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Items: 42

1.

Antitumor Activity of Abnormal Cannabidiol and Its Analog O-1602 in Taxol-Resistant Preclinical Models of Breast Cancer.

Tomko A, O'Leary L, Trask H, Achenbach JC, Hall SR, Goralski KB, Ellis LD, Dupré DJ.

Front Pharmacol. 2019 Sep 27;10:1124. doi: 10.3389/fphar.2019.01124. eCollection 2019.

2.

More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer.

Goralski KB, Jackson AE, McKeown BT, Sinal CJ.

Int J Mol Sci. 2019 Sep 26;20(19). pii: E4778. doi: 10.3390/ijms20194778. Review.

3.

Isolation of a jadomycin incorporating L-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells.

Forget SM, Robertson AW, Hall SR, MacLeod JM, Overy DP, Kerr RG, Goralski KB, Jakeman DL.

J Antibiot (Tokyo). 2018 Aug;71(8):722-730. doi: 10.1038/s41429-018-0060-0. Epub 2018 Apr 26.

PMID:
29700425
4.

Post Polyketide Synthase Carbon-Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae.

Robertson AW, MacLeod JM, MacIntyre LW, Forget SM, Hall SR, Bennett LG, Correa H, Kerr RG, Goralski KB, Jakeman DL.

J Org Chem. 2018 Feb 16;83(4):1876-1890. doi: 10.1021/acs.joc.7b02823. Epub 2018 Jan 29.

PMID:
29313335
5.

Jadomycins Inhibit Type II Topoisomerases and Promote DNA Damage and Apoptosis in Multidrug-Resistant Triple-Negative Breast Cancer Cells.

Hall SR, Toulany J, Bennett LG, Martinez-Farina CF, Robertson AW, Jakeman DL, Goralski KB.

J Pharmacol Exp Ther. 2017 Nov;363(2):196-210. doi: 10.1124/jpet.117.241125. Epub 2017 Sep 13.

PMID:
28904004
6.

An observational study examining the effects of a surgically induced inflammatory response on the distribution of morphine and its metabolites into cerebrospinal fluid.

Wang Y, Goralski KB, Roberts DJ, Landry K, Issa ME, Sleno L, Julien LC, Wood J, Hall RI.

Can J Anaesth. 2017 Oct;64(10):1009-1022. doi: 10.1007/s12630-017-0933-x. Epub 2017 Jul 14.

PMID:
28710563
7.

Bariatric Surgery-Induced Resolution of Hypertension and Obstructive Sleep Apnea: Impact of Modulation of Body Fat, Ectopic Fat, Autonomic Nervous Activity, Inflammatory and Adipokine Profiles.

Auclair A, Biertho L, Marceau S, Hould FS, Biron S, Lebel S, Julien F, Lescelleur O, Lacasse Y, Piché ME, Cianflone K, Parlee SD, Goralski K, Martin J, Bastien M, St-Pierre DH, Poirier P.

Obes Surg. 2017 Dec;27(12):3156-3164. doi: 10.1007/s11695-017-2737-z.

PMID:
28555408
8.

CMKLR1 activation ex vivo does not increase proportionally to serum total chemerin in obese humans.

Toulany J, Parlee SD, Sinal CJ, Slayter K, McNeil S, Goralski KB.

Endocr Connect. 2016 Nov;5(6):70-81. Epub 2016 Nov 8.

9.

The Effects of CKD on Cytochrome P450-Mediated Drug Metabolism.

Ladda MA, Goralski KB.

Adv Chronic Kidney Dis. 2016 Mar;23(2):67-75. doi: 10.1053/j.ackd.2015.10.002. Review.

PMID:
26979145
10.

Biliopancreatic diversion with duodenal switch modifies plasma chemerin in early and late post-operative periods.

Parlee SD, Wang Y, Poirier P, Lapointe M, Martin J, Bastien M, Cianflone K, Goralski KB.

Obesity (Silver Spring). 2015 Jun;23(6):1201-8. doi: 10.1002/oby.21084. Epub 2015 May 9.

11.

Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism.

Hall SR, Blundon HL, Ladda MA, Robertson AW, Martinez-Farina CF, Jakeman DL, Goralski KB.

Pharmacol Res Perspect. 2015 Mar;3(2):e00110. doi: 10.1002/prp2.110.

12.

An evaluation of oral dabigatran etexilate pharmacokinetics and pharmacodynamics in hemodialysis.

Wilson JA, Goralski KB, Soroka SD, Morrison M, Mossop P, Sleno L, Wang Y, Anderson DR.

J Clin Pharmacol. 2014 Aug;54(8):901-9. doi: 10.1002/jcph.335. Epub 2014 May 28.

PMID:
24846496
13.

Jadomycins are cytotoxic to ABCB1-, ABCC1-, and ABCG2-overexpressing MCF7 breast cancer cells.

Issa ME, Hall SR, Dupuis SN, Graham CL, Jakeman DL, Goralski KB.

Anticancer Drugs. 2014 Mar;25(3):255-69. doi: 10.1097/CAD.0000000000000043.

PMID:
24231527
14.

Elastase and tryptase govern TNFα-mediated production of active chemerin by adipocytes.

Parlee SD, McNeil JO, Muruganandan S, Sinal CJ, Goralski KB.

PLoS One. 2012;7(12):e51072. doi: 10.1371/journal.pone.0051072. Epub 2012 Dec 5.

15.

Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.

Issa ME, Muruganandan S, Ernst MC, Parlee SD, Zabel BA, Butcher EC, Sinal CJ, Goralski KB.

Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1621-31. doi: 10.1152/ajpcell.00187.2011. Epub 2012 Mar 28.

16.

Jadomycins derived from the assimilation and incorporation of norvaline and norleucine.

