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Items: 49

1.

Silica-Supported Molybdenum Oxo Alkylidenes: Bridging the Gap between Internal and Terminal Olefin Metathesis.

Pucino M, Zhai F, Gordon CP, Mance D, Hoveyda AH, Schrock RR, Copéret C.

Angew Chem Int Ed Engl. 2019 May 17. doi: 10.1002/anie.201903325. [Epub ahead of print]

PMID:
31099940
2.

Alkyne gem-Hydrogenation: Formation of Pianostool Ruthenium Carbene Complexes and Analysis of Their Chemical Character.

Biberger T, Gordon CP, Leutzsch M, Peil S, Guthertz A, Copéret C, Fürstner A.

Angew Chem Int Ed Engl. 2019 Jun 24;58(26):8845-8850. doi: 10.1002/anie.201904255. Epub 2019 May 17.

PMID:
31025788
3.

Chemical Shift Tensors - Why Should We Care?

Gordon CP, Copéret C.

Chimia (Aarau). 2019 Apr 24;73(4):252-256. doi: 10.2533/chimia.2019.252.

PMID:
30975252
4.

Synthesis and Cytotoxicity of Octahydroepoxyisoindole-7-carboxylic Acids and Norcantharidin-Amide Hybrids as Norcantharidin Analogues.

Hizartzidis L, Gilbert J, Gordon CP, Sakoff JA, McCluskey A.

ChemMedChem. 2019 Jun 18;14(12):1152-1161. doi: 10.1002/cmdc.201900180. Epub 2019 May 14.

PMID:
30938091
5.

Oxygen transfer in electrophilic epoxidation probed by 17O NMR: differentiating between oxidants and role of spectator metal oxo.

Ehinger C, Gordon CP, Copéret C.

Chem Sci. 2018 Dec 3;10(6):1786-1795. doi: 10.1039/c8sc04868a. eCollection 2019 Feb 14.

6.

Corrigendum: Promoting Terminal Olefin Metathesis with a Supported Cationic Molybdenum Imido Alkylidene N-Heterocyclic Carbene Catalyst.

Pucino M, Inoue M, Gordon CP, Schowner R, Stöhr L, Sen S, Hegedüs C, Robé E, Tóth F, Buchmeiser MR, Copéret C.

Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16593. doi: 10.1002/anie.201812451. Epub 2018 Nov 16. No abstract available.

PMID:
30548132
7.

Correction to "Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes".

Engl PS, Santiago CB, Gordon CP, Liao WC, Fedorov A, Copéret C, Sigman MS, Togni A.

J Am Chem Soc. 2018 Dec 26;140(51):18227-18228. doi: 10.1021/jacs.8b12730. Epub 2018 Dec 13. No abstract available.

PMID:
30543408
8.

π-Bond Character in Metal-Alkyl Compounds for C-H Activation: How, When, and Why?

Gordon CP, Culver DB, Conley MP, Eisenstein O, Andersen RA, Copéret C.

J Am Chem Soc. 2019 Jan 9;141(1):648-656. doi: 10.1021/jacs.8b11951. Epub 2018 Dec 26.

PMID:
30525557
9.

Promoting Terminal Olefin Metathesis with a Supported Cationic Molybdenum Imido Alkylidene N-Heterocyclic Carbene Catalyst.

Pucino M, Inoue M, Gordon CP, Schowner R, Stöhr L, Sen S, Hegedüs C, Robé E, Tóth F, Buchmeiser MR, Copéret C.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14566-14569. doi: 10.1002/anie.201808233. Epub 2018 Oct 1. Erratum in: Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16593.

PMID:
30221823
10.

Small-Molecule Inhibitors of the NusB-NusE Protein-Protein Interaction with Antibiotic Activity.

Cossar PJ, Abdel-Hamid MK, Ma C, Sakoff JA, Trinh TN, Gordon CP, Lewis PJ, McCluskey A.

ACS Omega. 2017 Jul 31;2(7):3839-3857. doi: 10.1021/acsomega.7b00273. Epub 2017 Jul 25.

11.

Low-Coordinated Titanium(III) Alkyl-Molecular and Surface-Complexes: Detailed Structure from Advanced EPR Spectroscopy.

Allouche F, Klose D, Gordon CP, Ashuiev A, Wörle M, Kalendra V, Mougel V, Copéret C, Jeschke G.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14533-14537. doi: 10.1002/anie.201806497. Epub 2018 Jul 18.

PMID:
29949230
12.

NMR chemical shift analysis decodes olefin oligo- and polymerization activity of d0 group 4 metal complexes.

Gordon CP, Shirase S, Yamamoto K, Andersen RA, Eisenstein O, Copéret C.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5867-E5876. doi: 10.1073/pnas.1803382115. Epub 2018 Jun 11.

13.

Metal alkyls programmed to generate metal alkylidenes by α-H abstraction: prognosis from NMR chemical shift.

Gordon CP, Yamamoto K, Searles K, Shirase S, Andersen RA, Eisenstein O, Copéret C.

Chem Sci. 2018 Jan 5;9(7):1912-1918. doi: 10.1039/c7sc05039a. eCollection 2018 Feb 21.

