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Items: 1 to 50 of 119

1.

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients.

Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Bastaki M, Davidsen JM, Harman CL, McGowen MM, Taylor SV.

Food Chem Toxicol. 2019 Oct 8:110870. doi: 10.1016/j.fct.2019.110870. [Epub ahead of print]

2.

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.

Malik DE, David RM, Gooderham NJ.

Arch Toxicol. 2019 Oct;93(10):3005-3020. doi: 10.1007/s00204-019-02558-8. Epub 2019 Sep 12.

3.

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function.

Alkandari A, Ashrafian H, Sathyapalan T, Darzi A, Holmes E, Athanasiou T, Atkin SL, Gooderham NJ.

Front Endocrinol (Lausanne). 2019 May 21;10:319. doi: 10.3389/fendo.2019.00319. eCollection 2019.

4.

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Bastaki M, Davidsen JM, Harman CL, McGowen M, Taylor SV.

Food Chem Toxicol. 2019 Feb;124:192-218. doi: 10.1016/j.fct.2018.11.052. Epub 2018 Nov 24.

5.

Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens.

David RM, Gooderham NJ.

Arch Toxicol. 2018 Dec;92(12):3459-3469. doi: 10.1007/s00204-018-2319-4. Epub 2018 Sep 26.

6.

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells.

Malik DE, David RM, Gooderham NJ.

Arch Toxicol. 2018 Oct;92(10):3223-3239. doi: 10.1007/s00204-018-2291-z. Epub 2018 Aug 24.

7.

The safety evaluation of food flavouring substances: the role of metabolic studies.

Smith RL, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Guengerich FP, Rietjens IMCM, Bastaki M, Harman CL, McGowen MM, Taylor SV.

Toxicol Res (Camb). 2018 Mar 28;7(4):618-646. doi: 10.1039/c7tx00254h. eCollection 2018 Jul 1. Review.

8.

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans.

Alkandari A, Ashrafian H, Sathyapalan T, Sedman P, Darzi A, Holmes E, Athanasiou T, Atkin SL, Gooderham NJ.

BMC Obes. 2018 May 31;5:20. doi: 10.1186/s40608-018-0199-z. eCollection 2018.

10.

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food.

Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Davidsen JM, Harman CL, Taylor SV.

Food Chem Toxicol. 2018 Mar;113:171-178. doi: 10.1016/j.fct.2018.01.021. Epub 2018 Jan 31.

11.

2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells.

Saleh AF, Bachman M, Priestley CC, Gooderham NJ, Andersson P, Henry SP, Edmunds NJ, Fellows MD.

Toxicol Sci. 2018 May 1;163(1):70-78. doi: 10.1093/toxsci/kfy005.

12.

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.

Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD.

Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8.

13.

Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting.

Harling L, Lambert J, Ashrafian H, Darzi A, Gooderham NJ, Athanasiou T.

J Cardiothorac Surg. 2017 Aug 18;12(1):70. doi: 10.1186/s13019-017-0632-2.

14.

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV.

Food Chem Toxicol. 2017 Jan;99:40-59. doi: 10.1016/j.fct.2016.10.023. Epub 2016 Nov 9. Review.

15.

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Akingbasote JA, Foster AJ, Jones HB, David R, Gooderham NJ, Wilson ID, Kenna JG.

Toxicol Res (Camb). 2016 Nov 9;6(1):81-88. doi: 10.1039/c6tx00376a. eCollection 2017 Jan 1.

16.

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results.

Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Smith RL, Bastaki M, Harman CL, McGowen MM, Taylor SV.

Food Chem Toxicol. 2016 Dec;98(Pt B):201-209. doi: 10.1016/j.fct.2016.10.020. Epub 2016 Oct 20. Review.

17.

The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions.

Saleh AF, Fellows MD, Ying L, Gooderham NJ, Priestley CC.

Toxicol Sci. 2017 Jan;155(1):101-111. doi: 10.1093/toxsci/kfw179. Epub 2016 Sep 21.

18.

Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner.

Osborne M, Haltalli M, Currie R, Wright J, Gooderham NJ.

