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Risk factors for vitamin D deficiency in sickle cell disease.

Han J, Zhang X, Saraf SL, Gowhari M, Molokie RE, Hassan J, Jain S, Shah BN, Abbasi T, Machado RF, Gordeuk VR.

Br J Haematol. 2018 Jun;181(6):828-835. doi: 10.1111/bjh.15270. Epub 2018 May 16.


Hydroxycarbamide adherence and cumulative dose associated with hospital readmission in sickle cell disease: a 6-year population-based cohort study.

Zhou J, Han J, Nutescu EA, Gordeuk VR, Saraf SL, Calip GS.

Br J Haematol. 2018 Jul;182(2):259-270. doi: 10.1111/bjh.15396. Epub 2018 May 16.


Fixed Low-Dose Hydroxyurea for the Treatment of Adults with Sickle Cell Anemia in Nigeria.

Tayo BO, Akingbola TS, Saraf SL, Shah BN, Ezekekwu CA, Sonubi O, Hsu LL, Cooper RS, Gordeuk VR.

Am J Hematol. 2018 May 14. doi: 10.1002/ajh.25143. [Epub ahead of print] No abstract available.


Haploidentical Peripheral Blood Stem Cell Transplantation Demonstrates Stable Engraftment in Adults with Sickle Cell Disease.

Saraf SL, Oh AL, Patel PR, Sweiss K, Koshy M, Campbell-Lee S, Gowhari M, Jain S, Peace D, Quigley JG, Khan I, Molokie RE, Mahmud N, Gordeuk VR, Rondelli D.

Biol Blood Marrow Transplant. 2018 Apr 12. pii: S1083-8791(18)30185-X. doi: 10.1016/j.bbmt.2018.03.031. [Epub ahead of print]


Patrolling the endothelium in sickle cell disease.

Gordeuk VR.

Blood. 2018 Apr 5;131(14):1503-1505. doi: 10.1182/blood-2018-02-832139. No abstract available.


Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

Zhang DL, Wu J, Shah BN, Greutélaers KC, Ghosh MC, Ollivierre H, Su XZ, Thuma PE, Bedu-Addo G, Mockenhaupt FP, Gordeuk VR, Rouault TA.

Science. 2018 Mar 30;359(6383):1520-1523. doi: 10.1126/science.aal2022.


Red blood cell alloimmunization in sickle cell disease: assessment of transfusion protocols during two time periods.

Campbell-Lee SA, Gvozdjan K, Choi KM, Chen YF, Saraf SL, Hsu LL, Gordeuk VR, Strauss RG, Triulzi DJ.

Transfusion. 2018 Mar 23. doi: 10.1111/trf.14588. [Epub ahead of print]


Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models.

Saraf SL, Sysol JR, Susma A, Setty S, Zhang X, Gudehithlu KP, Arruda JAL, Singh AK, Machado RF, Gordeuk VR.

Transl Res. 2018 Jul;197:1-11. doi: 10.1016/j.trsl.2018.01.007. Epub 2018 Feb 2.


Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia.

Jerebtsova M, Saraf SL, Soni S, Afangbedji N, Lin X, Raslan R, Gordeuk VR, Nekhai S.

Am J Hematol. 2018 Aug;93(4):E107-E109. doi: 10.1002/ajh.25036. Epub 2018 Feb 5. No abstract available.


Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease.

Field JJ, Majerus E, Gordeuk VR, Gowhari M, Hoppe C, Heeney MM, Achebe M, George A, Chu H, Sheehan B, Puligandla M, Neuberg D, Lin G, Linden J, Nathan DG.

Blood Adv. 2017 Aug 28;1(20):1645-1649. doi: 10.1182/bloodadvances.2017009613. eCollection 2017 Sep 12. Erratum in: Blood Adv. 2017 Oct 19;1(23 ):2058.


Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis.

Jerebtsova M, Saraf SL, Lin X, Lee G, Adjei EA, Kumari N, Afangbedji N, Raslan R, McLean C, Gordeuk VR, Nekhai S.

Am J Hematol. 2018 Feb;93(2):E45-E47. doi: 10.1002/ajh.24965. Epub 2017 Nov 27. No abstract available.