14.

The renascence of continuous-flow peptide synthesis - an abridged account of solid and solution-based approaches.

Gordon CP.

Org Biomol Chem. 2018 Jan 3;16(2):180-196. doi: 10.1039/c7ob02759a. Review.

PMID:
29255827
15.

Molecular and Silica-Supported Molybdenum Alkyne Metathesis Catalysts: Influence of Electronics and Dynamics on Activity Revealed by Kinetics, Solid-State NMR, and Chemical Shift Analysis.

Estes DP, Gordon CP, Fedorov A, Liao WC, Ehrhorn H, Bittner C, Zier ML, Bockfeld D, Chan KW, Eisenstein O, Raynaud C, Tamm M, Copéret C.

J Am Chem Soc. 2017 Dec 6;139(48):17597-17607. doi: 10.1021/jacs.7b09934. Epub 2017 Nov 20.

PMID:
29083916
16.

Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes.

Engl PS, Santiago CB, Gordon CP, Liao WC, Fedorov A, Copéret C, Sigman MS, Togni A.

J Am Chem Soc. 2017 Sep 20;139(37):13117-13125. doi: 10.1021/jacs.7b06947. Epub 2017 Sep 11. Erratum in: J Am Chem Soc. 2018 Dec 26;140(51):18227-18228.

PMID:
28820588
17.

Metathesis Activity Encoded in the Metallacyclobutane Carbon-13 NMR Chemical Shift Tensors.

Gordon CP, Yamamoto K, Liao WC, Allouche F, Andersen RA, Copéret C, Raynaud C, Eisenstein O.

ACS Cent Sci. 2017 Jul 26;3(7):759-768. doi: 10.1021/acscentsci.7b00174. Epub 2017 Jun 14.

18.

Active Sites in Supported Single-Site Catalysts: An NMR Perspective.

Copéret C, Liao WC, Gordon CP, Ong TC.

J Am Chem Soc. 2017 Aug 9;139(31):10588-10596. doi: 10.1021/jacs.6b12981. Epub 2017 Jul 17.

PMID:
28657741
19.

Orbital Analysis of Carbon-13 Chemical Shift Tensors Reveals Patterns to Distinguish Fischer and Schrock Carbenes.

Yamamoto K, Gordon CP, Liao WC, Copéret C, Raynaud C, Eisenstein O.

Angew Chem Int Ed Engl. 2017 Aug 14;56(34):10127-10131. doi: 10.1002/anie.201701537. Epub 2017 Jun 7.

PMID:
28590040
20.

Efficient phosphine-mediated formal C(sp3)-C(sp3) coupling reactions of alkyl halides in batch and flow.

Tran UPN, Hock KJ, Gordon CP, Koenigs RM, Nguyen TV.

Chem Commun (Camb). 2017 May 2;53(36):4950-4953. doi: 10.1039/c7cc02033c.

PMID:
28422202
21.

Small molecule Hedgehog pathway antagonists.

Trinh TN, McLaughlin EA, Gordon CP, Bernstein IR, Pye VJ, Redgrove KA, McCluskey A.

Org Biomol Chem. 2017 Apr 5;15(14):3046-3059. doi: 10.1039/c6ob01959e.

PMID:
28318003
22.

Identification and validation of small molecule modulators of the NusB-NusE interaction.

Cossar PJ, Ma C, Gordon CP, Ambrus JI, Lewis PJ, McCluskey A.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):162-167. doi: 10.1016/j.bmcl.2016.11.091. Epub 2016 Dec 1.

PMID:
27964882
23.

Cytotoxicity of a Series of Norcantharidin-Inspired Tetrahydroepoxyisoindole Carboxamides.

Spare LK, Falsetta P, Gilbert J, Harman DG, Baker MA, Li F, McCluskey A, Clegg JK, Sakoff JA, Aldrich-Wright JR, Gordon CP.

ChemMedChem. 2017 Jan 20;12(2):130-145. doi: 10.1002/cmdc.201600573. Epub 2017 Jan 3.

PMID:
27921386
24.

Transition Metal Intercalators as Anticancer Agents-Recent Advances.

Deo KM, Pages BJ, Ang DL, Gordon CP, Aldrich-Wright JR.

Int J Mol Sci. 2016 Oct 31;17(11). pii: E1818. Review.

25.

Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR.

J Med Chem. 2016 Oct 13;59(19):8879-8888. Epub 2016 Sep 15.

26.

Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors.

Trinh TN, McLaughlin EA, Abdel-Hamid MK, Gordon CP, Bernstein IR, Pye V, Cossar P, Sakoff JA, McCluskey A.

Org Biomol Chem. 2016 Jul 14;14(26):6304-15. doi: 10.1039/c6ob00606j. Epub 2016 Jun 7.

PMID:
27272335
27.

The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.

Dalton N, Gordon CP, Boyle TP, Vandegraaf N, Deadman J, Rhodes DI, Coates JA, Pyne SG, Keller PA, Bremner JB.

