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Items: 1 to 50 of 119

1.

Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.

Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J.

Cell Mol Life Sci. 2019 Jul 30. doi: 10.1007/s00018-019-03254-7. [Epub ahead of print]

PMID:
31363815
2.

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.

Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A.

Nat Genet. 2019 Aug;51(8):1233-1243. doi: 10.1038/s41588-019-0470-3. Epub 2019 Jul 29.

PMID:
31358993
3.

Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer.

Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC.

Pancreas. 2019 Jul;48(6):759-779. doi: 10.1097/MPA.0000000000001335.

PMID:
31206467
4.

Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.

Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I.

Pancreas. 2019 Apr;48(4):459-470. doi: 10.1097/MPA.0000000000001298. Review.

PMID:
30973461
5.

Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice.

Alahmari AA, Sreekumar B, Patel V, Ashat M, Alexandre M, Uduman AK, Akinbiyi EO, Ceplenski A, Shugrue CA, Kolodecik TR, Tashkandi N, Messenger SW, Groblewski GE, Gorelick FS, Thrower EC.

PLoS One. 2018 Jun 5;13(6):e0197362. doi: 10.1371/journal.pone.0197362. eCollection 2018.

6.

Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.

Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z Jr, Gukovsky I, Gukovskaya AS.

Gastroenterology. 2018 Feb;154(3):689-703. doi: 10.1053/j.gastro.2017.10.012. Epub 2017 Oct 23.

7.

The serum protein renalase reduces injury in experimental pancreatitis.

Kolodecik TR, Reed AM, Date K, Shugrue CA, Patel V, Chung SL, Desir GV, Gorelick FS.

J Biol Chem. 2017 Dec 22;292(51):21047-21059. doi: 10.1074/jbc.M117.789776. Epub 2017 Oct 17.

8.

Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.

Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ.

Am J Pathol. 2017 Dec;187(12):2726-2743. doi: 10.1016/j.ajpath.2017.08.017. Epub 2017 Sep 19.

9.

Do Animal Models of Acute Pancreatitis Reproduce Human Disease?

Gorelick FS, Lerch MM.

Cell Mol Gastroenterol Hepatol. 2017 Jun 10;4(2):251-262. doi: 10.1016/j.jcmgh.2017.05.007. eCollection 2017 Sep. Review.

10.

Bidirectional regulation of Aβ levels by Presenilin 1.

Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22.

11.

Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.

Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7148-7153. doi: 10.1073/pnas.1705240114. Epub 2017 May 22.

12.

Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar.

Chung C, Gorelick FS.

Cell Mol Gastroenterol Hepatol. 2016 May 24;2(4):405-406. doi: 10.1016/j.jcmgh.2016.05.002. eCollection 2016 Jul. No abstract available.

13.

Advances in pancreatology: 2016.

Gorelick FS.

Curr Opin Gastroenterol. 2016 Sep;32(5):392-393. doi: 10.1097/MOG.0000000000000299. No abstract available.

14.

Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Srinivasan P, Thrower EC, Gorelick FS, Said HM.

Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G874-83. doi: 10.1152/ajpgi.00461.2015. Epub 2016 Mar 17.

15.

Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells.

Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said HM.

PLoS One. 2015 Dec 3;10(12):e0143575. doi: 10.1371/journal.pone.0143575. eCollection 2015.

16.

Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.

Messenger SW, Thomas DD, Cooley MM, Jones EK, Falkowski MA, August BK, Fernandez LA, Gorelick FS, Groblewski GE.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):695-709.

17.

Low pH enhances connexin32 degradation in the pancreatic acinar cell.

Reed AM, Kolodecik T, Husain SZ, Gorelick FS.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G24-32. doi: 10.1152/ajpgi.00010.2014. Epub 2014 May 8.

18.

Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.

Messenger SW, Thomas DD, Falkowski MA, Byrne JA, Gorelick FS, Groblewski GE.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 15;305(6):G439-52. doi: 10.1152/ajpgi.00143.2013. Epub 2013 Jul 18.

19.

Models of acute and chronic pancreatitis.

Lerch MM, Gorelick FS.

Gastroenterology. 2013 Jun;144(6):1180-93. doi: 10.1053/j.gastro.2012.12.043. Review.

PMID:
23622127
20.

Calcium ameliorates diarrhea in immunocompromised children.

Cheng SX, Bai HX, Gonzalez-Peralta R, Mistry PK, Gorelick FS.

J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):641-4. doi: 10.1097/MPG.0b013e3182868946.

21.

Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS.

PLoS One. 2012;7(7):e41320. doi: 10.1371/journal.pone.0041320. Epub 2012 Jul 23.

22.

Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses.

Alexandre M, Uduman AK, Minervini S, Raoof A, Shugrue CA, Akinbiyi EO, Patel V, Shitia M, Kolodecik TR, Patton R, Gorelick FS, Thrower EC.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G696-704. doi: 10.1152/ajpgi.00138.2012. Epub 2012 Jul 26.

23.

Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

Shugrue CA, Alexandre M, Diaz de Villalvilla A, Kolodecik TR, Young LH, Gorelick FS, Thrower EC.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G723-32. doi: 10.1152/ajpgi.00082.2012. Epub 2012 Jul 19.

24.

The emerging role of smoking in the development of pancreatitis.

Alexandre M, Pandol SJ, Gorelick FS, Thrower EC.

Pancreatology. 2011;11(5):469-74. doi: 10.1159/000332196. Epub 2011 Oct 5. Review.

25.

Environmental and genetic stressors and the unfolded protein response in exocrine pancreatic function - a hypothesis.

