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Items: 1 to 50 of 66

1.

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.

Abrahams MR, Joseph SB, Garrett N, Tyers L, Moeser M, Archin N, Council OD, Matten D, Zhou S, Doolabh D, Anthony C, Goonetilleke N, Karim SA, Margolis DM, Pond SK, Williamson C, Swanstrom R.

Sci Transl Med. 2019 Oct 9;11(513). pii: eaaw5589. doi: 10.1126/scitranslmed.aaw5589.

PMID:
31597754
2.

HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy.

Xu Y, Trumble IM, Warren JA, Clutton G, Abad-Fernandez M, Kirchnerr J, Adimora AA, Deeks SG, Margolis DM, Kuruc JD, Gay CL, Archin NM, Mollan KR, Hudgens M, Goonetilleke N.

Mol Ther Methods Clin Dev. 2019 Aug 14;15:9-17. doi: 10.1016/j.omtm.2019.07.008. eCollection 2019 Dec 13.

3.

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure.

Goonetilleke N, Clutton G, Swanstrom R, Joseph SB.

Front Immunol. 2019 Aug 22;10:1966. doi: 10.3389/fimmu.2019.01966. eCollection 2019.

4.

Precision mouse models with expanded tropism for human pathogens.

Wahl A, De C, Abad Fernandez M, Lenarcic EM, Xu Y, Cockrell AS, Cleary RA, Johnson CE, Schramm NJ, Rank LM, Newsome IG, Vincent HA, Sanders W, Aguilera-Sandoval CR, Boone A, Hildebrand WH, Dayton PA, Baric RS, Pickles RJ, Braunstein M, Moorman NJ, Goonetilleke N, Victor Garcia J.

Nat Biotechnol. 2019 Oct;37(10):1163-1173. doi: 10.1038/s41587-019-0225-9. Epub 2019 Aug 26.

PMID:
31451733
5.

Harnessing CD8+ T Cells Under HIV Antiretroviral Therapy.

Warren JA, Clutton G, Goonetilleke N.

Front Immunol. 2019 Feb 26;10:291. doi: 10.3389/fimmu.2019.00291. eCollection 2019. Review.

6.

Anti-chlamydia IgG and IgA are insufficient to prevent endometrial chlamydia infection in women, and increased anti-chlamydia IgG is associated with enhanced risk for incident infection.

Darville T, Albritton HL, Zhong W, Dong L, O'Connell CM, Poston TB, Quayle AJ, Goonetilleke N, Wiesenfeld HC, Hillier SL, Zheng X.

Am J Reprod Immunol. 2019 May;81(5):e13103. doi: 10.1111/aji.13103. Epub 2019 Mar 18.

PMID:
30784128
7.

A Reproducible, Objective Method Using MitoTracker® Fluorescent Dyes to Assess Mitochondrial Mass in T Cells by Flow Cytometry.

Clutton G, Mollan K, Hudgens M, Goonetilleke N.

Cytometry A. 2019 Apr;95(4):450-456. doi: 10.1002/cyto.a.23705. Epub 2018 Dec 21.

8.

Human cytomegalovirus-vectored vaccines against HIV.

Abad-Fernandez M, Goonetilleke N.

Curr Opin HIV AIDS. 2019 Mar;14(2):137-142. doi: 10.1097/COH.0000000000000524.

PMID:
30562176
9.

HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.

Sung JA, Patel S, Clohosey ML, Roesch L, Tripic T, Kuruc JD, Archin N, Hanley PJ, Cruz CR, Goonetilleke N, Eron JJ, Rooney CM, Gay CL, Bollard CM, Margolis DM.

Mol Ther. 2018 Oct 3;26(10):2496-2506. doi: 10.1016/j.ymthe.2018.08.015. Epub 2018 Sep 21.

10.

Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection.

Peng BJ, Carlson JM, Liu MKP, Gao F, Goonetilleke N, McMichael AJ, Borrow P, Gilmour J, Heath SL, Hunter E, Bansal A, Goepfert PA.

J Virol. 2018 Sep 12;92(19). pii: e00711-18. doi: 10.1128/JVI.00711-18. Print 2018 Oct 1.