Ethnic and genetic factors of iron status in women of reproductive age.

Gordeuk VR, Brannon PM.

Am J Clin Nutr. 2017 Dec;106(Suppl 6):1594S-1599S. doi: 10.3945/ajcn.117.155853. Epub 2017 Oct 25.


Program expansion of a day hospital dedicated to manage sickle cell pain.

Han J, Saraf SL, Kavoliunaite L, Jain S, Hassan J, Hsu LL, Molokie RE, Gordeuk VR, Gowhari M.

Am J Hematol. 2018 Jan;93(1):E20-E21. doi: 10.1002/ajh.24938. Epub 2017 Oct 31. No abstract available.


Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts.

Saraf SL, Akingbola TS, Shah BN, Ezekekwu CA, Sonubi O, Zhang X, Hsu LL, Gladwin MT, Machado RF, Cooper RS, Gordeuk VR, Tayo BO.

Blood Adv. 2017 Apr 25;1(11):693-698. doi: 10.1182/bloodadvances.2017005231.


Characterization of opioid use in sickle cell disease.

Han J, Zhou J, Saraf SL, Gordeuk VR, Calip GS.

Pharmacoepidemiol Drug Saf. 2018 May;27(5):479-486. doi: 10.1002/pds.4291. Epub 2017 Aug 16.


Erythropoiesis-stimulating agents in sickle cell anaemia.

Han J, Zhou J, Kondragunta V, Zhang X, Molokie RE, Gowhari M, Hassan J, Jain S, Calip GS, Gordeuk VR, Saraf SL.

Br J Haematol. 2017 Jul 27. doi: 10.1111/bjh.14846. [Epub ahead of print] No abstract available.


Use of anti-inflammatory analgesics in sickle-cell disease.

Han J, Saraf SL, Lash JP, Gordeuk VR.

J Clin Pharm Ther. 2017 Oct;42(5):656-660. doi: 10.1111/jcpt.12592. Epub 2017 Jul 10.


Hemochromatosis, iron-loading anemia, and SMAD.

Gordeuk VR.

Blood. 2017 Jul 6;130(1):6-7. doi: 10.1182/blood-2017-05-782656. No abstract available.


Losartan for the nephropathy of sickle cell anemia: A phase-2, multicenter trial.

Quinn CT, Saraf SL, Gordeuk VR, Fitzhugh CD, Creary SE, Bodas P, George A, Raj AB, Nero AC, Terrell CE, McCord L, Lane A, Ackerman HC, Yang Y, Niss O, Taylor MD, Devarajan P, Malik P.

Am J Hematol. 2017 Sep;92(9):E520-E528. doi: 10.1002/ajh.24810. Epub 2017 Jul 19.


Increased vancomycin dosing requirements in sickle cell disease due to hyperfiltration-dependent and independent pathways.

Han J, Zhang X, Oderinde J, Saraf SL, Gowhari M, Hassan J, Jain S, Gordeuk VR, Molokie RE.

Haematologica. 2017 Aug;102(8):e282-e284. doi: 10.3324/haematol.2017.169128. Epub 2017 May 4. No abstract available.


Association of circulating transcriptomic profiles with mortality in sickle cell disease.

Desai AA, Lei Z, Bahroos N, Maienschein-Cline M, Saraf SL, Zhang X, Shah BN, Nouraie SM, Abbasi T, Patel AR, Lang RM, Lussier Y, Garcia JGN, Gordeuk VR, Machado RF.

Blood. 2017 Jun 1;129(22):3009-3016. doi: 10.1182/blood-2016-11-752279. Epub 2017 Apr 3.


Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.

Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R.

J Mol Med (Berl). 2017 Jun;95(6):665-670. doi: 10.1007/s00109-017-1519-3. Epub 2017 Feb 23.


Preventing delayed hemolytic transfusion reactions in sickle cell disease.

Castro O, Oneal P, Medina A, Onojobi G, Gordeuk VR.

Transfusion. 2016 Nov;56(11):2899-2900. doi: 10.1111/trf.13784. No abstract available.


