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The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance.

Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS.

Clin Cancer Res. 2019 Jul 30. doi: 10.1158/1078-0432.CCR-19-1423. [Epub ahead of print]


Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer.

Wadosky KM, Wang Y, Zhang X, Goodrich DW.

J Vis Exp. 2019 Jun 13;(148). doi: 10.3791/59710.


Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy.

Knudsen ES, Pruitt SC, Hershberger PA, Witkiewicz AK, Goodrich DW.

Trends Cancer. 2019 May;5(5):308-324. doi: 10.1016/j.trecan.2019.03.005. Epub 2019 Apr 30. Review.


Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression.

Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, Ye Z, Ma T, Wu Q, Rodrigues DN, Kohli M, Jimenez R, Wang L, Goodrich DW, de Bono J, Dong H, Wu H, Zhu R, Huang H.

Mol Cell. 2019 Jan 3;73(1):22-35.e6. doi: 10.1016/j.molcel.2018.10.034. Epub 2018 Dec 6.


Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells.

Wadosky KM, Shourideh M, Goodrich DW, Koochekpour S.

Prostate. 2019 Feb;79(2):140-150. doi: 10.1002/pros.23719. Epub 2018 Oct 2.


Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase.

Song JH, Singh N, Luevano LA, Padi SKR, Okumura K, Olive V, Black SM, Warfel NA, Goodrich DW, Kraft AS.

Mol Cancer Ther. 2018 Dec;17(12):2710-2721. doi: 10.1158/1535-7163.MCT-18-0374. Epub 2018 Sep 6.


An approach for controlling the timing and order of engineered mutations in mice.

Goodrich MM, Talhouk R, Zhang X, Goodrich DW.

Genesis. 2018 Aug;56(8):e23243. doi: 10.1002/dvg.23243. Epub 2018 Aug 23.


Non-canonical functions of the RB protein in cancer.

Dick FA, Goodrich DW, Sage J, Dyson NJ.

Nat Rev Cancer. 2018 Jul;18(7):442-451. doi: 10.1038/s41568-018-0008-5. Review.


TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.

Labbé DP, Sweeney CJ, Brown M, Galbo P, Rosario S, Wadosky KM, Ku SY, Sjöström M, Alshalalfa M, Erho N, Davicioni E, Karnes RJ, Schaeffer EM, Jenkins RB, Den RB, Ross AE, Bowden M, Huang Y, Gray KP, Feng FY, Spratt DE, Goodrich DW, Eng KH, Ellis L.

Clin Cancer Res. 2017 Nov 15;23(22):7072-7083. doi: 10.1158/1078-0432.CCR-17-0413. Epub 2017 Sep 12.


Evasion of targeted cancer therapy through stem-cell-like reprogramming.

Wadosky KM, Ellis L, Goodrich DW.

Mol Cell Oncol. 2017 Feb 16;4(2):e1291397. doi: 10.1080/23723556.2017.1291397. eCollection 2017.


SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.

Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL.

Science. 2017 Jan 6;355(6320):84-88. doi: 10.1126/science.aah4307.


Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.

Ku SY, Rosario S, Wang Y, Mu P, Seshadri M, Goodrich ZW, Goodrich MM, Labbé DP, Gomez EC, Wang J, Long HW, Xu B, Brown M, Loda M, Sawyers CL, Ellis L, Goodrich DW.

Science. 2017 Jan 6;355(6320):78-83. doi: 10.1126/science.aah4199.


Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer.

Ellis L, Ku S, Li Q, Azabdaftari G, Seliski J, Olson B, Netherby CS, Tang DG, Abrams SI, Goodrich DW, Pili R.

Prostate. 2016 Sep;76(13):1192-202. doi: 10.1002/pros.23206. Epub 2016 May 26.


Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer.

Kumar S, Chaudhary AK, Kumar R, O'Malley J, Dubrovska A, Wang X, Yadav N, Goodrich DW, Chandra D.

Mol Oncol. 2016 Aug;10(7):949-65. doi: 10.1016/j.molonc.2016.03.007. Epub 2016 Mar 31.


Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.

Chinnam M, Wang X, Zhang X, Goodrich DW.

Mol Cell Biol. 2016 May 16;36(11):1621-7. doi: 10.1128/MCB.01003-15. Print 2016 Jun 1.


Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.

Samant MD, Jackson CM, Felix CL, Jones AJ, Goodrich DW, Foster BA, Huss WJ.

Stem Cells Dev. 2015 May 15;24(10):1236-51. doi: 10.1089/scd.2014.0293. Epub 2015 Feb 25.


The Thoc1 ribonucleoprotein and prostate cancer progression.

Chinnam M, Wang Y, Zhang X, Gold DL, Khoury T, Nikitin AY, Foster BA, Li Y, Bshara W, Morrison CD, Payne Ondracek RD, Mohler JL, Goodrich DW.

J Natl Cancer Inst. 2014 Oct 8;106(11). pii: dju306. doi: 10.1093/jnci/dju306. Print 2014 Nov.


The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.