Pandol SJ, Gorelick FS, Lugea A.

Front Physiol. 2011 Mar 10;2:8. doi: 10.3389/fphys.2011.00008. eCollection 2011.

26.

Investigating the pathobiology of alcoholic pancreatitis.

Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS, Gukovsky I.

Alcohol Clin Exp Res. 2011 May;35(5):830-7. doi: 10.1111/j.1530-0277.2010.01408.x. Epub 2011 Feb 1. Review.

27.

Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage.

Lugea A, Tischler D, Nguyen J, Gong J, Gukovsky I, French SW, Gorelick FS, Pandol SJ.

Gastroenterology. 2011 Mar;140(3):987-97. doi: 10.1053/j.gastro.2010.11.038. Epub 2010 Nov 25.

28.

Low extracellular pH induces damage in the pancreatic acinar cell by enhancing calcium signaling.

Reed AM, Husain SZ, Thrower E, Alexandre M, Shah A, Gorelick FS, Nathanson MH.

J Biol Chem. 2011 Jan 21;286(3):1919-26. doi: 10.1074/jbc.M110.158329. Epub 2010 Nov 17.

29.

Molecular and cellular mechanisms of pancreatic injury.

Thrower EC, Gorelick FS, Husain SZ.

Curr Opin Gastroenterol. 2010 Sep;26(5):484-9. doi: 10.1097/MOG.0b013e32833d119e. Review.

30.

Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits.

Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, Buse JB.

Diabetes Care. 2010 Feb;33(2):428-33. doi: 10.2337/dc09-1499. No abstract available.

31.

Alcohol abuse, endoplasmic reticulum stress and pancreatitis.

Pandol SJ, Gorelick FS, Gerloff A, Lugea A.

Dig Dis. 2010;28(6):776-82. doi: 10.1159/000327212. Epub 2011 Apr 27. Review.

32.

The acinar cell and early pancreatitis responses.

Gorelick FS, Thrower E.

Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S10-4. doi: 10.1016/j.cgh.2009.07.036.

33.

Inflammation and carcinogenesis in the pancreas and biliary tract: mechanisms and practice.

Shimosegawa T, Gorelick FS.

Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S1-2. doi: 10.1016/j.cgh.2009.08.021. No abstract available.

PMID:
19896089
34.

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.

Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya AS.

J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1. Erratum in: J Clin Invest. 2013 Apr 1;123(4)1844.

35.

Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini.

Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr, Gorelick FS, Pandol SJ.

Pancreas. 2009 Nov;38(8):930-5. doi: 10.1097/MPA.0b013e3181b8476a.

36.

Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats.

Bhoomagoud M, Jung T, Atladottir J, Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC, Gorelick FS.

Gastroenterology. 2009 Sep;137(3):1083-92. doi: 10.1053/j.gastro.2009.05.041. Epub 2009 May 18.

37.

New insights into the mechanisms of pancreatitis.

Gaisano HY, Gorelick FS.

Gastroenterology. 2009 Jun;136(7):2040-4. doi: 10.1053/j.gastro.2009.04.023. Epub 2009 Apr 18. Review. No abstract available.

PMID:
19379751
38.

The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells.

Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr, Pandol SJ, Gorelick FS.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1344-53. doi: 10.1152/ajpgi.00020.2008. Epub 2008 Apr 3.

39.

Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin.

Husain SZ, Grant WM, Gorelick FS, Nathanson MH, Shah AU.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1594-9. Epub 2007 Mar 1.

40.

Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini.

Chaudhuri A, Husain SZ, Kolodecik TR, Grant WM, Gorelick FS.

Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1403-10. Epub 2007 Jan 18.

41.

Acute pancreatitis.

Nagar AB, Gorelick FS.

Curr Opin Gastroenterol. 2002 Sep;18(5):552-7.

PMID:
17033332
42.

Vacuolar adenosine triphosphatase and pancreatic acinar cell function.

Gorelick FS, Shugrue CA, Kolodecik TR, Thrower EC.

J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S18-21. Review.

PMID:
16958663
43.

The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle.

Siddiqi SA, Siddiqi S, Mahan J, Peggs K, Gorelick FS, Mansbach CM 2nd.

J Biol Chem. 2006 Jul 28;281(30):20974-82. Epub 2006 May 30.

44.

Vesicle-associated membrane protein 7 is expressed in intestinal ER.

Siddiqi SA, Mahan J, Siddiqi S, Gorelick FS, Mansbach CM 2nd.

J Cell Sci. 2006 Mar 1;119(Pt 5):943-50.

45.

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1941-6. Epub 2006 Jan 31.

46.

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. Epub 2006 Jan 31.

47.

Zymogen activation in a reconstituted pancreatic acinar cell system.

Thrower EC, Diaz de Villalvilla AP, Kolodecik TR, Gorelick FS.

Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G894-902. Epub 2005 Dec 8.

48.

Effects of pancreatic duct ligation on pancreatic response to bombesin.

Otani T, Matsukura A, Takamoto T, Seyama Y, Shimizu Y, Shinomiya M, Usui H, Gorelick FS, Makuuchi M.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G633-9. Epub 2005 Nov 17.

49.

The ryanodine receptor mediates early zymogen activation in pancreatitis.

Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14386-91. Epub 2005 Sep 26.

50.

Presentation of the AGA Distinguished Achievement Award to Henry J. Binder, MD.

Anderson JM, Gorelick FS, Nathanson MH.

Gastroenterology. 2005 Jun;128(7):2147-51. No abstract available.

PMID:
15940645

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