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Items: 1 to 50 of 243

1.

Sequencing and Affinity Determination of Antigen-Specific B Lymphocytes from Peripheral Blood.

Schofield P, Vazquez-Lombardi R, Abdelatti M, Nevoltris D, Goodnow CC, Christ D, Reed JH.

Methods Mol Biol. 2018;1827:287-309. doi: 10.1007/978-1-4939-8648-4_15.

PMID:
30196503
2.

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen.

Wagle MV, Marchingo JM, Howitt J, Tan SS, Goodnow CC, Parish IA.

Cell Rep. 2018 Jul 17;24(3):577-584. doi: 10.1016/j.celrep.2018.06.060.

3.

Understanding Immune Tolerance of Cancer: Re-Purposing Insights from Fetal Allografts and Microbes.

Barnet MB, Blinman P, Cooper W, Boyer MJ, Kao S, Goodnow CC.

Bioessays. 2018 Aug;40(8):e1800050. doi: 10.1002/bies.201800050. Epub 2018 Jun 4. Review.

PMID:
29869436
4.

αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors.

Wirasinha RC, Singh M, Archer SK, Chan A, Harrison PF, Goodnow CC, Daley SR.

Immunol Cell Biol. 2018 Jul;96(6):553-561. doi: 10.1111/imcb.12047. Epub 2018 May 3.

PMID:
29726044
5.

Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome.

Wang JJ, Reed JH, Colella AD, Russell AJ, Murray-Brown W, Chataway TK, Jackson KJL, Goodnow CC, Gordon TP.

Arthritis Rheumatol. 2018 Apr 26. doi: 10.1002/art.40539. [Epub ahead of print]

PMID:
29697211
6.

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle.

Rizzetto S, Koppstein DNP, Samir J, Singh M, Reed JH, Cai CH, Lloyd AR, Eltahla AA, Goodnow CC, Luciani F.

Bioinformatics. 2018 Aug 15;34(16):2846-2847. doi: 10.1093/bioinformatics/bty203.

PMID:
29659703
7.

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.

PMID:
29650674
8.

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.

Alshekaili J, Chand R, Lee CE, Corley S, Kwong K, Papa I, Fulcher DA, Randall KL, Leiding JW, Ma CS, Wilkins MR, Uzel G, Goodnow CC, Vinuesa CG, Tangye SG, Cook MC.

Sci Rep. 2018 Feb 23;8(1):3529. doi: 10.1038/s41598-018-21389-8.

9.

Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Yap JY, Wirasinha RC, Chan A, Howard DR, Goodnow CC, Daley SR.

Immunology. 2018 Jul;154(3):522-532. doi: 10.1111/imm.12904. Epub 2018 Feb 27.

PMID:
29411880
10.

A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Oakes SR, Gallego-Ortega D, Stanford PM, Junankar S, Au WWY, Kikhtyak Z, von Korff A, Sergio CM, Law AMK, Castillo LE, Allerdice SL, Young AIJ, Piggin C, Whittle B, Bertram E, Naylor MJ, Roden DL, Donovan J, Korennykh A, Goodnow CC, O'Bryan MK, Ormandy CJ.

PLoS Genet. 2017 Nov 8;13(11):e1007072. doi: 10.1371/journal.pgen.1007072. eCollection 2017 Nov.

11.

Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM.

Wang JQ, Jeelall YS, Humburg P, Batchelor EL, Kaya SM, Yoo HM, Goodnow CC, Horikawa K.

J Exp Med. 2017 Sep 4;214(9):2759-2776. doi: 10.1084/jem.20161454. Epub 2017 Jul 12.

12.

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation.

Burnett DL, Parish IA, Masle-Farquhar E, Brink R, Goodnow CC.

Immunol Cell Biol. 2017 Oct;95(9):775-788. doi: 10.1038/icb.2017.50. Epub 2017 Jun 14.

13.

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

Miosge LA, Sontani Y, Chuah A, Horikawa K, Russell TA, Mei Y, Wagle MV, Howard DR, Enders A, Tscharke DC, Goodnow CC, Parish IA.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5216-E5225. doi: 10.1073/pnas.1705795114. Epub 2017 Jun 12.

14.

IL-2 prevents deletion of developing T-regulatory cells in the thymus.

Hu DY, Wirasinha RC, Goodnow CC, Daley SR.

Cell Death Differ. 2017 Jun;24(6):1007-1016. doi: 10.1038/cdd.2017.38. Epub 2017 May 12.

15.

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells.

Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J.

Nat Commun. 2016 Nov 14;7:13373. doi: 10.1038/ncomms13373.

16.

IgD attenuates the IgM-induced anergy response in transitional and mature B cells.

Sabouri Z, Perotti S, Spierings E, Humburg P, Yabas M, Bergmann H, Horikawa K, Roots C, Lambe S, Young C, Andrews TD, Field M, Enders A, Reed JH, Goodnow CC.

