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Items: 5

1.

Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D.

Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27.

2.

Global analysis of protein folding using massively parallel design, synthesis, and testing.

Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D.

Science. 2017 Jul 14;357(6347):168-175. doi: 10.1126/science.aan0693.

3.

A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics.

Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ.

Nat Chem Biol. 2017 Jan;13(1):119-126. doi: 10.1038/nchembio.2244. Epub 2016 Nov 21.

4.

Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.

Goreshnik I, Brock AM, Maly DJ.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):4951-5. doi: 10.1016/j.bmcl.2011.06.134. Epub 2011 Jul 13.

PMID:
21807512
5.

A small molecule-regulated guanine nucleotide exchange factor.

Goreshnik I, Maly DJ.

J Am Chem Soc. 2010 Jan 27;132(3):938-40. doi: 10.1021/ja907886v.

PMID:
20020680

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