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Items: 1 to 50 of 90

1.

Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin.

Ali T, Bednarska J, Vassilopoulos S, Tran M, Diakonov IA, Ziyadeh-Isleem A, Guicheney P, Gorelik J, Korchev YE, Reilly MM, Bitoun M, Shevchuk A.

FASEB J. 2019 Apr 24:fj201802635R. doi: 10.1096/fj.201802635R. [Epub ahead of print]

2.

Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains.

Wright PT, Sanchez-Alonso JL, Lucarelli C, Alvarez-Laviada A, Poulet CE, Bello SO, Faggian G, Terracciano CM, Gorelik J.

Front Physiol. 2018 Sep 19;9:1302. doi: 10.3389/fphys.2018.01302. eCollection 2018.

3.

Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain.

Bastug-Özel Z, Wright PT, Kraft AE, Pavlovic D, Howie J, Froese A, Fuller W, Gorelik J, Shattock MJ, Nikolaev VO.

Cardiovasc Res. 2019 Mar 1;115(3):546-555. doi: 10.1093/cvr/cvy221.

PMID:
30165515
4.

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation.

Veeraraghavan R, Hoeker GS, Alvarez-Laviada A, Hoagland D, Wan X, King DR, Sanchez-Alonso J, Chen C, Jourdan J, Isom LL, Deschenes I, Smyth JW, Gorelik J, Poelzing S, Gourdie RG.

Elife. 2018 Aug 14;7. pii: e37610. doi: 10.7554/eLife.37610.

5.

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP.

Subramanian H, Froese A, Jönsson P, Schmidt H, Gorelik J, Nikolaev VO.

Nat Commun. 2018 Jun 22;9(1):2446. doi: 10.1038/s41467-018-04891-5.

6.

The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains.

Bhogal NK, Hasan A, Gorelik J.

J Cardiovasc Dev Dis. 2018 May 3;5(2). pii: E25. doi: 10.3390/jcdd5020025. Review.

7.

Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5.

Ibrahim E, Diakonov I, Arunthavarajah D, Swift T, Goodwin M, McIlvride S, Nikolova V, Williamson C, Gorelik J.

Sci Rep. 2018 May 8;8(1):7110. doi: 10.1038/s41598-018-25569-4.

8.

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik J.

Cell Rep. 2018 Apr 10;23(2):459-469. doi: 10.1016/j.celrep.2018.03.053.

9.

Heart and bile acids - Clinical consequences of altered bile acid metabolism.

Vasavan T, Ferraro E, Ibrahim E, Dixon P, Gorelik J, Williamson C.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1345-1355. doi: 10.1016/j.bbadis.2017.12.039. Epub 2018 Jan 6. Review.

10.

Investigation of cardiac fibroblasts using myocardial slices.

Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C, Dufton NP, Simon A, Sikkel MB, Faggian G, Randi AM, Gorelik J, Harding SE, Terracciano CM.

Cardiovasc Res. 2018 Jan 1;114(1):77-89. doi: 10.1093/cvr/cvx152.

11.

Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis.

Adeyemi O, Alvarez-Laviada A, Schultz F, Ibrahim E, Trauner M, Williamson C, Glukhov AV, Gorelik J.

PLoS One. 2017 Sep 21;12(9):e0183167. doi: 10.1371/journal.pone.0183167. eCollection 2017.

12.

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.

Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik J.

Cardiovasc Res. 2017 Jun 1;113(7):770-782. doi: 10.1093/cvr/cvx074.

13.

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M.

Nat Commun. 2017 Apr 20;8:15031. doi: 10.1038/ncomms15031.

14.

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

Sanchez-Alonso JL, Bhargava A, O'Hara T, Glukhov AV, Schobesberger S, Bhogal N, Sikkel MB, Mansfield C, Korchev YE, Lyon AR, Punjabi PP, Nikolaev VO, Trayanova NA, Gorelik J.

Circ Res. 2016 Sep 30;119(8):944-55. doi: 10.1161/CIRCRESAHA.116.308698. Epub 2016 Aug 29.

