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Multiple determinants and consequences of cohesion fatigue in mammalian cells.

Sapkota H, Wasiak E, Daum JR, Gorbsky GJ.

Mol Biol Cell. 2018 Aug 1;29(15):1811-1824. doi: 10.1091/mbc.E18-05-0315. Epub 2018 May 30.


Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model.

Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ.

Stem Cell Res. 2018 Jan;26:1-7. doi: 10.1016/j.scr.2017.11.009. Epub 2017 Nov 21.


Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.

Sivakumar S, Gorbsky GJ.

Biol Open. 2017 Nov 15;6(11):1672-1679. doi: 10.1242/bio.026930.


GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms.

Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ.

J Cell Biol. 2017 Oct 2;216(10):3117-3132. doi: 10.1083/jcb.201610012. Epub 2017 Aug 18.


The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.

Potapova T, Gorbsky GJ.

Biology (Basel). 2017 Feb 8;6(1). pii: E12. doi: 10.3390/biology6010012. Review.


The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.

Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ.

Elife. 2016 Mar 16;5. pii: e12902. doi: 10.7554/eLife.12902.


Spatiotemporal regulation of the anaphase-promoting complex in mitosis.

Sivakumar S, Gorbsky GJ.

Nat Rev Mol Cell Biol. 2015 Feb;16(2):82-94. doi: 10.1038/nrm3934. Review.


The spindle checkpoint and chromosome segregation in meiosis.

Gorbsky GJ.

FEBS J. 2015 Jul;282(13):2471-87. doi: 10.1111/febs.13166. Epub 2015 Jan 12. Review.


Live-cell fluorescence imaging for phenotypic analysis of mitosis.

Sivakumar S, Daum JR, Gorbsky GJ.

Methods Mol Biol. 2014;1170:549-62. doi: 10.1007/978-1-4939-0888-2_31.


The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit.

Sivakumar S, Daum JR, Tipton AR, Rankin S, Gorbsky GJ.

Mol Biol Cell. 2014 Mar;25(5):594-605. doi: 10.1091/mbc.E13-07-0421. Epub 2014 Jan 8.


Cohesion fatigue.

Gorbsky GJ.

Curr Biol. 2013 Nov 18;23(22):R986-R988. doi: 10.1016/j.cub.2013.08.017. No abstract available.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.


Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.

Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM.

J Cell Biol. 2012 Oct 15;199(2):251-68. doi: 10.1083/jcb.201205106.


Cohesion fatigue induces chromatid separation in cells delayed at metaphase.

Daum JR, Potapova TA, Sivakumar S, Daniel JJ, Flynn JN, Rankin S, Gorbsky GJ.

Curr Biol. 2011 Jun 21;21(12):1018-24. doi: 10.1016/j.cub.2011.05.032. Epub 2011 Jun 9.


Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited.

Potapova TA, Sivakumar S, Flynn JN, Li R, Gorbsky GJ.

Mol Biol Cell. 2011 Apr 15;22(8):1191-206. doi: 10.1091/mbc.E10-07-0599. Epub 2011 Feb 16.


Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM.

Science. 2010 Oct 8;330(6001):231-5. doi: 10.1126/science.1189435. Epub 2010 Aug 12.


Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication.

Hu L, Potapova TA, Li S, Rankin S, Gorbsky GJ, Angeletti PC, Ceresa BP.

Virology. 2010 Sep 30;405(2):342-51. doi: 10.1016/j.virol.2010.06.025. Epub 2010 Jul 6.


Duct tape for broken chromosomes.

Gorbsky GJ.

Cell. 2010 Jan 22;140(2):178-80. doi: 10.1016/j.cell.2010.01.005.


The dynamics of DNA topoisomerase IIalpha in living cells.

Daum JR, Mo YY, Gorbsky GJ.

Methods Mol Biol. 2009;582:233-44. doi: 10.1007/978-1-60761-340-4_18.


Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.

Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ.

Curr Biol. 2009 Sep 15;19(17):1467-72. doi: 10.1016/j.cub.2009.07.017. Epub 2009 Jul 30.


Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.

Salmela AL, Pouwels J, Varis A, Kukkonen AM, Toivonen P, Halonen PK, Perälä M, Kallioniemi O, Gorbsky GJ, Kallio MJ.