Nat Commun. 2016 Nov 10;7:13381. doi: 10.1038/ncomms13381.

17.

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

Koay HF, Gherardin NA, Enders A, Loh L, Mackay LK, Almeida CF, Russ BE, Nold-Petry CA, Nold MF, Bedoui S, Chen Z, Corbett AJ, Eckle SB, Meehan B, d'Udekem Y, Konstantinov IE, Lappas M, Liu L, Goodnow CC, Fairlie DP, Rossjohn J, Chong MM, Kedzierska K, Berzins SP, Belz GT, McCluskey J, Uldrich AP, Godfrey DI, Pellicci DG.

Nat Immunol. 2016 Nov;17(11):1300-1311. doi: 10.1038/ni.3565. Epub 2016 Sep 26.

PMID:
27668799
18.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS.

J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6.

19.

Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

Tangye SG, Pillay B, Randall KL, Avery DT, Phan TG, Gray P, Ziegler JB, Smart JM, Peake J, Arkwright PD, Hambleton S, Orange J, Goodnow CC, Uzel G, Casanova JL, Lugo Reyes SO, Freeman AF, Su HC, Ma CS.

J Allergy Clin Immunol. 2017 Mar;139(3):933-949. doi: 10.1016/j.jaci.2016.07.016. Epub 2016 Aug 20.

PMID:
27554822
20.

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.

Wang JQ, Beutler B, Goodnow CC, Horikawa K.

Blood. 2016 Sep 22;128(12):1604-8. doi: 10.1182/blood-2016-03-708065. Epub 2016 Jul 25.

21.

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy.

Parish IA, Stamp LA, Lorenzo AM, Fowler SM, Sontani Y, Miosge LA, Howard DR, Goodnow CC, Young HM, Furness JB.

Am J Pathol. 2016 Sep;186(9):2254-61. doi: 10.1016/j.ajpath.2016.04.016. Epub 2016 Jul 16.

22.

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.

Reed JH, Jackson J, Christ D, Goodnow CC.

J Exp Med. 2016 Jun 27;213(7):1255-65. doi: 10.1084/jem.20151978. Epub 2016 Jun 13.

23.

DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations.

Andrews TD, Jeelall Y, Talaulikar D, Goodnow CC, Field MA.

PeerJ. 2016 May 24;4:e2074. doi: 10.7717/peerj.2074. eCollection 2016.

24.

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.

Wu Z, Liang R, Ohnesorg T, Cho V, Lam W, Abhayaratna WP, Gatenby PA, Perera C, Zhang Y, Whittle B, Sinclair A, Goodnow CC, Field M, Andrews TD, Cook MC.

PLoS Genet. 2016 May 26;12(5):e1006067. doi: 10.1371/journal.pgen.1006067. eCollection 2016 May.

25.

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.

Hillhouse EE, Liston A, Collin R, Desautels E, Goodnow CC, Lesage S.

Immunol Cell Biol. 2016 Aug;94(7):709-13. doi: 10.1038/icb.2016.27. Epub 2016 Apr 5.

PMID:
27046082
26.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A.

Nat Genet. 2016 May;48(5):519-27. doi: 10.1038/ng.3531. Epub 2016 Mar 21.

27.

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM.

Nature. 2016 Apr 21;532(7599):402. doi: 10.1038/nature16541. Epub 2016 Jan 13. No abstract available.

PMID:
26760210
28.

Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Lim SL, Qu ZP, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling AL, Bergmann M, Goodnow CC, Ormandy CJ, Wong L, Mann J, Scott HS, Jamsai D, Adelson DL, O'Bryan MK.

PLoS Genet. 2015 Dec 29;11(12):e1005782. doi: 10.1371/journal.pgen.1005782. eCollection 2015 Dec. No abstract available.

29.

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM.

Nature. 2015 Dec 17;528(7582):370-5. doi: 10.1038/nature16165. Epub 2015 Dec 9. Erratum in: Nature. 2016 Apr 21;532(7599):402.

PMID:
26649818
30.

Reliably Detecting Clinically Important Variants Requires Both Combined Variant Calls and Optimized Filtering Strategies.

Field MA, Cho V, Andrews TD, Goodnow CC.

PLoS One. 2015 Nov 23;10(11):e0143199. doi: 10.1371/journal.pone.0143199. eCollection 2015.

31.

A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development.

Hu DY, Yap JY, Wirasinha RC, Howard DR, Goodnow CC, Daley SR.

Immunol Cell Biol. 2016 Apr;94(4):357-66. doi: 10.1038/icb.2015.95. Epub 2015 Oct 29.

PMID:
26510893
32.

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Lim SL, Qu ZP, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling AL, Bergmann M, Goodnow CC, Ormandy CJ, Wong L, Mann J, Scott HS, Jamsai D, Adelson DL, O'Bryan MK.

