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Items: 1 to 50 of 211

1.

Multigene Biomarkers of Pyrethroid Exposure: Exploratory Experiments.

Kostich MS, Bencic DC, Batt AL, See MJ, Flick RW, Gordon DA, Lazorchak JM, Biales AD.

Environ Toxicol Chem. 2019 Nov;38(11):2436-2446. doi: 10.1002/etc.4552. Epub 2019 Oct 3.

PMID:
31365144
2.

Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

Li J, Kennedy LJ, Walker SJ, Wang H, Li JJ, Hong Z, O'Connor SP, Ye XY, Chen S, Wu S, Yoon DS, Nayeem A, Camac DM, Ramamurthy V, Morin PE, Sheriff S, Wang M, Harper TW, Golla R, Seethala R, Harrity T, Ponticiello RP, Morgan NN, Taylor JR, Zebo R, Maxwell B, Moulin F, Gordon DA, Robl JA.

ACS Med Chem Lett. 2018 Nov 13;9(12):1170-1174. doi: 10.1021/acsmedchemlett.8b00307. eCollection 2018 Dec 13.

PMID:
30613321
3.

Multivariate multiple regression models of poly(ethylene-terephthalate) film degradation under outdoor and multi-stressor accelerated weathering exposures.

Gordon DA, Huang WH, Burns DM, French RH, Bruckman LS.

PLoS One. 2018 Dec 20;13(12):e0209016. doi: 10.1371/journal.pone.0209016. eCollection 2018.

4.

Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.

Duclos F, Abell LM, Harden DG, Pike K, Nowak K, Locke GA, Duke GJ, Liu X, Fernando G, Shaw SA, Vokits BP, Wurtz NR, Viet A, Valente MN, Stachura S, Sleph P, Khan JA, Gao J, Dongre AR, Zhao L, Wexler RR, Gordon DA, Kick EK.

Medchemcomm. 2017 Oct 26;8(11):2093-2099. doi: 10.1039/c7md00268h. eCollection 2017 Nov 1.

5.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

Hangeland JJ, Abell LM, Adam LP, Jiang J, Friends TJ, Haque LE, Neels J, Onorato JM, Chen AYA, Taylor DS, Yin X, Harrity TW, Basso MD, Yang R, Sleph PG, Gordon DA, Huang CS, Wexler RR, Finlay HJ, Lawrence RM.

ACS Med Chem Lett. 2018 Jun 15;9(7):673-678. doi: 10.1021/acsmedchemlett.8b00138. eCollection 2018 Jul 12.

6.

Mini-Review: Stemflow as a Resource Limitation to Near-Stem Soils.

Van Stan JT, Gordon DA.

Front Plant Sci. 2018 Feb 27;9:248. doi: 10.3389/fpls.2018.00248. eCollection 2018. Review.

7.

Self-Assembling Cyclic d,l-α-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents.

Zhao Y, Leman LJ, Search DJ, Garcia RA, Gordon DA, Maryanoff BE, Ghadiri MR.

ACS Cent Sci. 2017 Jun 28;3(6):639-646. doi: 10.1021/acscentsci.7b00154. Epub 2017 Jun 13.

8.

Tools to minimize interlaboratory variability in vitellogenin gene expression monitoring programs.

Jastrow A, Gordon DA, Auger KM, Punska EC, Arcaro KF, Keteles K, Winkelman D, Lattier D, Biales A, Lazorchak JM.

Environ Toxicol Chem. 2017 Nov;36(11):3102-3107. doi: 10.1002/etc.3885. Epub 2017 Aug 14.

9.

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.

Ye XY, Chen SY, Wu S, Yoon DS, Wang H, Hong Z, O'Connor SP, Li J, Li JJ, Kennedy LJ, Walker SJ, Nayeem A, Sheriff S, Camac DM, Ramamurthy V, Morin PE, Zebo R, Taylor JR, Morgan NN, Ponticiello RP, Harrity T, Apedo A, Golla R, Seethala R, Wang M, Harper TW, Sleczka BG, He B, Kirby M, Leahy DK, Li J, Hanson RL, Guo Z, Li YX, DiMarco JD, Scaringe R, Maxwell B, Moulin F, Barrish JC, Gordon DA, Robl JA.

J Med Chem. 2017 Jun 22;60(12):4932-4948. doi: 10.1021/acs.jmedchem.7b00211. Epub 2017 Jun 5.

PMID:
28537398
10.

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294.

PMID:
28053157
11.

Initial development of a multigene 'omics-based exposure biomarker for pyrethroid pesticides.

Biales AD, Kostich MS, Batt AL, See MJ, Flick RW, Gordon DA, Lazorchak JM, Bencic DC.