A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.


Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia.

Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR.

Haematologica. 2017 May;102(5):e166-e169. doi: 10.3324/haematol.2016.158170. Epub 2017 Jan 19. No abstract available.


Reply to Ruan X et al: "A comment on pattern of opioid use in sickle cell disease".

Han J, Saraf SL, Machado RF, Gordeuk VR.

Am J Hematol. 2017 Apr;92(4):E43. doi: 10.1002/ajh.24646. Epub 2017 Feb 7. No abstract available.


Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.

Ataga KI, Kutlar A, Kanter J, Liles D, Cancado R, Friedrisch J, Guthrie TH, Knight-Madden J, Alvarez OA, Gordeuk VR, Gualandro S, Colella MP, Smith WR, Rollins SA, Stocker JW, Rother RP.

N Engl J Med. 2017 Feb 2;376(5):429-439. doi: 10.1056/NEJMoa1611770. Epub 2016 Dec 3.


ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease.

Kim K, Li J, Barazia A, Tseng A, Youn SW, Abbadessa G, Yu Y, Schwartz B, Andrews RK, Gordeuk VR, Cho J.

Haematologica. 2017 Feb;102(2):246-259. doi: 10.3324/haematol.2016.151159. Epub 2016 Oct 6.


Patterns of opioid use in sickle cell disease.

Han J, Saraf SL, Zhang X, Gowhari M, Molokie RE, Hassan J, Alhandalous C, Jain S, Younge J, Abbasi T, Machado RF, Gordeuk VR.

Am J Hematol. 2016 Nov;91(11):1102-1106. doi: 10.1002/ajh.24498. Epub 2016 Aug 8.


APOL1, α-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.

Saraf SL, Shah BN, Zhang X, Han J, Tayo BO, Abbasi T, Ostrower A, Guzman E, Molokie RE, Gowhari M, Hassan J, Jain S, Cooper RS, Machado RF, Lash JP, Gordeuk VR.

Haematologica. 2017 Jan;102(1):e1-e6. doi: 10.3324/haematol.2016.154153. Epub 2016 Sep 22. No abstract available.


Impact of a Clinical Pharmacy Service on the Management of Patients in a Sickle Cell Disease Outpatient Center.

Han J, Bhat S, Gowhari M, Gordeuk VR, Saraf SL.

Pharmacotherapy. 2016 Nov;36(11):1166-1172. doi: 10.1002/phar.1834. Epub 2016 Oct 3.


Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.

Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF.

PLoS One. 2016 Sep 16;11(9):e0163013. doi: 10.1371/journal.pone.0163013. eCollection 2016.


Safety of chronic transdermal fentanyl use in patients receiving hemodialysis.

Han J, Saraf SL, Gordeuk VR, Gowhari M.

Am J Health Syst Pharm. 2016 Jul 1;73(13):947-8. doi: 10.2146/ajhp150748. No abstract available.


Outcome Disparities in Caucasian and Non-Caucasian Patients With Myeloproliferative Neoplasms.

Khan I, Shergill A, Saraf SL, Chen YF, Patel PR, Quigley JG, Peace D, Gordeuk VR, Hoffman R, Rondelli D.

Clin Lymphoma Myeloma Leuk. 2016 Jun;16(6):350-7. doi: 10.1016/j.clml.2016.02.036. Epub 2016 Mar 8.


Utility of the revised cardiac risk index for predicting postsurgical morbidity in Hb SC and Hb Sβ+-thalassemia sickle cell disease.

Rosenberg A, Selounski V, Wardak H, Han J, Gowhari M, Hassan J, Jain S, Molokie RE, Gordeuk VR, Saraf SL.

Am J Hematol. 2016 Jun;91(6):E316-7. doi: 10.1002/ajh.24363. Epub 2016 Apr 24. No abstract available.


Pathophysiology and treatment of pulmonary hypertension in sickle cell disease.

Gordeuk VR, Castro OL, Machado RF.

Blood. 2016 Feb 18;127(7):820-8. doi: 10.1182/blood-2015-08-618561. Epub 2016 Jan 12. Review.


Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.