15.

Angular Approach Scanning Ion Conductance Microscopy.

Shevchuk A, Tokar S, Gopal S, Sanchez-Alonso JL, Tarasov AI, Vélez-Ortega AC, Chiappini C, Rorsman P, Stevens MM, Gorelik J, Frolenkov GI, Klenerman D, Korchev YE.

Biophys J. 2016 May 24;110(10):2252-65. doi: 10.1016/j.bpj.2016.04.017.

16.

Surface Chemistry and Microtopography of Parylene C Films Control the Morphology and Microtubule Density of Cardiac Myocytes.

Trantidou T, Humphrey EJ, Poulet C, Gorelik J, Prodromakis T, Terracciano CM.

Tissue Eng Part C Methods. 2016 May;22(5):464-72. doi: 10.1089/ten.TEC.2015.0581. Epub 2016 Apr 20.

17.

Erratum: Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.

Leo-Macias A, Agullo-Pascual E, Sanchez-Alonso JL, Keegan S, Lin X, Arcos T, Feng-Xia-Liang, Korchev YE, Gorelik J, Fenyö D, Rothenberg E, Delmar M.

Nat Commun. 2016 Feb 22;7:10919. doi: 10.1038/ncomms10919. No abstract available.

18.

Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis.

Zhang Y, Clausmeyer J, Babakinejad B, Córdoba AL, Ali T, Shevchuk A, Takahashi Y, Novak P, Edwards C, Lab M, Gopal S, Chiappini C, Anand U, Magnani L, Coombes RC, Gorelik J, Matsue T, Schuhmann W, Klenerman D, Sviderskaya EV, Korchev Y.

ACS Nano. 2016 Mar 22;10(3):3214-3221. doi: 10.1021/acsnano.5b05211. Epub 2016 Feb 1.

19.

Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.

Leo-Macias A, Agullo-Pascual E, Sanchez-Alonso JL, Keegan S, Lin X, Arcos T, Feng-Xia-Liang, Korchev YE, Gorelik J, Fenyö D, Rothenberg E, Rothenberg E, Delmar M.

Nat Commun. 2016 Jan 20;7:10342. doi: 10.1038/ncomms10342. Erratum in: Nat Commun. 2016;7:10919. Rothenberg, Eli [Added].

20.

The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts.

Schultz F, Hasan A, Alvarez-Laviada A, Miragoli M, Bhogal N, Wells S, Poulet C, Chambers J, Williamson C, Gorelik J.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):149-63. doi: 10.1016/j.pbiomolbio.2016.01.003. Epub 2016 Jan 8.

21.

Nanoscale, Voltage-Driven Application of Bioactive Substances onto Cells with Organized Topography.

Schobesberger S, Jönsson P, Buzuk A, Korchev Y, Siggers J, Gorelik J.

Biophys J. 2016 Jan 5;110(1):141-6. doi: 10.1016/j.bpj.2015.11.017.

22.

Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes.

Miragoli M, Sanchez-Alonso JL, Bhargava A, Wright PT, Sikkel M, Schobesberger S, Diakonov I, Novak P, Castaldi A, Cattaneo P, Lyon AR, Lab MJ, Gorelik J.

Cell Rep. 2016 Jan 5;14(1):140-151. doi: 10.1016/j.celrep.2015.12.014. Epub 2015 Dec 24.

23.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

24.

Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes.

Glukhov AV, Balycheva M, Sanchez-Alonso JL, Ilkan Z, Alvarez-Laviada A, Bhogal N, Diakonov I, Schobesberger S, Sikkel MB, Bhargava A, Faggian G, Punjabi PP, Houser SR, Gorelik J.

Circulation. 2015 Dec 22;132(25):2372-84. doi: 10.1161/CIRCULATIONAHA.115.018131. Epub 2015 Oct 8.

25.

Studying GPCR/cAMP pharmacology from the perspective of cellular structure.

Wright PT, Schobesberger S, Gorelik J.

Front Pharmacol. 2015 Jul 17;6:148. doi: 10.3389/fphar.2015.00148. eCollection 2015. Review.