Carcinogenesis. 2009 Jun;30(6):1032-40. doi: 10.1093/carcin/bgp101. Epub 2009 Apr 24.


ICIS and Aurora B coregulate the microtubule depolymerase Kif2a.

Knowlton AL, Vorozhko VV, Lan W, Gorbsky GJ, Stukenberg PT.

Curr Biol. 2009 May 12;19(9):758-63. doi: 10.1016/j.cub.2009.03.018. Epub 2009 Mar 26.


A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor.

DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ.

Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3.


Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.

Potapova TA, Daum JR, Byrd KS, Gorbsky GJ.

Mol Biol Cell. 2009 Mar;20(6):1737-48. doi: 10.1091/mbc.E08-07-0771. Epub 2009 Jan 21.


Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion.

Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP.

Virology. 2009 Feb 5;384(1):125-34. doi: 10.1016/j.virol.2008.10.011. Epub 2008 Nov 28.


Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.

Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ.

Chromosoma. 2008 Apr;117(2):169-79. Epub 2007 Dec 4.


Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.

Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ.

Cell Cycle. 2007 Jul 1;6(13):1579-85. Epub 2007 May 16.


Spindle checkpoint function and cellular sensitivity to antimitotic drugs.

Yamada HY, Gorbsky GJ.

Mol Cancer Ther. 2006 Dec;5(12):2963-9. Review. No abstract available.


The reversibility of mitotic exit in vertebrate cells.

Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ.

Nature. 2006 Apr 13;440(7086):954-8.


Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.

Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ.

Curr Biol. 2005 Jun 21;15(12):1078-89.


Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity.

Beardmore VA, Ahonen LJ, Gorbsky GJ, Kallio MJ.

J Cell Sci. 2004 Aug 15;117(Pt 18):4033-42. Epub 2004 Jul 27.


Mitosis: MCAK under the aura of Aurora B.

Gorbsky GJ.

Curr Biol. 2004 May 4;14(9):R346-8. Review.


The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.

McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT.

Curr Biol. 2004 Jan 20;14(2):131-7.


The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

McCleland ML, Gardner RD, Kallio MJ, Daum JR, Gorbsky GJ, Burke DJ, Stukenberg PT.

Genes Dev. 2003 Jan 1;17(1):101-14.


The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.

Topper LM, Campbell MS, Tugendreich S, Daum JR, Burke DJ, Hieter P, Gorbsky GJ.

Cell Cycle. 2002 Jul-Aug;1(4):282-92.


Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells.

Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ.

J Cell Biol. 2002 Sep 2;158(5):841-7. Epub 2002 Aug 26.


Both alpha and beta isoforms of mammalian DNA topoisomerase II associate with chromosomes in mitosis.

Null AP, Hudson J, Gorbsky GJ.

Cell Growth Differ. 2002 Jul;13(7):325-33.


Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis.

Tavormina PA, Côme MG, Hudson JR, Mo YY, Beck WT, Gorbsky GJ.

J Cell Biol. 2002 Jul 8;158(1):23-9. Epub 2002 Jul 8.


Regulation of microtubule stability and mitotic progression by survivin.

Giodini A, Kallio MJ, Wall NR, Gorbsky GJ, Tognin S, Marchisio PC, Symons M, Altieri DC.

Cancer Res. 2002 May 1;62(9):2462-7.


Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions.

Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW.

J Biol Chem. 2002 Jun 21;277(25):23054-64. Epub 2002 Apr 8.


The mitotic spindle checkpoint.

Gorbsky GJ.

Curr Biol. 2001 Dec 11;11(24):R1001-4. No abstract available.


Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.

Topper LM, Bastians H, Ruderman JV, Gorbsky GJ.

J Cell Biol. 2001 Aug 20;154(4):707-17. Erratum in: J Cell Biol 2002 Jul 22;158(2):371.


Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling.

Escargueil AE, Plisov SY, Skladanowski A, Borgne A, Meijer L, Gorbsky GJ, Larsen AK.

FASEB J. 2001 Oct;15(12):2288-90. Epub 2001 Aug 17.


The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome.

Daum JR, Tugendreich S, Topper LM, Jorgensen PM, Hoog C, Hieter P, Gorbsky GJ.

Curr Biol. 2000 Nov 30;10(23):R850-2. No abstract available.

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