Kord Valeshabad A, Wanek J, Molokie RE, Machado RF, Gordeuk VR, Shahidi M.

Clin Case Rep. 2015 Nov 6;3(12):1038-41. doi: 10.1002/ccr3.439. eCollection 2015 Dec.


Osteoclast activation and sickle bone disease.

Gordeuk VR.

Blood. 2015 Nov 12;126(20):2259-60. doi: 10.1182/blood-2015-09-669333. No abstract available.


Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease.

Tatari-Calderone Z, Gordish-Dressman H, Fasano R, Riggs M, Fortier C, Campbell AD, Charron D, Gordeuk VR, Luban NL, Vukmanovic S, Tamouza R.

Hum Immunol. 2016 Jan;77(1):35-40. doi: 10.1016/j.humimm.2015.10.010. Epub 2015 Oct 22.


Platelets decline during Vaso-occlusive crisis as a predictor of acute chest syndrome in sickle cell disease.

Alhandalous CH, Han J, Hsu L, Gowhari M, Hassan J, Molokie R, Abbasi TA, Gordeuk VR.

Am J Hematol. 2015 Dec;90(12):E228-9. doi: 10.1002/ajh.24214. Epub 2015 Nov 17. No abstract available.


Nonmyeloablative Stem Cell Transplantation with Alemtuzumab/Low-Dose Irradiation to Cure and Improve the Quality of Life of Adults with Sickle Cell Disease.

Saraf SL, Oh AL, Patel PR, Jalundhwala Y, Sweiss K, Koshy M, Campbell-Lee S, Gowhari M, Hassan J, Peace D, Quigley JG, Khan I, Molokie RE, Hsu LL, Mahmud N, Levinson DJ, Pickard AS, Garcia JG, Gordeuk VR, Rondelli D.

Biol Blood Marrow Transplant. 2016 Mar;22(3):441-8. doi: 10.1016/j.bbmt.2015.08.036. Epub 2015 Sep 5.


Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy.

Kord Valeshabad A, Wanek J, Saraf SL, Gaynes BI, Gordeuk VR, Molokie RE, Shahidi M.

Am J Nephrol. 2015;41(6):487-93. doi: 10.1159/000438678. Epub 2015 Aug 5.


Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy.

Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JA, Gladwin MT, Singh AK, Gordeuk VR.

Haematologica. 2015 Oct;100(10):1275-84. doi: 10.3324/haematol.2015.124875. Epub 2015 Jul 23.


Blood transfusion and 30-day readmission rate in adult patients hospitalized with sickle cell disease crisis.

Nouraie M, Gordeuk VR.

Transfusion. 2015 Oct;55(10):2331-8. doi: 10.1111/trf.13155. Epub 2015 Jun 30.


Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.

Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR.

Hum Genet. 2015 Aug;134(8):895-904. doi: 10.1007/s00439-015-1572-3. Epub 2015 May 30.


A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia.

McDevitt MA, Xie J, Ganapathy-Kanniappan S, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R.

J Exp Med. 2015 May 4;212(5):825. doi: 10.1084/jem.2005239804172015c. No abstract available.


Complications in children and adolescents with Chuvash polycythemia.

Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk VR.

Blood. 2015 Jan 8;125(2):414-5. doi: 10.1182/blood-2014-10-604660. No abstract available.


Iron, inflammation, and early death in adults with sickle cell disease.

van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG 6th, Kato GJ.

Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.


Hyperfiltration is associated with the development of microalbuminuria in patients with sickle cell anemia.

Vazquez B, Shah B, Zhang X, Lash JP, Gordeuk VR, Saraf SL.

Am J Hematol. 2014 Dec;89(12):1156-7. doi: 10.1002/ajh.23817. Epub 2014 Aug 27. No abstract available.


A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, Walston JD, Gordeuk VR, Berger NA, Reuben D, Prchal J, Rao SV, Roy CN, Supiano MA, Schrier SL, Cohen HJ.

Blood Cells Mol Dis. 2014 Dec;53(4):221-30. doi: 10.1016/j.bcmd.2014.06.003. Epub 2014 Jul 25.

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