Org Biomol Chem. 2016 Jul 7;14(25):6010-23. doi: 10.1039/c6ob00950f. Epub 2016 May 26.

PMID:
27225230
28.

The expanding utility of continuous flow hydrogenation.

Cossar PJ, Hizartzidis L, Simone MI, McCluskey A, Gordon CP.

Org Biomol Chem. 2015 Jul 14;13(26):7119-30. doi: 10.1039/c5ob01067e. Epub 2015 Jun 15. Review.

PMID:
26073166
29.

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function.

Baker MA, Weinberg A, Hetherington L, Villaverde AI, Velkov T, Baell J, Gordon CP.

Biol Reprod. 2015 Apr;92(4):108. doi: 10.1095/biolreprod.114.126680. Epub 2015 Feb 11.

PMID:
25673561
30.

An efficient continuous flow approach to furnish furan-based biaryls.

Trinh TN, Hizartzidis L, Lin AJ, Harman DG, McCluskey A, Gordon CP.

Org Biomol Chem. 2014 Dec 21;12(47):9562-71. doi: 10.1039/c4ob01641f. Epub 2014 Oct 21.

PMID:
25333944
31.

Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.

Gordon CP, Williams P, Chan WC.

J Med Chem. 2013 Feb 28;56(4):1389-404. doi: 10.1021/jm3014635. Epub 2013 Jan 22.

32.

Development of second-generation indole-based dynamin GTPase inhibitors.

Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2013 Jan 10;56(1):46-59. doi: 10.1021/jm300844m. Epub 2012 Dec 18.

PMID:
23167654
33.

Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA.

Bioorg Med Chem. 2011 Sep 15;19(18):5734-41. doi: 10.1016/j.bmc.2011.01.031. Epub 2011 Feb 1.

PMID:
21855357
34.

Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.

Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O'Brien TJ, McCluskey A, Robinson PJ.

Mol Cancer Ther. 2011 Sep;10(9):1553-62. doi: 10.1158/1535-7163.MCT-11-0067. Epub 2011 Jul 12.

35.

Driver distraction and driver inattention: definition, relationship and taxonomy.

Regan MA, Hallett C, Gordon CP.

Accid Anal Prev. 2011 Sep;43(5):1771-81. doi: 10.1016/j.aap.2011.04.008. Epub 2011 May 4.

PMID:
21658505
36.

Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3277-81. doi: 10.1016/j.bmcl.2011.04.031. Epub 2011 Apr 13.

PMID:
21536433
37.

Investigation of the one-pot synthesis of quinolin-2-(1H)-ones and the discovery of a variation of the three-component Ugi reaction.

Gordon CP, Young KA, Hizartzidis L, Deane FM, McCluskey A.

Org Biomol Chem. 2011 Mar 7;9(5):1419-28.

PMID:
21427800
38.

Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi.

Wright AD, McCluskey A, Robertson MJ, MacGregor KA, Gordon CP, Guenther J.

Org Biomol Chem. 2011 Jan 21;9(2):400-7. doi: 10.1039/c0ob00326c. Epub 2010 Nov 2.

PMID:
21042642
39.

The antiplasmodial activity of norcantharidin analogs.

Bajsa J, McCluskey A, Gordon CP, Stewart SG, Hill TA, Sahu R, Duke SO, Tekwani BL.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6688-95. doi: 10.1016/j.bmcl.2010.09.004. Epub 2010 Sep 7.

PMID:
20888768
40.

The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening.

Odell LR, Howan D, Gordon CP, Robertson MJ, Chau N, Mariana A, Whiting AE, Abagyan R, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.

J Med Chem. 2010 Jul 22;53(14):5267-80. doi: 10.1021/jm100442u.

PMID:
20575553
41.

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M.

Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161. Epub 2010 Jun 22.

42.

Calcineurin activity is required for the completion of cytokinesis.

Chircop M, Malladi CS, Lian AT, Page SL, Zavortink M, Gordon CP, McCluskey A, Robinson PJ.

Cell Mol Life Sci. 2010 Nov;67(21):3725-37. doi: 10.1007/s00018-010-0401-z. Epub 2010 May 23.

PMID:
20496096
43.

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.

Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A.

J Med Chem. 2010 May 27;53(10):4094-102. doi: 10.1021/jm100119c.

PMID:
20426422
44.

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m.

PMID:
19459681
45.

Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

ChemMedChem. 2008 Dec;3(12):1878-92. doi: 10.1002/cmdc.200800192.

PMID:
19025735
46.

Control of HIV through the inhibition of HIV-1 integrase: a medicinal chemistry perspective.

Gordon CP, Griffith R, Keller PA.

Med Chem. 2007 Mar;3(2):199-220. Review.

PMID:
17348857
47.

Control of hepatitis C: a medicinal chemistry perspective.

Gordon CP, Keller PA.

J Med Chem. 2005 Jan 13;48(1):1-20. Review. No abstract available.

PMID:
15633995
48.
49.

Multicore myopathy in a patient with anhidrotic ectodermal dysplasia.

Gordon CP, Litz S.

Can J Anaesth. 1992 Nov;39(9):966-8.

PMID:
1451226

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