou-Bai A, Patereli A, Stefanaki K, Rontogianni D, Muñoz-Espín D, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2019 Jan;177:88-90. doi: 10.1016/j.mad.2018.02.005. Epub 2018 Feb 25.

PMID:
29490231
23.

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC.

Nat Commun. 2018 Feb 22;9(1):771. doi: 10.1038/s41467-018-03224-w.

24.

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.

25.

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG.

BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1.

26.

Localized Synchrotron Irradiation of Mouse Skin Induces Persistent Systemic Genotoxic and Immune Responses.

Ventura J, Lobachevsky PN, Palazzolo JS, Forrester H, Haynes NM, Ivashkevich A, Stevenson AW, Hall CJ, Ntargaras A, Kotsaris V, Pollakis GC, Potsi G, Skordylis K, Terzoudi G, Pateras IS, Gorgoulis VG, Georgakilas AG, Sprung CN, Martin OA.

Cancer Res. 2017 Nov 15;77(22):6389-6399. doi: 10.1158/0008-5472.CAN-17-1066. Epub 2017 Nov 7.

27.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance.

Myrianthopoulos V, Lozach O, Zareifi D, Alexopoulos L, Meijer L, Gorgoulis VG, Mikros E.

Int J Mol Sci. 2017 Oct 6;18(10). pii: E2102. doi: 10.3390/ijms18102102.

28.

Proteome Stability as a Key Factor of Genome Integrity.

Gumeni S, Evangelakou Z, Gorgoulis VG, Trougakos IP.

Int J Mol Sci. 2017 Sep 22;18(10). pii: E2036. doi: 10.3390/ijms18102036. Review.

29.

Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway.

Havaki S, Vlachou V, Zampetidis CP, Selemenakis P, Kotsinas A, Mavrogonatou E, Rizou SV, Kyrodimos E, Evangelou K, Kletsas D, Giatromanolaki A, Gorgoulis VG.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1920. doi: 10.3390/ijms18091920.

30.

MiR-signing gastrointestinal (con-)tract cancer.

Gorgoulis VG, Pateras IS, Kotsinas A.

Oncotarget. 2017 May 2;8(18):29536-29537. doi: 10.18632/oncotarget.15701. No abstract available.

31.

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses.

Souli MP, Klonos P, Fragopoulou AF, Mavragani IV, Pateras IS, Kostomitsopoulos N, Margaritis LH, Zoumpoulis P, Kaklamanis L, Kletsas D, Gorgoulis VG, Kyritsis A, Pissis P, Georgakilas AG.

Int J Mol Sci. 2017 Apr 15;18(4). pii: E838. doi: 10.3390/ijms18040838.

32.

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis.

Kalisperati P, Spanou E, Pateras IS, Korkolopoulou P, Varvarigou A, Karavokyros I, Gorgoulis VG, Vlachoyiannopoulos PG, Sougioultzis S.

Front Genet. 2017 Feb 27;8:20. doi: 10.3389/fgene.2017.00020. eCollection 2017. Review.

33.

Erratum to 'Exploring and exploiting the systemic effects of deregulated replication licensing' [Seminars in Cancer Biology 37-38C, (2016) 3-15].

Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG.

Semin Cancer Biol. 2017 Apr;43:180. doi: 10.1016/j.semcancer.2017.02.002. Epub 2017 Feb 21. No abstract available.

PMID:
28254408
34.

Robust, universal biomarker assay to detect senescent cells in biological specimens.

Evangelou K, Lougiakis N, Rizou SV, Kotsinas A, Kletsas D, Muñoz-Espín D, Kastrinakis NG, Pouli N, Marakos P, Townsend P, Serrano M, Bartek J, Gorgoulis VG.

Aging Cell. 2017 Feb;16(1):192-197. doi: 10.1111/acel.12545. Epub 2016 Nov 17.

35.

RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.

Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M.

Cell Death Differ. 2017 Apr;24(4):694-704. doi: 10.1038/cdd.2016.126. Epub 2017 Feb 3.

36.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.

Sotiriou SK, Kamileri I, Lugli N, Evangelou K, Da-Ré C, Huber F, Padayachy L, Tardy S, Nicati NL, Barriot S, Ochs F, Lukas C, Lukas J, Gorgoulis VG, Scapozza L, Halazonetis TD.

Mol Cell. 2016 Dec 15;64(6):1127-1134. doi: 10.1016/j.molcel.2016.10.038.

37.

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN, Georgopoulou U, Gorgoulis VG, Dalekos GN, Aidinis V.

Hepatology. 2017 Apr;65(4):1369-1383. doi: 10.1002/hep.28973. Epub 2017 Feb 7.

PMID:
27981605
38.

DNA Damage Response and Autophagy: A Meaningful Partnership.

Eliopoulos AG, Havaki S, Gorgoulis VG.

Front Genet. 2016 Nov 21;7:204. eCollection 2016. Review.

39.

The Janus face of p21.

Evangelou K, Galanos P, Gorgoulis VG.

Mol Cell Oncol. 2016 Jul 29;3(5):e1215776. eCollection 2016.

40.

Validation and development of MTH1 inhibitors for treatment of cancer.

Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T.

Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8.

41.
42.

p21WAF1/Cip1 - PCNA: Fatal attraction.

Galanos P, Pappas G, Gorgoulis VG.

Cell Cycle. 2016 Dec;15(23):3153-3154. Epub 2016 Aug 11. No abstract available.

43.

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells.

Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5757-64. doi: 10.1073/pnas.1603252113. Epub 2016 Aug 11.

44.

Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus.

Souliotis VL, Vougas K, Gorgoulis VG, Sfikakis PP.

Arthritis Res Ther. 2016 Aug 4;18(1):182. doi: 10.1186/s13075-016-1081-3.

45.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Liakou E, Mavrogonatou E, Pratsinis H, Rizou S, Evangelou K, Panagiotou PN, Karamanos NK, Gorgoulis VG, Kletsas D.

Aging (Albany NY). 2016 Aug;8(8):1650-69. doi: 10.18632/aging.100989.

46.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG.

Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20.

47.

Systemic dna damage: Mechanisms, effects and mitigation strategies.

Georgakilas AG, Gorgoulis VG.

Semin Cancer Biol. 2016 Jun;37-38:1-2. doi: 10.1016/j.semcancer.2016.04.001. Epub 2016 Apr 22. No abstract available.

PMID:
27113557
48.

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

Georgakopoulou E, Evangelou K, Havaki S, Townsend P, Kanavaros P, Gorgoulis VG.

Mech Ageing Dev. 2016 Jun;156:17-24. doi: 10.1016/j.mad.2016.03.010. Epub 2016 Apr 6. Review.

PMID:
27060261
49.

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.

Del Bel Belluz L, Guidi R, Pateras IS, Levi L, Mihaljevic B, Rouf SF, Wrande M, Candela M, Turroni S, Nastasi C, Consolandi C, Peano C, Tebaldi T, Viero G, Gorgoulis VG, Krejsgaard T, Rhen M, Frisan T.

PLoS Pathog. 2016 Apr 7;12(4):e1005528. doi: 10.1371/journal.ppat.1005528. eCollection 2016 Apr.

50.

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.

Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R, Baniyash M, Pikarsky E, Gorgoulis VG, Oren M.

Cell Rep. 2016 Feb 16;14(6):1462-1476. doi: 10.1016/j.celrep.2016.01.020. Epub 2016 Feb 4.

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