Aquat Toxicol. 2016 Oct;179:27-35. doi: 10.1016/j.aquatox.2016.08.004. Epub 2016 Aug 12.

PMID:
27564377
12.

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME.

J Med Chem. 2015 Nov 25;58(22):9010-26. doi: 10.1021/acs.jmedchem.5b01363. Epub 2015 Nov 17.

PMID:
26524347
13.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM.

Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10.

14.

P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.

Garcia RA, Yan M, Search D, Zhang R, Carson NL, Ryan CS, Smith-Monroy C, Zheng J, Chen J, Kong Y, Tang H, Hellings SE, Wardwell-Swanson J, Dinchuk JE, Psaltis GC, Gordon DA, Glunz PW, Gargalovic PS.

PLoS One. 2014 Oct 31;9(10):e111385. doi: 10.1371/journal.pone.0111385. eCollection 2014.

15.

Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders.

Yoon DS, Wu SC, Seethala R, Golla R, Nayeem A, Everlof JG, Gordon DA, Hamann LG, Robl JA.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5045-9. doi: 10.1016/j.bmcl.2014.09.012. Epub 2014 Sep 16.

PMID:
25266782
16.

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

Li J, Kennedy LJ, Wang H, Li JJ, Walker SJ, Hong Z, O'Connor SP, Nayeem A, Camac DM, Morin PE, Sheriff S, Wang M, Harper T, Golla R, Seethala R, Harrity T, Ponticiello RP, Morgan NN, Taylor JR, Zebo R, Gordon DA, Robl JA.

ACS Med Chem Lett. 2014 May 22;5(7):803-8. doi: 10.1021/ml500144h. eCollection 2014 Jul 10.

17.

Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

Ye XY, Yoon D, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Apedo A, Li YX, He B, Kirby M, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):654-60. doi: 10.1016/j.bmcl.2013.11.066. Epub 2013 Dec 5.

PMID:
24360604
18.

A new approach for the laboratory culture of the fathead minnow, Pimephales promelas.

Gordon DA, Smith ME, Wratschko M, Agard D, Holden L, Wilcox S, Lazorchak JM.

Environ Toxicol Chem. 2014 Jan;33(1):126-33. doi: 10.1002/etc.2396. Epub 2013 Nov 5.

PMID:
24115165
19.

Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.

Arcari JT, Beebe JS, Berliner MA, Bernardo V, Boehm M, Borzillo GV, Clark T, Cohen BD, Connell RD, Frost HN, Gordon DA, Hungerford WM, Kakar SM, Kanter A, Keene NF, Knauth EA, Lagreca SD, Lu Y, Martinez-Alsina L, Marx MA, Morris J, Patel NC, Savage D, Soderstrom CI, Thompson C, Tkalcevic G, Tom NJ, Vajdos FF, Valentine JJ, Vincent PW, Wessel MD, Chen JM.

Bioorg Med Chem Lett. 2013 May 15;23(10):3059-63. doi: 10.1016/j.bmcl.2013.03.012. Epub 2013 Mar 21.

PMID:
23566514
20.

Molecular cloning, expression, and hormonal regulation of the chicken microsomal triglyceride transfer protein.

Ivessa NE, Rehberg E, Kienzle B, Seif F, Hermann R, Hermann M, Schneider WJ, Gordon DA.

Gene. 2013 Jul 1;523(1):1-9. doi: 10.1016/j.gene.2013.03.102. Epub 2013 Mar 29.

PMID:
23542778
21.

11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice.

García RA, Search DJ, Lupisella JA, Ostrowski J, Guan B, Chen J, Yang WP, Truong A, He A, Zhang R, Yan M, Hellings SE, Gargalovic PS, Ryan CS, Watson LM, Langish RA, Shipkova PA, Carson NL, Taylor JR, Yang R, Psaltis GC, Harrity TW, Robl JA, Gordon DA.

PLoS One. 2013;8(2):e53192. doi: 10.1371/journal.pone.0053192. Epub 2013 Feb 1.

22.

Assessing impacts of land-applied manure from concentrated animal feeding operations on fish populations and communities.

Leet JK, Lee LS, Gall HE, Goforth RR, Sassman S, Gordon DA, Lazorchak JM, Smith ME, Jafvert CT, Sepúlveda MS.

Environ Sci Technol. 2012 Dec 18;46(24):13440-7. doi: 10.1021/es302599t. Epub 2012 Dec 4. Erratum in: Environ Sci Technol. 2013 Mar 5;47(5):2431. Javfert, Chad T [corrected to Jafvert, Chad T].

PMID:
23171355
23.

Incidence of bilateral scapholunate dissociation in symptomatic and asymptomatic wrists.