Pitzonka L, Ullas S, Chinnam M, Povinelli BJ, Fisher DT, Golding M, Appenheimer MM, Nemeth MJ, Evans S, Goodrich DW.

PLoS One. 2014 May 15;9(5):e97628. doi: 10.1371/journal.pone.0097628. eCollection 2014.


A transgenic mouse model for early prostate metastasis to lymph nodes.

Ko HK, Akakura S, Peresie J, Goodrich DW, Foster BA, Gelman IH.

Cancer Res. 2014 Feb 1;74(3):945-53. doi: 10.1158/0008-5472.CAN-13-1157. Erratum in: Cancer Res. 2014 Apr 15;74(8):2374.


The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.

Pitzonka L, Wang X, Ullas S, Wolff DW, Wang Y, Goodrich DW.

Mol Cell Biol. 2013 Sep;33(17):3505-14. doi: 10.1128/MCB.00751-13. Epub 2013 Jul 1.


The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.

Song F, Fan C, Wang X, Goodrich DW.

PLoS One. 2013;8(2):e57995. doi: 10.1371/journal.pone.0057995. Epub 2013 Feb 27.


RB1, development, and cancer.

Chinnam M, Goodrich DW.

Curr Top Dev Biol. 2011;94:129-69. doi: 10.1016/B978-0-12-380916-2.00005-X. Review.


E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.

Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Foster BA, Nikitin AY, Wills M, Goodrich DW.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):704-9. doi: 10.1073/pnas.1015027108. Epub 2010 Dec 27.


Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse.

Xiao H, Zhang X, Goodrich DW.

Genesis. 2010 Feb;48(2):121-6. doi: 10.1002/dvg.20589.


Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.

Wang X, Chinnam M, Wang J, Wang Y, Zhang X, Marcon E, Moens P, Goodrich DW.

Mol Cell Biol. 2009 May;29(10):2794-803. doi: 10.1128/MCB.01633-08. Epub 2009 Mar 23.


Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.

Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D.

Ann Clin Lab Sci. 2008 Spring;38(2):105-12.


Cancer cells and normal cells differ in their requirements for Thoc1.

Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW.

Cancer Res. 2007 Jul 15;67(14):6657-64.


An allelic series for studying the mouse Thoc1 gene.

Wang X, Li Y, Zhang X, Goodrich DW.

Genesis. 2007 Jan;45(1):32-7.


Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study.

Chanan-Khan A, Miller KC, Musial L, Lawrence D, Padmanabhan S, Takeshita K, Porter CW, Goodrich DW, Bernstein ZP, Wallace P, Spaner D, Mohr A, Byrne C, Hernandez-Ilizaliturri F, Chrystal C, Starostik P, Czuczman MS.

J Clin Oncol. 2006 Dec 1;24(34):5343-9. Epub 2006 Nov 6.


The retinoblastoma tumor-suppressor gene, the exception that proves the rule.

Goodrich DW.

Oncogene. 2006 Aug 28;25(38):5233-43. Review.


Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

Zhou Z, Flesken-Nikitin A, Corney DC, Wang W, Goodrich DW, Roy-Burman P, Nikitin AY.

Cancer Res. 2006 Aug 15;66(16):7889-98.


Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.

Wang X, Chang Y, Li Y, Zhang X, Goodrich DW.

Mol Cell Biol. 2006 Jun;26(11):4362-7.


An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.

Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW.

Mol Cell Biol. 2006 Feb;26(4):1527-37.


Adenovirus-mediated N5 gene transfer inhibits tumor growth and metastasis of human carcinoma in nude mice.

Yin S, Bailiang W, Xie K, Goodrich DW.

Cancer Gene Ther. 2002 Aug;9(8):665-72.


Cell cycle regulation of c-Jun N-terminal kinase activity at the centrosomes.

MacCorkle-Chosnek RA, VanHooser A, Goodrich DW, Brinkley BR, Tan TH.

Biochem Biophys Res Commun. 2001 Nov 23;289(1):173-80.


The nuclear death domain protein p84N5 activates a G2/M cell cycle checkpoint prior to the onset of apoptosis.

Doostzadeh-Cizeron J, Terry NH, Goodrich DW.

J Biol Chem. 2001 Jan 12;276(2):1127-32.


Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-kappa B activation.

Doostzadeh-Cizeron J, Yin S, Goodrich DW.

J Biol Chem. 2000 Aug 18;275(33):25336-41.


Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein.

Doostzadeh-Cizeron J, Evans R, Yin S, Goodrich DW.

Mol Biol Cell. 1999 Oct;10(10):3251-61.


Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation.

Van Hooser A, Goodrich DW, Allis CD, Brinkley BR, Mancini MA.

J Cell Sci. 1998 Dec;111 ( Pt 23):3497-506.


Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

Connell-Crowley L, Harper JW, Goodrich DW.

Mol Biol Cell. 1997 Feb;8(2):287-301.


Molecular characterization of the retinoblastoma susceptibility gene.

Goodrich DW, Lee WH.

Biochim Biophys Acta. 1993 May 25;1155(1):43-61. Review.


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