Toxicology. 2016 Jul 1;363-364:10-8. doi: 10.1016/j.tox.2016.07.008. Epub 2016 Jul 15.

19.

Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation.

Harling L, Lambert J, Ashrafian H, Darzi A, Gooderham NJ, Athanasiou T.

Eur J Cardiothorac Surg. 2017 Jan;51(1):73-78. doi: 10.1093/ejcts/ezw245. Epub 2016 Jul 15.

20.
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22.

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.

Kamola PJ, Kitson JD, Turner G, Maratou K, Eriksson S, Panjwani A, Warnock LC, Douillard Guilloux GA, Moores K, Koppe EL, Wixted WE, Wilson PA, Gooderham NJ, Gant TW, Clark KL, Hughes SA, Edbrooke MR, Parry JD.

Nucleic Acids Res. 2015 Oct 15;43(18):8638-50. doi: 10.1093/nar/gkv857. Epub 2015 Sep 3.

23.

IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b.

Patel SA, Gooderham NJ.

Mol Cancer Res. 2015 Nov;13(11):1502-8. doi: 10.1158/1541-7786.MCR-15-0147. Epub 2015 Jul 16.

24.

The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.

Kadir NH, David R, Rossiter JT, Gooderham NJ.

Toxicology. 2015 Aug 6;334:59-71. doi: 10.1016/j.tox.2015.06.002. Epub 2015 Jun 9.

25.

Effects of treatment with androgen receptor ligands on microRNA expression of prostate cancer cells.

Segal CV, Koufaris C, Powell C, Gooderham NJ.

Toxicology. 2015 Jul 3;333:45-52. doi: 10.1016/j.tox.2015.04.002. Epub 2015 Apr 3.

26.

Aspartame sensitivity? A double blind randomised crossover study.

Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL.

PLoS One. 2015 Mar 18;10(3):e0116212. doi: 10.1371/journal.pone.0116212. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126039.

27.

Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery.

Wu Q, Li JV, Seyfried F, le Roux CW, Ashrafian H, Athanasiou T, Fenske W, Darzi A, Nicholson JK, Holmes E, Gooderham NJ.

Int J Obes (Lond). 2015 Jul;39(7):1126-34. doi: 10.1038/ijo.2015.33. Epub 2015 Mar 18.

28.

Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.

Saleh AF, Priestley CC, Gooderham NJ, Fellows MD.

Toxicol Sci. 2015 May;145(1):169-76. doi: 10.1093/toxsci/kfv043. Epub 2015 Feb 20.

29.

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.

Patel SA, Bhambra U, Charalambous MP, David RM, Edwards RJ, Lightfoot T, Boobis AR, Gooderham NJ.

Br J Cancer. 2014 Dec 9;111(12):2287-96. doi: 10.1038/bjc.2014.540. Epub 2014 Oct 21.

30.

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.

Papaioannou MD, Koufaris C, Gooderham NJ.

Toxicol Lett. 2014 Aug 17;229(1):9-16. doi: 10.1016/j.toxlet.2014.05.021. Epub 2014 May 28.

31.

Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.

Rietjens IM, Cohen SM, Fukushima S, Gooderham NJ, Hecht S, Marnett LJ, Smith RL, Adams TB, Bastaki M, Harman CG, Taylor SV.

Chem Res Toxicol. 2014 Jul 21;27(7):1092-103. doi: 10.1021/tx500109s. Epub 2014 Jun 11.

32.

Using microRNA profiles to predict and evaluate hepatic carcinogenic potential.

Gooderham NJ, Koufaris C.

Toxicol Lett. 2014 Jul 15;228(2):127-32. doi: 10.1016/j.toxlet.2014.04.015. Epub 2014 Apr 30. Review.

33.

GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients.

Marnett LJ, Cohen SM, Fukushima S, Gooderham NJ, Hecht SS, Rietjens IM, Smith RL, Adams TB, Bastaki M, Harman CL, McGowen MM, Taylor SV.

J Food Sci. 2014 Apr;79(4):R428-41. doi: 10.1111/1750-3841.12407. Epub 2014 Apr 1.

PMID:
24689743
34.

Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and ¹H-NMR-based extracellular metabonomic assays.