PLoS Genet. 2015 Oct 23;11(10):e1005620. doi: 10.1371/journal.pgen.1005620. eCollection 2015 Oct. Erratum in: PLoS Genet. 2015 Dec;11(12):e1005782.

33.

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.

Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG, Athanasopoulos V.

Elife. 2015 Oct 23;4. pii: e08698. doi: 10.7554/eLife.08698.

34.

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.

Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16.

PMID:
26375259
35.

SnapShot: Interactions between B Cells and T Cells.

Tangye SG, Brink R, Goodnow CC, Phan TG.

Cell. 2015 Aug 13;162(4):926-6.e1. doi: 10.1016/j.cell.2015.07.055.

36.

Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5189-98. doi: 10.1073/pnas.1511585112. Epub 2015 Aug 12.

37.

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers.

Rahimpour A, Koay HF, Enders A, Clanchy R, Eckle SB, Meehan B, Chen Z, Whittle B, Liu L, Fairlie DP, Goodnow CC, McCluskey J, Rossjohn J, Uldrich AP, Pellicci DG, Godfrey DI.

J Exp Med. 2015 Jun 29;212(7):1095-108. doi: 10.1084/jem.20142110. Epub 2015 Jun 22.

38.

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Liu Y, DeBoer K, de Kretser DM, O'Donnell L, O'Connor AE, Merriner DJ, Okuda H, Whittle B, Jans DA, Efthymiadis A, McLachlan RI, Ormandy CJ, Goodnow CC, Jamsai D, O'Bryan MK.

PLoS Genet. 2015 Mar 17;11(3):e1005090. doi: 10.1371/journal.pgen.1005090. eCollection 2015 Mar.

39.

Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency.

Flesch IE, Randall KL, Hollett NA, Di Law H, Miosge LA, Sontani Y, Goodnow CC, Tscharke DC.

Immunol Cell Biol. 2015 Jul;93(6):517-21. doi: 10.1038/icb.2015.32. Epub 2015 Mar 17.

40.

Reducing the search space for causal genetic variants with VASP.

Field MA, Cho V, Cook MC, Enders A, Vinuesa CG, Whittle B, Andrews TD, Goodnow CC.

Bioinformatics. 2015 Jul 15;31(14):2377-9. doi: 10.1093/bioinformatics/btv135. Epub 2015 Mar 8.

41.

T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: implications for human immunodeficiency.

Hillen KM, Gather R, Enders A, Pircher H, Aichele P, Fisch P, Blumenthal B, Schamel WW, Straub T, Goodnow CC, Ehl S.

J Immunol. 2015 Mar 15;194(6):2725-34. doi: 10.4049/jimmunol.1400328. Epub 2015 Feb 11.

42.

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.

Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC.

J Immunol. 2015 Mar 15;194(6):2587-95. doi: 10.4049/jimmunol.1400326. Epub 2015 Feb 6.

43.

A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.

Taupin D, Lam W, Rangiah D, McCallum L, Whittle B, Zhang Y, Andrews D, Field M, Goodnow CC, Cook MC.

Hum Genome Var. 2015 Apr 16;2:15013. doi: 10.1038/hgv.2015.13. eCollection 2015.

44.

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.

Han BY, Wu S, Foo CS, Horton RM, Jenne CN, Watson SR, Whittle B, Goodnow CC, Cyster JG.

Elife. 2014 Oct 24;3. doi: 10.7554/eLife.03549.

45.

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

Lee CE, Fulcher DA, Whittle B, Chand R, Fewings N, Field M, Andrews D, Goodnow CC, Cook MC.

Blood. 2014 Nov 6;124(19):2964-72. doi: 10.1182/blood-2014-06-578542. Epub 2014 Sep 18.

46.

Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing.

Ellyard JI, Jerjen R, Martin JL, Lee AY, Field MA, Jiang SH, Cappello J, Naumann SK, Andrews TD, Scott HS, Casarotto MG, Goodnow CC, Chaitow J, Pascual V, Hertzog P, Alexander SI, Cook MC, Vinuesa CG.

Arthritis Rheumatol. 2014 Dec;66(12):3382-6.

47.

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.

48.

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.

Enders A, Short A, Miosge LA, Bergmann H, Sontani Y, Bertram EM, Whittle B, Balakishnan B, Yoshida K, Sjollema G, Field MA, Andrews TD, Hagiwara H, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4513-8. doi: 10.1073/pnas.1402739111. Epub 2014 Mar 10.

49.

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance.

Wang JQ, Jeelall YS, Beutler B, Horikawa K, Goodnow CC.

J Exp Med. 2014 Mar 10;211(3):413-26. doi: 10.1084/jem.20131424. Epub 2014 Feb 17.

50.

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.

Altin JA, Daley SR, Howitt J, Rickards HJ, Batkin AK, Horikawa K, Prasad SJ, Nelms KA, Kumar S, Wu LC, Tan SS, Cook MC, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2067-74. doi: 10.1073/pnas.1322739111. Epub 2014 Jan 13.

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