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Items: 1 to 50 of 197

1.

Paternal Exercise Improves Glucose Metabolism in Adult Offspring.

Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coehlo AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ.

Diabetes. 2018 Oct 21. pii: db180667. doi: 10.2337/db18-0667. [Epub ahead of print]

PMID:
30344184
2.

Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.

Sun XL, Lessard SJ, An D, Koh HJ, Esumi H, Hirshman MF, Goodyear LJ.

J Cell Biochem. 2018 Sep 7. doi: 10.1002/jcb.27425. [Epub ahead of print]

PMID:
30256437
3.

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.

Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME.

Mol Metab. 2018 Nov;17:61-70. doi: 10.1016/j.molmet.2018.08.002. Epub 2018 Aug 11.

4.

Postexercise improvement in glucose uptake occurs concomitant with greater γ3-AMPK activation and AS160 phosphorylation in rat skeletal muscle.

Wang H, Arias EB, Pataky MW, Goodyear LJ, Cartee GD.

Am J Physiol Endocrinol Metab. 2018 Aug 21. doi: 10.1152/ajpendo.00020.2018. [Epub ahead of print]

PMID:
30130149
5.

JNK regulates muscle remodeling via myostatin/SMAD inhibition.

Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ.

Nat Commun. 2018 Aug 2;9(1):3030. doi: 10.1038/s41467-018-05439-3.

6.

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 Aug;43(9):1934-1942. doi: 10.1038/s41386-018-0103-z. Epub 2018 May 24.

PMID:
29875450
7.

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.

Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ.

Cell Metab. 2018 Jun 5;27(6):1357. doi: 10.1016/j.cmet.2018.04.023. No abstract available.

8.

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake.

Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ.

Cell Metab. 2018 May 1;27(5):1111-1120.e3. doi: 10.1016/j.cmet.2018.03.020. Erratum in: Cell Metab. 2018 Jun 5;27(6):1357.

PMID:
29719226
9.

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384b.

PMID:
29117173
10.

Tribbles 3 regulates protein turnover in mouse skeletal muscle.

Choi RH, McConahay A, Jeong HW, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ.

Biochem Biophys Res Commun. 2017 Nov 25;493(3):1236-1242. doi: 10.1016/j.bbrc.2017.09.134. Epub 2017 Sep 27.

PMID:
28962861
11.

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy.

Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z.

Nat Commun. 2017 Sep 15;8(1):548. doi: 10.1038/s41467-017-00520-9.

12.

Maternal Exercise Improves Glucose Tolerance in Female Offspring.

Stanford KI, Takahashi H, So K, Alves-Wagner AB, Prince NB, Lehnig AC, Getchell KM, Lee MY, Hirshman MF, Goodyear LJ.

Diabetes. 2017 Aug;66(8):2124-2136. doi: 10.2337/db17-0098. Epub 2017 Jun 1.

13.

Muscle-Adipose Tissue Cross Talk.

Stanford KI, Goodyear LJ.

Cold Spring Harb Perspect Med. 2018 Aug 1;8(8). pii: a029801. doi: 10.1101/cshperspect.a029801. Review.

14.

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.

Nat Med. 2017 May;23(5):631-637. doi: 10.1038/nm.4297. Epub 2017 Mar 27. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

15.

Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men.

Motiani P, Virtanen KA, Motiani KK, Eskelinen JJ, Middelbeek RJ, Goodyear LJ, Savolainen AM, Kemppainen J, Jensen J, Din MU, Saunavaara V, Parkkola R, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC.

Diabetes Obes Metab. 2017 Oct;19(10):1379-1388. doi: 10.1111/dom.12947. Epub 2017 Jul 6.

16.

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling.

May FJ, Baer LA, Lehnig AC, So K, Chen EY, Gao F, Narain NR, Gushchina L, Rose A, Doseff AI, Kiebish MA, Goodyear LJ, Stanford KI.

Cell Rep. 2017 Feb 7;18(6):1558-1572. doi: 10.1016/j.celrep.2017.01.038.

17.

Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice.

Mul JD, Zheng J, Goodyear LJ.

eNeuro. 2016 Dec 29;3(6). pii: ENEURO.0201-16.2016. doi: 10.1523/ENEURO.0201-16.2016. eCollection 2016 Nov-Dec.

18.

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.

Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, De Sousa-Coelho AL, Daher G, Manoli I, Sysol JR, Isganaitis E, Jessen N, Goodyear LJ, Beebe K, Gall W, Venditti CP, Patti ME.

Mol Metab. 2016 Aug 6;5(10):926-936. doi: 10.1016/j.molmet.2016.08.001. eCollection 2016 Oct.

19.

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15.

20.

Exercise regulation of adipose tissue.

Stanford KI, Goodyear LJ.

Adipocyte. 2016 May 18;5(2):153-62. doi: 10.1080/21623945.2016.1191307. eCollection 2016 Apr-Jun. Review.

21.

Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.

Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH.

Diabetologia. 2016 Aug;59(8):1769-77. doi: 10.1007/s00125-016-3990-8. Epub 2016 May 21.

22.

Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation.

Ernande L, Stanford KI, Thoonen R, Zhang H, Clerte M, Hirshman MF, Goodyear LJ, Bloch KD, Buys ES, Scherrer-Crosbie M.

J Appl Physiol (1985). 2016 Apr 15;120(8):825-32. doi: 10.1152/japplphysiol.00634.2015. Epub 2016 Jan 28.

23.

Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling.

Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):783-91. doi: 10.1016/j.bbrc.2016.01.064. Epub 2016 Jan 20.

24.

The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.

Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, Goodyear LJ.