11.

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.

Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B, Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF, Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH, McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F.

Nat Commun. 2018 May 15;9(1):1928. doi: 10.1038/s41467-018-04217-5.

12.

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.

Liu D, Wang C, Hora B, Zuo T, Goonetilleke N, Liu MKP, Berrong M, Ferrari G, McMichael AJ, Bhattacharya T, Perelson AS, Gao F.

Retrovirology. 2017 Oct 10;14(1):46. doi: 10.1186/s12977-017-0371-4.

13.

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak GH, Sanders-Buell E, Chenine AL, Eller MA, Goonetilleke N, Thomas R, Leviyang S, Harbolick EA, Bose M, Pham P, Oropeza C, Poltavee K, O'Sullivan AM, Billings E, Merbah M, Costanzo MC, Warren JA, Slike B, Li H, Peachman KK, Fischer W, Gao F, Cicala C, Arthos J, Eller LA, O'Connell RJ, Sinei S, Maganga L, Kibuuka H, Nitayaphan S, Rao M, Marovich MA, Krebs SJ, Rolland M, Korber BT, Shaw GM, Michael NL, Robb ML, Tovanabutra S, Kim JH.

PLoS Pathog. 2017 Sep 14;13(9):e1006620. doi: 10.1371/journal.ppat.1006620. eCollection 2017 Sep.

14.

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak GH, Sanders-Buell E, Chenine AL, Eller MA, Goonetilleke N, Thomas R, Leviyang S, Harbolick EA, Bose M, Pham P, Oropeza C, Poltavee K, O'Sullivan AM, Billings E, Merbah M, Costanzo MC, Warren JA, Slike B, Li H, Peachman KK, Fischer W, Gao F, Cicala C, Arthos J, Eller LA, O'Connell RJ, Sinei S, Maganga L, Kibuuka H, Nitayaphan S, Rao M, Marovich MA, Krebs SJ, Rolland M, Korber BT, Shaw GM, Michael NL, Robb ML, Tovanabutra S, Kim JH.

PLoS Pathog. 2017 Jul 31;13(7):e1006510. doi: 10.1371/journal.ppat.1006510. eCollection 2017 Jul. Erratum in: PLoS Pathog. 2017 Sep 14;13(9):e1006620.

15.

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency.

Archin NM, Kirchherr JL, Sung JA, Clutton G, Sholtis K, Xu Y, Allard B, Stuelke E, Kashuba AD, Kuruc JD, Eron J, Gay CL, Goonetilleke N, Margolis DM.

J Clin Invest. 2017 Aug 1;127(8):3126-3135. doi: 10.1172/JCI92684. Epub 2017 Jul 17.

16.

A Role for Photobiomodulation in the Prevention of Myocardial Ischemic Reperfusion Injury: A Systematic Review and Potential Molecular Mechanisms.

Liebert A, Krause A, Goonetilleke N, Bicknell B, Kiat H.

Sci Rep. 2017 Feb 9;7:42386. doi: 10.1038/srep42386. Review.

17.

Corrigendum: The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function.

Clutton G, Xu Y, Baldoni PL, Mollan KR, Kirchherr J, Newhard W, Cox K, Kuruc JD, Kashuba A, Barnard R, Archin N, Gay CL, Hudgens MG, Margolis DM, Goonetilleke N.

Sci Rep. 2016 Oct 3;6:34430. doi: 10.1038/srep34430. No abstract available.

18.

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

Demers KR, Makedonas G, Buggert M, Eller MA, Ratcliffe SJ, Goonetilleke N, Li CK, Eller LA, Rono K, Maganga L, Nitayaphan S, Kibuuka H, Routy JP, Slifka MK, Haynes BF, McMichael AJ, Bernard NF, Robb ML, Betts MR.

PLoS Pathog. 2016 Aug 3;12(8):e1005805. doi: 10.1371/journal.ppat.1005805. eCollection 2016 Aug.

19.

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function.

Clutton G, Xu Y, Baldoni PL, Mollan KR, Kirchherr J, Newhard W, Cox K, Kuruc JD, Kashuba A, Barnard R, Archin N, Gay CL, Hudgens MG, Margolis DM, Goonetilleke N.