26.

Microdomain-specific localization of functional ion channels in cardiomyocytes: an emerging concept of local regulation and remodelling.

Balycheva M, Faggian G, Glukhov AV, Gorelik J.

Biophys Rev. 2015 Mar;7(1):43-62. doi: 10.1007/s12551-014-0159-x. Epub 2015 Jan 15.

27.

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM.

Nat Med. 2014 Jun;20(6):624-32. doi: 10.1038/nm.3543. Epub 2014 May 18.

28.

Side-specific mechanical properties of valve endothelial cells.

Miragoli M, Yacoub MH, El-Hamamsy I, Sanchez-Alonso JL, Moshkov A, Mongkoldhumrongkul N, Padala M, Paramagurunathan S, Sarathchandra P, Korchev YE, Gorelik J, Chester AH.

Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H15-24.

29.

Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.

Götz KR, Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Kuhn M, Gorelik J, Balligand JL, Nikolaev VO.

Circ Res. 2014 Apr 11;114(8):1235-45. doi: 10.1161/CIRCRESAHA.114.302437. Epub 2014 Mar 5.

PMID:
24599804
30.

Imaging single nanoparticle interactions with human lung cells using fast ion conductance microscopy.

Novak P, Shevchuk A, Ruenraroengsak P, Miragoli M, Thorley AJ, Klenerman D, Lab MJ, Tetley TD, Gorelik J, Korchev YE.

Nano Lett. 2014 Mar 12;14(3):1202-7. doi: 10.1021/nl404068p. Epub 2014 Feb 24.

PMID:
24555574
31.

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J.

J Mol Cell Cardiol. 2014 Feb;67:38-48. doi: 10.1016/j.yjmcc.2013.12.003. Epub 2013 Dec 15.

32.

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels.

Novak P, Gorelik J, Vivekananda U, Shevchuk AI, Ermolyuk YS, Bailey RJ, Bushby AJ, Moss GW, Rusakov DA, Klenerman D, Kullmann DM, Volynski KE, Korchev YE.

Neuron. 2013 Sep 18;79(6):1067-77. doi: 10.1016/j.neuron.2013.07.012.

33.

Recording single-channel currents using "smart patch-clamp" technique.

Bhargava A, Gorelik J.

Methods Mol Biol. 2013;998:189-97. doi: 10.1007/978-1-62703-351-0_14.

PMID:
23529430
34.

Super-resolution scanning patch clamp reveals clustering of functional ion channels in adult ventricular myocyte.

Bhargava A, Lin X, Novak P, Mehta K, Korchev Y, Delmar M, Gorelik J.

Circ Res. 2013 Apr 12;112(8):1112-1120. doi: 10.1161/CIRCRESAHA.111.300445. Epub 2013 Feb 25.

35.

Spatial control of the βAR system in heart failure: the transverse tubule and beyond.

Gorelik J, Wright PT, Lyon AR, Harding SE.

Cardiovasc Res. 2013 May 1;98(2):216-24. doi: 10.1093/cvr/cvt005. Epub 2013 Jan 23. Review.

36.

Functional interaction between charged nanoparticles and cardiac tissue: a new paradigm for cardiac arrhythmia?

Miragoli M, Novak P, Ruenraroengsak P, Shevchuk AI, Korchev YE, Lab MJ, Tetley TD, Gorelik J.

Nanomedicine (Lond). 2013 May;8(5):725-737. doi: 10.2217/nnm.12.125. Epub 2012 Nov 12.

37.

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart.

Ibrahim M, Siedlecka U, Buyandelger B, Harada M, Rao C, Moshkov A, Bhargava A, Schneider M, Yacoub MH, Gorelik J, Knöll R, Terracciano CM.

Hum Mol Genet. 2013 Jan 15;22(2):372-83. doi: 10.1093/hmg/dds434. Epub 2012 Oct 25.

38.

The scanning ion conductance microscope for cellular physiology.

Lab MJ, Bhargava A, Wright PT, Gorelik J.

Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H1-11. doi: 10.1152/ajpheart.00499.2012. Epub 2012 Oct 19. Review.

39.

Cardiomyocyte Ca2+ handling and structure is regulated by degree and duration of mechanical load variation.

Ibrahim M, Kukadia P, Siedlecka U, Cartledge JE, Navaratnarajah M, Tokar S, Van Doorn C, Tsang VT, Gorelik J, Yacoub MH, Terracciano CM.

J Cell Mol Med. 2012 Dec;16(12):2910-8. doi: 10.1111/j.1582-4934.2012.01611.x.

40.

High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy.

Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SE.

Circulation. 2012 Aug 7;126(6):697-706. doi: 10.1161/CIRCULATIONAHA.112.111591. Epub 2012 Jun 25.

41.

Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy.

Takahashi Y, Shevchuk AI, Novak P, Babakinejad B, Macpherson J, Unwin PR, Shiku H, Gorelik J, Klenerman D, Korchev YE, Matsue T.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11540-5. doi: 10.1073/pnas.1203570109. Epub 2012 May 18.

42.

An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy.

Shevchuk AI, Novak P, Taylor M, Diakonov IA, Ziyadeh-Isleem A, Bitoun M, Guicheney P, Lab MJ, Gorelik J, Merrifield CJ, Klenerman D, Korchev YE.

J Cell Biol. 2012 May 14;197(4):499-508. doi: 10.1083/jcb.201109130. Epub 2012 May 7.

43.

Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca(2+)-induced Ca(2+)release in a rodent model of heart failure.

Ibrahim M, Navaratnarajah M, Siedlecka U, Rao C, Dias P, Moshkov AV, Gorelik J, Yacoub MH, Terracciano CM.

Eur J Heart Fail. 2012 Jun;14(6):571-80. doi: 10.1093/eurjhf/hfs038. Epub 2012 Apr 1.

44.

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure.

Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J.

Circ Heart Fail. 2012 May 1;5(3):357-65. doi: 10.1161/CIRCHEARTFAILURE.111.964692. Epub 2012 Mar 28.

45.

Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study.

Potter CM, Schobesberger S, Lundberg MH, Weinberg PD, Mitchell JA, Gorelik J.

PLoS One. 2012;7(2):e31228. doi: 10.1371/journal.pone.0031228. Epub 2012 Feb 16.

46.

Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices.

Weber B, Schoenauer R, Papadopulos F, Modregger P, Peter S, Stampanoni M, Mauri A, Mazza E, Gorelik J, Agarkova I, Frese L, Breymann C, Kretschmar O, Hoerstrup SP.

Biomaterials. 2011 Dec;32(36):9630-41. doi: 10.1016/j.biomaterials.2011.07.070. Epub 2011 Oct 5.

PMID:
21978890
47.

A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart.

Miragoli M, Kadir SH, Sheppard MN, Salvarani N, Virta M, Wells S, Lab MJ, Nikolaev VO, Moshkov A, Hague WM, Rohr S, Williamson C, Gorelik J.

Hepatology. 2011 Oct;54(4):1282-92. doi: 10.1002/hep.24492. Epub 2011 Aug 1.

48.

The structure and function of cardiac t-tubules in health and disease.

Ibrahim M, Gorelik J, Yacoub MH, Terracciano CM.

Proc Biol Sci. 2011 Sep 22;278(1719):2714-23. doi: 10.1098/rspb.2011.0624. Epub 2011 Jun 22. Review.

49.

Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy.

Williamson C, Miragoli M, Sheikh Abdul Kadir S, Abu-Hayyeh S, Papacleovoulou G, Geenes V, Gorelik J.

Dig Dis. 2011;29(1):58-61. doi: 10.1159/000324130. Epub 2011 Jun 17. Review.

PMID:
21691106
50.

Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe.

Shevchuk AI, Novak P, Takahashi Y, Clarke R, Miragoli M, Babakinejad B, Gorelik J, Korchev YE, Klenerman D.

Nanomedicine (Lond). 2011 Apr;6(3):565-75. doi: 10.2217/nnm.10.154.

PMID:
21542692

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