Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.
Wang Z, Zhou H, Zheng H, Zhou X, Shen G, Teng X, Liu X, Zhang J, Wei X, Hu Z, Zeng F, Hu Y, Hu J, Wang X, Chen S, Cheng J, Zhang C, Gui Y, Zou S, Hao Y, Zhao Q, Wu W, Zhou Y, Cui K, Huang N, Wei Y, Li W, Li J.
Wang Z, et al.
Autophagy. 2021 Feb;17(2):529-552. doi: 10.1080/15548627.2020.1725381. Epub 2020 Feb 16.
Autophagy. 2021.
PMID: 32019420
Free PMC article.
We also found that an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5) and GORASP2 (golgi reassembly stacking protein 2) promoted psoriasiform KC inflammation. ...Thus, this study uncovered a novel autophagy mechanism …
We also found that an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5) and GORASP …