Sci Rep. 2016 Aug 2;6:30749. doi: 10.1038/srep30749. Erratum in: Sci Rep. 2016 Oct 03;6:34430.

20.

Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control.

Watters SA, Mlcochova P, Maldarelli F, Goonetilleke N, Pillay D, Gupta RK.

PLoS One. 2016 Jul 12;11(7):e0158854. doi: 10.1371/journal.pone.0158854. eCollection 2016.

21.

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable.

Barton JP, Goonetilleke N, Butler TC, Walker BD, McMichael AJ, Chakraborty AK.

Nat Commun. 2016 May 23;7:11660. doi: 10.1038/ncomms11660.

22.

Cohort Profile: The Flu Watch Study.

Fragaszy EB, Warren-Gash C, Wang L, Copas A, Dukes O, Edmunds WJ, Goonetilleke N, Harvey G, Johnson AM, Kovar J, Lim MS, McMichael A, Millett ER, Nazareth I, Nguyen-Van-Tam JS, Tabassum F, Watson JM, Wurie F, Zambon M, Hayward AC; Flu Watch Group.

Int J Epidemiol. 2017 Apr 1;46(2):e18. doi: 10.1093/ije/dyv370. No abstract available.

23.

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.

Eller MA, Goonetilleke N, Tassaneetrithep B, Eller LA, Costanzo MC, Johnson S, Betts MR, Krebs SJ, Slike BM, Nitayaphan S, Rono K, Tovanabutra S, Maganga L, Kibuuka H, Jagodzinski L, Peel S, Rolland M, Marovich MA, Kim JH, Michael NL, Robb ML, Streeck H.

J Virol. 2016 Mar 28;90(8):4005-4016. doi: 10.1128/JVI.02785-15. Print 2016 Apr.

24.

Natural T Cell-mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.

Hayward AC, Wang L, Goonetilleke N, Fragaszy EB, Bermingham A, Copas A, Dukes O, Millett ER, Nazareth I, Nguyen-Van-Tam JS, Watson JM, Zambon M; Flu Watch Group, Johnson AM, McMichael AJ.

Am J Respir Crit Care Med. 2015 Jun 15;191(12):1422-31. doi: 10.1164/rccm.201411-1988OC.

25.

Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo.

Smith NM, Mlcochova P, Watters SA, Aasa-Chapman MM, Rabin N, Moore S, Edwards SG, Garson JA, Grant PR, Ferns RB, Kashuba A, Mayor NP, Schellekens J, Marsh SG, McMichael AJ, Perelson AS, Pillay D, Goonetilleke N, Gupta RK.

Clin Infect Dis. 2015 Jul 1;61(1):120-8. doi: 10.1093/cid/civ219. Epub 2015 Mar 16.

26.

Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.

Hancock G, Yang H, Yorke E, Wainwright E, Bourne V, Frisbee A, Payne TL, Berrong M, Ferrari G, Chopera D, Hanke T, Mothe B, Brander C, McElrath MJ, McMichael A, Goonetilleke N, Tomaras GD, Frahm N, Dorrell L.

PLoS Pathog. 2015 Feb 27;11(2):e1004658. doi: 10.1371/journal.ppat.1004658. eCollection 2015 Feb.

27.

Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.

Liu D, Zuo T, Hora B, Song H, Kong W, Yu X, Goonetilleke N, Bhattacharya T, Perelson AS, Haynes BF, McMichael AJ, Gao F.

Retrovirology. 2014 Nov 19;11:101. doi: 10.1186/s12977-014-0101-0.

28.

Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

Ritchie AJ, Cai F, Smith NM, Chen S, Song H, Brackenridge S, Abdool Karim SS, Korber BT, McMichael AJ, Gao F, Goonetilleke N.

Retrovirology. 2014 Sep 12;11:69. doi: 10.1186/s12977-014-0069-9.

29.

Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.

Song H, Hora B, Bhattacharya T, Goonetilleke N, Liu MK, Wiehe K, Li H, Iyer SS, McMichael AJ, Perelson AS, Gao F.

PLoS One. 2014 Jul 16;9(7):e102734. doi: 10.1371/journal.pone.0102734. eCollection 2014.