J Clin Invest. 2016 Feb;126(2):560-70.

25.

Contraction stimulates muscle glucose uptake independent of atypical PKC.

Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ.

Physiol Rep. 2015 Nov;3(11). pii: e12565. doi: 10.14814/phy2.12565.

26.

Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation.

Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD.

Mol Metab. 2015 Jul 17;4(10):692-705. doi: 10.1016/j.molmet.2015.07.003. eCollection 2015 Oct.

27.

Exercise and Regulation of Carbohydrate Metabolism.

Mul JD, Stanford KI, Hirshman MF, Goodyear LJ.

Prog Mol Biol Transl Sci. 2015;135:17-37. doi: 10.1016/bs.pmbts.2015.07.020. Epub 2015 Aug 20. Review.

28.

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH.

EMBO Rep. 2015 Oct;16(10):1378-93. doi: 10.15252/embr.201540837. Epub 2015 Aug 24.

29.

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.

Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR.

Nat Commun. 2015 Aug 24;6:8054. doi: 10.1038/ncomms9054.

30.

Erratum. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes 2015;64:2361-2368.

Stanford KI, Middelbeek RJ, Goodyear LJ.

Diabetes. 2015 Sep;64(9):3334. doi: 10.2337/db15-er09. No abstract available.

31.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH.

Nat Med. 2015 Jul;21(7):760-8. doi: 10.1038/nm.3881. Epub 2015 Jun 15.

32.

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations.

Stanford KI, Middelbeek RJ, Goodyear LJ.

Diabetes. 2015 Jul;64(7):2361-8. doi: 10.2337/db15-0227. Epub 2015 Jun 7. Review. Erratum in: Diabetes. 2015 Sep;64(9):3334.

33.

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, Kahn CR.

Cell Rep. 2015 May 26;11(8):1220-35. doi: 10.1016/j.celrep.2015.04.037. Epub 2015 May 14.

34.

A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ.

Diabetes. 2015 Jun;64(6):2002-14. doi: 10.2337/db14-0704. Epub 2015 Jan 20.

35.

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.

Stanford KI, Goodyear LJ.

Adv Physiol Educ. 2014 Dec;38(4):308-14. doi: 10.1152/advan.00080.2014. Review.

36.

Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring.

Stanford KI, Lee MY, Getchell KM, So K, Hirshman MF, Goodyear LJ.

Diabetes. 2015 Feb;64(2):427-33. doi: 10.2337/db13-1848. Epub 2014 Sep 9.

37.

Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling.

Rivas DA, Lessard SJ, Rice NP, Lustgarten MS, So K, Goodyear LJ, Parnell LD, Fielding RA.

FASEB J. 2014 Sep;28(9):4133-47. doi: 10.1096/fj.14-254490. Epub 2014 Jun 13.

38.

Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise.

Vendelbo MH, Møller AB, Treebak JT, Gormsen LC, Goodyear LJ, Wojtaszewski JF, Jørgensen JO, Møller N, Jessen N.

J Appl Physiol (1985). 2014 Aug 1;117(3):289-96. doi: 10.1152/japplphysiol.00044.2014. Epub 2014 May 29.

39.

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ.

Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5.

40.

Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.

An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, Goodyear LJ.

Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R925-33. doi: 10.1152/ajpregu.00027.2014. Epub 2014 Apr 16.

41.

The therapeutic potential of brown adipose tissue.

Stanford KI, Goodyear LJ.

Hepatobiliary Surg Nutr. 2013 Oct;2(5):286-7. doi: 10.3978/j.issn.2304-3881.2013.09.02. No abstract available.

42.

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle.

Treebak JT, Pehmøller C, Kristensen JM, Kjøbsted R, Birk JB, Schjerling P, Richter EA, Goodyear LJ, Wojtaszewski JF.

J Physiol. 2014 Jan 15;592(2):351-75. doi: 10.1113/jphysiol.2013.266338. Epub 2013 Nov 18.

43.

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle.

Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Frøsig C, Leick L, Fentz J, Jørgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT.

J Physiol. 2013 Oct 15;591(20):5207-20. doi: 10.1113/jphysiol.2013.259515. Epub 2013 Aug 5.

44.

Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation.

Olesen J, Ringholm S, Nielsen MM, Brandt CT, Pedersen JT, Halling JF, Goodyear LJ, Pilegaard H.

Exp Gerontol. 2013 Nov;48(11):1274-84. doi: 10.1016/j.exger.2013.07.015. Epub 2013 Aug 3.

45.

Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo.

Lauritzen HP, Brandauer J, Schjerling P, Koh HJ, Treebak JT, Hirshman MF, Galbo H, Goodyear LJ.

Diabetes. 2013 Sep;62(9):3081-92. doi: 10.2337/db12-1261. Epub 2013 Jun 12.

46.

Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle.

Middelbeek RJ, Chambers MA, Tantiwong P, Treebak JT, An D, Hirshman MF, Musi N, Goodyear LJ.

Nutr Diabetes. 2013 Jun 10;3:e74. doi: 10.1038/nutd.2013.13.

47.

Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.

Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z.

Cell Rep. 2013 May 30;3(5):1449-56. doi: 10.1016/j.celrep.2013.04.023. Epub 2013 May 23.

48.

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.

Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ.

Nat Commun. 2013;4:1871. doi: 10.1038/ncomms2851.

49.

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ.

Diabetes. 2013 Aug;62(8):2717-27. doi: 10.2337/db13-0062. Epub 2013 Apr 22.

50.

Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation.

Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E631-9. doi: 10.1152/ajpendo.00494.2012. Epub 2013 Jan 15.

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