Picha BM, Konstantakos EK, Gordon DA.

J Hand Surg Am. 2012 Jun;37(6):1130-5. doi: 10.1016/j.jhsa.2012.03.020. Epub 2012 May 1.

PMID:
22551952
24.

Atypical mycobacterial brain abscess presenting as a spindle cell lesion in an immunocompetent patient.

Arkun K, Gordon DA, Lincoln C, Levi M, Bello J, Keller CE, Weidenheim KM.

Clin Neuropathol. 2012 May-Jun;31(3):155-8. No abstract available.

25.

Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1).

Wu SC, Yoon D, Chin J, van Kirk K, Seethala R, Golla R, He B, Harrity T, Kunselman LK, Morgan NN, Ponticiello RP, Taylor JR, Zebo R, Harper TW, Li W, Wang M, Zhang L, Sleczka BG, Nayeem A, Sheriff S, Camac DM, Morin PE, Everlof JG, Li YX, Ferraro CA, Kieltyka K, Shou W, Vath MB, Zvyaga TA, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6693-8. doi: 10.1016/j.bmcl.2011.09.058. Epub 2011 Sep 21.

PMID:
21983444
26.

Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

Ye XY, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Li YX, He B, Kirby M, Gordon DA, Robl JA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6699-704. doi: 10.1016/j.bmcl.2011.09.055. Epub 2011 Sep 21.

PMID:
21983439
27.

Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).

Wang H, Robl JA, Hamann LG, Simpkins L, Golla R, Li YX, Seethala R, Zvyaga T, Gordon DA, Li JJ.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4146-9. doi: 10.1016/j.bmcl.2011.05.101.

PMID:
21689935
28.

A more rapid publication process.

Pigott Y, Gordon DA.

J Rheumatol. 2011 Jan;38(1):1-2. doi: 10.3899/jrheum.100998. No abstract available.

PMID:
21196580
29.

Philip Hench, a Nobel link in the evolution of the Canada Gairdner International Awards.

Gordon DA, Anastassiades T.

J Rheumatol. 2010 Jan;37(1):195-8. doi: 10.3899/jrheum.091047. No abstract available.

PMID:
20040640
30.

Development of a simulated round of golf.

Hayes PR, van Paridon K, French DN, Thomas K, Gordon DA.

Int J Sports Physiol Perform. 2009 Dec;4(4):506-16.

PMID:
20029101
31.

Enhanced gastrointestinal motility with orally active ghrelin receptor agonists.

Charoenthongtrakul S, Giuliana D, Longo KA, Govek EK, Nolan A, Gagne S, Morgan K, Hixon J, Flynn N, Murphy BJ, Hernández AS, Li J, Tino JA, Gordon DA, DiStefano PS, Geddes BJ.

J Pharmacol Exp Ther. 2009 Jun;329(3):1178-86. doi: 10.1124/jpet.108.150193. Epub 2009 Feb 27.

PMID:
19252061
32.

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).

Zhai W, Flynn N, Longhi DA, Tino JA, Murphy BJ, Slusarchyk D, Gordon DA, Pendri A, Shi S, Stoffel R, Ma B, Sofia MJ, Gerritz SW.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5083-6. doi: 10.1016/j.bmcl.2008.07.120. Epub 2008 Aug 3.

PMID:
18722770
33.

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

Wang H, Ruan Z, Li JJ, Simpkins LM, Smirk RA, Wu SC, Hutchins RD, Nirschl DS, Van Kirk K, Cooper CB, Sutton JC, Ma Z, Golla R, Seethala R, Salyan ME, Nayeem A, Krystek SR Jr, Sheriff S, Camac DM, Morin PE, Carpenter B, Robl JA, Zahler R, Gordon DA, Hamann LG.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3168-72. doi: 10.1016/j.bmcl.2008.04.069. Epub 2008 May 1.

PMID:
18485702
34.

Relationships between improvements in symptoms and patient assessments of bladder condition, symptom bother and health-related quality of life in patients with overactive bladder treated with tolterodine.

Coyne KS, Elinoff V, Gordon DA, Deng DY, Brodsky M, Glasser DB, Jumadilova Z, Carlsson M.

Int J Clin Pract. 2008 Jun;62(6):925-31. doi: 10.1111/j.1742-1241.2008.01778.x.

PMID:
18479285
35.

Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

Liu J, Prudom CE, Nass R, Pezzoli SS, Oliveri MC, Johnson ML, Veldhuis P, Gordon DA, Howard AD, Witcher DR, Geysen HM, Gaylinn BD, Thorner MO.

J Clin Endocrinol Metab. 2008 May;93(5):1980-7. doi: 10.1210/jc.2007-2235. Epub 2008 Mar 18.

36.