30.

Proteome-wide analysis of HIV-specific naive and memory CD4(+) T cells in unexposed blood donors.

Campion SL, Brodie TM, Fischer W, Korber BT, Rossetti A, Goonetilleke N, McMichael AJ, Sallusto F.

J Exp Med. 2014 Jun 30;211(7):1273-80. doi: 10.1084/jem.20130555. Epub 2014 Jun 23.

31.

Comparative community burden and severity of seasonal and pandemic influenza: results of the Flu Watch cohort study.

Hayward AC, Fragaszy EB, Bermingham A, Wang L, Copas A, Edmunds WJ, Ferguson N, Goonetilleke N, Harvey G, Kovar J, Lim MS, McMichael A, Millett ER, Nguyen-Van-Tam JS, Nazareth I, Pebody R, Tabassum F, Watson JM, Wurie FB, Johnson AM, Zambon M; Flu Watch Group.

Lancet Respir Med. 2014 Jun;2(6):445-54. doi: 10.1016/S2213-2600(14)70034-7. Epub 2014 Mar 17.

32.

Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.

Pala P, Serwanga J, Watera C, Ritchie AJ, Moodie Z, Wang M, Goonetilleke N, Birabwa E, Hughes P, Senkaali D, Nakiboneka R, Grosskurth H, Haynes B, McMichael A, Kaleebu P; Center for HIV/AIDS Vaccine Immunology.

J Virol. 2013 Aug;87(16):9053-63. doi: 10.1128/JVI.00721-13. Epub 2013 Jun 12.

33.

Immunology. Antigen processing takes a new direction.

Goonetilleke N, McMichael AJ.

Science. 2013 May 24;340(6135):937-8. doi: 10.1126/science.1239649. No abstract available.

PMID:
23704564
34.

HIV-1 vaccines: let's get physical.

Goonetilleke N, McMichael AJ.

Immunity. 2013 Mar 21;38(3):410-3. doi: 10.1016/j.immuni.2013.02.017.

35.

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.

Liu MK, Hawkins N, Ritchie AJ, Ganusov VV, Whale V, Brackenridge S, Li H, Pavlicek JW, Cai F, Rose-Abrahams M, Treurnicht F, Hraber P, Riou C, Gray C, Ferrari G, Tanner R, Ping LH, Anderson JA, Swanstrom R; CHAVI Core B, Cohen M, Karim SS, Haynes B, Borrow P, Perelson AS, Shaw GM, Hahn BH, Williamson C, Korber BT, Gao F, Self S, McMichael A, Goonetilleke N.

J Clin Invest. 2013 Jan;123(1):380-93. doi: 10.1172/JCI65330. Epub 2012 Dec 10.

36.

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.

Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F.

Retrovirology. 2012 Oct 30;9:89. doi: 10.1186/1742-4690-9-89.

37.

Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells.

Riou C, Treurnicht F, Abrahams MR, Mlisana K, Liu MK, Goonetilleke N, Koup R, Roederer M, Abdool Karim S, de Bruyn G, Williamson C, Gray CM, Burgers WA; CAPRISA 002 Study Team.

J Immunol. 2012 Oct 15;189(8):3838-47. doi: 10.4049/jimmunol.1201488. Epub 2012 Sep 10.

38.

Short communication: broader T cell responses directed against human immunodeficiency virus type 1 in infected Chinese individuals through blood-borne transmission in comparison with mucosal transmission.

Zhou D, Zhang X, Li W, Xu X, Goonetilleke N, Yang H, Dong T, Yan H.

AIDS Res Hum Retroviruses. 2013 Jan;29(1):89-93. doi: 10.1089/AID.2011.0314. Epub 2012 Jun 27.

39.

Comparison of sexual behavior and HIV risk between two HIV-1 serodiscordant couple cohorts: the CHAVI 002 study.

Ritchie AJ, Kuldanek K, Moodie Z, Wang ZM, Fox J, Nsubuga RN, Legg K, Birabwa EF, Kaleebu P, McMichael AJ, Watera C, Goonetilleke N, Fidler S.