Irfan A, Cauchi M, Edmands W, Gooderham NJ, Njuguna J, Zhu H.

Toxicol Sci. 2014 Apr;138(2):354-64. doi: 10.1093/toxsci/kfu009. Epub 2014 Jan 21.

35.

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome.

Koufaris C, Wright J, Osborne M, Currie RA, Gooderham NJ.

Toxicology. 2013 Dec 15;314(2-3):247-53. doi: 10.1016/j.tox.2013.10.004. Epub 2013 Oct 21.

36.

Are differences in microRNA regulation implicated in species-dependent response to toxicological exposures?

Koufaris C, Gooderham NJ.

Toxicol Sci. 2013 Feb;131(2):337-42. doi: 10.1093/toxsci/kfs302. Epub 2012 Oct 22. Review.

37.

A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation.

Reshat R, Priestley CC, Gooderham NJ.

Mutagenesis. 2012 Nov;27(6):713-9. doi: 10.1093/mutage/ges037. Epub 2012 Aug 21.

PMID:
22914677
38.

Mutagenesis by an antisense oligonucleotide and its degradation product.

Reshat R, Priestley CC, Gooderham NJ.

Toxicol Sci. 2012 Dec;130(2):319-27. doi: 10.1093/toxsci/kfs247. Epub 2012 Aug 7.

39.

Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens.

Koufaris C, Wright J, Currie RA, Gooderham NJ.

Toxicol Sci. 2012 Aug;128(2):532-43. doi: 10.1093/toxsci/kfs170. Epub 2012 May 12.

40.

Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents.

Li JV, Reshat R, Wu Q, Ashrafian H, Bueter M, le Roux CW, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes E, Gooderham NJ.

Front Microbiol. 2011 Sep 13;2:183. doi: 10.3389/fmicb.2011.00183. eCollection 2011.

41.

Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling.

Edmands WM, Beckonert OP, Stella C, Campbell A, Lake BG, Lindon JC, Holmes E, Gooderham NJ.

J Proteome Res. 2011 Oct 7;10(10):4513-21. doi: 10.1021/pr200326k. Epub 2011 Aug 31.

42.

Metabolic surgery and cancer: protective effects of bariatric procedures.

Ashrafian H, Ahmed K, Rowland SP, Patel VM, Gooderham NJ, Holmes E, Darzi A, Athanasiou T.

Cancer. 2011 May 1;117(9):1788-99. doi: 10.1002/cncr.25738. Epub 2010 Nov 29. Review.

43.

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.

Lauber SN, Gooderham NJ.

Toxicology. 2011 Jan 11;279(1-3):139-45. doi: 10.1016/j.tox.2010.10.004. Epub 2010 Oct 15.

PMID:
20951759
44.

A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.

Gu D, McNaughton L, Lemaster D, Lake BG, Gooderham NJ, Kadlubar FF, Turesky RJ.

Chem Res Toxicol. 2010 Apr 19;23(4):788-801. doi: 10.1021/tx900436m.

45.

A molecular beacon approach to detecting RAD52 expression in response to DNA damage in human cells.

Riches LC, Lynch AM, Gooderham NJ.

Toxicol In Vitro. 2010 Mar;24(2):652-60. doi: 10.1016/j.tiv.2009.09.019. Epub 2009 Sep 30.

PMID:
19799994
46.

Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.

Charalambous MP, Lightfoot T, Speirs V, Horgan K, Gooderham NJ.

Br J Cancer. 2009 Jul 7;101(1):106-15. doi: 10.1038/sj.bjc.6605120. Epub 2009 Jun 9.

47.

Biomonitoring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its carcinogenic metabolites in urine.

Fede JM, Thakur AP, Gooderham NJ, Turesky RJ.

Chem Res Toxicol. 2009 Jun;22(6):1096-105. doi: 10.1021/tx900052c.

48.

Early events in the mammalian response to DNA double-strand breaks.

Riches LC, Lynch AM, Gooderham NJ.

Mutagenesis. 2008 Sep;23(5):331-9. doi: 10.1093/mutage/gen039. Epub 2008 Jul 21. Review.

PMID:
18644834

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