Dupuis SN, Veinot T, Monro SM, Douglas SE, Syvitski RT, Goralski KB, McFarland SA, Jakeman DL.

J Nat Prod. 2011 Nov 28;74(11):2420-4. doi: 10.1021/np200689w. Epub 2011 Nov 3.

PMID:
22050382
17.

Oseltamivir pharmacokinetics in morbid obesity (OPTIMO trial).

Thorne-Humphrey LM, Goralski KB, Slayter KL, Hatchette TF, Johnston BL, McNeil SA; 2009 OPTIMO Study Group.

J Antimicrob Chemother. 2011 Sep;66(9):2083-91. doi: 10.1093/jac/dkr257. Epub 2011 Jun 23.

PMID:
21700623
18.

Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) target gene that promotes mesenchymal stem cell adipogenesis.

Muruganandan S, Parlee SD, Rourke JL, Ernst MC, Goralski KB, Sinal CJ.

J Biol Chem. 2011 Jul 8;286(27):23982-95. doi: 10.1074/jbc.M111.220491. Epub 2011 May 14.

19.

Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-{alpha}.

Parlee SD, Ernst MC, Muruganandan S, Sinal CJ, Goralski KB.

Endocrinology. 2010 Jun;151(6):2590-602. doi: 10.1210/en.2009-0794. Epub 2010 Apr 2.

PMID:
20363880
20.

Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes.

Ernst MC, Issa M, Goralski KB, Sinal CJ.

Endocrinology. 2010 May;151(5):1998-2007. doi: 10.1210/en.2009-1098. Epub 2010 Mar 12.

PMID:
20228173
21.

Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain.

Roberts DJ, Goralski KB, Renton KW, Julien LC, Webber AM, Sleno L, Volmer DA, Hall RI.

Crit Care Med. 2009 Oct;37(10):2767-74. doi: 10.1097/CCM.0b013e3181b755d5.

PMID:
19865006
22.

Elucidation of chemerin and chemokine-like receptor-1 function in adipocytes by adenoviral-mediated shRNA knockdown of gene expression.

Goralski KB, Sinal CJ.

Methods Enzymol. 2009;460:289-312. doi: 10.1016/S0076-6879(09)05214-8.

PMID:
19446731
23.

A critical overview of the influence of inflammation and infection on P-glycoprotein expression and activity in the brain.

Roberts DJ, Goralski KB.

Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1245-64. doi: 10.1517/17425255.4.10.1245 . Review.

PMID:
18798696
24.

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.

Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, Sinal CJ.

Drug Metab Dispos. 2008 Feb;36(2):205-16. doi: 10.1124/dmd.107.018747.

PMID:
18218849
25.

Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism.

Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ.

J Biol Chem. 2007 Sep 21;282(38):28175-88. Epub 2007 Jul 16.

26.

Type 2 diabetes and cardiovascular disease: getting to the fat of the matter.

Goralski KB, Sinal CJ.

Can J Physiol Pharmacol. 2007 Jan;85(1):113-32. Review.

PMID:
17487251
27.

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC.

Circ Res. 2006 Aug 18;99(4):442-50. Epub 2006 Jul 20.

28.

NH4+ modulates renal tubule amantadine transport independently of intracellular pH changes.

Goralski KB, Bose R, Sitar DS.

Eur J Pharmacol. 2006 Jul 10;541(1-2):87-94. Epub 2006 May 7.

PMID:
16750190
29.

The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat.

Abdulla D, Goralski KB, Renton KW.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):1-10. Epub 2006 May 18.

PMID:
16712892
30.

Brain cyclosporin A levels are determined by ontogenic regulation of mdr1a expression.

Goralski KB, Acott PD, Fraser AD, Worth D, Sinal CJ.

Drug Metab Dispos. 2006 Feb;34(2):288-95. Epub 2005 Nov 22.

PMID:
16303871
31.

The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation.

Abdulla D, Goralski KB, Del Busto Cano EG, Renton KW.

Drug Metab Dispos. 2005 Oct;33(10):1521-31. Epub 2005 Jul 8.

PMID:
16006567
32.

Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation.

Goralski KB, Abdulla D, Sinal CJ, Arsenault A, Renton KW.

Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G434-43. Epub 2005 May 5.

33.

Paradoxical cyclosporine A requirements in pediatric renal transplants receiving high-dose steroids.

Hardy KW, Crocker JF, McLellan H, Goralski KB, Renton KW, Acott PD.

J Clin Pharmacol. 2005 Feb;45(2):161-7.

PMID:
15647408
34.

Chipping away at gallstones.

Goralski KB, Sinal CJ.

Nat Med. 2004 Dec;10(12):1301-2. No abstract available.

PMID:
15580253
35.

Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats.

Goralski KB, Renton KW.

Toxicol Appl Pharmacol. 2004 May 1;196(3):381-9.

PMID:
15094308
36.

Relative analgesic potencies of levobupivacaine and ropivacaine for epidural analgesia in labor.

Polley LS, Columb MO, Naughton NN, Wagner DS, van de Ven CJ, Goralski KH.

Anesthesiology. 2003 Dec;99(6):1354-8.

PMID:
14639148
37.

Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.

Goralski KB, Hartmann G, Piquette-Miller M, Renton KW.

Br J Pharmacol. 2003 May;139(1):35-48.

38.

The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.

Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS.

J Pharmacol Exp Ther. 2002 Dec;303(3):959-68.

PMID:
12438515
39.
41.
42.

L(+)- and D(-)-lactate modulate rat renal tubular accumulation of amantadine in the presence and absence of bicarbonate.

Escobar MR, Goralski K, Sitar DS.

J Pharmacol Exp Ther. 1995 Dec;275(3):1317-23.

PMID:
8531098

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