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

Hernández AS, Swartz SG, Slusarchyk D, Yan M, Seethala RK, Sleph P, Grover G, Dickinson K, Giupponi L, Harper TW, Humphreys WG, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA, Robl JA, Tino JA.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2067-72. doi: 10.1016/j.bmcl.2008.01.100. Epub 2008 Jan 31.

PMID:
18282707
37.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

Hernández AS, Cheng PT, Musial CM, Swartz SG, George RJ, Grover G, Slusarchyk D, Seethala RK, Smith M, Dickinson K, Giupponi L, Longhi DA, Flynn N, Murphy BJ, Gordon DA, Biller SA, Robl JA, Tino JA.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5928-33. Epub 2007 Aug 23.

PMID:
17869100
38.

Cofactor-specific modulation of 11beta-hydroxysteroid dehydrogenase 1 inhibitor potency.

Sahni-Arya B, Flynn MJ, Bergeron L, Salyan ME, Pedicord DL, Golla R, Ma Z, Wang H, Seethala R, Wu SC, Li JJ, Nayeem A, Gates C, Hamann LG, Gordon DA, Blat Y.

Biochim Biophys Acta. 2007 Sep;1774(9):1184-91. Epub 2007 Jul 19.

PMID:
17707701
39.

Effects of eutrophication on vitellogenin gene expression in male fathead minnows (Pimephales promelas) exposed to 17alpha-ethynylestradiol in field mesocosms.

Gordon DA, Toth GP, Graham DW, Lazorchak JM, Reddy TV, Knapp CW, deNoyelles F Jr, Campbell S, Lattier DL.

Environ Pollut. 2006 Aug;142(3):559-66. Epub 2006 Jan 18.

PMID:
16413089
40.

Obvious radiographic scapholunate dissociation: X-ray the other wrist.

Vitello W, Gordon DA.

Am J Orthop (Belle Mead NJ). 2005 Jul;34(7):347-51.

PMID:
16130354
41.

Responses of molecular indicators of exposure in mesocosms: common carp (Cyprinus carpio) exposed to the herbicides alachlor and atrazine.

Chang LW, Toth GP, Gordon DA, Graham DW, Meier JR, Knapp CW, deNoyelles FJ Jr, Campbell S, Lattier DL.

Environ Toxicol Chem. 2005 Jan;24(1):190-7.

PMID:
15683183
42.

Discovery of a potent and novel motilin agonist.

Li JJ, Chao HG, Wang H, Tino JA, Lawrence RM, Ewing WR, Ma Z, Yan M, Slusarchyk D, Seethala R, Sun H, Li D, Burford NT, Stoffel RH, Salyan ME, Li CY, Witkus M, Zhao N, Rich A, Gordon DA.

J Med Chem. 2004 Mar 25;47(7):1704-8.

PMID:
15027861
43.

Medical publication ethics.

Gordon DA.

J Rheumatol. 2003 Aug;30(8):1851-6. No abstract available.

PMID:
12913946
44.

Fibromyalgia--real or imagined?

Gordon DA.

J Rheumatol. 2003 Aug;30(8):1665. Review. No abstract available.

PMID:
12913917
45.

17alpha-ethynylestradiol-induced vitellogenin gene transcription quantified in livers of adult males, larvae, and gills of fathead minnows (Pimephales promelas).

Lattier DL, Reddy TV, Gordon DA, Lazorchak JM, Smith ME, Williams DE, Wiechman B, Flick RW, Miracle AL, Toth GP.

Environ Toxicol Chem. 2002 Nov;21(11):2385-93.

PMID:
12389918
46.

Origin and Phylogeny of Microbes Living in Permanent Antarctic Lake Ice.

Gordon DA, Priscu J, Giovannoni S.

Microb Ecol. 2000 Apr;39(3):197-202.

PMID:
12035096
47.

Use of molecular markers to study the effects of environmental impacts on genetic diversity in brown bullhead (Ameirus nebulosus) populations.

Silbiger RN, Leonard AC, Dimsoski P, Foré S, Guttman SI, Roth AC, Gordon DA, Wessendarp T, Toth GP, Smith MK.

Environ Toxicol Chem. 2001 Nov;20(11):2580-7.

PMID:
11699785
48.

Vitellogenin gene transcription: a relative quantitative exposure indicator of environmental estrogens.

Lattier DL, Gordon DA, Burks DJ, Toth GP.

Environ Toxicol Chem. 2001 Sep;20(9):1979-85.

PMID:
11521824
49.

Wallace Graham--a life in Canadian rheumatology.

Gordon DA, Inman RD.

J Rheumatol. 2000 Jul;27(7):1590-1. No abstract available.

PMID:
10914837
50.

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