PLoS One. 2012;7(5):e37727. doi: 10.1371/journal.pone.0037727. Epub 2012 May 22.

40.

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection.

Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, Whale VE, Goonetilleke N, Borrow P, Ferrari G, Betts MR, Haynes BF, McMichael AJ, Gray CM.

J Immunol. 2012 Mar 1;188(5):2198-206. doi: 10.4049/jimmunol.1102813. Epub 2012 Jan 27.

41.

Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.

Arnoczy GS, Ferrari G, Goonetilleke N, Corrah T, Li H, Kuruc J, Schmitz JL, McGee K, Hicks C, Eron JJ; Center for HIV/AIDS Vaccine Immunology AI067854.

AIDS Res Hum Retroviruses. 2012 Aug;28(8):789-92.

42.

The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.

Mahlokozera T, Kang HH, Goonetilleke N, Stacey AR, Lovingood RV, Denny TN, Kalilani L, Bunn JE, Meshnick SR, Borrow P, Letvin NL, Permar SR; Center for HIV/AIDS Vaccine Immunology.

PLoS One. 2011;6(8):e23735. doi: 10.1371/journal.pone.0023735. Epub 2011 Aug 23.

43.

Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.

Ganusov VV, Goonetilleke N, Liu MK, Ferrari G, Shaw GM, McMichael AJ, Borrow P, Korber BT, Perelson AS.

J Virol. 2011 Oct;85(20):10518-28. doi: 10.1128/JVI.00655-11. Epub 2011 Aug 10.

44.

An early HIV mutation within an HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1.

Brackenridge S, Evans EJ, Toebes M, Goonetilleke N, Liu MK, di Gleria K, Schumacher TN, Davis SJ, McMichael AJ, Gillespie GM.

J Virol. 2011 Jun;85(11):5415-22. doi: 10.1128/JVI.00238-11. Epub 2011 Mar 23.

45.

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

Ferrari G, Korber B, Goonetilleke N, Liu MK, Turnbull EL, Salazar-Gonzalez JF, Hawkins N, Self S, Watson S, Betts MR, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras GD, Haynes BF, Gray CM, Borrow P, Roederer M, McMichael AJ, Weinhold KJ.

PLoS Pathog. 2011 Feb 10;7(2):e1001273. doi: 10.1371/journal.ppat.1001273.

46.

Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.

Ritchie AJ, Campion SL, Kopycinski J, Moodie Z, Wang ZM, Pandya K, Moore S, Liu MK, Brackenridge S, Kuldanek K, Legg K, Cohen MS, Delwart EL, Haynes BF, Fidler S, McMichael AJ, Goonetilleke N.

J Virol. 2011 Apr;85(7):3507-16. doi: 10.1128/JVI.02444-10. Epub 2011 Jan 26.

47.

Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.

Corrah TW, Goonetilleke N, Kopycinski J, Deeks SG, Cohen MS, Borrow P, McMichael A, Brackenridge S.

J Virol. 2011 Apr;85(7):3367-74. doi: 10.1128/JVI.02276-10. Epub 2011 Jan 19.

48.

Improved detection of latent Mycobacterium tuberculosis infection in HIV-1 seropositive individuals using cultured cellular assays.

Campion S, Cohen MS, McMichael AJ, Galvin S, Goonetilleke N.

Eur J Immunol. 2011 Jan;41(1):255-7. doi: 10.1002/eji.201040296. Epub 2010 Dec 1. No abstract available.

49.

The immune response during acute HIV-1 infection: clues for vaccine development.

McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF.

Nat Rev Immunol. 2010 Jan;10(1):11-23. doi: 10.1038/nri2674. Epub 2009 Dec 11. Review.

50.

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection.

Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, Keele BF, Learn GH, Turnbull EL, Salazar MG, Weinhold KJ, Moore S; CHAVI Clinical Core B, Letvin N, Haynes BF, Cohen MS, Hraber P, Bhattacharya T, Borrow P, Perelson AS, Hahn BH, Shaw GM, Korber BT, McMichael AJ.

J Exp Med. 2009 Jun 8;206(6):1253-72. doi: 10.1084/jem.20090365. Epub 2009 Jun 1.

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