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Items: 13


Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer.

Duplaquet L, Figeac M, Leprêtre F, Frandemiche C, Villenet C, Sebda S, Sarafan-Vasseur N, Bénozène M, Vinchent A, Goormachtigh G, Wicquart L, Rousseau N, Beaussire L, Truant S, Michel P, Sabourin JC, Galateau-Sallé F, Copin MC, Zalcman G, De Launoit Y, Fafeur V, Tulasne D.

Mol Cancer Ther. 2019 Jun;18(6):1137-1148. doi: 10.1158/1535-7163.MCT-18-0582. Epub 2019 Mar 29.


Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.

Le Goff A, Ji Z, Leclercq B, Bourette RP, Mougel A, Guerardel C, de Launoit Y, Vicogne J, Goormachtigh G, Fafeur V.

J Biol Chem. 2012 Oct 12;287(42):35382-96. doi: 10.1074/jbc.M112.409797. Epub 2012 Aug 22.


Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.

Lucas S, Taront S, Magnan C, Fauconnier L, Delacre M, Macia L, Delanoye A, Verwaerde C, Spriet C, Saule P, Goormachtigh G, Héliot L, Ktorza A, Movassat J, Polakowska R, Auriault C, Poulain-Godefroy O, Di Santo J, Froguel P, Wolowczuk I.

PLoS One. 2012;7(6):e40351. doi: 10.1371/journal.pone.0040351. Epub 2012 Jun 29.


Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells.

Ndour PA, Brocqueville G, Ouk TS, Goormachtigh G, Morales O, Mougel A, Bertout J, Melnyk O, Fafeur V, Feuillard J, Coll J, Adriaenssens E.

J Virol. 2012 Apr;86(7):3934-43. doi: 10.1128/JVI.05747-11. Epub 2012 Jan 18.


A one-pot three-segment ligation strategy for protein chemical synthesis.

Ollivier N, Vicogne J, Vallin A, Drobecq H, Desmet R, El Mahdi O, Leclercq B, Goormachtigh G, Fafeur V, Melnyk O.

Angew Chem Int Ed Engl. 2012 Jan 2;51(1):209-13. doi: 10.1002/anie.201105837. Epub 2011 Nov 16. No abstract available.


Polysaccharide microarrays: application to the identification of heparan sulphate mimetics.

Dheur J, Dendane N, Desmet R, Dahmani F, Goormachtigh G, Vicogne J, Fafeur V, Melnyk O.

Methods Mol Biol. 2012;808:231-40. doi: 10.1007/978-1-61779-373-8_16.


Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF/SF-MET signaling.

Goormachtigh G, Ji Z, Le Goff A, Fafeur V.

Biochem Biophys Res Commun. 2011 Aug 12;411(4):780-5. doi: 10.1016/j.bbrc.2011.07.024. Epub 2011 Jul 18.


Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.

Faumont N, Le Clorennec C, Teira P, Goormachtigh G, Coll J, Canitrot Y, Cazaux C, Hoffmann JS, Brousset P, Delsol G, Feuillard J, Meggetto F.

Cancer Res. 2009 Jun 15;69(12):5177-85. doi: 10.1158/0008-5472.CAN-08-2866. Epub 2009 Jun 2.


Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage.

Deheuninck J, Goormachtigh G, Foveau B, Ji Z, Leroy C, Ancot F, Villeret V, Tulasne D, Fafeur V.

Cell Signal. 2009 Sep;21(9):1455-63. doi: 10.1016/j.cellsig.2009.05.005. Epub 2009 May 18.


Caspase cleavage of the MET receptor generates an HGF interfering fragment.

Deheuninck J, Foveau B, Goormachtigh G, Leroy C, Ji Z, Tulasne D, Fafeur V.

Biochem Biophys Res Commun. 2008 Mar 14;367(3):573-7. doi: 10.1016/j.bbrc.2007.12.177. Epub 2008 Jan 8.


Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways.

Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, Le Clorennec C, Feuillard J, Bornkamm GW, Auriault C, Manet E, Fafeur V, Adriaenssens E, Coll J.

J Virol. 2006 Aug;80(15):7382-93.


A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways.

Adriaenssens E, Mougel A, Goormachtigh G, Loing E, Fafeur V, Auriault C, Coll J.

Oncogene. 2004 Apr 8;23(15):2681-93. Erratum in: Oncogene. 2004 Oct 21;23(49):8184.


Human monocytic cell lines transformed in vitro by Epstein-Barr virus display a type II latency and LMP-1-dependent proliferation.

Masy E, Adriaenssens E, Montpellier C, Crépieux P, Mougel A, Quatannens B, Goormachtigh G, Faumont N, Meggetto F, Auriault C, Groux H, Coll J.

J Virol. 2002 Jul;76(13):6460-72.

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